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Metastatic Renal Cell Carcinoma

MedGen UID:
1661275
Concept ID:
C4721698
Neoplastic Process
Synonym: Metastatic renal cell carcinoma
SNOMED CT: Metastatic renal cell carcinoma (702392008); Metastatic renal cell carcinoma (838281000)

Definition

Renal cell carcinoma that has spread from the kidney to other anatomic sites. [from NCI]

Professional guidelines

PubMed

Gebrael G, Sahu KK, Agarwal N, Maughan BL
Hum Vaccin Immunother 2023 Dec 31;19(1):2193528. Epub 2023 Apr 16 doi: 10.1080/21645515.2023.2193528. PMID: 37062953Free PMC Article
Roussel E, Beuselinck B, Albersen M
Nat Rev Urol 2022 Aug;19(8):455-456. Epub 2022 Jun 9 doi: 10.1038/s41585-022-00615-z. PMID: 35681057
Louie PK, Sayari AJ, Frank RM, An HS, Colman MW
JBJS Rev 2019 Sep;7(9):e7. doi: 10.2106/JBJS.RVW.19.00002. PMID: 31567620

Recent clinical studies

Etiology

Grünwald V, Powles T, Kopyltsov E, Kozlov V, Alonso-Gordoa T, Eto M, Hutson T, Motzer R, Winquist E, Maroto P, Keam B, Procopio G, Wong S, Melichar B, Rolland F, Oya M, Rodriguez-Lopez K, Saito K, McKenzie J, Porta C
Eur Urol Oncol 2023 Aug;6(4):437-446. Epub 2023 Jan 29 doi: 10.1016/j.euo.2023.01.010. PMID: 36720658Free PMC Article
Dilme RV, Rivas JG, Campi R, Puente J, Jerez T, Enikeev D, Esperto F, Sierra JM
Curr Urol Rep 2021 Oct 16;22(11):54. doi: 10.1007/s11934-021-01073-7. PMID: 34654989
Becher E, Jericevic D, Huang WC
Urol Clin North Am 2020 Aug;47(3):389-397. Epub 2020 Jun 11 doi: 10.1016/j.ucl.2020.04.004. PMID: 32600540
Dr Hall B, Abel EJ
Urol Clin North Am 2020 Aug;47(3):379-388. Epub 2020 Jun 10 doi: 10.1016/j.ucl.2020.04.012. PMID: 32600539
Motzer RJ, Hutson TE, Glen H, Michaelson MD, Molina A, Eisen T, Jassem J, Zolnierek J, Maroto JP, Mellado B, Melichar B, Tomasek J, Kremer A, Kim HJ, Wood K, Dutcus C, Larkin J
Lancet Oncol 2015 Nov;16(15):1473-1482. Epub 2015 Oct 22 doi: 10.1016/S1470-2045(15)00290-9. PMID: 26482279

Diagnosis

Abrahams JM, Song Z
Am J Gastroenterol 2024 Feb 1;119(2):243. Epub 2023 Oct 19 doi: 10.14309/ajg.0000000000002533. PMID: 37782264
Bakouny Z, El Zarif T, Dudani S, Connor Wells J, Gan CL, Donskov F, Shapiro J, Davis ID, Parnis F, Ravi P, Steinharter JA, Agarwal N, Alva A, Wood L, Kapoor A, Ruiz Morales JM, Kollmannsberger C, Beuselinck B, Xie W, Heng DYC, Choueiri TK
Eur Urol 2023 Feb;83(2):145-151. Epub 2022 Oct 20 doi: 10.1016/j.eururo.2022.10.004. PMID: 36272943
Grossen A, Kastens DJ, Salem G
Clin Gastroenterol Hepatol 2020 Dec;18(13):e153. Epub 2019 Sep 6 doi: 10.1016/j.cgh.2019.08.051. PMID: 31499248
Ramalingam S, George DJ, Harrison MR
Clin Adv Hematol Oncol 2018 Feb;16(2):110-114. PMID: 29741510
Heng DY, Xie W, Regan MM, Harshman LC, Bjarnason GA, Vaishampayan UN, Mackenzie M, Wood L, Donskov F, Tan MH, Rha SY, Agarwal N, Kollmannsberger C, Rini BI, Choueiri TK
Lancet Oncol 2013 Feb;14(2):141-8. Epub 2013 Jan 9 doi: 10.1016/S1470-2045(12)70559-4. PMID: 23312463Free PMC Article

