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Advanced Malignant Digestive System Neoplasm

MedGen UID:
1780145
Concept ID:
C5446611
Neoplastic Process

Definition

A malignant digestive system neoplasm that has spread extensively to other anatomic sites or is no longer responding to treatment. [from NCI]

Professional guidelines

PubMed

Xia JY, Aadam AA
J Surg Oncol 2022 Jun;125(7):1104-1109. doi: 10.1002/jso.26844. PMID: 35481909Free PMC Article
Biller LH, Schrag D
JAMA 2021 Feb 16;325(7):669-685. doi: 10.1001/jama.2021.0106. PMID: 33591350
Cappell MS
Gastroenterol Clin North Am 2008 Mar;37(1):1-24, v. doi: 10.1016/j.gtc.2007.12.002. PMID: 18313537

Recent clinical studies

Etiology

Wang D, Cabalag CS, Clemons NJ, DuBois RN
Gastroenterology 2021 Dec;161(6):1813-1829. Epub 2021 Oct 2 doi: 10.1053/j.gastro.2021.09.059. PMID: 34606846
Blay JY, Kang YK, Nishida T, von Mehren M
Nat Rev Dis Primers 2021 Mar 18;7(1):22. doi: 10.1038/s41572-021-00254-5. PMID: 33737510
Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC
JAMA Oncol 2017 Oct 1;3(10):1335-1342. doi: 10.1001/jamaoncol.2017.0589. PMID: 28448665Free PMC Article
Keung EZ, Raut CP
Surg Clin North Am 2017 Apr;97(2):437-452. doi: 10.1016/j.suc.2016.12.001. PMID: 28325196
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article

Diagnosis

Tao Y, Xing S, Zuo S, Bao P, Jin Y, Li Y, Li M, Wu Y, Chen S, Wang X, Zhu Y, Feng Y, Zhang X, Wang X, Xi Q, Lu Q, Wang P, Lu ZJ
Cell Rep Med 2023 Nov 21;4(11):101281. doi: 10.1016/j.xcrm.2023.101281. PMID: 37992683Free PMC Article
Blay JY, Kang YK, Nishida T, von Mehren M
Nat Rev Dis Primers 2021 Mar 18;7(1):22. doi: 10.1038/s41572-021-00254-5. PMID: 33737510
von Mehren M, Joensuu H
J Clin Oncol 2018 Jan 10;36(2):136-143. Epub 2017 Dec 8 doi: 10.1200/JCO.2017.74.9705. PMID: 29220298Free PMC Article
Ito T, Igarashi H, Jensen RT
Best Pract Res Clin Gastroenterol 2012 Dec;26(6):737-53. doi: 10.1016/j.bpg.2012.12.003. PMID: 23582916Free PMC Article
Haluszka O, Tokar JL, Greenwald BD
Curr Probl Cancer 2005 Mar-Apr;29(2):37-112. doi: 10.1016/j.currproblcancer.2005.03.001. PMID: 16100845

Therapy

Sestito M, Pratt H, Schmidt C, Thomay A
J Surg Oncol 2024 Jan;129(1):48-62. Epub 2023 Nov 27 doi: 10.1002/jso.27530. PMID: 38010879
Wang G, Huang Y, Zhou L, Yang H, Lin H, Zhou S, Tan Z, Qian J
Crit Rev Oncol Hematol 2024 Jun;198:104197. Epub 2023 Nov 10 doi: 10.1016/j.critrevonc.2023.104197. PMID: 37951282
Janjigian YY, Van Cutsem E, Muro K, Wainberg Z, Al-Batran SE, Hyung WJ, Molena D, Marcovitz M, Ruscica D, Robbins SH, Negro A, Tabernero J
Future Oncol 2022 Jun;18(20):2465-2473. Epub 2022 May 10 doi: 10.2217/fon-2022-0093. PMID: 35535555
Blay JY, Kang YK, Nishida T, von Mehren M
Nat Rev Dis Primers 2021 Mar 18;7(1):22. doi: 10.1038/s41572-021-00254-5. PMID: 33737510
Hutchings CJ
Expert Opin Biol Ther 2020 Aug;20(8):925-935. Epub 2020 Apr 8 doi: 10.1080/14712598.2020.1745770. PMID: 32264722

