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Recurrent Myeloproliferative Neoplasm

MedGen UID:
1712796
•Concept ID:
C5237728
•
Neoplastic Process

Definition

The reemergence of a myeloproliferative neoplasm after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Myeloproliferative Neoplasm

Professional guidelines

PubMed

Chronic neutrophilic leukemia and atypical chronic myeloid leukemia: 2024 update on diagnosis, genetics, risk stratification, and management.
Szuber N, Orazi A, Tefferi A
Am J Hematol 2024 Jul;99(7):1360-1387. Epub 2024 Apr 21 doi: 10.1002/ajh.27321. PMID: 38644693
European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article

Recent clinical studies

Etiology

2024 update on allogeneic hematopoietic stem cell transplant for myelofibrosis: A review of current data and applications on risk stratification and management.
Ali H, Bacigalupo A
Am J Hematol 2024 May;99(5):938-945. Epub 2024 Mar 7 doi: 10.1002/ajh.27274. PMID: 38450790
Blast phase myeloproliferative neoplasm: contemporary review and 2024 treatment algorithm.
Tefferi A, Alkhateeb H, Gangat N
Blood Cancer J 2023 Jul 18;13(1):108. doi: 10.1038/s41408-023-00878-8. PMID: 37460550Free PMC Article
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Myeloproliferative neoplasms and pregnancy: Overview and practice recommendations.
Gangat N, Tefferi A
Am J Hematol 2021 Mar 1;96(3):354-366. Epub 2020 Dec 28 doi: 10.1002/ajh.26067. PMID: 33296529
Leukemia secondary to myeloproliferative neoplasms.
Dunbar AJ, Rampal RK, Levine R
Blood 2020 Jul 2;136(1):61-70. doi: 10.1182/blood.2019000943. PMID: 32430500Free PMC Article

Diagnosis

European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Myeloid sarcoma: An overview.
Ramia de Cap M, Chen W
Semin Diagn Pathol 2023 May;40(3):129-139. Epub 2023 Apr 17 doi: 10.1053/j.semdp.2023.04.009. PMID: 37149396
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Leukemia secondary to myeloproliferative neoplasms.
Dunbar AJ, Rampal RK, Levine R
Blood 2020 Jul 2;136(1):61-70. doi: 10.1182/blood.2019000943. PMID: 32430500Free PMC Article
Another gastroenteritis?
Biskup E, Necek M, Changjin Q
Praxis (Bern 1994) 2016 May 11;105(10):581-6. doi: 10.1024/1661-8157/a002350. PMID: 27167481

Therapy

2024 update on allogeneic hematopoietic stem cell transplant for myelofibrosis: A review of current data and applications on risk stratification and management.
Ali H, Bacigalupo A
Am J Hematol 2024 May;99(5):938-945. Epub 2024 Mar 7 doi: 10.1002/ajh.27274. PMID: 38450790
Chronic myeloid leukemia: 2022 update on diagnosis, therapy, and monitoring.
Jabbour E, Kantarjian H
Am J Hematol 2022 Sep;97(9):1236-1256. Epub 2022 Jul 6 doi: 10.1002/ajh.26642. PMID: 35751859
Myeloproliferative neoplasms and pregnancy: Overview and practice recommendations.
Gangat N, Tefferi A
Am J Hematol 2021 Mar 1;96(3):354-366. Epub 2020 Dec 28 doi: 10.1002/ajh.26067. PMID: 33296529
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article
Leukemia secondary to myeloproliferative neoplasms.
Dunbar AJ, Rampal RK, Levine R
Blood 2020 Jul 2;136(1):61-70. doi: 10.1182/blood.2019000943. PMID: 32430500Free PMC Article

