U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Localized Leiomyosarcoma

MedGen UID:
163507
•Concept ID:
C0855057
•
Neoplastic Process
Synonyms: Leiomyosarcoma Nonmetastatic; Non-Metastatic Leiomyosarcoma; Primary leiomyosarcoma
SNOMED CT: Primary leiomyosarcoma (423807009)

Definition

Leiomyosarcoma that is confined to a specific site without evidence of spread to other anatomic sites. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVLocalized Leiomyosarcoma

Professional guidelines

PubMed

The biology and treatment of leiomyosarcomas.
Kerrison WGJ, Thway K, Jones RL, Huang PH
Crit Rev Oncol Hematol 2023 Apr;184:103955. Epub 2023 Mar 7 doi: 10.1016/j.critrevonc.2023.103955. PMID: 36893945
Retroperitoneal tumors: Review of diagnosis and management.
Sassa N
Int J Urol 2020 Dec;27(12):1058-1070. Epub 2020 Sep 10 doi: 10.1111/iju.14361. PMID: 32914475
Role of radiotherapy treatment of uterine sarcoma.
Sampath S, Gaffney DK
Best Pract Res Clin Obstet Gynaecol 2011 Dec;25(6):761-72. Epub 2011 Jul 23 doi: 10.1016/j.bpobgyn.2011.06.004. PMID: 21783424

Recent clinical studies

Etiology

Cutaneous Mesenchymal Sarcomas.
Walocko F, Christensen RE, Worley B, Alam M
Dermatol Clin 2023 Jan;41(1):133-140. Epub 2022 Oct 28 doi: 10.1016/j.det.2022.07.011. PMID: 36410974
Doxorubicin alone versus doxorubicin with trabectedin followed by trabectedin alone as first-line therapy for metastatic or unresectable leiomyosarcoma (LMS-04): a randomised, multicentre, open-label phase 3 trial.
Pautier P, Italiano A, Piperno-Neumann S, Chevreau C, Penel N, Firmin N, Boudou-Rouquette P, Bertucci F, Balleyguier C, Lebrun-Ly V, Ray-Coquard I, Kalbacher E, Bardet A, Bompas E, Collard O, Isambert N, Guillemet C, Rios M, Archambaud B, Duffaud F; French Sarcoma Group
Lancet Oncol 2022 Aug;23(8):1044-1054. Epub 2022 Jul 11 doi: 10.1016/S1470-2045(22)00380-1. PMID: 35835135
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Systemic treatment in adult uterine sarcomas.
Desar IME, Ottevanger PB, Benson C, van der Graaf WTA
Crit Rev Oncol Hematol 2018 Feb;122:10-20. Epub 2017 Dec 14 doi: 10.1016/j.critrevonc.2017.12.009. PMID: 29458779
Cutaneous leiomyosarcoma.
Porter CJ, Januszkiewicz JS
Plast Reconstr Surg 2002 Mar;109(3):964-7. doi: 10.1097/00006534-200203000-00024. PMID: 11884817

Diagnosis

Pelvic soft tissue sarcomas.
Sarre-Lazcano C, Dumitra S, Fiore M
Eur J Surg Oncol 2023 Jun;49(6):1102-1110. Epub 2022 Jun 4 doi: 10.1016/j.ejso.2022.06.003. PMID: 35725682
Being the ultimate travel companion of a patient with uterine leiomyosarcoma.
Grignani G, Merlini A, Aliberti S
Future Oncol 2022 Sep;18(29s):17-23. Epub 2022 Sep 28 doi: 10.2217/fon-2022-0637. PMID: 36169665
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Primary pulmonary leiomyosarcoma.
Shen W, Chen J, Wei S, Wang X, Li X, Zhou Q
J Chin Med Assoc 2014 Jan;77(1):49-51. Epub 2013 Nov 18 doi: 10.1016/j.jcma.2013.10.009. PMID: 24263234
Cutaneous leiomyosarcoma.
Ikari Y, Tokuhashi I, Haramoto I, Morita M, Chiba T, Shimoda N, Mizoguchi M, Seki K, Tadokoro M, Ohya K
J Dermatol 1992 Feb;19(2):99-104. doi: 10.1111/j.1346-8138.1992.tb03188.x. PMID: 1377726

Therapy

Doxorubicin-Trabectedin with Trabectedin Maintenance in Leiomyosarcoma.
Pautier P, Italiano A, Piperno-Neumann S, Chevreau C, Penel N, Firmin N, Boudou-Rouquette P, Bertucci F, Lebrun-Ly V, Ray-Coquard I, Kalbacher E, Bompas E, Collard O, Isambert N, Guillemet C, Rios M, Le Cesne A, Balleyguier C, Archambaud B, Duffaud F; French Sarcoma Group
N Engl J Med 2024 Sep 5;391(9):789-799. doi: 10.1056/NEJMoa2403394. PMID: 39231341
Doxorubicin alone versus doxorubicin with trabectedin followed by trabectedin alone as first-line therapy for metastatic or unresectable leiomyosarcoma (LMS-04): a randomised, multicentre, open-label phase 3 trial.
Pautier P, Italiano A, Piperno-Neumann S, Chevreau C, Penel N, Firmin N, Boudou-Rouquette P, Bertucci F, Balleyguier C, Lebrun-Ly V, Ray-Coquard I, Kalbacher E, Bardet A, Bompas E, Collard O, Isambert N, Guillemet C, Rios M, Archambaud B, Duffaud F; French Sarcoma Group
Lancet Oncol 2022 Aug;23(8):1044-1054. Epub 2022 Jul 11 doi: 10.1016/S1470-2045(22)00380-1. PMID: 35835135
Hormone Replacement Therapy in Cancer Survivors - Review of the Literature.
Deli T, Orosz M, Jakab A
Pathol Oncol Res 2020 Jan;26(1):63-78. Epub 2019 Jan 8 doi: 10.1007/s12253-018-00569-x. PMID: 30617760Free PMC Article
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Gastrointestinal stromal tumors.
Blanke CD, Eisenberg BL, Heinrich MC
Curr Treat Options Oncol 2001 Dec;2(6):485-91. doi: 10.1007/s11864-001-0070-0. PMID: 12057094

