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Resectable Osteosarcoma

MedGen UID:
1693492
•Concept ID:
C5206724
•
Neoplastic Process

Definition

Osteosarcoma that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Osteosarcoma

Professional guidelines

PubMed

Orphan drugs revisited: cost-effectiveness analysis of the addition of mifamurtide to the conventional treatment of osteosarcoma.
Brosa M, García del Muro X, Mora J, Villacampa A, Pozo-Rubio T, Cubells L, Montoto C
Expert Rev Pharmacoecon Outcomes Res 2015 Apr;15(2):331-40. Epub 2014 Oct 29 doi: 10.1586/14737167.2015.972378. PMID: 25354299
Mifamurtide: a review of its use in the treatment of osteosarcoma.
Frampton JE
Paediatr Drugs 2010 Jun;12(3):141-53. doi: 10.2165/11204910-000000000-00000. PMID: 20481644
Intra-arterial infusion of radiosensitizer (BUdR) combined with hypofractionated irradiation and chemotherapy for primary treatment of osteogenic sarcoma.
Martinez A, Goffinet DR, Donaldson SS, Bagshaw MA, Kaplan HS
Int J Radiat Oncol Biol Phys 1985 Jan;11(1):123-8. doi: 10.1016/0360-3016(85)90370-0. PMID: 3855408

Recent clinical studies

Etiology

A longitudinal evaluation on 3-year change of anxiety and depression, and their risk factors among parents of childhood and adolescence patients with resectable osteosarcoma: A cohort study.
Meng J, Wu J, Zhang X, Guo L, Li H
Medicine (Baltimore) 2022 Oct 21;101(42):e30981. doi: 10.1097/MD.0000000000030981. PMID: 36281181Free PMC Article
The addition of the immunomodulator mifamurtide to adjuvant chemotherapy for early osteosarcoma: a retrospective analysis.
Kokkali S, Kotsantis I, Magou E, Sophia T, Kormas T, Diakoumis G, Spathas N, Psyrri A, Ardavanis A
Invest New Drugs 2022 Jun;40(3):668-675. Epub 2022 Mar 21 doi: 10.1007/s10637-022-01225-7. PMID: 35312944
Disease progression in osteosarcoma: a multistate model for the EURAMOS-1 (European and American Osteosarcoma Study) randomised clinical trial.
Hazewinkel AD, Lancia C, Anninga J, van de Sande M, Whelan J, Gelderblom H, Fiocco M
BMJ Open 2022 Mar 4;12(3):e053083. doi: 10.1136/bmjopen-2021-053083. PMID: 35246418Free PMC Article
EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.
Whelan JS, Bielack SS, Marina N, Smeland S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T, Böhling T, Calaminus G, Capra M, Deffenbaugh C, Dhooge C, Eriksson M, Flanagan AM, Gelderblom H, Goorin A, Gorlick R, Gosheger G, Grimer RJ, Hall KS, Helmke K, Hogendoorn PC, Jundt G, Kager L, Kuehne T, Lau CC, Letson GD, Meyer J, Meyers PA, Morris C, Mottl H, Nadel H, Nagarajan R, Randall RL, Schomberg P, Schwarz R, Teot LA, Sydes MR, Bernstein M; EURAMOS collaborators
Ann Oncol 2015 Feb;26(2):407-14. Epub 2014 Nov 24 doi: 10.1093/annonc/mdu526. PMID: 25421877Free PMC Article
Intra-arterial infusion of radiosensitizer (BUdR) combined with hypofractionated irradiation and chemotherapy for primary treatment of osteogenic sarcoma.
Martinez A, Goffinet DR, Donaldson SS, Bagshaw MA, Kaplan HS
Int J Radiat Oncol Biol Phys 1985 Jan;11(1):123-8. doi: 10.1016/0360-3016(85)90370-0. PMID: 3855408

