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Thyroid Gland Follicular Carcinoma, Widely Invasive

MedGen UID:
1655103
•Concept ID:
C4744587
•
Neoplastic Process
Synonym: FTC, Widely Invasive

Definition

A follicular carcinoma of the thyroid gland with extension into surrounding thyroid or extrathyroid tissues. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVThyroid Gland Follicular Carcinoma, Widely Invasive

Professional guidelines

PubMed

Evaluation of the follicular patterned thyroid lesions based on the WHO 2022 criteria with an emphasis on the grey-zone lesions.
Misra S, Dhawan S, Badwal S, Sengupta A, Khosla A, Agarwal SK, Rao S
Ann Diagn Pathol 2024 Aug;71:152282. Epub 2024 Feb 14 doi: 10.1016/j.anndiagpath.2024.152282. PMID: 38522359
Management of follicular thyroid carcinoma should be individualised based on degree of capsular and vascular invasion.
O'Neill CJ, Vaughan L, Learoyd DL, Sidhu SB, Delbridge LW, Sywak MS
Eur J Surg Oncol 2011 Feb;37(2):181-5. Epub 2010 Dec 8 doi: 10.1016/j.ejso.2010.11.005. PMID: 21144693
Classification and treatment of follicular thyroid neoplasms are discordant between and within medical specialties.
Perrier ND, Ituarte PH, Treseler P, D'Avanzo A, Siperstein A, Duh QY, Clark OH
Surgery 1999 Dec;126(6):1063-8; discussion 1069. doi: 10.1067/msy.2099.101424. PMID: 10598189

Recent clinical studies

Etiology

Clinical and Histopathological Risk Factors for Radioactive Iodine-Refractory Follicular and Oncocytic Thyroid Carcinoma.
Stegenga MT, van Velsen EFS, Oudijk L, Verburg FA, van Ginhoven TM, Peeters RP, Medici M, Visser WE, van Kemenade FJ
J Clin Endocrinol Metab 2024 Nov 18;109(12):e2334-e2341. doi: 10.1210/clinem/dgae084. PMID: 38349206Free PMC Article
Risk factors for death of follicular thyroid carcinoma: a systematic review and meta-analysis.
Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H
Endocrine 2023 Dec;82(3):457-466. Epub 2023 Oct 7 doi: 10.1007/s12020-023-03466-9. PMID: 37804444Free PMC Article
Follicular and Hurthle Cell Carcinoma: Comparison of Clinicopathological Features and Clinical Outcomes.
Matsuura D, Yuan A, Wang L, Ranganath R, Adilbay D, Harries V, Patel S, Tuttle M, Xu B, Ghossein R, Ganly I
Thyroid 2022 Mar;32(3):245-254. doi: 10.1089/thy.2021.0424. PMID: 35078345Free PMC Article
Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations.
Park H, Shin HC, Yang H, Heo J, Ki CS, Kim HS, Kim JH, Hahn SY, Chung YJ, Kim SW, Chung JH, Oh YL, Kim TH
Mod Pathol 2022 Feb;35(2):186-192. Epub 2021 Sep 8 doi: 10.1038/s41379-021-00907-6. PMID: 34497362Free PMC Article
Diagnostic and therapeutic strategies for minimally and widely invasive follicular thyroid carcinomas.
Huang CC, Hsueh C, Liu FH, Chao TC, Lin JD
Surg Oncol 2011 Mar;20(1):1-6. Epub 2009 Jul 10 doi: 10.1016/j.suronc.2009.06.006. PMID: 19596568

