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Refractory Esophageal Carcinoma

MedGen UID:
1755850
•Concept ID:
C5419203
•
Neoplastic Process

Definition

Esophageal carcinoma that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Esophageal Carcinoma

Professional guidelines

PubMed

Research Progress on Mechanism and Management of Adverse Drug Reactions of Anlotinib.
Li S, Wang H
Drug Des Devel Ther 2023;17:3429-3437. Epub 2023 Nov 15 doi: 10.2147/DDDT.S426898. PMID: 38024530Free PMC Article
Camrelizumab and metronomic capecitabine for patients with treatment-refractory solid tumors (McCREST trial).
Zhou C, Shangguan C, Shi M, Xi W, Wu J, Yang H, Guo L, Cai Q, Shi Y, Liu J, Zhang J
Future Oncol 2022 Jul;18(23):2495-2503. Epub 2022 Jun 15 doi: 10.2217/fon-2021-1579. PMID: 35703115
Cryotherapy in the management of premalignant and malignant conditions of the esophagus.
Lal P, Thota PN
World J Gastroenterol 2018 Nov 21;24(43):4862-4869. doi: 10.3748/wjg.v24.i43.4862. PMID: 30487696Free PMC Article

Recent clinical studies

Etiology

Liver resection after Transjugular Portosystemic Stent Shunt (TIPSS).
Sliwinski S, Trojan J, Mader C, Vogl T, Bechstein W
Z Gastroenterol 2023 Apr;61(4):390-393. Epub 2022 Jun 13 doi: 10.1055/a-1791-2192. PMID: 35697061
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial.
Kato K, Cho BC, Takahashi M, Okada M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Kodani M, Kitagawa Y
Lancet Oncol 2019 Nov;20(11):1506-1517. Epub 2019 Sep 30 doi: 10.1016/S1470-2045(19)30626-6. PMID: 31582355
CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer.
Janjigian YY, Bendell J, Calvo E, Kim JW, Ascierto PA, Sharma P, Ott PA, Peltola K, Jaeger D, Evans J, de Braud F, Chau I, Harbison CT, Dorange C, Tschaika M, Le DT
J Clin Oncol 2018 Oct 1;36(28):2836-2844. Epub 2018 Aug 15 doi: 10.1200/JCO.2017.76.6212. PMID: 30110194Free PMC Article
Caustic ingestion in children-A review.
Arnold M, Numanoglu A
Semin Pediatr Surg 2017 Apr;26(2):95-104. Epub 2017 Feb 3 doi: 10.1053/j.sempedsurg.2017.02.002. PMID: 28550877
Minimally invasive esophagectomy for dysplastic Barrett's esophagus.
Markar SR, Hanna G
World J Surg 2015 Mar;39(3):608-14. doi: 10.1007/s00268-014-2746-1. PMID: 25145822

Diagnosis

Gastroesophageal Reflux Disease Is Not a Great Screening Criterion: Time to Move on to Other Strategies for Controlling the Burden of Esophageal Adenocarcinoma.
Rubenstein JH
Am J Gastroenterol 2022 Nov 1;117(11):1759-1761. Epub 2022 Sep 26 doi: 10.14309/ajg.0000000000001998. PMID: 36327434Free PMC Article
Postoperative chylothorax with a duplicated left-sided thoracic duct: a case report and review of the literature.
Haneda R, Booka E, Ishii K, Kikuchi H, Hiramatsu Y, Kamiya K, Aramaki T, Takeuchi H, Tsubosa Y
Gen Thorac Cardiovasc Surg 2020 Nov;68(11):1350-1353. Epub 2020 May 8 doi: 10.1007/s11748-020-01374-7. PMID: 32385642
Refractory Hypercalcemia in Squamous Cell Carcinoma of the Esophagus-a Case Report and Review of Literature.
Arif H, Beg M, Zahid S, Sial M, Talwar A, Christou A, Babich M
J Gastrointest Cancer 2019 Dec;50(4):939-942. doi: 10.1007/s12029-018-0124-1. PMID: 29862439
Caustic ingestion in children-A review.
Arnold M, Numanoglu A
Semin Pediatr Surg 2017 Apr;26(2):95-104. Epub 2017 Feb 3 doi: 10.1053/j.sempedsurg.2017.02.002. PMID: 28550877
Minimally invasive esophagectomy for dysplastic Barrett's esophagus.
Markar SR, Hanna G
World J Surg 2015 Mar;39(3):608-14. doi: 10.1007/s00268-014-2746-1. PMID: 25145822

