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Conjunctival Reactive Lymphoid Hyperplasia

MedGen UID:
1782661
•Concept ID:
C5446512
•
Pathologic Function

Definition

A polyclonal proliferation of lymphoid tissue in the conjunctiva that typically occurs in young adults. It usually presents as a unilateral, red or orange, painless swelling and is probably caused by chronic antigen stimulation. (WHO 2018) [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVConjunctival Reactive Lymphoid Hyperplasia

Recent clinical studies

Etiology

Iatrogenic Immunodeficiency-associated Lymphoproliferative Disorder Resembling B-cell Pseudo-lymphoma on the Lip and Conjunctivae.
Miyagawa F, Aoki Y, Hayashino A, Sotozono C, Asada H
Acta Derm Venereol 2019 Jun 1;99(7):683-684. doi: 10.2340/00015555-3172. PMID: 30868170
Benign reactive lymphoid hyperplasia of the conjunctiva in childhood.
AlAkeely AG, Alkatan HM, Alsuhaibani AH, AlKhalidi H, Safieh LA, Coupland SE, Edward DP
Br J Ophthalmol 2017 Jul;101(7):933-939. Epub 2016 Nov 29 doi: 10.1136/bjophthalmol-2016-309030. PMID: 27899370
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Paediatric and adolescent elevated conjunctival lesions in the plical area: lymphoma or reactive lymphoid hyperplasia?
Beykin G, Pe'er J, Amir G, Frenkel S
Br J Ophthalmol 2014 May;98(5):645-50. Epub 2013 Oct 25 doi: 10.1136/bjophthalmol-2013-303527. PMID: 24162623
Unifocal and multifocal reactive lymphoid hyperplasia vs follicular lymphoma of the ocular adnexa.
Stacy RC, Jakobiec FA, Schoenfield L, Singh AD
Am J Ophthalmol 2010 Sep;150(3):412-426.e1. doi: 10.1016/j.ajo.2010.04.007. PMID: 20599186

Diagnosis

Chronic Follicular Conjunctivitis in a Middle-aged Woman.
Hadjokas NP, Reidy JJ, Farooq AV
JAMA Ophthalmol 2018 Jul 1;136(7):833-834. doi: 10.1001/jamaophthalmol.2017.6189. PMID: 29801089
Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Benign reactive lymphoid hyperplasia of the conjunctiva in childhood.
AlAkeely AG, Alkatan HM, Alsuhaibani AH, AlKhalidi H, Safieh LA, Coupland SE, Edward DP
Br J Ophthalmol 2017 Jul;101(7):933-939. Epub 2016 Nov 29 doi: 10.1136/bjophthalmol-2016-309030. PMID: 27899370
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Conjunctival Lymphoid Hyperplasia Associated With Multiple Recurrent Chalazia.
Detorakis ET, Tsatsos M, Kymionis G
Ophthalmic Plast Reconstr Surg 2015 Jul-Aug;31(4):335-6. doi: 10.1097/IOP.0000000000000440. PMID: 26164039

Therapy

Histopathologic Analysis of Conjunctival Lymphoproliferative Disease After Topical Brimonidine Use.
Hwang HB, Kim SY, Ohn K, Kim SY
J Ocul Pharmacol Ther 2019 Nov;35(9):503-511. Epub 2019 Aug 2 doi: 10.1089/jop.2019.0037. PMID: 31373838
Chronic Follicular Conjunctivitis in a Middle-aged Woman.
Hadjokas NP, Reidy JJ, Farooq AV
JAMA Ophthalmol 2018 Jul 1;136(7):833-834. doi: 10.1001/jamaophthalmol.2017.6189. PMID: 29801089
Benign Reactive Lymphoid Hyperplasia of the Conjunctiva Treated With Cyclosporine.
Parikh RN, Sandhu HS, Massaro-Giordano G, Goldstein SM, OʼBrien JM
Cornea 2018 Feb;37(2):255-257. doi: 10.1097/ICO.0000000000001452. PMID: 29135567
Topical steroids eye drops in conjunctival reactive lymphoid hyperplasia: Case report.
Moraes BRM, Nascimento MVDD, Neto EDDS, Santo RM
Medicine (Baltimore) 2017 Nov;96(47):e8656. doi: 10.1097/MD.0000000000008656. PMID: 29381940Free PMC Article
Positive Response to Methylprednisolone in a Child with Reactive Lymphoid Hyperplasia of the Conjunctiva.
Brazert A, Gotz-Wieckowska A
Semin Ophthalmol 2015;30(5-6):446-9. Epub 2014 Feb 7 doi: 10.3109/08820538.2013.874476. PMID: 24506534

