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Metastatic Neuroblastoma

MedGen UID:
1660128
•Concept ID:
C4722306
•
Neoplastic Process

Definition

A neuroblastoma that has metastasized from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Neuroblastoma

Professional guidelines

PubMed

Mechanisms, Characteristics, and Treatment of Neuropathic Pain and Peripheral Neuropathy Associated with Dinutuximab in Neuroblastoma Patients.
Mastrangelo S, Rivetti S, Triarico S, Romano A, Attinà G, Maurizi P, Ruggiero A
Int J Mol Sci 2021 Nov 23;22(23) doi: 10.3390/ijms222312648. PMID: 34884452Free PMC Article
Incidence, Survival, and Treatment of Localized and Metastatic Neuroblastoma in Germany 1979-2015.
Berthold F, Spix C, Kaatsch P, Lampert F
Paediatr Drugs 2017 Dec;19(6):577-593. doi: 10.1007/s40272-017-0251-3. PMID: 28786082Free PMC Article
Hypothyroidism after treatment of metastatic neuroblastoma.
Lackner H, Urban C, Sovinz P, Nebl A, Schmidt S, Benesch M, Schwinger W
Pediatr Blood Cancer 2010 Oct;55(4):768. doi: 10.1002/pbc.22593. PMID: 20806369

Recent clinical studies

Etiology

Risk factors and novel predictive models for metastatic neuroblastoma in children.
Lin Y, Wang Z, Liu S
Eur J Surg Oncol 2023 Dec;49(12):107110. Epub 2023 Oct 6 doi: 10.1016/j.ejso.2023.107110. PMID: 37862722
Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.
Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550Free PMC Article
GD2-targeted immunotherapy and radioimmunotherapy.
Dobrenkov K, Cheung NK
Semin Oncol 2014 Oct;41(5):589-612. Epub 2014 Jul 21 doi: 10.1053/j.seminoncol.2014.07.003. PMID: 25440605Free PMC Article
CT and MRI of pediatric skull lesions with fluid-fluid levels.
Nabavizadeh SA, Bilaniuk LT, Feygin T, Shekdar KV, Zimmerman RA, Vossough A
AJNR Am J Neuroradiol 2014 Mar;35(3):604-8. Epub 2013 Aug 22 doi: 10.3174/ajnr.A3712. PMID: 23969345Free PMC Article
Breast masses in childhood and adolescence. A presentation of 17 cases and a review of the literature.
Boothroyd A, Carty H
Pediatr Radiol 1994;24(2):81-4. doi: 10.1007/BF02020157. PMID: 8078727

Diagnosis

Metastatic neuroblastoma mimicking an infantile hemangioma.
Chiloeches Fernández C, Feito Rodríguez M, Rodríguez Bandera A, Quintana Castanedo L, Ruiz Bravo E, de Lucas Laguna R
Pediatr Dermatol 2021 Jan;38(1):316-317. Epub 2020 Oct 25 doi: 10.1111/pde.14421. PMID: 33099811
Intraoperative discovery of neuroblastoma in an infant with pulmonary atresia.
McElhinney DB, Reddy VM, Feuerstein BG, Marx GR, Hanley FL
Ann Thorac Surg 1997 Dec;64(6):1827-9. doi: 10.1016/s0003-4975(97)01067-9. PMID: 9436587
Metastatic neuroblastoma.
Luisiri A, Sundaram M, Silberstein MJ, Graviss ER, McGuire M
Orthopedics 1986 Nov;9(11):1586, 1589-91. doi: 10.3928/0147-7447-19861101-16. PMID: 3797355
Coagulopathy of disseminated neuroblastoma.
Scott JP, Morgan E
J Pediatr 1983 Aug;103(2):219-22. doi: 10.1016/s0022-3476(83)80348-5. PMID: 6875712
Chemotherapy of metastatic neuroblastoma.
Hartmann JR
J Pediatr Surg 1968 Feb;3(1):181-2. doi: 10.1016/0022-3468(68)91012-9. PMID: 5655572

Therapy

Venetoclax plus cyclophosphamide and topotecan in heavily pre-treated relapsed metastatic neuroblastoma: a single center case series.
De Ioris MA, Fabozzi F, Del Bufalo F, Del Baldo G, Villani MF, Cefalo MG, Garganese MC, Stracuzzi A, Tangari F, Greco AM, Giovannoni I, Carta R, D'Andrea ML, Mastronuzzi A, Locatelli F
Sci Rep 2023 Nov 7;13(1):19295. doi: 10.1038/s41598-023-44993-9. PMID: 37935707Free PMC Article
Anti-GD2 Directed Immunotherapy for High-Risk and Metastatic Neuroblastoma.
Chan GC, Chan CM
Biomolecules 2022 Feb 24;12(3) doi: 10.3390/biom12030358. PMID: 35327550Free PMC Article
Sustained Response to Entrectinib in an Infant With a Germline ALKAL2 Variant and Refractory Metastatic Neuroblastoma With Chromosomal 2p Gain and Anaplastic Lymphoma Kinase and Tropomyosin Receptor Kinase Activation.
Treis D, Umapathy G, Fransson S, Guan J, Mendoza-García P, Siaw JT, Wessman S, Gordon Murkes L, Stenman JJE, Djos A, Elfman LHM, Johnsen JI, Hallberg B, Palmer RH, Martinsson T, Kogner P
JCO Precis Oncol 2022 Jan;6:e2100271. doi: 10.1200/PO.21.00271. PMID: 35085006Free PMC Article
Constitutive Signaling from an Engineered IL7 Receptor Promotes Durable Tumor Elimination by Tumor-Redirected T Cells.
Shum T, Omer B, Tashiro H, Kruse RL, Wagner DL, Parikh K, Yi Z, Sauer T, Liu D, Parihar R, Castillo P, Liu H, Brenner MK, Metelitsa LS, Gottschalk S, Rooney CM
Cancer Discov 2017 Nov;7(11):1238-1247. Epub 2017 Aug 22 doi: 10.1158/2159-8290.CD-17-0538. PMID: 28830878Free PMC Article
Chemotherapy of metastatic neuroblastoma.
Hartmann JR
J Pediatr Surg 1968 Feb;3(1):181-2. doi: 10.1016/0022-3468(68)91012-9. PMID: 5655572