Therapy

Motzer RJ, Powles T, Atkins MB, Escudier B, McDermott DF, Alekseev BY, Lee JL, Suarez C, Stroyakovskiy D, De Giorgi U, Donskov F, Mellado B, Banchereau R, Hamidi H, Khan O, Craine V, Huseni M, Flinn N, Dubey S, Rini BI
JAMA Oncol 2022 Feb 1;8(2):275-280. doi: 10.1001/jamaoncol.2021.5981. PMID: 34940781Free PMC Article
Rappold PM, Silagy AW, Kotecha RR, Hakimi AA
J Surg Oncol 2021 Mar;123(3):739-750. doi: 10.1002/jso.26339. PMID: 33595892Free PMC Article
Chowdhury N, Drake CG
Urol Clin North Am 2020 Nov;47(4):419-431. doi: 10.1016/j.ucl.2020.07.009. PMID: 33008493
McDermott DF, Rini BI
BJU Int 2007 May;99(5 Pt B):1282-8. doi: 10.1111/j.1464-410X.2007.06818.x. PMID: 17441925
Drug Ther Bull 1993 Apr 13;31(8):29-30. PMID: 8348884

Prognosis

Yanagisawa T, Mori K, Matsukawa A, Kawada T, Katayama S, Bekku K, Laukhtina E, Rajwa P, Quhal F, Pradere B, Fukuokaya W, Iwatani K, Murakami M, Bensalah K, Grünwald V, Schmidinger M, Shariat SF, Kimura T
Cancer Immunol Immunother 2024 Jan 30;73(2):38. doi: 10.1007/s00262-023-03621-1. PMID: 38289361Free PMC Article
Plimack ER, Powles T, Stus V, Gafanov R, Nosov D, Waddell T, Alekseev B, Pouliot F, Melichar B, Soulières D, Borchiellini D, McDermott RS, Vynnychenko I, Chang YH, Tamada S, Atkins MB, Li C, Perini R, Molife LR, Bedke J, Rini BI
Eur Urol 2023 Nov;84(5):449-454. Epub 2023 Jul 25 doi: 10.1016/j.eururo.2023.06.006. PMID: 37500340
Albiges L, Tannir NM, Burotto M, McDermott D, Plimack ER, Barthélémy P, Porta C, Powles T, Donskov F, George S, Kollmannsberger CK, Gurney H, Grimm MO, Tomita Y, Castellano D, Rini BI, Choueiri TK, Saggi SS, McHenry MB, Motzer RJ
ESMO Open 2020 Nov;5(6):e001079. doi: 10.1136/esmoopen-2020-001079. PMID: 33246931Free PMC Article
Motzer RJ, Rini BI, McDermott DF, Arén Frontera O, Hammers HJ, Carducci MA, Salman P, Escudier B, Beuselinck B, Amin A, Porta C, George S, Neiman V, Bracarda S, Tykodi SS, Barthélémy P, Leibowitz-Amit R, Plimack ER, Oosting SF, Redman B, Melichar B, Powles T, Nathan P, Oudard S, Pook D, Choueiri TK, Donskov F, Grimm MO, Gurney H, Heng DYC, Kollmannsberger CK, Harrison MR, Tomita Y, Duran I, Grünwald V, McHenry MB, Mekan S, Tannir NM; CheckMate 214 investigators
Lancet Oncol 2019 Oct;20(10):1370-1385. Epub 2019 Aug 16 doi: 10.1016/S1470-2045(19)30413-9. PMID: 31427204Free PMC Article
Heng DY, Xie W, Regan MM, Harshman LC, Bjarnason GA, Vaishampayan UN, Mackenzie M, Wood L, Donskov F, Tan MH, Rha SY, Agarwal N, Kollmannsberger C, Rini BI, Choueiri TK
Lancet Oncol 2013 Feb;14(2):141-8. Epub 2013 Jan 9 doi: 10.1016/S1470-2045(12)70559-4. PMID: 23312463Free PMC Article

