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Recurrent T-Cell Prolymphocytic Leukemia

MedGen UID:
1668022
•Concept ID:
C4725631
•
Neoplastic Process

Definition

The reemergence of T-cell prolymphocytic leukemia after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent T-Cell Prolymphocytic Leukemia

Professional guidelines

PubMed

Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Gaillard JB, Chapiro E, Daudignon A, Nadal N, Penther D, Chauzeix J, Nguyen-Khac F, Veronese L, Lefebvre C
Curr Res Transl Med 2023 Oct-Dec;71(4):103428. Epub 2023 Oct 31 doi: 10.1016/j.retram.2023.103428. PMID: 38016421
Venetoclax treatment of patients with relapsed T-cell prolymphocytic leukemia.
Hampel PJ, Parikh SA, Call TG, Shah MV, Bennani NN, Al-Kali A, Rabe KG, Wang Y, Muchtar E, Leis JF, Kenderian SS, Koehler AB, Schwager SM, Slager SL, Kay NE, Hanson CA, Van Dyke DL, Shi M, Ding W
Blood Cancer J 2021 Mar 2;11(3):47. doi: 10.1038/s41408-021-00443-1. PMID: 33654067Free PMC Article
Management of prolymphocytic leukemia.
Dearden C
Hematology Am Soc Hematol Educ Program 2015;2015:361-7. doi: 10.1182/asheducation-2015.1.361. PMID: 26637744

Recent clinical studies

Etiology

Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Gaillard JB, Chapiro E, Daudignon A, Nadal N, Penther D, Chauzeix J, Nguyen-Khac F, Veronese L, Lefebvre C
Curr Res Transl Med 2023 Oct-Dec;71(4):103428. Epub 2023 Oct 31 doi: 10.1016/j.retram.2023.103428. PMID: 38016421
Allogeneic hematopoietic cell transplantation in T-cell prolymphocytic leukemia: A single-center experience.
Dholaria BR, Ayala E, Sokol L, Nishihori T, Chavez JC, Hussaini M, Kumar A, Kharfan-Dabaja MA
Leuk Res 2018 Apr;67:1-5. Epub 2018 Jan 31 doi: 10.1016/j.leukres.2018.01.009. PMID: 29407180
Mature T-cell leukemias: Molecular and Clinical Aspects.
Bailey NG, Elenitoba-Johnson KS
Curr Hematol Malig Rep 2015 Dec;10(4):421-8. doi: 10.1007/s11899-015-0288-8. PMID: 26433891
Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.
Bergmann AK, Schneppenheim S, Seifert M, Betts MJ, Haake A, Lopez C, Maria Murga Penas E, Vater I, Jayne S, Dyer MJ, Schrappe M, Dührsen U, Ammerpohl O, Russell RB, Küppers R, Dürig J, Siebert R
Genes Chromosomes Cancer 2014 Apr;53(4):309-16. Epub 2014 Jan 21 doi: 10.1002/gcc.22141. PMID: 24446122
Mature T-cell leukemias.
Ravandi F, Kantarjian H, Jones D, Dearden C, Keating M, O'Brien S
Cancer 2005 Nov 1;104(9):1808-18. doi: 10.1002/cncr.21405. PMID: 16136598

Diagnosis

Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Gaillard JB, Chapiro E, Daudignon A, Nadal N, Penther D, Chauzeix J, Nguyen-Khac F, Veronese L, Lefebvre C
Curr Res Transl Med 2023 Oct-Dec;71(4):103428. Epub 2023 Oct 31 doi: 10.1016/j.retram.2023.103428. PMID: 38016421
Recurrence of T-Cell Prolymphocytic Leukemia With a Rare Presentation as Diffuse Generalized Skin Lesion.
Wasifuddin M, Sabzposh H, Sun L, Wu R, Wang JC
J Investig Med High Impact Case Rep 2023 Jan-Dec;11:23247096231176223. doi: 10.1177/23247096231176223. PMID: 37219076Free PMC Article
Molecular characterization of Novel ATM fusions in chronic lymphocytic leukemia and T-cell prolymphocytic leukemia.
Kanagal-Shamanna R, Bao H, Kearney H, Smoley S, Tang Z, Luthra R, Yang H, Zhang S, Lin P, Wu D, Medeiros LJ, Lu X
Leuk Lymphoma 2022 Apr;63(4):865-875. Epub 2021 Dec 13 doi: 10.1080/10428194.2021.2010061. PMID: 34898335
Allogeneic hematopoietic cell transplantation in T-cell prolymphocytic leukemia: A single-center experience.
Dholaria BR, Ayala E, Sokol L, Nishihori T, Chavez JC, Hussaini M, Kumar A, Kharfan-Dabaja MA
Leuk Res 2018 Apr;67:1-5. Epub 2018 Jan 31 doi: 10.1016/j.leukres.2018.01.009. PMID: 29407180
Mature T-cell leukemias.
Ravandi F, Kantarjian H, Jones D, Dearden C, Keating M, O'Brien S
Cancer 2005 Nov 1;104(9):1808-18. doi: 10.1002/cncr.21405. PMID: 16136598