Diagnosis

Clinical and Histopathological Risk Factors for Radioactive Iodine-Refractory Follicular and Oncocytic Thyroid Carcinoma.
Stegenga MT, van Velsen EFS, Oudijk L, Verburg FA, van Ginhoven TM, Peeters RP, Medici M, Visser WE, van Kemenade FJ
J Clin Endocrinol Metab 2024 Nov 18;109(12):e2334-e2341. doi: 10.1210/clinem/dgae084. PMID: 38349206Free PMC Article
Prognosis and influencing factors of follicular thyroid cancer.
Shen J, Yan M, Chen L, Ou D, Yao J, Feng N, Zhou X, Lei Z, Xu D
Cancer Med 2024 Jan;13(1):e6727. Epub 2023 Dec 16 doi: 10.1002/cam4.6727. PMID: 38102879Free PMC Article
Prognostic factors for follicular thyroid carcinoma: the importance of vascular invasion.
Ito Y, Hirokawa M, Masuoka H, Higashiyama T, Kihara M, Onoda N, Miya A, Miyauchi A
Endocr J 2022 Sep 28;69(9):1149-1156. Epub 2022 Apr 29 doi: 10.1507/endocrj.EJ22-0077. PMID: 35491160
Ultrasonographic features for differentiating follicular thyroid carcinoma and follicular adenoma.
Kuo TC, Wu MH, Chen KY, Hsieh MS, Chen A, Chen CN
Asian J Surg 2020 Jan;43(1):339-346. Epub 2019 Jun 8 doi: 10.1016/j.asjsur.2019.04.016. PMID: 31182260
Diagnostic and therapeutic strategies for minimally and widely invasive follicular thyroid carcinomas.
Huang CC, Hsueh C, Liu FH, Chao TC, Lin JD
Surg Oncol 2011 Mar;20(1):1-6. Epub 2009 Jul 10 doi: 10.1016/j.suronc.2009.06.006. PMID: 19596568

Therapy

Clinical Outcomes and Implications of Radioactive Iodine Therapy on Cancer-specific Survival in WHO Classification of FTC.
Li G, Ye Z, Wei T, Zhu J, Li Z, Lei J
J Clin Endocrinol Metab 2024 Aug 13;109(9):2294-2305. doi: 10.1210/clinem/dgae122. PMID: 38436929
Clinical and Histopathological Risk Factors for Radioactive Iodine-Refractory Follicular and Oncocytic Thyroid Carcinoma.
Stegenga MT, van Velsen EFS, Oudijk L, Verburg FA, van Ginhoven TM, Peeters RP, Medici M, Visser WE, van Kemenade FJ
J Clin Endocrinol Metab 2024 Nov 18;109(12):e2334-e2341. doi: 10.1210/clinem/dgae084. PMID: 38349206Free PMC Article
Prognostic factors of minimally invasive follicular thyroid carcinoma: extensive vascular invasion significantly affects patient prognosis.
Ito Y, Hirokawa M, Masuoka H, Yabuta T, Kihara M, Higashiyama T, Takamura Y, Kobayashi K, Miya A, Miyauchi A
Endocr J 2013;60(5):637-42. Epub 2013 Jan 18 doi: 10.1507/endocrj.ej12-0419. PMID: 23327839
Outcomes and prognostic factors of 251 patients with minimally invasive follicular thyroid carcinoma.
Sugino K, Kameyama K, Ito K, Nagahama M, Kitagawa W, Shibuya H, Ohkuwa K, Yano Y, Uruno T, Akaishi J, Suzuki A, Masaki C, Ito K
Thyroid 2012 Aug;22(8):798-804. doi: 10.1089/thy.2012.0051. PMID: 22853727
Diagnostic and therapeutic strategies for minimally and widely invasive follicular thyroid carcinomas.
Huang CC, Hsueh C, Liu FH, Chao TC, Lin JD
Surg Oncol 2011 Mar;20(1):1-6. Epub 2009 Jul 10 doi: 10.1016/j.suronc.2009.06.006. PMID: 19596568