Diagnosis

Dynamic Prediction of Overall Survival for Patients with Osteosarcoma: A Retrospective Analysis of the EURAMOS-1 Clinical Trial Data.
Spreafico M, Hazewinkel AD, Gelderblom H, Fiocco M
Curr Oncol 2024 Jun 22;31(7):3630-3642. doi: 10.3390/curroncol31070267. PMID: 39057139Free PMC Article
The addition of the immunomodulator mifamurtide to adjuvant chemotherapy for early osteosarcoma: a retrospective analysis.
Kokkali S, Kotsantis I, Magou E, Sophia T, Kormas T, Diakoumis G, Spathas N, Psyrri A, Ardavanis A
Invest New Drugs 2022 Jun;40(3):668-675. Epub 2022 Mar 21 doi: 10.1007/s10637-022-01225-7. PMID: 35312944
Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma.
Im HJ, Kim TS, Park SY, Min HS, Kim JH, Kang HG, Park SE, Kwon MM, Yoon JH, Park HJ, Kim SK, Park BK
Eur J Nucl Med Mol Imaging 2012 Jan;39(1):39-49. Epub 2011 Sep 28 doi: 10.1007/s00259-011-1936-4. PMID: 21953008
Mifamurtide: a review of its use in the treatment of osteosarcoma.
Frampton JE
Paediatr Drugs 2010 Jun;12(3):141-53. doi: 10.2165/11204910-000000000-00000. PMID: 20481644
Therapy for osteosarcoma: where do we go from here?
Chou AJ, Geller DS, Gorlick R
Paediatr Drugs 2008;10(5):315-27. doi: 10.2165/00148581-200810050-00005. PMID: 18754698

Therapy

The addition of the immunomodulator mifamurtide to adjuvant chemotherapy for early osteosarcoma: a retrospective analysis.
Kokkali S, Kotsantis I, Magou E, Sophia T, Kormas T, Diakoumis G, Spathas N, Psyrri A, Ardavanis A
Invest New Drugs 2022 Jun;40(3):668-675. Epub 2022 Mar 21 doi: 10.1007/s10637-022-01225-7. PMID: 35312944
EURAMOS-1, an international randomised study for osteosarcoma: results from pre-randomisation treatment.
Whelan JS, Bielack SS, Marina N, Smeland S, Jovic G, Hook JM, Krailo M, Anninga J, Butterfass-Bahloul T, Böhling T, Calaminus G, Capra M, Deffenbaugh C, Dhooge C, Eriksson M, Flanagan AM, Gelderblom H, Goorin A, Gorlick R, Gosheger G, Grimer RJ, Hall KS, Helmke K, Hogendoorn PC, Jundt G, Kager L, Kuehne T, Lau CC, Letson GD, Meyer J, Meyers PA, Morris C, Mottl H, Nadel H, Nagarajan R, Randall RL, Schomberg P, Schwarz R, Teot LA, Sydes MR, Bernstein M; EURAMOS collaborators
Ann Oncol 2015 Feb;26(2):407-14. Epub 2014 Nov 24 doi: 10.1093/annonc/mdu526. PMID: 25421877Free PMC Article
Mifamurtide: a review of its use in the treatment of osteosarcoma.
Frampton JE
Paediatr Drugs 2010 Jun;12(3):141-53. doi: 10.2165/11204910-000000000-00000. PMID: 20481644
Therapy for osteosarcoma: where do we go from here?
Chou AJ, Geller DS, Gorlick R
Paediatr Drugs 2008;10(5):315-27. doi: 10.2165/00148581-200810050-00005. PMID: 18754698
Intra-arterial infusion of radiosensitizer (BUdR) combined with hypofractionated irradiation and chemotherapy for primary treatment of osteogenic sarcoma.
Martinez A, Goffinet DR, Donaldson SS, Bagshaw MA, Kaplan HS
Int J Radiat Oncol Biol Phys 1985 Jan;11(1):123-8. doi: 10.1016/0360-3016(85)90370-0. PMID: 3855408

