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Increased CSF citrulline concentration

MedGen UID:
1692896
•Concept ID:
C5139631
•
Finding
Synonym: High citrulline levels in cerebrospinal fluid
 
HPO: HP:0500246

Definition

Abnormally increased levels of citrulline in cerebrospinal fluid. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVIncreased CSF citrulline concentration

Recent clinical studies

Etiology

Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage.
Mader MM, Böger R, Appel D, Schwedhelm E, Haddad M, Mohme M, Lamszus K, Westphal M, Czorlich P, Hannemann J
J Cereb Blood Flow Metab 2021 Aug;41(8):1964-1977. Epub 2021 Jan 18 doi: 10.1177/0271678X20983216. PMID: 33461409Free PMC Article
Changes in concentration of cerebrospinal fluid components in patients with traumatic brain injury.
Toczyłowska B, Chalimoniuk M, Wodowska M, Mayzner-Zawadzk E
Brain Res 2006 Aug 9;1104(1):183-9. Epub 2006 Jun 21 doi: 10.1016/j.brainres.2006.05.057. PMID: 16793028
Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways.
Larson AA, Giovengo SL, Russell JI, Michalek JE
Pain 2000 Aug;87(2):201-211. doi: 10.1016/S0304-3959(00)00284-0. PMID: 10924813
Amino acid concentration in dementia of the Alzheimer type and multi-infarct dementia.
Mochizuki Y, Oishi M, Hara M, Takasu T
Ann Clin Lab Sci 1996 May-Jun;26(3):275-8. PMID: 8726221

Diagnosis

Neutrophil extracellular traps and neutrophil-related mediators in human thyroid cancer.
Modestino L, Cristinziano L, Poto R, Ventrici A, Trocchia M, Ferrari SM, Fallahi P, Paparo SR, Marone G, Antonelli A, Varricchi G, Galdiero MR
Front Immunol 2023;14:1167404. Epub 2023 Aug 29 doi: 10.3389/fimmu.2023.1167404. PMID: 37705974Free PMC Article
Neutrophil extracellular traps and neutrophil-derived mediators as possible biomarkers in bronchial asthma.
Varricchi G, Modestino L, Poto R, Cristinziano L, Gentile L, Postiglione L, Spadaro G, Galdiero MR
Clin Exp Med 2022 May;22(2):285-300. Epub 2021 Aug 3 doi: 10.1007/s10238-021-00750-8. PMID: 34342773Free PMC Article
Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS).
Krzystek-Korpacka M, Wiśniewski J, Fleszar MG, Bednarz-Misa I, Bronowicka-Szydełko A, Gacka M, Masłowski L, Kędzior K, Witkiewicz W, Gamian A
Oxid Med Cell Longev 2019;2019:5965721. Epub 2019 Jul 14 doi: 10.1155/2019/5965721. PMID: 31396302Free PMC Article
A case of transient neonatal citrullinemia.
Ohtake A, Takayanagi M, Ogura N, Nakajima H
Eur J Pediatr 1983 Oct;141(1):60-1. doi: 10.1007/BF00445674. PMID: 6641770

Therapy

An exploratory metabolomic comparison of participants with fast or absent functional progression from 2CARE, a randomized, double-blind clinical trial in Huntington's disease.
McGarry A, Hunter K, Gaughan J, Auinger P, Ferraro TN, Pradhan B, Ferrucci L, Egan JM, Moaddel R
Sci Rep 2024 Jan 11;14(1):1101. doi: 10.1038/s41598-023-50553-y. PMID: 38212353Free PMC Article

Prognosis

An exploratory metabolomic comparison of participants with fast or absent functional progression from 2CARE, a randomized, double-blind clinical trial in Huntington's disease.
McGarry A, Hunter K, Gaughan J, Auinger P, Ferraro TN, Pradhan B, Ferrucci L, Egan JM, Moaddel R
Sci Rep 2024 Jan 11;14(1):1101. doi: 10.1038/s41598-023-50553-y. PMID: 38212353Free PMC Article
Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS).
Krzystek-Korpacka M, Wiśniewski J, Fleszar MG, Bednarz-Misa I, Bronowicka-Szydełko A, Gacka M, Masłowski L, Kędzior K, Witkiewicz W, Gamian A
Oxid Med Cell Longev 2019;2019:5965721. Epub 2019 Jul 14 doi: 10.1155/2019/5965721. PMID: 31396302Free PMC Article
Changes in the concentrations of amino acids in the cerebrospinal fluid that correlate with pain in patients with fibromyalgia: implications for nitric oxide pathways.
Larson AA, Giovengo SL, Russell JI, Michalek JE
Pain 2000 Aug;87(2):201-211. doi: 10.1016/S0304-3959(00)00284-0. PMID: 10924813
Citrullinaemia with rapidly fatal neonatal course.
Van Der Zee SP, Trijbels JM, Monnens LA, Hommes FA, Schretlen ED
Arch Dis Child 1971 Dec;46(250):847-51. doi: 10.1136/adc.46.250.847. PMID: 5129187Free PMC Article

Clinical prediction guides

Intrathecal and systemic alterations of L-arginine metabolism in patients after intracerebral hemorrhage.
Mader MM, Böger R, Appel D, Schwedhelm E, Haddad M, Mohme M, Lamszus K, Westphal M, Czorlich P, Hannemann J
J Cereb Blood Flow Metab 2021 Aug;41(8):1964-1977. Epub 2021 Jan 18 doi: 10.1177/0271678X20983216. PMID: 33461409Free PMC Article
Effect of blood contamination of cerebrospinal fluid on amino acids, biogenic amines, pterins and vitamins.
Batllori M, Casado M, Sierra C, Salgado MDC, Marti-Sanchez L, Maynou J, Fernandez G, Garcia-Cazorla A, Ormazabal A, Molero-Luis M, Artuch R
Fluids Barriers CNS 2019 Nov 14;16(1):34. doi: 10.1186/s12987-019-0154-5. PMID: 31727079Free PMC Article
Metabolites of the Nitric Oxide (NO) Pathway Are Altered and Indicative of Reduced NO and Arginine Bioavailability in Patients with Cardiometabolic Diseases Complicated with Chronic Wounds of Lower Extremities: Targeted Metabolomics Approach (LC-MS/MS).
Krzystek-Korpacka M, Wiśniewski J, Fleszar MG, Bednarz-Misa I, Bronowicka-Szydełko A, Gacka M, Masłowski L, Kędzior K, Witkiewicz W, Gamian A
Oxid Med Cell Longev 2019;2019:5965721. Epub 2019 Jul 14 doi: 10.1155/2019/5965721. PMID: 31396302Free PMC Article
Changes in concentration of cerebrospinal fluid components in patients with traumatic brain injury.
Toczyłowska B, Chalimoniuk M, Wodowska M, Mayzner-Zawadzk E
Brain Res 2006 Aug 9;1104(1):183-9. Epub 2006 Jun 21 doi: 10.1016/j.brainres.2006.05.057. PMID: 16793028
Cerebrospinal fluid and plasma concentrations of nitric oxide metabolites are increased in dementia with Lewy bodies.
Molina JA, Leza JC, Ortiz S, Moro MA, Pérez S, Lizasoaín I, Urigüen L, Oliva JM, Manzanares J
Neurosci Lett 2002 Nov 22;333(2):151-3. doi: 10.1016/s0304-3940(02)01026-1. PMID: 12419502

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