Prognosis

Clinical and Histopathological Risk Factors for Radioactive Iodine-Refractory Follicular and Oncocytic Thyroid Carcinoma.
Stegenga MT, van Velsen EFS, Oudijk L, Verburg FA, van Ginhoven TM, Peeters RP, Medici M, Visser WE, van Kemenade FJ
J Clin Endocrinol Metab 2024 Nov 18;109(12):e2334-e2341. doi: 10.1210/clinem/dgae084. PMID: 38349206Free PMC Article
Prevalence of Differentiated High-Grade Thyroid Carcinoma Among Well-Differentiated Tumors: A Systematic Review and Meta-Analysis.
Poma AM, Macerola E, Ghossein RA, Tallini G, Basolo F
Thyroid 2024 Mar;34(3):314-323. doi: 10.1089/thy.2023.0350. PMID: 38115626Free PMC Article
Prognosis and influencing factors of follicular thyroid cancer.
Shen J, Yan M, Chen L, Ou D, Yao J, Feng N, Zhou X, Lei Z, Xu D
Cancer Med 2024 Jan;13(1):e6727. Epub 2023 Dec 16 doi: 10.1002/cam4.6727. PMID: 38102879Free PMC Article
Risk factors for death of follicular thyroid carcinoma: a systematic review and meta-analysis.
Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H
Endocrine 2023 Dec;82(3):457-466. Epub 2023 Oct 7 doi: 10.1007/s12020-023-03466-9. PMID: 37804444Free PMC Article
Follicular and Hurthle Cell Carcinoma: Comparison of Clinicopathological Features and Clinical Outcomes.
Matsuura D, Yuan A, Wang L, Ranganath R, Adilbay D, Harries V, Patel S, Tuttle M, Xu B, Ghossein R, Ganly I
Thyroid 2022 Mar;32(3):245-254. doi: 10.1089/thy.2021.0424. PMID: 35078345Free PMC Article

Clinical prediction guides

Clinical Outcomes and Implications of Radioactive Iodine Therapy on Cancer-specific Survival in WHO Classification of FTC.
Li G, Ye Z, Wei T, Zhu J, Li Z, Lei J
J Clin Endocrinol Metab 2024 Aug 13;109(9):2294-2305. doi: 10.1210/clinem/dgae122. PMID: 38436929
Prognostic factors for follicular thyroid carcinoma: the importance of vascular invasion.
Ito Y, Hirokawa M, Masuoka H, Higashiyama T, Kihara M, Onoda N, Miya A, Miyauchi A
Endocr J 2022 Sep 28;69(9):1149-1156. Epub 2022 Apr 29 doi: 10.1507/endocrj.EJ22-0077. PMID: 35491160
Molecular classification of follicular thyroid carcinoma based on TERT promoter mutations.
Park H, Shin HC, Yang H, Heo J, Ki CS, Kim HS, Kim JH, Hahn SY, Chung YJ, Kim SW, Chung JH, Oh YL, Kim TH
Mod Pathol 2022 Feb;35(2):186-192. Epub 2021 Sep 8 doi: 10.1038/s41379-021-00907-6. PMID: 34497362Free PMC Article
Expression and clinicopathological role of miR146a in thyroid follicular carcinoma.
Pignatti E, Vighi E, Magnani E, Kara E, Roncati L, Maiorana A, Santi D, Madeo B, Cioni K, Carani C, Rochira V, Simoni M, Brigante G
Endocrine 2019 Jun;64(3):575-583. Epub 2019 Jan 30 doi: 10.1007/s12020-019-01845-9. PMID: 30701447
Comprehensive Genetic Analysis of Follicular Thyroid Carcinoma Predicts Prognosis Independent of Histology.
Nicolson NG, Murtha TD, Dong W, Paulsson JO, Choi J, Barbieri AL, Brown TC, Kunstman JW, Larsson C, Prasad ML, Korah R, Lifton RP, Juhlin CC, Carling T
J Clin Endocrinol Metab 2018 Jul 1;103(7):2640-2650. doi: 10.1210/jc.2018-00277. PMID: 29726952

Recent systematic reviews

Prevalence of Differentiated High-Grade Thyroid Carcinoma Among Well-Differentiated Tumors: A Systematic Review and Meta-Analysis.
Poma AM, Macerola E, Ghossein RA, Tallini G, Basolo F
Thyroid 2024 Mar;34(3):314-323. doi: 10.1089/thy.2023.0350. PMID: 38115626Free PMC Article
Risk factors for death of follicular thyroid carcinoma: a systematic review and meta-analysis.
Zhang T, He L, Wang Z, Dong W, Sun W, Zhang P, Zhang H
Endocrine 2023 Dec;82(3):457-466. Epub 2023 Oct 7 doi: 10.1007/s12020-023-03466-9. PMID: 37804444Free PMC Article

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