Therapy

Treatment of refractory esophageal stenosis after endoscopic submucosal dissection with magnetic compression anastomosis.
Zhang M, Sha H, Lu G, Xue H, Lv Y, Yan X
Endoscopy 2024 Dec;56(S 01):E280-E282. Epub 2024 Mar 20 doi: 10.1055/a-2279-6910. PMID: 38508574Free PMC Article
Precision medicine for human cancers with Notch signaling dysregulation (Review).
Katoh M, Katoh M
Int J Mol Med 2020 Feb;45(2):279-297. Epub 2019 Dec 4 doi: 10.3892/ijmm.2019.4418. PMID: 31894255Free PMC Article
Nivolumab versus chemotherapy in patients with advanced oesophageal squamous cell carcinoma refractory or intolerant to previous chemotherapy (ATTRACTION-3): a multicentre, randomised, open-label, phase 3 trial.
Kato K, Cho BC, Takahashi M, Okada M, Lin CY, Chin K, Kadowaki S, Ahn MJ, Hamamoto Y, Doki Y, Yen CC, Kubota Y, Kim SB, Hsu CH, Holtved E, Xynos I, Kodani M, Kitagawa Y
Lancet Oncol 2019 Nov;20(11):1506-1517. Epub 2019 Sep 30 doi: 10.1016/S1470-2045(19)30626-6. PMID: 31582355
Camrelizumab: First Global Approval.
Markham A, Keam SJ
Drugs 2019 Aug;79(12):1355-1361. doi: 10.1007/s40265-019-01167-0. PMID: 31313098
Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study.
Doi T, Shitara K, Naito Y, Shimomura A, Fujiwara Y, Yonemori K, Shimizu C, Shimoi T, Kuboki Y, Matsubara N, Kitano A, Jikoh T, Lee C, Fujisaki Y, Ogitani Y, Yver A, Tamura K
Lancet Oncol 2017 Nov;18(11):1512-1522. Epub 2017 Oct 13 doi: 10.1016/S1470-2045(17)30604-6. PMID: 29037983

Prognosis

Liver resection after Transjugular Portosystemic Stent Shunt (TIPSS).
Sliwinski S, Trojan J, Mader C, Vogl T, Bechstein W
Z Gastroenterol 2023 Apr;61(4):390-393. Epub 2022 Jun 13 doi: 10.1055/a-1791-2192. PMID: 35697061
Refractory Hypercalcemia in Squamous Cell Carcinoma of the Esophagus-a Case Report and Review of Literature.
Arif H, Beg M, Zahid S, Sial M, Talwar A, Christou A, Babich M
J Gastrointest Cancer 2019 Dec;50(4):939-942. doi: 10.1007/s12029-018-0124-1. PMID: 29862439
Safety, pharmacokinetics, and antitumour activity of trastuzumab deruxtecan (DS-8201), a HER2-targeting antibody-drug conjugate, in patients with advanced breast and gastric or gastro-oesophageal tumours: a phase 1 dose-escalation study.
Doi T, Shitara K, Naito Y, Shimomura A, Fujiwara Y, Yonemori K, Shimizu C, Shimoi T, Kuboki Y, Matsubara N, Kitano A, Jikoh T, Lee C, Fujisaki Y, Ogitani Y, Yver A, Tamura K
Lancet Oncol 2017 Nov;18(11):1512-1522. Epub 2017 Oct 13 doi: 10.1016/S1470-2045(17)30604-6. PMID: 29037983
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Kang YK, Boku N, Satoh T, Ryu MH, Chao Y, Kato K, Chung HC, Chen JS, Muro K, Kang WK, Yeh KH, Yoshikawa T, Oh SC, Bai LY, Tamura T, Lee KW, Hamamoto Y, Kim JG, Chin K, Oh DY, Minashi K, Cho JY, Tsuda M, Chen LT
Lancet 2017 Dec 2;390(10111):2461-2471. Epub 2017 Oct 6 doi: 10.1016/S0140-6736(17)31827-5. PMID: 28993052
Caustic ingestion in children-A review.
Arnold M, Numanoglu A
Semin Pediatr Surg 2017 Apr;26(2):95-104. Epub 2017 Feb 3 doi: 10.1053/j.sempedsurg.2017.02.002. PMID: 28550877

