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Metastatic Primary Peritoneal Serous Adenocarcinoma

MedGen UID:
1726246
•Concept ID:
C5418957
•
Neoplastic Process

Definition

Primary peritoneal serous adenocarcinoma that has spread from its original site of growth to another anatomic site. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMetastatic Primary Peritoneal Serous Adenocarcinoma

Professional guidelines

PubMed

BRCA testing in women with high-grade serous ovarian cancer: gynecologic oncologist-initiated testing compared with genetics referral.
Piedimonte S, Power J, Foulkes WD, Weber E, Palma L, Schiavi A, Ambrosio E, Konci R, Gilbert L, Jardon K, Baret L, Zeng X
Int J Gynecol Cancer 2020 Nov;30(11):1757-1761. Epub 2020 Aug 5 doi: 10.1136/ijgc-2020-001261. PMID: 32759180
Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Diagnostic and therapeutic management of cancer of an unknown primary.
Pavlidis N, Briasoulis E, Hainsworth J, Greco FA
Eur J Cancer 2003 Sep;39(14):1990-2005. doi: 10.1016/s0959-8049(03)00547-1. PMID: 12957453

Recent clinical studies

Etiology

Neoadjuvant and adjuvant pembrolizumab in advanced high-grade serous carcinoma: the randomized phase II NeoPembrOV clinical trial.
Ray-Coquard IL, Savoye AM, Schiffler C, Mouret-Reynier MA, Derbel O, Kalbacher E, LeHeurteur M, Martinez A, Cornila C, Martinez M, Bengrine Lefevre L, Priou F, Cloarec N, Venat L, Selle F, Berton D, Collard O, Coquan E, Le Saux O, Treilleux I, Gouerant S, Angelergues A, Joly F, Tredan O
Nat Commun 2024 Jul 16;15(1):5931. doi: 10.1038/s41467-024-46999-x. PMID: 39013870Free PMC Article
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
MILO/ENGOT-ov11: Binimetinib Versus Physician's Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.
Monk BJ, Grisham RN, Banerjee S, Kalbacher E, Mirza MR, Romero I, Vuylsteke P, Coleman RL, Hilpert F, Oza AM, Westermann A, Oehler MK, Pignata S, Aghajanian C, Colombo N, Drill E, Cibula D, Moore KN, Christy-Bittel J, Del Campo JM, Berger R, Marth C, Sehouli J, O'Malley DM, Churruca C, Boyd AP, Kristensen G, Clamp A, Ray-Coquard I, Vergote I
J Clin Oncol 2020 Nov 10;38(32):3753-3762. Epub 2020 Aug 21 doi: 10.1200/JCO.20.01164. PMID: 32822286Free PMC Article
Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
p21WAF1/CIP1 protein expression in primary ovarian cancer.
Ferrandina G, Stoler A, Fagotti A, Fanfani F, Sacco R, De Pasqua A, Mancuso S, Scambia G
Int J Oncol 2000 Dec;17(6):1231-5. doi: 10.3892/ijo.17.6.1231. PMID: 11078810

Diagnosis

Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article
An unusual inguinal "hernia"--the value of hernioscopic assessment.
Nair A, Vijay V, Francis D
Surg Laparosc Endosc Percutan Tech 2007 Aug;17(4):349-50. doi: 10.1097/SLE.0b013e31806dbae9. PMID: 17710067
Diagnostic and therapeutic management of cancer of an unknown primary.
Pavlidis N, Briasoulis E, Hainsworth J, Greco FA
Eur J Cancer 2003 Sep;39(14):1990-2005. doi: 10.1016/s0959-8049(03)00547-1. PMID: 12957453
Role of immunohistochemistry in distinguishing epithelial peritoneal mesotheliomas from peritoneal and ovarian serous carcinomas.
Ordóñez NG
Am J Surg Pathol 1998 Oct;22(10):1203-14. doi: 10.1097/00000478-199810000-00005. PMID: 9777982

Therapy

Neoadjuvant and adjuvant pembrolizumab in advanced high-grade serous carcinoma: the randomized phase II NeoPembrOV clinical trial.
Ray-Coquard IL, Savoye AM, Schiffler C, Mouret-Reynier MA, Derbel O, Kalbacher E, LeHeurteur M, Martinez A, Cornila C, Martinez M, Bengrine Lefevre L, Priou F, Cloarec N, Venat L, Selle F, Berton D, Collard O, Coquan E, Le Saux O, Treilleux I, Gouerant S, Angelergues A, Joly F, Tredan O
Nat Commun 2024 Jul 16;15(1):5931. doi: 10.1038/s41467-024-46999-x. PMID: 39013870Free PMC Article
MILO/ENGOT-ov11: Binimetinib Versus Physician's Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.
Monk BJ, Grisham RN, Banerjee S, Kalbacher E, Mirza MR, Romero I, Vuylsteke P, Coleman RL, Hilpert F, Oza AM, Westermann A, Oehler MK, Pignata S, Aghajanian C, Colombo N, Drill E, Cibula D, Moore KN, Christy-Bittel J, Del Campo JM, Berger R, Marth C, Sehouli J, O'Malley DM, Churruca C, Boyd AP, Kristensen G, Clamp A, Ray-Coquard I, Vergote I
J Clin Oncol 2020 Nov 10;38(32):3753-3762. Epub 2020 Aug 21 doi: 10.1200/JCO.20.01164. PMID: 32822286Free PMC Article
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article
The predictors of response to neoadjuvant chemotherapy in advanced epithelial ovarian cancer.
Yildirim Y, Ertas IE, Dogan A, Gultekin OE, Gultekin E
J Surg Oncol 2012 Feb;105(2):200-5. Epub 2011 Aug 3 doi: 10.1002/jso.22053. PMID: 21815151
p21WAF1/CIP1 protein expression in primary ovarian cancer.
Ferrandina G, Stoler A, Fagotti A, Fanfani F, Sacco R, De Pasqua A, Mancuso S, Scambia G
Int J Oncol 2000 Dec;17(6):1231-5. doi: 10.3892/ijo.17.6.1231. PMID: 11078810

