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Recurrent Ganglioneuroblastoma

MedGen UID:
1726489
•Concept ID:
C5420253
•
Neoplastic Process
Synonym: Relapsed Ganglioneuroblastoma

Definition

The reemergence of ganglioneuroblastoma after a period of remission. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRecurrent Ganglioneuroblastoma

Professional guidelines

PubMed

Anatomic patterns of relapse and progression following treatment with (131) I-MIBG in relapsed or refractory neuroblastoma.
Fishel Ben Kenan R, Polishchuk AL, Hawkins RA, Braunstein SE, Matthay KK, DuBois SG, Haas-Kogan DA
Pediatr Blood Cancer 2022 Feb;69(2):e29396. Epub 2021 Oct 18 doi: 10.1002/pbc.29396. PMID: 34662499
The clinical management and outcomes of cervical neuroblastic tumors.
Jackson JR, Tran HC, Stein JE, Shimada H, Patel AM, Marachelian A, Kim ES
J Surg Res 2016 Jul;204(1):109-13. Epub 2016 Apr 23 doi: 10.1016/j.jss.2016.04.030. PMID: 27451875Free PMC Article
Diagnosis and follow-up of neuroblastoma by means of iodine-123 metaiodobenzylguanidine scintigraphy and bone scan, and the influence of histology.
Hadj-Djilani NL, Lebtahi NE, Delaloye AB, Laurini R, Beck D
Eur J Nucl Med 1995 Apr;22(4):322-9. doi: 10.1007/BF00941848. PMID: 7607262

Recent clinical studies

Etiology

Anatomic patterns of relapse and progression following treatment with (131) I-MIBG in relapsed or refractory neuroblastoma.
Fishel Ben Kenan R, Polishchuk AL, Hawkins RA, Braunstein SE, Matthay KK, DuBois SG, Haas-Kogan DA
Pediatr Blood Cancer 2022 Feb;69(2):e29396. Epub 2021 Oct 18 doi: 10.1002/pbc.29396. PMID: 34662499
Robotic Surgery in Pediatric Oncology: Lessons Learned from the First 100 Tumors-A Nationwide Experience.
Blanc T, Meignan P, Vinit N, Ballouhey Q, Pio L, Capito C, Harte C, Vatta F, Galmiche-Rolland L, Minard V, Orbach D, Berteloot L, Muller C, Kohaut J, Broch A, Braik K, Binet A, Heloury Y, Fourcade L, Lardy H, Sarnacki S
Ann Surg Oncol 2022 Feb;29(2):1315-1326. Epub 2021 Sep 14 doi: 10.1245/s10434-021-10777-6. PMID: 34523002
Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial.
Mody R, Naranjo A, Van Ryn C, Yu AL, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Sondel PM, Bender JG, Maris JM, Park JR, Bagatell R
Lancet Oncol 2017 Jul;18(7):946-957. Epub 2017 May 23 doi: 10.1016/S1470-2045(17)30355-8. PMID: 28549783Free PMC Article
Primary cervical ganglioneuroblastoma.
Manjaly JG, Alexander VR, Pepper CM, Ifeacho SN, Hewitt RJ, Hartley BE
Int J Pediatr Otorhinolaryngol 2015 Jul;79(7):1007-12. Epub 2015 Apr 22 doi: 10.1016/j.ijporl.2015.04.012. PMID: 25921075
Needle localization of small pediatric tumors for surgical biopsy.
Hardaway BW, Hoffer FA, Rao BN
Pediatr Radiol 2000 May;30(5):318-22. doi: 10.1007/s002470050748. PMID: 10836594

Diagnosis

Ganglioneuroblastoma intermixed: Clinicopathological implications of diagnosis at presentation and genomic correlations.
Nezami BG, Modak S, Cardenas FI, Sarungbam J, Sirintrapun SJ, Gopalan A, Chen Y, Al-Ahmadie H, Fine SW, Reuter VE, Tickoo SK
Pediatr Blood Cancer 2023 Aug;70(8):e30434. Epub 2023 May 26 doi: 10.1002/pbc.30434. PMID: 37243318Free PMC Article
Primary cervical ganglioneuroblastoma, nodular subtype.
McGann EK, Goldberg AM, Lelegren MJ, Pickle JC, Bak MJ, Mark JR
Auris Nasus Larynx 2022 Oct;49(5):889-892. Epub 2021 Apr 16 doi: 10.1016/j.anl.2021.03.010. PMID: 33867181
Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial.
Mody R, Naranjo A, Van Ryn C, Yu AL, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Sondel PM, Bender JG, Maris JM, Park JR, Bagatell R
Lancet Oncol 2017 Jul;18(7):946-957. Epub 2017 May 23 doi: 10.1016/S1470-2045(17)30355-8. PMID: 28549783Free PMC Article
Primary cervical ganglioneuroblastoma.
Manjaly JG, Alexander VR, Pepper CM, Ifeacho SN, Hewitt RJ, Hartley BE
Int J Pediatr Otorhinolaryngol 2015 Jul;79(7):1007-12. Epub 2015 Apr 22 doi: 10.1016/j.ijporl.2015.04.012. PMID: 25921075
Prenatally diagnosed cystic neuroblastoma.
Hamada Y, Ikebukuro K, Sato M, Tanano A, Kato Y, Takada K, Hioki K
Pediatr Surg Int 1999;15(1):71-4. doi: 10.1007/s003830050518. PMID: 9914363

