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Desmoplastic medulloblastoma of cerebellum

MedGen UID:
1716506
•Concept ID:
C2182929
•
Neoplastic Process

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDesmoplastic medulloblastoma of cerebellum

Professional guidelines

PubMed

Factors affecting survival of medulloblastoma in children: the changing concept of management.
Wong TT, Liu YL, Ho DM, Chang KP, Liang ML, Chen HH, Lee YY, Chang FC, Lin SC, Hsu TR, Chen KW, Kwang WK, Hou WY, Wang CY, Yen SH, Guo WY, Chen YW
Childs Nerv Syst 2015 Oct;31(10):1687-98. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2884-2. PMID: 26351222
Management of pediatric and adult patients with medulloblastoma.
Martin AM, Raabe E, Eberhart C, Cohen KJ
Curr Treat Options Oncol 2014 Dec;15(4):581-94. doi: 10.1007/s11864-014-0306-4. PMID: 25194927Free PMC Article
Medulloblastoma cerebelli; diagnosis, treatment and survivals, with a report of 56 cases.
INGRAHAM FD, BAILEY OT, BARKER WF
N Engl J Med 1948 Feb 5;238(6):171-4. doi: 10.1056/NEJM194802052380601. PMID: 18899228

Recent clinical studies

Etiology

Unified rhombic lip origins of group 3 and group 4 medulloblastoma.
Smith KS, Bihannic L, Gudenas BL, Haldipur P, Tao R, Gao Q, Li Y, Aldinger KA, Iskusnykh IY, Chizhikov VV, Scoggins M, Zhang S, Edwards A, Deng M, Glass IA, Overman LM, Millman J, Sjoboen AH, Hadley J, Golser J, Mankad K, Sheppard H, Onar-Thomas A, Gajjar A, Robinson GW, Hovestadt V, Orr BA, Patay Z, Millen KJ, Northcott PA
Nature 2022 Sep;609(7929):1012-1020. Epub 2022 Sep 21 doi: 10.1038/s41586-022-05208-9. PMID: 36131015Free PMC Article
Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.
Liu APY, Smith KS, Kumar R, Paul L, Bihannic L, Lin T, Maass KK, Pajtler KW, Chintagumpala M, Su JM, Bouffet E, Fisher MJ, Gururangan S, Cohn R, Hassall T, Hansford JR, Klimo P Jr, Boop FA, Stewart CF, Harreld JH, Merchant TE, Tatevossian RG, Neale G, Lear M, Klco JM, Orr BA, Ellison DW, Gilbertson RJ, Onar-Thomas A, Gajjar A, Robinson GW, Northcott PA
Cancer Cell 2021 Nov 8;39(11):1519-1530.e4. Epub 2021 Oct 21 doi: 10.1016/j.ccell.2021.09.012. PMID: 34678152Free PMC Article
Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Medulloblastoma.
Northcott PA, Robinson GW, Kratz CP, Mabbott DJ, Pomeroy SL, Clifford SC, Rutkowski S, Ellison DW, Malkin D, Taylor MD, Gajjar A, Pfister SM
Nat Rev Dis Primers 2019 Feb 14;5(1):11. doi: 10.1038/s41572-019-0063-6. PMID: 30765705
Molecular subgroups of medulloblastoma: the current consensus.
Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM
Acta Neuropathol 2012 Apr;123(4):465-72. Epub 2011 Dec 2 doi: 10.1007/s00401-011-0922-z. PMID: 22134537Free PMC Article

Diagnosis

Unified rhombic lip origins of group 3 and group 4 medulloblastoma.
Smith KS, Bihannic L, Gudenas BL, Haldipur P, Tao R, Gao Q, Li Y, Aldinger KA, Iskusnykh IY, Chizhikov VV, Scoggins M, Zhang S, Edwards A, Deng M, Glass IA, Overman LM, Millman J, Sjoboen AH, Hadley J, Golser J, Mankad K, Sheppard H, Onar-Thomas A, Gajjar A, Robinson GW, Hovestadt V, Orr BA, Patay Z, Millen KJ, Northcott PA
Nature 2022 Sep;609(7929):1012-1020. Epub 2022 Sep 21 doi: 10.1038/s41586-022-05208-9. PMID: 36131015Free PMC Article
Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.
Liu APY, Smith KS, Kumar R, Paul L, Bihannic L, Lin T, Maass KK, Pajtler KW, Chintagumpala M, Su JM, Bouffet E, Fisher MJ, Gururangan S, Cohn R, Hassall T, Hansford JR, Klimo P Jr, Boop FA, Stewart CF, Harreld JH, Merchant TE, Tatevossian RG, Neale G, Lear M, Klco JM, Orr BA, Ellison DW, Gilbertson RJ, Onar-Thomas A, Gajjar A, Robinson GW, Northcott PA
Cancer Cell 2021 Nov 8;39(11):1519-1530.e4. Epub 2021 Oct 21 doi: 10.1016/j.ccell.2021.09.012. PMID: 34678152Free PMC Article
Medulloblastoma.
Northcott PA, Robinson GW, Kratz CP, Mabbott DJ, Pomeroy SL, Clifford SC, Rutkowski S, Ellison DW, Malkin D, Taylor MD, Gajjar A, Pfister SM
Nat Rev Dis Primers 2019 Feb 14;5(1):11. doi: 10.1038/s41572-019-0063-6. PMID: 30765705
Cerebellar tumors.
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066
Molecular subgroups of medulloblastoma: the current consensus.
Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM
Acta Neuropathol 2012 Apr;123(4):465-72. Epub 2011 Dec 2 doi: 10.1007/s00401-011-0922-z. PMID: 22134537Free PMC Article