Prognosis

MILO/ENGOT-ov11: Binimetinib Versus Physician's Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.
Monk BJ, Grisham RN, Banerjee S, Kalbacher E, Mirza MR, Romero I, Vuylsteke P, Coleman RL, Hilpert F, Oza AM, Westermann A, Oehler MK, Pignata S, Aghajanian C, Colombo N, Drill E, Cibula D, Moore KN, Christy-Bittel J, Del Campo JM, Berger R, Marth C, Sehouli J, O'Malley DM, Churruca C, Boyd AP, Kristensen G, Clamp A, Ray-Coquard I, Vergote I
J Clin Oncol 2020 Nov 10;38(32):3753-3762. Epub 2020 Aug 21 doi: 10.1200/JCO.20.01164. PMID: 32822286Free PMC Article
Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Therapeutic strategies in epithelial ovarian cancer.
Kim A, Ueda Y, Naka T, Enomoto T
J Exp Clin Cancer Res 2012 Feb 13;31(1):14. doi: 10.1186/1756-9966-31-14. PMID: 22330607Free PMC Article
The predictors of response to neoadjuvant chemotherapy in advanced epithelial ovarian cancer.
Yildirim Y, Ertas IE, Dogan A, Gultekin OE, Gultekin E
J Surg Oncol 2012 Feb;105(2):200-5. Epub 2011 Aug 3 doi: 10.1002/jso.22053. PMID: 21815151
Is there a taxane-free interval that predicts response to taxanes as a later-line treatment of recurrent ovarian or primary peritoneal cancer?
McCourt C, Dessie S, Bradley AM, Schwartz J, Brard L, Dizon DS
Int J Gynecol Cancer 2009 Apr;19(3):343-7. doi: 10.1111/IGC.0b013e3181a12eb9. PMID: 19407557

Clinical prediction guides

Neoadjuvant and adjuvant pembrolizumab in advanced high-grade serous carcinoma: the randomized phase II NeoPembrOV clinical trial.
Ray-Coquard IL, Savoye AM, Schiffler C, Mouret-Reynier MA, Derbel O, Kalbacher E, LeHeurteur M, Martinez A, Cornila C, Martinez M, Bengrine Lefevre L, Priou F, Cloarec N, Venat L, Selle F, Berton D, Collard O, Coquan E, Le Saux O, Treilleux I, Gouerant S, Angelergues A, Joly F, Tredan O
Nat Commun 2024 Jul 16;15(1):5931. doi: 10.1038/s41467-024-46999-x. PMID: 39013870Free PMC Article
Genomic catastrophe, the peritoneal cavity and ovarian cancer prevention.
Yoon JY, Chapel DB, Goebel E, Qian X, Mito JK, Horowitz NS, Miron A, Soong TR, Xian W, Crum CP
J Pathol 2022 Jul;257(3):255-261. Epub 2022 Apr 18 doi: 10.1002/path.5891. PMID: 35238033
MILO/ENGOT-ov11: Binimetinib Versus Physician's Choice Chemotherapy in Recurrent or Persistent Low-Grade Serous Carcinomas of the Ovary, Fallopian Tube, or Primary Peritoneum.
Monk BJ, Grisham RN, Banerjee S, Kalbacher E, Mirza MR, Romero I, Vuylsteke P, Coleman RL, Hilpert F, Oza AM, Westermann A, Oehler MK, Pignata S, Aghajanian C, Colombo N, Drill E, Cibula D, Moore KN, Christy-Bittel J, Del Campo JM, Berger R, Marth C, Sehouli J, O'Malley DM, Churruca C, Boyd AP, Kristensen G, Clamp A, Ray-Coquard I, Vergote I
J Clin Oncol 2020 Nov 10;38(32):3753-3762. Epub 2020 Aug 21 doi: 10.1200/JCO.20.01164. PMID: 32822286Free PMC Article
Diagnosis and management of metastatic neoplasms with unknown primary.
Bochtler T, Löffler H, Krämer A
Semin Diagn Pathol 2018 May;35(3):199-206. Epub 2017 Nov 26 doi: 10.1053/j.semdp.2017.11.013. PMID: 29203116
Is there a taxane-free interval that predicts response to taxanes as a later-line treatment of recurrent ovarian or primary peritoneal cancer?
McCourt C, Dessie S, Bradley AM, Schwartz J, Brard L, Dizon DS
Int J Gynecol Cancer 2009 Apr;19(3):343-7. doi: 10.1111/IGC.0b013e3181a12eb9. PMID: 19407557

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