Therapy

Clinical features and outcomes of opsoclonus myoclonus ataxia syndrome.
Yıldırım M, Öncel İ, Bektaş Ö, Tanalı G, Şahin S, Kutluk T, Teber S, Anlar B
Eur J Paediatr Neurol 2022 Nov;41:19-26. Epub 2022 Sep 20 doi: 10.1016/j.ejpn.2022.09.002. PMID: 36155293
Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial.
Mody R, Naranjo A, Van Ryn C, Yu AL, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Sondel PM, Bender JG, Maris JM, Park JR, Bagatell R
Lancet Oncol 2017 Jul;18(7):946-957. Epub 2017 May 23 doi: 10.1016/S1470-2045(17)30355-8. PMID: 28549783Free PMC Article
Laparoscopic adrenalectomy in children.
Lopes RI, Dénes FT, Bissoli J, Mendonca BB, Srougi M
J Pediatr Urol 2012 Aug;8(4):379-85. Epub 2011 Sep 29 doi: 10.1016/j.jpurol.2011.07.012. PMID: 21955529
Rituximab for treatment of opsoclonus-myoclonus syndrome in neuroblastoma.
Burke MJ, Cohn SL
Pediatr Blood Cancer 2008 Mar;50(3):679-80. doi: 10.1002/pbc.21009. PMID: 16900484
Disaloganglioside GD2 loss following monoclonal antibody therapy is rare in neuroblastoma.
Kramer K, Gerald WL, Kushner BH, Larson SM, Hameed M, Cheung NK
Med Pediatr Oncol 2001 Jan;36(1):194-6. doi: 10.1002/1096-911X(20010101)36:1<194::AID-MPO1046>3.0.CO;2-B. PMID: 11464881

Prognosis

Primary cervical ganglioneuroblastoma, nodular subtype.
McGann EK, Goldberg AM, Lelegren MJ, Pickle JC, Bak MJ, Mark JR
Auris Nasus Larynx 2022 Oct;49(5):889-892. Epub 2021 Apr 16 doi: 10.1016/j.anl.2021.03.010. PMID: 33867181
Irinotecan-temozolomide with temsirolimus or dinutuximab in children with refractory or relapsed neuroblastoma (COG ANBL1221): an open-label, randomised, phase 2 trial.
Mody R, Naranjo A, Van Ryn C, Yu AL, London WB, Shulkin BL, Parisi MT, Servaes SE, Diccianni MB, Sondel PM, Bender JG, Maris JM, Park JR, Bagatell R
Lancet Oncol 2017 Jul;18(7):946-957. Epub 2017 May 23 doi: 10.1016/S1470-2045(17)30355-8. PMID: 28549783Free PMC Article
Long-term follow-up results of the observation program for neuroblastoma detected at 6-month mass screening.
Arakawa A, Oguma E, Aihara T, Kishimoto H, Kikuchi A, Hanada R, Koh K
J Pediatr 2014 Oct;165(4):855-7.e1. Epub 2014 Aug 3 doi: 10.1016/j.jpeds.2014.06.055. PMID: 25091258
Ganglioneuroblastoma of filum terminale: case report.
Okudera Y, Miyakoshi N, Sugawara T, Hongo M, Kasukawa Y, Ishikawa Y, Shimada Y
J Neurosurg Spine 2014 Aug;21(2):270-4. Epub 2014 May 30 doi: 10.3171/2014.4.SPINE121002. PMID: 24878272
Primary pediatric neuroblastic tumors of the neck.
Moukheiber AK, Nicollas R, Roman S, Coze C, Triglia JM
Int J Pediatr Otorhinolaryngol 2001 Aug 20;60(2):155-61. doi: 10.1016/s0165-5876(01)00499-2. PMID: 11518594

Clinical prediction guides

Characteristics of benign neuroblastic tumors: Is surgery always necessary?
Whitlock RS, Mehl SC, Larson SK, Foster JH, Hicks J, Nuchtern JG, Sher AC, Vasudevan SA, Naik-Mathuria B
J Pediatr Surg 2022 Aug;57(8):1538-1543. Epub 2021 Jul 7 doi: 10.1016/j.jpedsurg.2021.07.002. PMID: 34281709
Long-term follow-up results of the observation program for neuroblastoma detected at 6-month mass screening.
Arakawa A, Oguma E, Aihara T, Kishimoto H, Kikuchi A, Hanada R, Koh K
J Pediatr 2014 Oct;165(4):855-7.e1. Epub 2014 Aug 3 doi: 10.1016/j.jpeds.2014.06.055. PMID: 25091258
Ganglioneuroblastic differentiation in a primary cutaneous malignant melanoma.
Grayson W, Maré LR
Am J Dermatopathol 2003 Feb;25(1):40-4. doi: 10.1097/00000372-200302000-00009. PMID: 12544099
Primary pediatric neuroblastic tumors of the neck.
Moukheiber AK, Nicollas R, Roman S, Coze C, Triglia JM
Int J Pediatr Otorhinolaryngol 2001 Aug 20;60(2):155-61. doi: 10.1016/s0165-5876(01)00499-2. PMID: 11518594
Observation of untreated patients with neuroblastoma detected by mass screening: a "wait and see" pilot study.
Yoneda A, Oue T, Imura K, Inoue M, Yagi K, Kawa K, Nishikawa M, Morimoto S, Nakayama M
Med Pediatr Oncol 2001 Jan;36(1):160-2. doi: 10.1002/1096-911X(20010101)36:1<160::AID-MPO1039>3.0.CO;2-G. PMID: 11464874

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