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Recurrent Acute Undifferentiated Leukemia

MedGen UID:
1640402
•Concept ID:
C2367458
•
Neoplastic Process
Synonym: Acute Undifferentiated Leukemia in Relapse

Definition

The reemergence of acute undifferentiated leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Acute Undifferentiated Leukemia

Professional guidelines

PubMed

FLAG-IDA in the treatment of refractory/relapsed acute leukaemias: single centre study.
Hashmi KU, Khan B, Ahmed P, Raza S, Hussain I, Mahmood A, Iqbal H, Malik HS, Anwar M
J Pak Med Assoc 2005 Jun;55(6):234-8. PMID: 16045091
Treatment of relapsed or refractory acute leukemia in childhood with bisantrene combined with high dose aracytine.
Leblanc T, Deméocq F, Leverger G, Baruchel A, Lemerle S, Vannier JP, Nelken B, Guillot T, Schaison G
Med Pediatr Oncol 1994;22(2):119-24. doi: 10.1002/mpo.2950220211. PMID: 8259097
A phase II study of high-dose cytosine arabinoside in the treatment of acute leukaemia in adults.
Barnett MJ, Rohatiner AZ, Ganesan TS, Richards MA, Miller A, Lister TA
Cancer Chemother Pharmacol 1987;19(2):169-71. doi: 10.1007/BF00254573. PMID: 3471368

Recent clinical studies

Etiology

Outcomes of patients undergoing third hematopoietic cell transplantation for hematologic malignancies.
Cox ER, Summers C, Milano F, Dahlberg A, Bleakley M, Sandmaier BM, Thakar MS
Ann Hematol 2024 Sep;103(9):3737-3743. Epub 2024 Jul 14 doi: 10.1007/s00277-024-05774-0. PMID: 39003390
Expression and prognostic value of hemopoietic cytokine receptors in acute myeloid leukemia (AML): implications for future therapeutical strategies.
Graf M, Hecht K, Reif S, Pelka-Fleischer R, Pfister K, Schmetzer H
Eur J Haematol 2004 Feb;72(2):89-106. doi: 10.1046/j.0902-4441.2003.00184.x. PMID: 14962246
Treatment of relapsed or refractory acute leukemia in childhood with bisantrene combined with high dose aracytine.
Leblanc T, Deméocq F, Leverger G, Baruchel A, Lemerle S, Vannier JP, Nelken B, Guillot T, Schaison G
Med Pediatr Oncol 1994;22(2):119-24. doi: 10.1002/mpo.2950220211. PMID: 8259097
Autologous bone marrow transplantation for acute leukemia: results and prognostic factors in 90 consecutive patients.
Sierra J, Grañena A, García J, Valls A, Carreras E, Rovira M, Canals C, Martínez E, Puntí C, Algara M
Bone Marrow Transplant 1993 Nov;12(5):517-23. PMID: 8298563
Antigens associated with acute leukemia detected in the primed lymphocyte test.
Reinsmoen NL, Kersey JH, Yunis EJ
J Natl Cancer Inst 1978 Mar;60(3):537-43. doi: 10.1093/jnci/60.3.537. PMID: 146747

Diagnosis

A "SURFin' Leukemia": Acute Lymphoblastic Leukemia Masquerading as a Syndrome of Undifferentiated Recurrent Fever.
De Nardi L, D'Agostin M, Naviglio S, Trombetta A, De Martino E, Tommasini A, Rabusin M
J Pediatr Hematol Oncol 2023 Nov 1;45(8):e1023-e1024. Epub 2023 Aug 25 doi: 10.1097/MPH.0000000000002750. PMID: 37625122
Genomic Landscape of Mixed-Phenotype Acute Leukemia.
Hennawi M, Pakasticali N, Tashkandi H, Hussaini M
Int J Mol Sci 2022 Sep 24;23(19) doi: 10.3390/ijms231911259. PMID: 36232559Free PMC Article
How I Diagnose Acute Leukemia of Ambiguous Lineage.
Weinberg OK, Arber DA
Am J Clin Pathol 2022 Jul 1;158(1):27-34. doi: 10.1093/ajcp/aqac070. PMID: 35775438
Relapsed Acute Promyelocytic Leukemia Lacks "Classic" Leukemic Promyelocyte Morphology and Can Create Diagnostic Challenges.
Dayton VJ, McKenna RW, Yohe SL, Dolan MM, Courville E, Alvarez H, Linden MA
Am J Clin Pathol 2017 Jan 1;147(1):69-76. doi: 10.1093/ajcp/aqw202. PMID: 28108472
Rhabdomyosarcoma presenting as acute leukemia.
Morandi S, Manna A, Sabattini E, Porcellini A
J Pediatr Hematol Oncol 1996 Aug;18(3):305-7. doi: 10.1097/00043426-199608000-00015. PMID: 8689348