Therapy

Serial assessment of measurable residual disease in medulloblastoma liquid biopsies.
Liu APY, Smith KS, Kumar R, Paul L, Bihannic L, Lin T, Maass KK, Pajtler KW, Chintagumpala M, Su JM, Bouffet E, Fisher MJ, Gururangan S, Cohn R, Hassall T, Hansford JR, Klimo P Jr, Boop FA, Stewart CF, Harreld JH, Merchant TE, Tatevossian RG, Neale G, Lear M, Klco JM, Orr BA, Ellison DW, Gilbertson RJ, Onar-Thomas A, Gajjar A, Robinson GW, Northcott PA
Cancer Cell 2021 Nov 8;39(11):1519-1530.e4. Epub 2021 Oct 21 doi: 10.1016/j.ccell.2021.09.012. PMID: 34678152Free PMC Article
Cerebellar tumors.
Guerreiro Stucklin AS, Grotzer MA
Handb Clin Neurol 2018;155:289-299. doi: 10.1016/B978-0-444-64189-2.00019-6. PMID: 29891066
Cerebellar mutism syndrome.
Catsman-Berrevoets C, Patay Z
Handb Clin Neurol 2018;155:273-288. doi: 10.1016/B978-0-444-64189-2.00018-4. PMID: 29891065
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Cerebellar mutism.
Pitsika M, Tsitouras V
J Neurosurg Pediatr 2013 Dec;12(6):604-14. Epub 2013 Sep 27 doi: 10.3171/2013.8.PEDS13168. PMID: 24073751

Prognosis

Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.
Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K, Ogurek S, Liu X, Rao R, Xing R, Wu LMN, Cui S, Xu L, Lin Y, Ma W, Tian S, Xie Q, Zhang L, Xin M, Wang X, Yue F, Zheng H, Liu Y, Stevenson CB, de Blank P, Perentesis JP, Gilbertson RJ, Li H, Ma J, Zhou W, Taylor MD, Lu QR
Nature 2022 Dec;612(7941):787-794. Epub 2022 Nov 30 doi: 10.1038/s41586-022-05487-2. PMID: 36450980
Childhood cerebellar tumours mirror conserved fetal transcriptional programs.
Vladoiu MC, El-Hamamy I, Donovan LK, Farooq H, Holgado BL, Sundaravadanam Y, Ramaswamy V, Hendrikse LD, Kumar S, Mack SC, Lee JJY, Fong V, Juraschka K, Przelicki D, Michealraj A, Skowron P, Luu B, Suzuki H, Morrissy AS, Cavalli FMG, Garzia L, Daniels C, Wu X, Qazi MA, Singh SK, Chan JA, Marra MA, Malkin D, Dirks P, Heisler L, Pugh T, Ng K, Notta F, Thompson EM, Kleinman CL, Joyner AL, Jabado N, Stein L, Taylor MD
Nature 2019 Aug;572(7767):67-73. Epub 2019 May 1 doi: 10.1038/s41586-019-1158-7. PMID: 31043743Free PMC Article
Medulloblastoma.
Northcott PA, Robinson GW, Kratz CP, Mabbott DJ, Pomeroy SL, Clifford SC, Rutkowski S, Ellison DW, Malkin D, Taylor MD, Gajjar A, Pfister SM
Nat Rev Dis Primers 2019 Feb 14;5(1):11. doi: 10.1038/s41572-019-0063-6. PMID: 30765705
Cerebellar mutism.
Tamburrini G, Frassanito P, Chieffo D, Massimi L, Caldarelli M, Di Rocco C
Childs Nerv Syst 2015 Oct;31(10):1841-51. Epub 2015 Sep 9 doi: 10.1007/s00381-015-2803-6. PMID: 26351234
Molecular subgroups of medulloblastoma: the current consensus.
Taylor MD, Northcott PA, Korshunov A, Remke M, Cho YJ, Clifford SC, Eberhart CG, Parsons DW, Rutkowski S, Gajjar A, Ellison DW, Lichter P, Gilbertson RJ, Pomeroy SL, Kool M, Pfister SM
Acta Neuropathol 2012 Apr;123(4):465-72. Epub 2011 Dec 2 doi: 10.1007/s00401-011-0922-z. PMID: 22134537Free PMC Article