Prognosis

2024 update on allogeneic hematopoietic stem cell transplant for myelofibrosis: A review of current data and applications on risk stratification and management.
Ali H, Bacigalupo A
Am J Hematol 2024 May;99(5):938-945. Epub 2024 Mar 7 doi: 10.1002/ajh.27274. PMID: 38450790
European LeukemiaNet laboratory recommendations for the diagnosis and management of chronic myeloid leukemia.
Cross NCP, Ernst T, Branford S, Cayuela JM, Deininger M, Fabarius A, Kim DDH, Machova Polakova K, Radich JP, Hehlmann R, Hochhaus A, Apperley JF, Soverini S
Leukemia 2023 Nov;37(11):2150-2167. Epub 2023 Oct 4 doi: 10.1038/s41375-023-02048-y. PMID: 37794101Free PMC Article
Myeloid sarcoma: An overview.
Ramia de Cap M, Chen W
Semin Diagn Pathol 2023 May;40(3):129-139. Epub 2023 Apr 17 doi: 10.1053/j.semdp.2023.04.009. PMID: 37149396
Molecular pathogenesis of the myeloproliferative neoplasms.
Greenfield G, McMullin MF, Mills K
J Hematol Oncol 2021 Jun 30;14(1):103. doi: 10.1186/s13045-021-01116-z. PMID: 34193229Free PMC Article
Myelodysplastic syndrome/myeloproliferative neoplasm overlap syndromes: a focused review.
Patnaik MM, Lasho T
Hematology Am Soc Hematol Educ Program 2020 Dec 4;2020(1):460-464. doi: 10.1182/hematology.2020000163. PMID: 33275673Free PMC Article

Clinical prediction guides

2024 update on allogeneic hematopoietic stem cell transplant for myelofibrosis: A review of current data and applications on risk stratification and management.
Ali H, Bacigalupo A
Am J Hematol 2024 May;99(5):938-945. Epub 2024 Mar 7 doi: 10.1002/ajh.27274. PMID: 38450790
How to improve treatment-free remission eligibility in chronic myeloid leukaemia?
Costa A, Breccia M
Br J Haematol 2024 Feb;204(2):434-448. Epub 2023 Dec 26 doi: 10.1111/bjh.19269. PMID: 38148564
The leukaemia stem cell: similarities, differences and clinical prospects in CML and AML.
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
T-cell acute lymphoblastic leukemia.
Raetz EA, Teachey DT
Hematology Am Soc Hematol Educ Program 2016 Dec 2;2016(1):580-588. doi: 10.1182/asheducation-2016.1.580. PMID: 27913532Free PMC Article
Efficacy and safety of a specific inhibitor of the BCR-ABL tyrosine kinase in chronic myeloid leukemia.
Druker BJ, Talpaz M, Resta DJ, Peng B, Buchdunger E, Ford JM, Lydon NB, Kantarjian H, Capdeville R, Ohno-Jones S, Sawyers CL
N Engl J Med 2001 Apr 5;344(14):1031-7. doi: 10.1056/NEJM200104053441401. PMID: 11287972

Recent systematic reviews

Second-Generation Tyrosine Kinase Inhibitor Discontinuation in Chronic Myeloid Leukemia Patients with Stable Deep Molecular Response: A Systematic Review and a Meta-Analysis.
Di Q, Deng H, Zhao Y, Li BY, Qin L
Comput Math Methods Med 2021;2021:3110622. Epub 2021 Dec 16 doi: 10.1155/2021/3110622. PMID: 34956393Free PMC Article
Coexistent antiphospholipid syndrome and myeloproliferative neoplasm.
Sayar Z, Nallamilli S, Efthymiou M, Lambert J, Cohen H
Lupus 2021 Aug;30(9):1502-1508. Epub 2021 Jul 1 doi: 10.1177/09612033211021154. PMID: 34192956
Prognostic role of pretreatment thrombocytosis on survival in patients with cervical cancer: a systematic review and meta-analysis.
Cao W, Yao X, Cen D, Zhi Y, Zhu N, Xu L
World J Surg Oncol 2019 Aug 2;17(1):132. doi: 10.1186/s12957-019-1676-7. PMID: 31375109Free PMC Article
Imatinib discontinuation in chronic myeloid leukaemia patients with undetectable BCR-ABL transcript level: A systematic review and a meta-analysis.
Campiotti L, Suter MB, Guasti L, Piazza R, Gambacorti-Passerini C, Grandi AM, Squizzato A
Eur J Cancer 2017 May;77:48-56. Epub 2017 Mar 30 doi: 10.1016/j.ejca.2017.02.028. PMID: 28365527
The association of pretreatment thrombocytosis with prognosis and clinicopathological significance in cervical cancer: a systematic review and meta-analysis.
Cheng J, Zeng Z, Ye Q, Zhang Y, Yan R, Liang C, Wang J, Li M, Yi M
Oncotarget 2017 Apr 11;8(15):24327-24336. doi: 10.18632/oncotarget.15358. PMID: 28212582Free PMC Article

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