Clinical prediction guides

Santoni M, Buti S, Myint ZW, Maruzzo M, Iacovelli R, Pichler M, Kopecky J, Kucharz J, Rizzo M, Galli L, Büttner T, De Giorgi U, Kanesvaran R, Fiala O, Grande E, Zucali PA, Kopp RM, Fornarini G, Bourlon MT, Scagliarini S, Molina-Cerrillo J, Aurilio G, Matrana MR, Pichler R, Cattrini C, Büchler T, Massari F, Seront E, Calabrò F, Pinto A, Berardi R, Zgura A, Mammone G, Ansari J, Atzori F, Chiari R, Bamias A, Caffo O, Procopio G, Sunela K, Bassanelli M, Ortega C, Grillone F, Landmesser J, Milella M, Messina C, Küronya Z, Mosca A, Bhuva D, Santini D, Vau N, Morelli F, Incorvaia L, Rebuzzi SE, Roviello G, Soares A, Bisonni R, Bimbatti D, Zabalza IO, Rizzo A, Mollica V, Sorgentoni G, Monteiro FSM, Battelli N, Bracarda S, Porta C
Eur Urol Oncol 2024 Feb;7(1):102-111. Epub 2023 Jul 21 doi: 10.1016/j.euo.2023.07.003. PMID: 37481365
Sazuka T, Arai T, Sato H, Goto Y, Sakamoto S, Ichikawa T
Int J Urol 2023 Nov;30(11):1054-1056. Epub 2023 Jul 11 doi: 10.1111/iju.15249. PMID: 37431967
Dilme RV, Rivas JG, Campi R, Puente J, Jerez T, Enikeev D, Esperto F, Sierra JM
Curr Urol Rep 2021 Oct 16;22(11):54. doi: 10.1007/s11934-021-01073-7. PMID: 34654989
Leibovich BC, Lohse CM, Cheville JC, Zaid HB, Boorjian SA, Frank I, Thompson RH, Parker WP
Eur Urol 2018 May;73(5):772-780. Epub 2018 Feb 3 doi: 10.1016/j.eururo.2018.01.005. PMID: 29398265
McDermott DF, Atkins MB
Semin Oncol 2006 Oct;33(5):583-7. doi: 10.1053/j.seminoncol.2006.06.004. PMID: 17045087

Recent systematic reviews

Yanagisawa T, Mori K, Matsukawa A, Kawada T, Katayama S, Bekku K, Laukhtina E, Rajwa P, Quhal F, Pradere B, Fukuokaya W, Iwatani K, Murakami M, Bensalah K, Grünwald V, Schmidinger M, Shariat SF, Kimura T
Cancer Immunol Immunother 2024 Jan 30;73(2):38. doi: 10.1007/s00262-023-03621-1. PMID: 38289361Free PMC Article
Aldin A, Besiroglu B, Adams A, Monsef I, Piechotta V, Tomlinson E, Hornbach C, Dressen N, Goldkuhle M, Maisch P, Dahm P, Heidenreich A, Skoetz N
Cochrane Database Syst Rev 2023 May 4;5(5):CD013798. doi: 10.1002/14651858.CD013798.pub2. PMID: 37146227Free PMC Article
Rathmell WK, Rumble RB, Van Veldhuizen PJ, Al-Ahmadie H, Emamekhoo H, Hauke RJ, Louie AV, Milowsky MI, Molina AM, Rose TL, Siva S, Zaorsky NG, Zhang T, Qamar R, Kungel TM, Lewis B, Singer EA
J Clin Oncol 2022 Sep 1;40(25):2957-2995. Epub 2022 Jun 21 doi: 10.1200/JCO.22.00868. PMID: 35728020
Alam MU, Jazayeri SB, Gautam S, Norez D, Kumar J, Tanneru K, Nguyen S, Costa J, Bandyk M, Ganapathi HP, Koochekpour S, Balaji KC
Am J Clin Oncol 2020 Jul;43(7):477-483. doi: 10.1097/COC.0000000000000695. PMID: 32251121
Coppin C, Porzsolt F, Autenrieth M, Kumpf J, Coldman A, Wilt TJ
Cochrane Database Syst Rev 2015 Dec 29;2015(12):CD001425. doi: 10.1002/14651858.CD001425.pub3. PMID: 26713838Free PMC Article

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