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Resectable Carcinoma of Unknown Primary

MedGen UID:
1733330
Concept ID:
C5418906
Neoplastic Process

Definition

A carcinoma of unknown primary that is amenable to surgical resection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVResectable Carcinoma of Unknown Primary

Professional guidelines

PubMed

Pierre ME, Manneh R, Hernández A, Rodríguez J, Fletcher AV, Ramírez HM, Niño OM, Gómez DA, Sanabria D, Contreras F, Pieschacón JR, Calderón PH
Rev Colomb Obstet Ginecol 2024 Jun 14;75(1) doi: 10.18597/rcog.4094. PMID: 39013199Free PMC Article
Ye W, Arnaud EH, Langerman A, Mannion K, Topf MC
Eur J Cancer Care (Engl) 2021 Nov;30(6):e13459. Epub 2021 May 1 doi: 10.1111/ecc.13459. PMID: 33932056
Chaudhari VA, Khobragade K, Bhandare M, Shrikhande SV
Chin Clin Oncol 2018 Oct;7(5):51. doi: 10.21037/cco.2018.08.08. PMID: 30395718

Recent clinical studies

Etiology

Labori KJ, Bratlie SO, Andersson B, Angelsen JH, Biörserud C, Björnsson B, Bringeland EA, Elander N, Garresori H, Grønbech JE, Haux J, Hemmingsson O, Liljefors MG, Myklebust TÅ, Nymo LS, Peltola K, Pfeiffer P, Sallinen V, Sandström P, Sparrelid E, Stenvold H, Søreide K, Tingstedt B, Verbeke C, Öhlund D, Klint L, Dueland S, Lassen K; Nordic Pancreatic Cancer Trial-1 study group
Lancet Gastroenterol Hepatol 2024 Mar;9(3):205-217. Epub 2024 Jan 15 doi: 10.1016/S2468-1253(23)00405-3. PMID: 38237621
Lu S, Zhang W, Wu L, Wang W, Zhang P; Neotorch Investigators, Fang W, Xing W, Chen Q, Yang L, Mei J, Tan L, Sun X, Xu S, Hu X, Yu G, Yu D, Yang N, Chen Y, Shan J, Xing L, Tian H, Zhang X, Zhou M, Fang H, Wu G, Liu Y, Ye M, Cao L, Jiang J, Li X, Zhu L, Li D, Kang M, Zhong A, Chen K, Wu N, Sun Q, Ma H, Cai K, Wang C, Lin G, Zhu K, Zhang Y, Zhang X, Hu H, Zhang W, Chen J, Yang Z, Hang X, Hu J, Huang Y, Zhang Z, Zhang L, Zhang L, Liu L, Lin D, Zhang J, Chen G, Li Y, Zhu L, Wang W, Yu W, Cao D, Keegan P, Yao S
JAMA 2024 Jan 16;331(3):201-211. doi: 10.1001/jama.2023.24735. PMID: 38227033Free PMC Article
Shitara K, Rha SY, Wyrwicz LS, Oshima T, Karaseva N, Osipov M, Yasui H, Yabusaki H, Afanasyev S, Park YK, Al-Batran SE, Yoshikawa T, Yanez P, Dib Bartolomeo M, Lonardi S, Tabernero J, Van Cutsem E, Janjigian YY, Oh DY, Xu J, Fang X, Shih CS, Bhagia P, Bang YJ; KEYNOTE-585 investigators
Lancet Oncol 2024 Feb;25(2):212-224. Epub 2023 Dec 19 doi: 10.1016/S1470-2045(23)00541-7. PMID: 38134948
Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, Vu HV, Lu S, Lee KY, Akewanlop C, Yu CJ, de Marinis F, Bonanno L, Domine M, Shepherd FA, Zeng L, Hodge R, Atasoy A, Rukazenkov Y, Herbst RS; ADAURA Investigators
N Engl J Med 2020 Oct 29;383(18):1711-1723. Epub 2020 Sep 19 doi: 10.1056/NEJMoa2027071. PMID: 32955177
Bex A, Mulders P, Jewett M, Wagstaff J, van Thienen JV, Blank CU, van Velthoven R, Del Pilar Laguna M, Wood L, van Melick HHE, Aarts MJ, Lattouf JB, Powles T, de Jong Md PhD IJ, Rottey S, Tombal B, Marreaud S, Collette S, Collette L, Haanen J
JAMA Oncol 2019 Feb 1;5(2):164-170. doi: 10.1001/jamaoncol.2018.5543. PMID: 30543350Free PMC Article

Diagnosis

Pierre ME, Manneh R, Hernández A, Rodríguez J, Fletcher AV, Ramírez HM, Niño OM, Gómez DA, Sanabria D, Contreras F, Pieschacón JR, Calderón PH
Rev Colomb Obstet Ginecol 2024 Jun 14;75(1) doi: 10.18597/rcog.4094. PMID: 39013199Free PMC Article
Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Fang SH, Lal G
Endocr Pract 2011 Mar-Apr;17 Suppl 1:36-43. doi: 10.4158/EP10310.RA. PMID: 21454239
Rodgers SE, Perrier ND
Curr Opin Oncol 2006 Jan;18(1):16-22. doi: 10.1097/01.cco.0000198019.53606.2b. PMID: 16357559

