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Refractory Pancreatic Ductal Adenocarcinoma

MedGen UID:
1712889
Concept ID:
C5237191
Neoplastic Process

Definition

Pancreatic ductal adenocarcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Pancreatic Ductal Adenocarcinoma

Professional guidelines

PubMed

Sonbol MB, Firwana B, Wang Z, Almader-Douglas D, Borad MJ, Makhoul I, Ramanathan RK, Ahn DH, Bekaii-Saab T
Cancer 2017 Dec 1;123(23):4680-4686. Epub 2017 Aug 17 doi: 10.1002/cncr.30927. PMID: 28817187

Recent clinical studies

Etiology

Augustinus S, Bieze M, Van Veldhuisen CL, Boermeester MA, Bonsing BA, Bouwense SAW, Bruno MJ, Busch OR, Ten Hoope W, Kallewaard JW, van Kranen HJ, Niesters M, Schellekens NCJ, Steegers MAH, Voermans RP, de Vos-Geelen J, Wilmink JW, Van Zundert JHM, van Eijck CH, Besselink MG, Hollmann MW; Dutch Pancreatic Cancer Group; Dutch Pancreatitis Study Group
Clin Transl Gastroenterol 2024 Sep 1;15(9):e1. doi: 10.14309/ctg.0000000000000760. PMID: 39320960Free PMC Article
Boilève A, Cartry J, Goudarzi N, Bedja S, Mathieu JRR, Bani MA, Nicolle R, Mouawia A, Bouyakoub R, Nicotra C, Ngo-Camus M, Job B, Lipson K, Boige V, Valéry M, Tarabay A, Dartigues P, Tselikas L, de Baere T, Italiano A, Cosconea S, Gelli M, Fernandez-de-Sevilla E, Annereau M, Malka D, Smolenschi C, Ducreux M, Hollebecque A, Jaulin F
Gastroenterology 2024 Oct;167(5):961-976.e13. Epub 2024 Jun 10 doi: 10.1053/j.gastro.2024.05.032. PMID: 38866343
Anbil S, Reiss KA
Curr Treat Options Oncol 2024 Mar;25(3):346-363. Epub 2024 Jan 4 doi: 10.1007/s11864-023-01174-0. PMID: 38311708
Huffman BM, Feng H, Parmar K, Wang J, Kapner KS, Kochupurakkal B, Martignetti DB, Sadatrezaei G, Abrams TA, Biller LH, Giannakis M, Ng K, Patel AK, Perez KJ, Singh H, Rubinson DA, Schlechter BL, Andrews E, Hannigan AM, Dunwell S, Getchell Z, Raghavan S, Wolpin BM, Fortier C, D'Andrea AD, Aguirre AJ, Shapiro GI, Cleary JM
Clin Cancer Res 2023 Dec 15;29(24):5047-5056. doi: 10.1158/1078-0432.CCR-23-2005. PMID: 37819936Free PMC Article
Dev R, Fortuno ES 3rd, Amaram-Davila JS, Haider A, Bruera E
Ann Palliat Med 2023 May;12(3):600-606. Epub 2023 Mar 14 doi: 10.21037/apm-22-1167. PMID: 37038067

Diagnosis

Sun Y, Patterson-Fortin J, Han S, Li Z, Nowicka Z, Hirohashi Y, Kilgas S, Yi JK, Spektor A, Fendler W, Konstantinopoulos PA, Chowdhury D
Nat Commun 2024 Aug 6;15(1):6676. doi: 10.1038/s41467-024-50999-2. PMID: 39107288Free PMC Article
Boilève A, Cartry J, Goudarzi N, Bedja S, Mathieu JRR, Bani MA, Nicolle R, Mouawia A, Bouyakoub R, Nicotra C, Ngo-Camus M, Job B, Lipson K, Boige V, Valéry M, Tarabay A, Dartigues P, Tselikas L, de Baere T, Italiano A, Cosconea S, Gelli M, Fernandez-de-Sevilla E, Annereau M, Malka D, Smolenschi C, Ducreux M, Hollebecque A, Jaulin F
Gastroenterology 2024 Oct;167(5):961-976.e13. Epub 2024 Jun 10 doi: 10.1053/j.gastro.2024.05.032. PMID: 38866343
Lumibao JC, Tremblay JR, Hsu J, Engle DD
J Exp Med 2022 Jun 6;219(6) Epub 2022 May 6 doi: 10.1084/jem.20211505. PMID: 35522218Free PMC Article
Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL
Mol Ther 2019 Nov 6;27(11):1919-1929. Epub 2019 Jul 30 doi: 10.1016/j.ymthe.2019.07.015. PMID: 31420241Free PMC Article
Ur Rehman SS, Lim K, Wang-Gillam A
Expert Rev Anticancer Ther 2016 May;16(5):485-92. Epub 2016 Apr 22 doi: 10.1080/14737140.2016.1174581. PMID: 27043737