Prognosis

Doxorubicin alone versus doxorubicin with trabectedin followed by trabectedin alone as first-line therapy for metastatic or unresectable leiomyosarcoma (LMS-04): a randomised, multicentre, open-label phase 3 trial.
Pautier P, Italiano A, Piperno-Neumann S, Chevreau C, Penel N, Firmin N, Boudou-Rouquette P, Bertucci F, Balleyguier C, Lebrun-Ly V, Ray-Coquard I, Kalbacher E, Bardet A, Bompas E, Collard O, Isambert N, Guillemet C, Rios M, Archambaud B, Duffaud F; French Sarcoma Group
Lancet Oncol 2022 Aug;23(8):1044-1054. Epub 2022 Jul 11 doi: 10.1016/S1470-2045(22)00380-1. PMID: 35835135
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Leiomyosarcoma of the hand.
Angelini A, Barastegui D, Gambarotti M, Ruggieri P
Handchir Mikrochir Plast Chir 2015 Apr;47(2):139-41. Epub 2015 Apr 21 doi: 10.1055/s-0034-1395605. PMID: 25897583
Personalizing surgical margins in retroperitoneal sarcomas.
Callegaro D, Fiore M, Gronchi A
Expert Rev Anticancer Ther 2015 May;15(5):553-67. Epub 2015 Mar 23 doi: 10.1586/14737140.2015.1028375. PMID: 25797538
Cutaneous leiomyosarcoma.
Porter CJ, Januszkiewicz JS
Plast Reconstr Surg 2002 Mar;109(3):964-7. doi: 10.1097/00006534-200203000-00024. PMID: 11884817

Clinical prediction guides

Preoperative Radiotherapy in Patients With Primary Retroperitoneal Sarcoma: EORTC-62092 Trial (STRASS) Versus Off-trial (STREXIT) Results.
Callegaro D, Raut CP, Ajayi T, Strauss D, Bonvalot S, Ng D, Stoeckle E, Fairweather M, Rutkowski P, van Houdt WJ, Gelderblom H, Sangalli C, Hayes A, Honoré C, Gladdy RA, Fau M, Haas R, Tzanis D, Miah AB, Chung P, Baldini EH, Marreaud S, Litiere S, Swallow CJ, Gronchi A
Ann Surg 2023 Jul 1;278(1):127-134. Epub 2022 Jul 14 doi: 10.1097/SLA.0000000000005492. PMID: 35833413
Pelvic soft tissue sarcomas.
Sarre-Lazcano C, Dumitra S, Fiore M
Eur J Surg Oncol 2023 Jun;49(6):1102-1110. Epub 2022 Jun 4 doi: 10.1016/j.ejso.2022.06.003. PMID: 35725682
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Uterine Leiomyosarcoma.
Juhasz-Böss I, Gabriel L, Bohle RM, Horn LC, Solomayer EF, Breitbach GP
Oncol Res Treat 2018;41(11):680-686. Epub 2018 Oct 16 doi: 10.1159/000494299. PMID: 30321869
Cutaneous leiomyosarcoma.
Porter CJ, Januszkiewicz JS
Plast Reconstr Surg 2002 Mar;109(3):964-7. doi: 10.1097/00006534-200203000-00024. PMID: 11884817

Recent systematic reviews

Leiomyosarcoma of the rectum: A systematic review of recent literature.
Annicchiarico A, Montali F, Baldinu M, Casali L, Virgilio E, Costi R
J Surg Oncol 2024 Feb;129(2):365-380. Epub 2023 Oct 10 doi: 10.1002/jso.27481. PMID: 37814590
Evaluation of the efficacy of systemic therapy for advanced uterine leiomyosarcoma: A systematic review, meta-analysis, and meta-regression analysis.
Ijaz I, Shahzad MN, Hosseinifard H, Liu S, Sefidan MO, Kahloon LE, Imani S, Hua Z, Zhang YQ
Cancer Med 2023 Jul;12(13):13894-13911. Epub 2023 Apr 20 doi: 10.1002/cam4.5930. PMID: 37081717Free PMC Article
Leiomyosarcoma in the extremities and trunk wall: systematic review and meta-analysis of the oncological outcomes.
Kannan S, Chong HH, Chew B, Ferguson JD, Galloway E, McCulloch T, Rankin KS, Ashford RU
World J Surg Oncol 2022 Apr 18;20(1):124. doi: 10.1186/s12957-022-02584-4. PMID: 35436892Free PMC Article
A Systematic Review of the Treatment of Superficial Leiomyosarcoma With Mohs Micrographic Surgery.
Murphy-Chutorian B, Routt E, Vinelli G, Ciocon D
Dermatol Surg 2019 Dec;45(12):1437-1441. doi: 10.1097/DSS.0000000000001992. PMID: 31397774
Neoadjuvant radiotherapy for retroperitoneal sarcoma: A systematic review.
Cheng H, Miura JT, Lalehzari M, Rajeev R, Donahue AE, Bedi M, Gamblin TC, Turaga KK, Johnston FM
J Surg Oncol 2016 May;113(6):628-34. Epub 2016 Mar 16 doi: 10.1002/jso.24221. PMID: 26990903

Supplemental Content

Table of contents

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...