Clinical prediction guides

CheckMate-032 Study: Efficacy and Safety of Nivolumab and Nivolumab Plus Ipilimumab in Patients With Metastatic Esophagogastric Cancer.
Janjigian YY, Bendell J, Calvo E, Kim JW, Ascierto PA, Sharma P, Ott PA, Peltola K, Jaeger D, Evans J, de Braud F, Chau I, Harbison CT, Dorange C, Tschaika M, Le DT
J Clin Oncol 2018 Oct 1;36(28):2836-2844. Epub 2018 Aug 15 doi: 10.1200/JCO.2017.76.6212. PMID: 30110194Free PMC Article
Nivolumab in patients with advanced gastric or gastro-oesophageal junction cancer refractory to, or intolerant of, at least two previous chemotherapy regimens (ONO-4538-12, ATTRACTION-2): a randomised, double-blind, placebo-controlled, phase 3 trial.
Kang YK, Boku N, Satoh T, Ryu MH, Chao Y, Kato K, Chung HC, Chen JS, Muro K, Kang WK, Yeh KH, Yoshikawa T, Oh SC, Bai LY, Tamura T, Lee KW, Hamamoto Y, Kim JG, Chin K, Oh DY, Minashi K, Cho JY, Tsuda M, Chen LT
Lancet 2017 Dec 2;390(10111):2461-2471. Epub 2017 Oct 6 doi: 10.1016/S0140-6736(17)31827-5. PMID: 28993052
Caustic ingestion in children-A review.
Arnold M, Numanoglu A
Semin Pediatr Surg 2017 Apr;26(2):95-104. Epub 2017 Feb 3 doi: 10.1053/j.sempedsurg.2017.02.002. PMID: 28550877
Minimally invasive esophagectomy for dysplastic Barrett's esophagus.
Markar SR, Hanna G
World J Surg 2015 Mar;39(3):608-14. doi: 10.1007/s00268-014-2746-1. PMID: 25145822
Current use of transjugular intrahepatic portosystemic shunts.
McCashland TM
Curr Gastroenterol Rep 2003 Feb;5(1):31-8. doi: 10.1007/s11894-003-0007-9. PMID: 12530946

Recent systematic reviews

Comparative efficacy and safety of immunotherapy for patients with advanced or metastatic esophageal squamous cell carcinoma: a systematic review and network Meta-analysis.
Gao TT, Shan JH, Yang YX, Zhang ZW, Liu SL, Xi M, Liu MZ, Zhao L
BMC Cancer 2022 Sep 17;22(1):992. doi: 10.1186/s12885-022-10086-5. PMID: 36115960Free PMC Article
Toward a Treatment Sequencing Strategy: A Systematic Review of Treatment Regimens in Advanced Gastric Cancer/Gastroesophageal Junction Adenocarcinoma.
Catenacci DV, Chao J, Muro K, Al-Batran SE, Klempner SJ, Wainberg ZA, Shah MA, Rha SY, Ohtsu A, Liepa AM, Knoderer H, Chatterjee A, Van Cutsem E
Oncologist 2021 Oct;26(10):e1704-e1729. Epub 2021 Sep 3 doi: 10.1002/onco.13907. PMID: 34288262Free PMC Article
The integration of immune checkpoint inhibitors with VEGF targeted agents in advanced gastric and gastroesophageal adenocarcinoma: a review on the rationale and results of early phase trials.
Saeed A, Park R, Sun W
J Hematol Oncol 2021 Jan 12;14(1):13. doi: 10.1186/s13045-021-01034-0. PMID: 33436042Free PMC Article
Salvage systemic therapy for advanced gastric and oesophago-gastric junction adenocarcinoma.
Tomita Y, Moldovan M, Chang Lee R, Hsieh AH, Townsend A, Price T
Cochrane Database Syst Rev 2020 Nov 19;11(11):CD012078. doi: 10.1002/14651858.CD012078.pub2. PMID: 33210731Free PMC Article

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