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Advanced Non-Functioning Neuroendocrine Tumor

MedGen UID:
1647844
Concept ID:
C4682864
Neoplastic Process
Synonyms: Advanced Non-Functioning Well Differentiated Neuroendocrine Neoplasm; Advanced Nonfunctional Neuroendocrine Tumor; Advanced Nonfunctional Well Differentiated Neuroendocrine Neoplasm; Advanced Nonfunctioning Well Differentiated Neuroendocrine Neoplasm

Definition

A non-functioning neuroendocrine tumor that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAdvanced Non-Functioning Neuroendocrine Tumor

Professional guidelines

PubMed

Lamarca A, Bartsch DK, Caplin M, Kos-Kudla B, Kjaer A, Partelli S, Rinke A, Janson ET, Thirlwell C, van Velthuysen MF, Vullierme MP, Pavel M
J Neuroendocrinol 2024 Sep;36(9):e13423. Epub 2024 Jul 8 doi: 10.1111/jne.13423. PMID: 38977327
Subash N, Papali MM, Bahadur KP, Avanthika C, Jhaveri S, Thannir S, Joshi M, Valisekka SS
Dis Mon 2022 Jul;68(7):101304. Epub 2021 Dec 28 doi: 10.1016/j.disamonth.2021.101304. PMID: 34972546
Dumlu EG, Karakoç D, Özdemir A
Int Surg 2015 Jun;100(6):1089-97. Epub 2015 Jan 15 doi: 10.9738/INTSURG-D-14-00204.1. PMID: 25590518Free PMC Article

Recent clinical studies

Etiology

Partelli S, Landoni L, Bartolomei M, Zerbi A, Grana CM, Boggi U, Butturini G, Casadei R, Salvia R, Falconi M
Br J Surg 2024 Aug 30;111(9) doi: 10.1093/bjs/znae178. PMID: 39213395Free PMC Article
La Salvia A, Modica R, Rossi RE, Spada F, Rinzivillo M, Panzuto F, Faggiano A, Cinieri S, Fazio N
Cancer Treat Rev 2023 Jun;117:102560. Epub 2023 Apr 17 doi: 10.1016/j.ctrv.2023.102560. PMID: 37088017
Caplin ME, Pavel M, Phan AT, Ćwikła JB, Sedláčková E, Thanh XT, Wolin EM, Ruszniewski P; CLARINET Investigators
Endocrine 2021 Feb;71(2):502-513. Epub 2020 Oct 14 doi: 10.1007/s12020-020-02475-2. PMID: 33052555Free PMC Article
Guarnotta V, Martini C, Davì MV, Pizza G, Colao A, Faggiano A; NIKE group
Endocrine 2018 Apr;60(1):15-27. Epub 2017 Oct 10 doi: 10.1007/s12020-017-1420-4. PMID: 29019150
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523

Diagnosis

Acher AW, Hallet J
Surg Clin North Am 2024 Oct;104(5):1095-1111. Epub 2024 Apr 23 doi: 10.1016/j.suc.2024.03.010. PMID: 39237166
Lamarca A, Bartsch DK, Caplin M, Kos-Kudla B, Kjaer A, Partelli S, Rinke A, Janson ET, Thirlwell C, van Velthuysen MF, Vullierme MP, Pavel M
J Neuroendocrinol 2024 Sep;36(9):e13423. Epub 2024 Jul 8 doi: 10.1111/jne.13423. PMID: 38977327
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Dumlu EG, Karakoç D, Özdemir A
Int Surg 2015 Jun;100(6):1089-97. Epub 2015 Jan 15 doi: 10.9738/INTSURG-D-14-00204.1. PMID: 25590518Free PMC Article
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523