Prognosis

Xia JY, Aadam AA
J Surg Oncol 2022 Jun;125(7):1104-1109. doi: 10.1002/jso.26844. PMID: 35481909Free PMC Article
Hu JX, Zhao CF, Chen WB, Liu QC, Li QW, Lin YY, Gao F
World J Gastroenterol 2021 Jul 21;27(27):4298-4321. doi: 10.3748/wjg.v27.i27.4298. PMID: 34366606Free PMC Article
Assarzadegan N, Montgomery E
Arch Pathol Lab Med 2021 Jun 1;145(6):664-677. doi: 10.5858/arpa.2019-0665-RA. PMID: 32233993Free PMC Article
Dasari A, Shen C, Halperin D, Zhao B, Zhou S, Xu Y, Shih T, Yao JC
JAMA Oncol 2017 Oct 1;3(10):1335-1342. doi: 10.1001/jamaoncol.2017.0589. PMID: 28448665Free PMC Article
Asija AP, Mejia AV, Prestipino A, Pillai MV
Am J Ther 2016 Mar-Apr;23(2):e550-7. doi: 10.1097/MJT.0b013e3182a1be76. PMID: 23942136

Clinical prediction guides

Mencel J, Alves A, Angelis V, Gerlinger M, Starling N
Crit Rev Oncol Hematol 2024 Jul;199:104387. Epub 2024 May 10 doi: 10.1016/j.critrevonc.2024.104387. PMID: 38734279
Tao Y, Xing S, Zuo S, Bao P, Jin Y, Li Y, Li M, Wu Y, Chen S, Wang X, Zhu Y, Feng Y, Zhang X, Wang X, Xi Q, Lu Q, Wang P, Lu ZJ
Cell Rep Med 2023 Nov 21;4(11):101281. doi: 10.1016/j.xcrm.2023.101281. PMID: 37992683Free PMC Article
Senchak J, Ahr K, von Mehren M
Curr Treat Options Oncol 2022 May;23(5):749-761. Epub 2022 Mar 28 doi: 10.1007/s11864-022-00958-0. PMID: 35349049
Chen L, Shan G
Cancer Lett 2021 May 1;505:49-57. Epub 2021 Feb 18 doi: 10.1016/j.canlet.2021.02.004. PMID: 33609610
Maines F, Caffo O, Veccia A, Galligioni E
Future Oncol 2015;11(4):691-702. doi: 10.2217/fon.14.253. PMID: 25686122

Recent systematic reviews

Shah MA, Kennedy EB, Alarcon-Rozas AE, Alcindor T, Bartley AN, Malowany AB, Bhadkamkar NA, Deighton DC, Janjigian Y, Karippot A, Khan U, King DA, Klute K, Lacy J, Lee JJ, Mehta R, Mukherjee S, Nagarajan A, Park H, Saeed A, Semrad TJ, Shitara K, Smyth E, Uboha NV, Vincelli M, Wainberg Z, Rajdev L
J Clin Oncol 2023 Mar 1;41(7):1470-1491. Epub 2023 Jan 5 doi: 10.1200/JCO.22.02331. PMID: 36603169
O'Sullivan DE, Sutherland RL, Town S, Chow K, Fan J, Forbes N, Heitman SJ, Hilsden RJ, Brenner DR
Clin Gastroenterol Hepatol 2022 Jun;20(6):1229-1240.e5. Epub 2021 Jan 29 doi: 10.1016/j.cgh.2021.01.037. PMID: 33524598
Liu S, Jiang T, Xiao L, Yang S, Liu Q, Gao Y, Chen G, Xiao W
Oncologist 2021 Sep;26(9):e1555-e1566. Epub 2021 Jun 7 doi: 10.1002/onco.13824. PMID: 33987952Free PMC Article
Gosavi R, Chia C, Michael M, Heriot AG, Warrier SK, Kong JC
Int J Colorectal Dis 2021 Oct;36(10):2063-2070. Epub 2021 May 4 doi: 10.1007/s00384-021-03945-3. PMID: 33945007
Kasi A, Abbasi S, Handa S, Al-Rajabi R, Saeed A, Baranda J, Sun W
JAMA Netw Open 2020 Dec 1;3(12):e2030097. doi: 10.1001/jamanetworkopen.2020.30097. PMID: 33326026Free PMC Article

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