Therapy

Labori KJ, Bratlie SO, Andersson B, Angelsen JH, Biörserud C, Björnsson B, Bringeland EA, Elander N, Garresori H, Grønbech JE, Haux J, Hemmingsson O, Liljefors MG, Myklebust TÅ, Nymo LS, Peltola K, Pfeiffer P, Sallinen V, Sandström P, Sparrelid E, Stenvold H, Søreide K, Tingstedt B, Verbeke C, Öhlund D, Klint L, Dueland S, Lassen K; Nordic Pancreatic Cancer Trial-1 study group
Lancet Gastroenterol Hepatol 2024 Mar;9(3):205-217. Epub 2024 Jan 15 doi: 10.1016/S2468-1253(23)00405-3. PMID: 38237621
Lu S, Zhang W, Wu L, Wang W, Zhang P; Neotorch Investigators, Fang W, Xing W, Chen Q, Yang L, Mei J, Tan L, Sun X, Xu S, Hu X, Yu G, Yu D, Yang N, Chen Y, Shan J, Xing L, Tian H, Zhang X, Zhou M, Fang H, Wu G, Liu Y, Ye M, Cao L, Jiang J, Li X, Zhu L, Li D, Kang M, Zhong A, Chen K, Wu N, Sun Q, Ma H, Cai K, Wang C, Lin G, Zhu K, Zhang Y, Zhang X, Hu H, Zhang W, Chen J, Yang Z, Hang X, Hu J, Huang Y, Zhang Z, Zhang L, Zhang L, Liu L, Lin D, Zhang J, Chen G, Li Y, Zhu L, Wang W, Yu W, Cao D, Keegan P, Yao S
JAMA 2024 Jan 16;331(3):201-211. doi: 10.1001/jama.2023.24735. PMID: 38227033Free PMC Article
Verschoor YL, van de Haar J, van den Berg JG, van Sandick JW, Kodach LL, van Dieren JM, Balduzzi S, Grootscholten C, IJsselsteijn ME, Veenhof AAFA, Hartemink KJ, Vollebergh MA, Jurdi A, Sharma S, Spickard E, Owers EC, Bartels-Rutten A, den Hartog P, de Miranda NFCC, van Leerdam ME, Haanen JBAG, Schumacher TN, Voest EE, Chalabi M
Nat Med 2024 Feb;30(2):519-530. Epub 2024 Jan 8 doi: 10.1038/s41591-023-02758-x. PMID: 38191613Free PMC Article
Shitara K, Rha SY, Wyrwicz LS, Oshima T, Karaseva N, Osipov M, Yasui H, Yabusaki H, Afanasyev S, Park YK, Al-Batran SE, Yoshikawa T, Yanez P, Dib Bartolomeo M, Lonardi S, Tabernero J, Van Cutsem E, Janjigian YY, Oh DY, Xu J, Fang X, Shih CS, Bhagia P, Bang YJ; KEYNOTE-585 investigators
Lancet Oncol 2024 Feb;25(2):212-224. Epub 2023 Dec 19 doi: 10.1016/S1470-2045(23)00541-7. PMID: 38134948
Wu YL, Tsuboi M, He J, John T, Grohe C, Majem M, Goldman JW, Laktionov K, Kim SW, Kato T, Vu HV, Lu S, Lee KY, Akewanlop C, Yu CJ, de Marinis F, Bonanno L, Domine M, Shepherd FA, Zeng L, Hodge R, Atasoy A, Rukazenkov Y, Herbst RS; ADAURA Investigators
N Engl J Med 2020 Oct 29;383(18):1711-1723. Epub 2020 Sep 19 doi: 10.1056/NEJMoa2027071. PMID: 32955177