Therapy

Boilève A, Cartry J, Goudarzi N, Bedja S, Mathieu JRR, Bani MA, Nicolle R, Mouawia A, Bouyakoub R, Nicotra C, Ngo-Camus M, Job B, Lipson K, Boige V, Valéry M, Tarabay A, Dartigues P, Tselikas L, de Baere T, Italiano A, Cosconea S, Gelli M, Fernandez-de-Sevilla E, Annereau M, Malka D, Smolenschi C, Ducreux M, Hollebecque A, Jaulin F
Gastroenterology 2024 Oct;167(5):961-976.e13. Epub 2024 Jun 10 doi: 10.1053/j.gastro.2024.05.032. PMID: 38866343
Ku B, Eisenbarth D, Baek S, Jeong TK, Kang JG, Hwang D, Noh MG, Choi C, Choi S, Seol T, Kim H, Kim YH, Woo SM, Kong SY, Lim DS
Cell Rep Med 2024 Mar 19;5(3):101461. Epub 2024 Mar 8 doi: 10.1016/j.xcrm.2024.101461. PMID: 38460517Free PMC Article
Uddin MH, Al-Hallak MN, Khan HY, Aboukameel A, Li Y, Bannoura SF, Dyson G, Kim S, Mzannar Y, Azar I, Odisho T, Mohamed A, Landesman Y, Kim S, Beydoun R, Mohammad RM, Philip PA, Shields AF, Azmi AS
Clin Transl Med 2023 Dec;13(12):e1513. doi: 10.1002/ctm2.1513. PMID: 38131168Free PMC Article
Bardia A, Messersmith WA, Kio EA, Berlin JD, Vahdat L, Masters GA, Moroose R, Santin AD, Kalinsky K, Picozzi V, O'Shaughnessy J, Gray JE, Komiya T, Lang JM, Chang JC, Starodub A, Goldenberg DM, Sharkey RM, Maliakal P, Hong Q, Wegener WA, Goswami T, Ocean AJ
Ann Oncol 2021 Jun;32(6):746-756. Epub 2021 Mar 16 doi: 10.1016/j.annonc.2021.03.005. PMID: 33741442
Haas AR, Tanyi JL, O'Hara MH, Gladney WL, Lacey SF, Torigian DA, Soulen MC, Tian L, McGarvey M, Nelson AM, Farabaugh CS, Moon E, Levine BL, Melenhorst JJ, Plesa G, June CH, Albelda SM, Beatty GL
Mol Ther 2019 Nov 6;27(11):1919-1929. Epub 2019 Jul 30 doi: 10.1016/j.ymthe.2019.07.015. PMID: 31420241Free PMC Article