Prognosis

Camrelizumab in combination with doxorubicin, cisplatin, ifosfamide, and methotrexate in neoadjuvant treatment of resectable osteosarcoma: A prospective, single-arm, exploratory phase II trial.
Tang Q, Zhang X, Zhu X, Xu H, Song G, Lu J, Wu H, Deng C, Ai F, Zhang Y, Wang J
Cancer Med 2024 Sep;13(18):e70206. doi: 10.1002/cam4.70206. PMID: 39324173Free PMC Article
Disease progression in osteosarcoma: a multistate model for the EURAMOS-1 (European and American Osteosarcoma Study) randomised clinical trial.
Hazewinkel AD, Lancia C, Anninga J, van de Sande M, Whelan J, Gelderblom H, Fiocco M
BMJ Open 2022 Mar 4;12(3):e053083. doi: 10.1136/bmjopen-2021-053083. PMID: 35246418Free PMC Article
Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma.
Im HJ, Kim TS, Park SY, Min HS, Kim JH, Kang HG, Park SE, Kwon MM, Yoon JH, Park HJ, Kim SK, Park BK
Eur J Nucl Med Mol Imaging 2012 Jan;39(1):39-49. Epub 2011 Sep 28 doi: 10.1007/s00259-011-1936-4. PMID: 21953008
Therapy for osteosarcoma: where do we go from here?
Chou AJ, Geller DS, Gorlick R
Paediatr Drugs 2008;10(5):315-27. doi: 10.2165/00148581-200810050-00005. PMID: 18754698
Intra-arterial infusion of radiosensitizer (BUdR) combined with hypofractionated irradiation and chemotherapy for primary treatment of osteogenic sarcoma.
Martinez A, Goffinet DR, Donaldson SS, Bagshaw MA, Kaplan HS
Int J Radiat Oncol Biol Phys 1985 Jan;11(1):123-8. doi: 10.1016/0360-3016(85)90370-0. PMID: 3855408

Clinical prediction guides

Camrelizumab in combination with doxorubicin, cisplatin, ifosfamide, and methotrexate in neoadjuvant treatment of resectable osteosarcoma: A prospective, single-arm, exploratory phase II trial.
Tang Q, Zhang X, Zhu X, Xu H, Song G, Lu J, Wu H, Deng C, Ai F, Zhang Y, Wang J
Cancer Med 2024 Sep;13(18):e70206. doi: 10.1002/cam4.70206. PMID: 39324173Free PMC Article
Dynamic Prediction of Overall Survival for Patients with Osteosarcoma: A Retrospective Analysis of the EURAMOS-1 Clinical Trial Data.
Spreafico M, Hazewinkel AD, Gelderblom H, Fiocco M
Curr Oncol 2024 Jun 22;31(7):3630-3642. doi: 10.3390/curroncol31070267. PMID: 39057139Free PMC Article
A longitudinal evaluation on 3-year change of anxiety and depression, and their risk factors among parents of childhood and adolescence patients with resectable osteosarcoma: A cohort study.
Meng J, Wu J, Zhang X, Guo L, Li H
Medicine (Baltimore) 2022 Oct 21;101(42):e30981. doi: 10.1097/MD.0000000000030981. PMID: 36281181Free PMC Article
Disease progression in osteosarcoma: a multistate model for the EURAMOS-1 (European and American Osteosarcoma Study) randomised clinical trial.
Hazewinkel AD, Lancia C, Anninga J, van de Sande M, Whelan J, Gelderblom H, Fiocco M
BMJ Open 2022 Mar 4;12(3):e053083. doi: 10.1136/bmjopen-2021-053083. PMID: 35246418Free PMC Article
Prediction of tumour necrosis fractions using metabolic and volumetric 18F-FDG PET/CT indices, after one course and at the completion of neoadjuvant chemotherapy, in children and young adults with osteosarcoma.
Im HJ, Kim TS, Park SY, Min HS, Kim JH, Kang HG, Park SE, Kwon MM, Yoon JH, Park HJ, Kim SK, Park BK
Eur J Nucl Med Mol Imaging 2012 Jan;39(1):39-49. Epub 2011 Sep 28 doi: 10.1007/s00259-011-1936-4. PMID: 21953008

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