Prognosis

Lymphoproliferative Tumors of the Ocular Adnexa.
Verdijk RM
Asia Pac J Ophthalmol (Phila) 2017 Mar-Apr;6(2):132-142. doi: 10.22608/APO.2016209. PMID: 28399341
Benign reactive lymphoid hyperplasia of the conjunctiva in childhood.
AlAkeely AG, Alkatan HM, Alsuhaibani AH, AlKhalidi H, Safieh LA, Coupland SE, Edward DP
Br J Ophthalmol 2017 Jul;101(7):933-939. Epub 2016 Nov 29 doi: 10.1136/bjophthalmol-2016-309030. PMID: 27899370
Lymphoid hyperplasia of the orbit and ocular adnexa: A clinical ​pathologic review.
Andrew NH, Coupland SE, Pirbhai A, Selva D
Surv Ophthalmol 2016 Nov-Dec;61(6):778-790. Epub 2016 Apr 26 doi: 10.1016/j.survophthal.2016.04.004. PMID: 27127077
Unifocal and multifocal reactive lymphoid hyperplasia vs follicular lymphoma of the ocular adnexa.
Stacy RC, Jakobiec FA, Schoenfield L, Singh AD
Am J Ophthalmol 2010 Sep;150(3):412-426.e1. doi: 10.1016/j.ajo.2010.04.007. PMID: 20599186
Ocular adnexal lymphoproliferative lesions.
Liesegang TJ
Mayo Clin Proc 1993 Oct;68(10):1003-10. doi: 10.1016/s0025-6196(12)62275-7. PMID: 8412350

Clinical prediction guides

Clinico-pathological correlation of lacrimal caruncle tumors: a retrospective analysis over 22 years at the University Eye Hospital Bonn.
Clemens AC, Loeffler KU, Holz FG, Herwig-Carl MC
Graefes Arch Clin Exp Ophthalmol 2022 Apr;260(4):1415-1425. Epub 2021 Oct 28 doi: 10.1007/s00417-021-05464-x. PMID: 34709452Free PMC Article
Histopathologic Analysis of Conjunctival Lymphoproliferative Disease After Topical Brimonidine Use.
Hwang HB, Kim SY, Ohn K, Kim SY
J Ocul Pharmacol Ther 2019 Nov;35(9):503-511. Epub 2019 Aug 2 doi: 10.1089/jop.2019.0037. PMID: 31373838
Conjunctival lymphoma arising from reactive lymphoid hyperplasia.
Fukuhara J, Kase S, Noda M, Ishijima K, Yamamoto T, Ishida S
World J Surg Oncol 2012 Sep 18;10:194. doi: 10.1186/1477-7819-10-194. PMID: 22985187Free PMC Article
Enhanced TKTL1 expression in malignant tumors of the ocular adnexa predicts clinical outcome.
Lange CA, Tisch-Rottensteiner J, Böhringer D, Martin G, Schwartzkopff J, Auw-Haedrich C
Ophthalmology 2012 Sep;119(9):1924-9. Epub 2012 Jun 1 doi: 10.1016/j.ophtha.2012.03.037. PMID: 22658715
Ocular adnexal lymphoproliferative lesions.
Liesegang TJ
Mayo Clin Proc 1993 Oct;68(10):1003-10. doi: 10.1016/s0025-6196(12)62275-7. PMID: 8412350

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