Prognosis

Pierre ME, Manneh R, Hernández A, Rodríguez J, Fletcher AV, Ramírez HM, Niño OM, Gómez DA, Sanabria D, Contreras F, Pieschacón JR, Calderón PH
Rev Colomb Obstet Ginecol 2024 Jun 14;75(1) doi: 10.18597/rcog.4094. PMID: 39013199Free PMC Article
Verschoor YL, van de Haar J, van den Berg JG, van Sandick JW, Kodach LL, van Dieren JM, Balduzzi S, Grootscholten C, IJsselsteijn ME, Veenhof AAFA, Hartemink KJ, Vollebergh MA, Jurdi A, Sharma S, Spickard E, Owers EC, Bartels-Rutten A, den Hartog P, de Miranda NFCC, van Leerdam ME, Haanen JBAG, Schumacher TN, Voest EE, Chalabi M
Nat Med 2024 Feb;30(2):519-530. Epub 2024 Jan 8 doi: 10.1038/s41591-023-02758-x. PMID: 38191613Free PMC Article
Luo J, Sanchez M, Lee E, Hertzler H, Luong N, Mazzola E, Finstein B, Tamen R, Brisbane G, Nguyen T, Paik PK, Chaft JE, Cheng ML, Khalil H, Piha-Paul SA, Sholl LM, Nishino M, Jänne PA, DuBois SG, Hanna GJ, Shapiro GI, French CA
J Thorac Oncol 2024 May;19(5):829-838. Epub 2023 Dec 27 doi: 10.1016/j.jtho.2023.12.022. PMID: 38154515Free PMC Article
Kunzmann V, Siveke JT, Algül H, Goekkurt E, Siegler G, Martens U, Waldschmidt D, Pelzer U, Fuchs M, Kullmann F, Boeck S, Ettrich TJ, Held S, Keller R, Klein I, Germer CT, Stein H, Friess H, Bahra M, Jakobs R, Hartlapp I, Heinemann V; German Pancreatic Cancer Working Group (AIO-PAK) and NEOLAP investigators
Lancet Gastroenterol Hepatol 2021 Feb;6(2):128-138. Epub 2020 Dec 16 doi: 10.1016/S2468-1253(20)30330-7. PMID: 33338442
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article

Clinical prediction guides

Pierre ME, Manneh R, Hernández A, Rodríguez J, Fletcher AV, Ramírez HM, Niño OM, Gómez DA, Sanabria D, Contreras F, Pieschacón JR, Calderón PH
Rev Colomb Obstet Ginecol 2024 Jun 14;75(1) doi: 10.18597/rcog.4094. PMID: 39013199Free PMC Article
Verschoor YL, van de Haar J, van den Berg JG, van Sandick JW, Kodach LL, van Dieren JM, Balduzzi S, Grootscholten C, IJsselsteijn ME, Veenhof AAFA, Hartemink KJ, Vollebergh MA, Jurdi A, Sharma S, Spickard E, Owers EC, Bartels-Rutten A, den Hartog P, de Miranda NFCC, van Leerdam ME, Haanen JBAG, Schumacher TN, Voest EE, Chalabi M
Nat Med 2024 Feb;30(2):519-530. Epub 2024 Jan 8 doi: 10.1038/s41591-023-02758-x. PMID: 38191613Free PMC Article
Nilsson K, Klevebro F, Sunde B, Rouvelas I, Lindblad M, Szabo E, Halldestam I, Smedh U, Wallner B, Johansson J, Johnsen G, Aahlin EK, Johannessen HO, Alexandersson von Döbeln G, Hjortland GO, Wang N, Shang Y, Borg D, Quaas A, Bartella I, Bruns C, Schröder W, Nilsson M
Ann Oncol 2023 Nov;34(11):1015-1024. Epub 2023 Aug 30 doi: 10.1016/j.annonc.2023.08.010. PMID: 37657554
Bellizzi AM
Hum Pathol 2020 Feb;96:8-33. Epub 2019 Dec 17 doi: 10.1016/j.humpath.2019.12.002. PMID: 31857137Free PMC Article
Gomez DR, Blumenschein GR Jr, Lee JJ, Hernandez M, Ye R, Camidge DR, Doebele RC, Skoulidis F, Gaspar LE, Gibbons DL, Karam JA, Kavanagh BD, Tang C, Komaki R, Louie AV, Palma DA, Tsao AS, Sepesi B, William WN, Zhang J, Shi Q, Wang XS, Swisher SG, Heymach JV
Lancet Oncol 2016 Dec;17(12):1672-1682. Epub 2016 Oct 24 doi: 10.1016/S1470-2045(16)30532-0. PMID: 27789196Free PMC Article

Recent systematic reviews

van Weert S, Rijken JA, Plantone F, Bloemena E, Vergeer MR, Lissenberg-Witte BI, Leemans CR
Clin Otolaryngol 2020 Sep;45(5):732-738. Epub 2020 May 25 doi: 10.1111/coa.13565. PMID: 32369264Free PMC Article
Bala MM, Riemsma RP, Wolff R, Pedziwiatr M, Mitus JW, Storman D, Swierz MJ, Kleijnen J
Cochrane Database Syst Rev 2019 Jul 10;7(7):CD009058. doi: 10.1002/14651858.CD009058.pub3. PMID: 31291464Free PMC Article
Lim KC, Chow PK, Allen JC, Siddiqui FJ, Chan ES, Tan SB
Br J Surg 2012 Dec;99(12):1622-9. Epub 2012 Sep 28 doi: 10.1002/bjs.8915. PMID: 23023956
Capurso G, Rinzivillo M, Bettini R, Boninsegna L, Delle Fave G, Falconi M
Br J Surg 2012 Nov;99(11):1480-6. Epub 2012 Sep 13 doi: 10.1002/bjs.8842. PMID: 22972490
Pentheroudakis G, Lazaridis G, Pavlidis N
Breast Cancer Res Treat 2010 Jan;119(1):1-11. doi: 10.1007/s10549-009-0554-3. PMID: 19771506

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