Therapy

Malignant transformations in a patient with a mediastinal germ cell tumour: lack of efficacy of bone marrow transplantation after chemotherapy on tumour recurrence.
Kassim Y, Penther D, Schneider P, Callat MP, Bastard C, Vannier JP
BMJ Case Rep 2012 Jun 14;2012 doi: 10.1136/bcr.08.2011.4663. PMID: 22707696Free PMC Article
Isolated gingival relapse of acute lymphoblastic leukemia after transplantation.
Au WY, Wong KY, Leung RY, Tong AC
J Oral Pathol Med 2008 Apr;37(4):249-51. doi: 10.1111/j.1600-0714.2007.00597.x. PMID: 18321346
Intraventricular concentration times time (C x T) methotrexate and cytarabine for patients with recurrent meningeal leukemia and lymphoma.
Moser AM, Adamson PC, Gillespie AJ, Poplack DG, Balis FM
Cancer 1999 Jan 15;85(2):511-6. doi: 10.1002/(sici)1097-0142(19990115)85:2<511::aid-cncr33>3.0.co;2-h. PMID: 10023723
Rhabdomyosarcoma presenting as acute leukemia.
Morandi S, Manna A, Sabattini E, Porcellini A
J Pediatr Hematol Oncol 1996 Aug;18(3):305-7. doi: 10.1097/00043426-199608000-00015. PMID: 8689348
Autologous bone marrow transplantation for acute leukemia: results and prognostic factors in 90 consecutive patients.
Sierra J, Grañena A, García J, Valls A, Carreras E, Rovira M, Canals C, Martínez E, Puntí C, Algara M
Bone Marrow Transplant 1993 Nov;12(5):517-23. PMID: 8298563

Prognosis

Outcomes of patients undergoing third hematopoietic cell transplantation for hematologic malignancies.
Cox ER, Summers C, Milano F, Dahlberg A, Bleakley M, Sandmaier BM, Thakar MS
Ann Hematol 2024 Sep;103(9):3737-3743. Epub 2024 Jul 14 doi: 10.1007/s00277-024-05774-0. PMID: 39003390
Methylation-Based Characterization of a New IDH2 Mutation in Sinonasal Undifferentiated Carcinoma.
Burgermeister S, Stoykova S, Krebs FS, Zoete V, Mbefo M, Egervari K, Reinhard A, Bisig B, Hewer E
Int J Mol Sci 2024 Jun 13;25(12) doi: 10.3390/ijms25126518. PMID: 38928223Free PMC Article
Genomic and global gene expression profiling in pediatric and young adult acute leukemia with PICALM::MLLT10 Fusion.
Ma J, Liu YC, Voss RK, Ma J, Palagani A, Caldwell E, Rosikiewicz W, Cardenas M, Foy S, Umeda M, Wilkinson MR, Inaba H, Klco JM, Rubnitz JE, Wang L
Leukemia 2024 May;38(5):981-990. Epub 2024 Mar 1 doi: 10.1038/s41375-024-02194-x. PMID: 38429501
Genomic Landscape of Mixed-Phenotype Acute Leukemia.
Hennawi M, Pakasticali N, Tashkandi H, Hussaini M
Int J Mol Sci 2022 Sep 24;23(19) doi: 10.3390/ijms231911259. PMID: 36232559Free PMC Article
Malignant transformations in a patient with a mediastinal germ cell tumour: lack of efficacy of bone marrow transplantation after chemotherapy on tumour recurrence.
Kassim Y, Penther D, Schneider P, Callat MP, Bastard C, Vannier JP
BMJ Case Rep 2012 Jun 14;2012 doi: 10.1136/bcr.08.2011.4663. PMID: 22707696Free PMC Article

Clinical prediction guides

Impaired cell fate through gain-of-function mutations in a chromatin reader.
Wan L, Chong S, Xuan F, Liang A, Cui X, Gates L, Carroll TS, Li Y, Feng L, Chen G, Wang SP, Ortiz MV, Daley SK, Wang X, Xuan H, Kentsis A, Muir TW, Roeder RG, Li H, Li W, Tjian R, Wen H, Allis CD
Nature 2020 Jan;577(7788):121-126. Epub 2019 Dec 18 doi: 10.1038/s41586-019-1842-7. PMID: 31853060Free PMC Article
Deletions of the transcription factor Ikaros in myeloproliferative neoplasms.
Jäger R, Gisslinger H, Passamonti F, Rumi E, Berg T, Gisslinger B, Pietra D, Harutyunyan A, Klampfl T, Olcaydu D, Cazzola M, Kralovics R
Leukemia 2010 Jul;24(7):1290-8. Epub 2010 May 27 doi: 10.1038/leu.2010.99. PMID: 20508609
Expression and prognostic value of hemopoietic cytokine receptors in acute myeloid leukemia (AML): implications for future therapeutical strategies.
Graf M, Hecht K, Reif S, Pelka-Fleischer R, Pfister K, Schmetzer H
Eur J Haematol 2004 Feb;72(2):89-106. doi: 10.1046/j.0902-4441.2003.00184.x. PMID: 14962246
CD4(+), CD56(+) DC2 acute leukemia is characterized by recurrent clonal chromosomal changes affecting 6 major targets: a study of 21 cases by the Groupe Français de Cytogénétique Hématologique.
Leroux D, Mugneret F, Callanan M, Radford-Weiss I, Dastugue N, Feuillard J, Le Mée F, Plessis G, Talmant P, Gachard N, Uettwiller F, Pages MP, Mozziconacci MJ, Eclache V, Sibille C, Avet-Loiseau H, Lafage-Pochitaloff M
Blood 2002 Jun 1;99(11):4154-9. doi: 10.1182/blood.v99.11.4154. PMID: 12010820
Immunophenotype of adult and childhood acute lymphoblastic leukemia: changes at first relapse and clinico-prognostic implications.
Guglielmi C, Cordone I, Boecklin F, Masi S, Valentini T, Vegna ML, Ferrari A, Testi AM, Foa R
Leukemia 1997 Sep;11(9):1501-7. doi: 10.1038/sj.leu.2400772. PMID: 9305605

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