Therapy

Partelli S, Landoni L, Bartolomei M, Zerbi A, Grana CM, Boggi U, Butturini G, Casadei R, Salvia R, Falconi M
Br J Surg 2024 Aug 30;111(9) doi: 10.1093/bjs/znae178. PMID: 39213395Free PMC Article
La Salvia A, Modica R, Rossi RE, Spada F, Rinzivillo M, Panzuto F, Faggiano A, Cinieri S, Fazio N
Cancer Treat Rev 2023 Jun;117:102560. Epub 2023 Apr 17 doi: 10.1016/j.ctrv.2023.102560. PMID: 37088017
Subash N, Papali MM, Bahadur KP, Avanthika C, Jhaveri S, Thannir S, Joshi M, Valisekka SS
Dis Mon 2022 Jul;68(7):101304. Epub 2021 Dec 28 doi: 10.1016/j.disamonth.2021.101304. PMID: 34972546
Ambrosini V, Kunikowska J, Baudin E, Bodei L, Bouvier C, Capdevila J, Cremonesi M, de Herder WW, Dromain C, Falconi M, Fani M, Fanti S, Hicks RJ, Kabasakal L, Kaltsas G, Lewington V, Minozzi S, Cinquini M, Öberg K, Oyen WJG, O'Toole D, Pavel M, Ruszniewski P, Scarpa A, Strosberg J, Sundin A, Taïeb D, Virgolini I, Wild D, Herrmann K, Yao J
Eur J Cancer 2021 Mar;146:56-73. Epub 2021 Feb 12 doi: 10.1016/j.ejca.2021.01.008. PMID: 33588146Free PMC Article
Caplin ME, Pavel M, Phan AT, Ćwikła JB, Sedláčková E, Thanh XT, Wolin EM, Ruszniewski P; CLARINET Investigators
Endocrine 2021 Feb;71(2):502-513. Epub 2020 Oct 14 doi: 10.1007/s12020-020-02475-2. PMID: 33052555Free PMC Article

Prognosis

Panzuto F, Lamarca A, Fazio N
Cancer Treat Rev 2024 Sep;129:102803. Epub 2024 Jul 14 doi: 10.1016/j.ctrv.2024.102803. PMID: 39029154
Subash N, Papali MM, Bahadur KP, Avanthika C, Jhaveri S, Thannir S, Joshi M, Valisekka SS
Dis Mon 2022 Jul;68(7):101304. Epub 2021 Dec 28 doi: 10.1016/j.disamonth.2021.101304. PMID: 34972546
Espinosa-Olarte P, La Salvia A, Riesco-Martinez MC, Anton-Pascual B, Garcia-Carbonero R
Rev Endocr Metab Disord 2021 Sep;22(3):595-614. Epub 2021 Apr 11 doi: 10.1007/s11154-021-09638-0. PMID: 33843007Free PMC Article
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555
O'Grady HL, Conlon KC
Eur J Surg Oncol 2008 Mar;34(3):324-32. Epub 2007 Oct 29 doi: 10.1016/j.ejso.2007.07.209. PMID: 17967523

Clinical prediction guides

Partelli S, Landoni L, Bartolomei M, Zerbi A, Grana CM, Boggi U, Butturini G, Casadei R, Salvia R, Falconi M
Br J Surg 2024 Aug 30;111(9) doi: 10.1093/bjs/znae178. PMID: 39213395Free PMC Article
Panzuto F, Lamarca A, Fazio N
Cancer Treat Rev 2024 Sep;129:102803. Epub 2024 Jul 14 doi: 10.1016/j.ctrv.2024.102803. PMID: 39029154
Okawa Y, Tsuchikawa T, Hatanaka KC, Matsui A, Tanaka K, Nakanishi Y, Asano T, Noji T, Nakamura T, Mitsuhashi T, Okamura K, Hatanaka Y, Hirano S
Pancreas 2022 Apr 1;51(4):338-344. Epub 2022 Jun 14 doi: 10.1097/MPA.0000000000002029. PMID: 35699685
Sato A, Masui T, Yogo A, Uchida Y, Nakano K, Anazawa T, Nagai K, Takaori K, Nakamoto Y, Uemoto S
J Hepatobiliary Pancreat Sci 2020 Jul;27(7):414-420. Epub 2020 May 14 doi: 10.1002/jhbp.734. PMID: 32196985
Cho CM
Korean J Gastroenterol 2019 Mar 25;73(3):124-131. doi: 10.4166/kjg.2019.73.3.124. PMID: 31013555

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