Prognosis

Boilève A, Cartry J, Goudarzi N, Bedja S, Mathieu JRR, Bani MA, Nicolle R, Mouawia A, Bouyakoub R, Nicotra C, Ngo-Camus M, Job B, Lipson K, Boige V, Valéry M, Tarabay A, Dartigues P, Tselikas L, de Baere T, Italiano A, Cosconea S, Gelli M, Fernandez-de-Sevilla E, Annereau M, Malka D, Smolenschi C, Ducreux M, Hollebecque A, Jaulin F
Gastroenterology 2024 Oct;167(5):961-976.e13. Epub 2024 Jun 10 doi: 10.1053/j.gastro.2024.05.032. PMID: 38866343
Zhou Y, Zhou X, Ben Q, Liu N, Wang J, Zhai Y, Bao Y, Zhou L
J Transl Med 2023 Dec 6;21(1):882. doi: 10.1186/s12967-023-04757-5. PMID: 38057853Free PMC Article
Yamamoto Y, Kasashima H, Fukui Y, Tsujio G, Yashiro M, Maeda K
Cancer Sci 2023 Jan;114(1):16-24. Epub 2022 Oct 19 doi: 10.1111/cas.15609. PMID: 36197901Free PMC Article
Hwang WL, Jagadeesh KA, Guo JA, Hoffman HI, Yadollahpour P, Reeves JW, Mohan R, Drokhlyansky E, Van Wittenberghe N, Ashenberg O, Farhi SL, Schapiro D, Divakar P, Miller E, Zollinger DR, Eng G, Schenkel JM, Su J, Shiau C, Yu P, Freed-Pastor WA, Abbondanza D, Mehta A, Gould J, Lambden C, Porter CBM, Tsankov A, Dionne D, Waldman J, Cuoco MS, Nguyen L, Delorey T, Phillips D, Barth JL, Kem M, Rodrigues C, Ciprani D, Roldan J, Zelga P, Jorgji V, Chen JH, Ely Z, Zhao D, Fuhrman K, Fropf R, Beechem JM, Loeffler JS, Ryan DP, Weekes CD, Ferrone CR, Qadan M, Aryee MJ, Jain RK, Neuberg DS, Wo JY, Hong TS, Xavier R, Aguirre AJ, Rozenblatt-Rosen O, Mino-Kenudson M, Castillo CF, Liss AS, Ting DT, Jacks T, Regev A
Nat Genet 2022 Aug;54(8):1178-1191. Epub 2022 Jul 28 doi: 10.1038/s41588-022-01134-8. PMID: 35902743Free PMC Article
Li J, Yuan S, Norgard RJ, Yan F, Sun YH, Kim IK, Merrell AJ, Sela Y, Jiang Y, Bhanu NV, Garcia BA, Vonderheide RH, Blanco A, Stanger BZ
Cancer Discov 2021 Mar;11(3):736-753. Epub 2020 Nov 6 doi: 10.1158/2159-8290.CD-20-0519. PMID: 33158848Free PMC Article

Clinical prediction guides

Boilève A, Cartry J, Goudarzi N, Bedja S, Mathieu JRR, Bani MA, Nicolle R, Mouawia A, Bouyakoub R, Nicotra C, Ngo-Camus M, Job B, Lipson K, Boige V, Valéry M, Tarabay A, Dartigues P, Tselikas L, de Baere T, Italiano A, Cosconea S, Gelli M, Fernandez-de-Sevilla E, Annereau M, Malka D, Smolenschi C, Ducreux M, Hollebecque A, Jaulin F
Gastroenterology 2024 Oct;167(5):961-976.e13. Epub 2024 Jun 10 doi: 10.1053/j.gastro.2024.05.032. PMID: 38866343
Pothuri VS, Hogg GD, Conant L, Borcherding N, James CA, Mudd J, Williams G, Seo YD, Hawkins WG, Pillarisetty VG, DeNardo DG, Fields RC
Oncoimmunology 2024;13(1):2320411. Epub 2024 Mar 15 doi: 10.1080/2162402X.2024.2320411. PMID: 38504847Free PMC Article
Amaria R, Knisely A, Vining D, Kopetz S, Overman MJ, Javle M, Antonoff MB, Tzeng CD, Wolff RA, Pant S, Lito K, Rangel K, Fellman B, Yuan Y, Lu KH, Sakellariou-Thompson D, Haymaker CL, Forget MA, Hwu P, Bernatchez C, Jazaeri AA
J Immunother Cancer 2024 Feb 2;12(2) doi: 10.1136/jitc-2023-006822. PMID: 38309721Free PMC Article
Newsom OJ, Sullivan LB
Cell Metab 2022 Nov 1;34(11):1617-1619. doi: 10.1016/j.cmet.2022.09.027. PMID: 36323232
Liudahl SM, Betts CB, Sivagnanam S, Morales-Oyarvide V, da Silva A, Yuan C, Hwang S, Grossblatt-Wait A, Leis KR, Larson W, Lavoie MB, Robinson P, Dias Costa A, Väyrynen SA, Clancy TE, Rubinson DA, Link J, Keith D, Horton W, Tempero MA, Vonderheide RH, Jaffee EM, Sheppard B, Goecks J, Sears RC, Park BS, Mori M, Nowak JA, Wolpin BM, Coussens LM
Cancer Discov 2021 Aug;11(8):2014-2031. Epub 2021 Mar 16 doi: 10.1158/2159-8290.CD-20-0841. PMID: 33727309Free PMC Article

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