Therapy

A Novel JAK2 Fusion in T-Cell Prolymphocytic Leukemia.
Eren OC, Stuver R, Zhou T, Zaidinski M, Moskowitz AJ, Horwitz SM, Ewalt MD, Zhang Y, Lim MS
Genes Chromosomes Cancer 2024 Jun;63(6):e23252. doi: 10.1002/gcc.23252. PMID: 39133763
Allogeneic hematopoietic cell transplantation in T-cell prolymphocytic leukemia: A single-center experience.
Dholaria BR, Ayala E, Sokol L, Nishihori T, Chavez JC, Hussaini M, Kumar A, Kharfan-Dabaja MA
Leuk Res 2018 Apr;67:1-5. Epub 2018 Jan 31 doi: 10.1016/j.leukres.2018.01.009. PMID: 29407180
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.
Johansson P, Klein-Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, Bergmann A, Scholtysik R, Brauser M, Lollies A, Siebert R, Zenz T, Dührsen U, Küppers R, Dürig J
Blood Cancer J 2018 Jan 19;8(1):11. doi: 10.1038/s41408-017-0036-5. PMID: 29352181Free PMC Article
Management of prolymphocytic leukemia.
Dearden C
Hematology Am Soc Hematol Educ Program 2015;2015:361-7. doi: 10.1182/asheducation-2015.1.361. PMID: 26637744
Mature T-cell leukemias.
Ravandi F, Kantarjian H, Jones D, Dearden C, Keating M, O'Brien S
Cancer 2005 Nov 1;104(9):1808-18. doi: 10.1002/cncr.21405. PMID: 16136598

Prognosis

A Novel JAK2 Fusion in T-Cell Prolymphocytic Leukemia.
Eren OC, Stuver R, Zhou T, Zaidinski M, Moskowitz AJ, Horwitz SM, Ewalt MD, Zhang Y, Lim MS
Genes Chromosomes Cancer 2024 Jun;63(6):e23252. doi: 10.1002/gcc.23252. PMID: 39133763
Noncanonical Function of AGO2 Augments T-cell Receptor Signaling in T-cell Prolymphocytic Leukemia.
Braun T, Stachelscheid J, Bley N, Oberbeck S, Otte M, Müller TA, Wahnschaffe L, Glaß M, Ommer K, Franitza M, Gathof B, Altmüller J, Hallek M, Auguin D, Hüttelmaier S, Schrader A, Herling M
Cancer Res 2022 May 3;82(9):1818-1831. doi: 10.1158/0008-5472.CAN-21-1908. PMID: 35259248
Management of prolymphocytic leukemia.
Dearden C
Hematology Am Soc Hematol Educ Program 2015;2015:361-7. doi: 10.1182/asheducation-2015.1.361. PMID: 26637744
Mature T-cell leukemias: Molecular and Clinical Aspects.
Bailey NG, Elenitoba-Johnson KS
Curr Hematol Malig Rep 2015 Dec;10(4):421-8. doi: 10.1007/s11899-015-0288-8. PMID: 26433891
Recurrent mutation of JAK3 in T-cell prolymphocytic leukemia.
Bergmann AK, Schneppenheim S, Seifert M, Betts MJ, Haake A, Lopez C, Maria Murga Penas E, Vater I, Jayne S, Dyer MJ, Schrappe M, Dührsen U, Ammerpohl O, Russell RB, Küppers R, Dürig J, Siebert R
Genes Chromosomes Cancer 2014 Apr;53(4):309-16. Epub 2014 Jan 21 doi: 10.1002/gcc.22141. PMID: 24446122

Clinical prediction guides

Cytogenetics in the management of mature T-cell and NK-cell neoplasms: Guidelines from the Groupe Francophone de Cytogénétique Hématologique (GFCH).
Gaillard JB, Chapiro E, Daudignon A, Nadal N, Penther D, Chauzeix J, Nguyen-Khac F, Veronese L, Lefebvre C
Curr Res Transl Med 2023 Oct-Dec;71(4):103428. Epub 2023 Oct 31 doi: 10.1016/j.retram.2023.103428. PMID: 38016421
SAMHD1 is recurrently mutated in T-cell prolymphocytic leukemia.
Johansson P, Klein-Hitpass L, Choidas A, Habenberger P, Mahboubi B, Kim B, Bergmann A, Scholtysik R, Brauser M, Lollies A, Siebert R, Zenz T, Dührsen U, Küppers R, Dürig J
Blood Cancer J 2018 Jan 19;8(1):11. doi: 10.1038/s41408-017-0036-5. PMID: 29352181Free PMC Article
Infiltration of the thyroid gland by T-cell prolymphocytic leukemia.
Fujiwara K, Fukuhara T, Kitano H, Okazaki T
Thyroid 2014 Aug;24(8):1314-8. Epub 2014 Jun 18 doi: 10.1089/thy.2013.0462. PMID: 24762052
A complex pattern of recurrent chromosomal losses and gains in T-cell prolymphocytic leukemia.
Soulier J, Pierron G, Vecchione D, Garand R, Brizard F, Sigaux F, Stern MH, Aurias A
Genes Chromosomes Cancer 2001 Jul;31(3):248-54. doi: 10.1002/gcc.1141. PMID: 11391795
Management of chronic lymphocytic leukaemia.
Kalil N, Cheson BD
Drugs Aging 2000 Jan;16(1):9-27. doi: 10.2165/00002512-200016010-00002. PMID: 10733261

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