Clinical prediction guides

Developmental basis of SHH medulloblastoma heterogeneity.
Gold MP, Ong W, Masteller AM, Ghasemi DR, Galindo JA, Park NR, Huynh NC, Donde A, Pister V, Saurez RA, Vladoiu MC, Hwang GH, Eisemann T, Donovan LK, Walker AD, Benetatos J, Dufour C, Garzia L, Segal RA, Wechsler-Reya RJ, Mesirov JP, Korshunov A, Pajtler KW, Pomeroy SL, Ayrault O, Davidson SM, Cotter JA, Taylor MD, Fraenkel E
Nat Commun 2024 Jan 8;15(1):270. doi: 10.1038/s41467-023-44300-0. PMID: 38191555Free PMC Article
Quality of Life in Paediatric Survivors of Medulloblastoma.
Tariq R, Saeed Baqai MW, Shamim MS
J Pak Med Assoc 2022 Nov;72(11):2339-2340. doi: 10.47391/JPMA.22-111. PMID: 37013321
Human fetal cerebellar cell atlas informs medulloblastoma origin and oncogenesis.
Luo Z, Xia M, Shi W, Zhao C, Wang J, Xin D, Dong X, Xiong Y, Zhang F, Berry K, Ogurek S, Liu X, Rao R, Xing R, Wu LMN, Cui S, Xu L, Lin Y, Ma W, Tian S, Xie Q, Zhang L, Xin M, Wang X, Yue F, Zheng H, Liu Y, Stevenson CB, de Blank P, Perentesis JP, Gilbertson RJ, Li H, Ma J, Zhou W, Taylor MD, Lu QR
Nature 2022 Dec;612(7941):787-794. Epub 2022 Nov 30 doi: 10.1038/s41586-022-05487-2. PMID: 36450980
Functional tracts of the cerebellum-essentials for the neurosurgeon.
Beez T, Munoz-Bendix C, Steiger HJ, Hänggi D
Neurosurg Rev 2021 Feb;44(1):273-278. Epub 2020 Feb 13 doi: 10.1007/s10143-020-01242-1. PMID: 32056026Free PMC Article
Cerebellar medulloblastoma in adults: report of 15 cases and review of the literature.
Iaconetta G, Lamaida E, Rossi A, Bernardo A, De Caro ML, Monticelli A, Maiuri F
Acta Neurol (Napoli) 1994 Feb-Apr;16(1-2):38-45. PMID: 8073915

Recent systematic reviews

Medical management for cerebellar mutism syndrome following posterior fossa surgery: A systematic review.
Turkistani AN, Alsharif TH, Aldhafeeri WF, Aljohani S, Alomar S
Clin Neurol Neurosurg 2024 Jul;242:108352. Epub 2024 May 23 doi: 10.1016/j.clineuro.2024.108352. PMID: 38823197
Cerebellar mutism syndrome caused by bilateral cerebellar hemorrhage in adults: a case report and review of the literature.
Zedde M, Grisendi I, Assenza F, Napoli M, Moratti C, Di Cecco G, Pavone C, Bonacini L, D'Aniello S, Pezzella FR, Romano A, Pavesi G, Valzania F, Pascarella R
Neurol Sci 2024 Sep;45(9):4161-4171. Epub 2024 May 9 doi: 10.1007/s10072-024-07571-z. PMID: 38724752
Neuroimaging Biomarkers and Neurocognitive Outcomes in Pediatric Medulloblastoma Patients: a Systematic Review.
Wauters M, Uyttebroeck A, De Waele L, Sleurs C, Jacobs S
Cerebellum 2021 Jun;20(3):462-480. Epub 2021 Jan 8 doi: 10.1007/s12311-020-01225-4. PMID: 33417160
Functional tracts of the cerebellum-essentials for the neurosurgeon.
Beez T, Munoz-Bendix C, Steiger HJ, Hänggi D
Neurosurg Rev 2021 Feb;44(1):273-278. Epub 2020 Feb 13 doi: 10.1007/s10143-020-01242-1. PMID: 32056026Free PMC Article

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