Prognosis

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Venetoclax plus cyclophosphamide and topotecan in heavily pre-treated relapsed metastatic neuroblastoma: a single center case series.
De Ioris MA, Fabozzi F, Del Bufalo F, Del Baldo G, Villani MF, Cefalo MG, Garganese MC, Stracuzzi A, Tangari F, Greco AM, Giovannoni I, Carta R, D'Andrea ML, Mastronuzzi A, Locatelli F
Sci Rep 2023 Nov 7;13(1):19295. doi: 10.1038/s41598-023-44993-9. PMID: 37935707Free PMC Article
Risk factors and novel predictive models for metastatic neuroblastoma in children.
Lin Y, Wang Z, Liu S
Eur J Surg Oncol 2023 Dec;49(12):107110. Epub 2023 Oct 6 doi: 10.1016/j.ejso.2023.107110. PMID: 37862722
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma.
Moghimi B, Muthugounder S, Jambon S, Tibbetts R, Hung L, Bassiri H, Hogarty MD, Barrett DM, Shimada H, Asgharzadeh S
Nat Commun 2021 Jan 21;12(1):511. doi: 10.1038/s41467-020-20785-x. PMID: 33479234Free PMC Article
Chemotherapy of metastatic neuroblastoma.
Hartmann JR
J Pediatr Surg 1968 Feb;3(1):181-2. doi: 10.1016/0022-3468(68)91012-9. PMID: 5655572

Clinical prediction guides

Single-cell analyses of metastatic bone marrow in human neuroblastoma reveals microenvironmental remodeling and metastatic signature.
Mei S, Alchahin AM, Embaie BT, Gavriliuc IM, Verhoeven BM, Zhao T, Li X, Jeffries NE, Pepich A, Sarkar H, Olsen TK, Wickström M, Stenman J, Reina-Bedoya O, Kharchenko PV, Saylor PJ, Johnsen JI, Sykes DB, Kogner P, Baryawno N
JCI Insight 2024 Feb 15;9(6) doi: 10.1172/jci.insight.173337. PMID: 38358826Free PMC Article
Venetoclax plus cyclophosphamide and topotecan in heavily pre-treated relapsed metastatic neuroblastoma: a single center case series.
De Ioris MA, Fabozzi F, Del Bufalo F, Del Baldo G, Villani MF, Cefalo MG, Garganese MC, Stracuzzi A, Tangari F, Greco AM, Giovannoni I, Carta R, D'Andrea ML, Mastronuzzi A, Locatelli F
Sci Rep 2023 Nov 7;13(1):19295. doi: 10.1038/s41598-023-44993-9. PMID: 37935707Free PMC Article
Risk factors and novel predictive models for metastatic neuroblastoma in children.
Lin Y, Wang Z, Liu S
Eur J Surg Oncol 2023 Dec;49(12):107110. Epub 2023 Oct 6 doi: 10.1016/j.ejso.2023.107110. PMID: 37862722
Preclinical assessment of the efficacy and specificity of GD2-B7H3 SynNotch CAR-T in metastatic neuroblastoma.
Moghimi B, Muthugounder S, Jambon S, Tibbetts R, Hung L, Bassiri H, Hogarty MD, Barrett DM, Shimada H, Asgharzadeh S
Nat Commun 2021 Jan 21;12(1):511. doi: 10.1038/s41467-020-20785-x. PMID: 33479234Free PMC Article
Establishment and characterization of new orthotopic and metastatic neuroblastoma models.
Daudigeos-Dubus E, LE Dret L, Rouffiac V, Bawa O, Leguerney I, Opolon P, Vassal G, Geoerger B
In Vivo 2014 Jul-Aug;28(4):425-34. PMID: 24982206

Recent systematic reviews

Incidence of subclinical and overt hypothyroidism in children treated with [131I]mIBG: a systematic review and meta-analysis.
Fiz F, Piticchio T, Bottoni G, Sorrentino S, Fragola M, Livellara V, Trimboli P, Piccardo A
Q J Nucl Med Mol Imaging 2024 Mar;68(1):40-47. Epub 2024 Feb 6 doi: 10.23736/S1824-4785.24.03552-0. PMID: 38319674

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