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Unresectable Hepatoblastoma

MedGen UID:
208914
•Concept ID:
C0854796
•
Neoplastic Process
Synonyms: Hepatoblastoma, Nonresectable; Non-Resectable Hepatoblastoma

Definition

Hepatoblastoma not amenable to surgical removal. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUnresectable Hepatoblastoma

Professional guidelines

PubMed

Beyond the Milan criteria for liver transplantation in children with hepatic tumours.
de Ville de Goyet J, Meyers RL, Tiao GM, Morland B
Lancet Gastroenterol Hepatol 2017 Jun;2(6):456-462. doi: 10.1016/S2468-1253(17)30084-5. PMID: 28497761
Efficacy of preoperative transcatheter arterial chemoembolization combined with systemic chemotherapy for treatment of unresectable hepatoblastoma in children.
Hirakawa M, Nishie A, Asayama Y, Fujita N, Ishigami K, Tajiri T, Taguchi T, Honda H
Jpn J Radiol 2014 Sep;32(9):529-36. Epub 2014 Jun 13 doi: 10.1007/s11604-014-0340-y. PMID: 24923584
Preoperative transcatheter selective arterial chemoembolization in treatment of unresectable hepatoblastoma in infants and children.
Li JP, Chu JP, Yang JY, Chen W, Wang Y, Huang YH
Cardiovasc Intervent Radiol 2008 Nov-Dec;31(6):1117-23. Epub 2008 Jun 17 doi: 10.1007/s00270-008-9373-x. PMID: 18560935

Recent clinical studies

Etiology

Prognostic Factors for Liver Transplantation in Unresectable Hepatoblastoma.
Triana Junco P, Cano EM, Dore M, Jimenez Gomez J, Sánchez Galán A, Vilanova-Sánchez A, Andres A, Encinas JL, Martinez L, Hernandez F, Lopez Santamaria M
Eur J Pediatr Surg 2019 Feb;29(1):28-32. Epub 2018 Aug 7 doi: 10.1055/s-0038-1668148. PMID: 30086577
Beyond the Milan criteria for liver transplantation in children with hepatic tumours.
de Ville de Goyet J, Meyers RL, Tiao GM, Morland B
Lancet Gastroenterol Hepatol 2017 Jun;2(6):456-462. doi: 10.1016/S2468-1253(17)30084-5. PMID: 28497761
Liver transplantation in the management of unresectable hepatoblastoma in children.
Meyers RL, Tiao GM, Dunn SP, Langham MR Jr
Front Biosci (Elite Ed) 2012 Jan 1;4(4):1293-302. doi: 10.2741/e460. PMID: 22201955
Living-related liver transplantation with removal of inferior vena cava for unresectable hepatoblastoma.
Hasegawa T, Kimura T, Ihara Y, Tazuke Y, Yoneda A, Kusafuka T, Fukuzawa M, Okuyama H, Inoue M
Pediatr Transplant 2006 Jun;10(4):521-4. doi: 10.1111/j.1399-3046.2006.00516.x. PMID: 16712615
Living-donor liver transplantation for hepatoblastoma.
Kasahara M, Ueda M, Haga H, Hiramatsu H, Kobayashi M, Adachi S, Sakamoto S, Oike F, Egawa H, Takada Y, Tanaka K
Am J Transplant 2005 Sep;5(9):2229-35. doi: 10.1111/j.1600-6143.2005.01003.x. PMID: 16095502

Diagnosis

Doxorubicin in combination with cisplatin, 5-flourouracil, and vincristine is feasible and effective in unresectable hepatoblastoma: A Children's Oncology Group study.
Katzenstein HM, Malogolowkin MH, Krailo MD, Piao J, Towbin AJ, McCarville MB, Tiao GM, Dunn SP, Langham MR, McGahren ED, Finegold MJ, Ranganathan S, Weldon CB, Thompson PA, Trobaugh-Lotrario AD, O'Neill AF, Furman WL, Chung N, Randazzo J, Rodriguez-Galindo C, Meyers RL
Cancer 2022 Mar 1;128(5):1057-1065. Epub 2021 Nov 11 doi: 10.1002/cncr.34014. PMID: 34762296Free PMC Article
Prognostic Factors for Liver Transplantation in Unresectable Hepatoblastoma.
Triana Junco P, Cano EM, Dore M, Jimenez Gomez J, Sánchez Galán A, Vilanova-Sánchez A, Andres A, Encinas JL, Martinez L, Hernandez F, Lopez Santamaria M
Eur J Pediatr Surg 2019 Feb;29(1):28-32. Epub 2018 Aug 7 doi: 10.1055/s-0038-1668148. PMID: 30086577
Microwave ablation combined with transcatheter arterial chemoembolization is effective for treating unresectable hepatoblastoma in infants and children.
Jiang Y, Zhou S, Shen G, Jiang H, Zhang J
Medicine (Baltimore) 2018 Oct;97(42):e12607. doi: 10.1097/MD.0000000000012607. PMID: 30334945Free PMC Article
Pediatric patient with end-stage kidney disease secondary to Eagle-Barrett syndrome and metastatic unresectable hepatoblastoma treated successfully with chemotherapy and liver-kidney transplant.
Ortiz D, Harden A, Corrales-Medina FF, Saigal G, Tekin A, Garcia J
Pediatr Transplant 2018 Mar;22(2) Epub 2018 Jan 22 doi: 10.1111/petr.13123. PMID: 29356335
Conversion of unresectable to resectable hepatoblastoma and long-term follow-up study.
Reynolds M
World J Surg 1995 Nov-Dec;19(6):814-6. doi: 10.1007/BF00299776. PMID: 8553671

Therapy

Pediatric patient with end-stage kidney disease secondary to Eagle-Barrett syndrome and metastatic unresectable hepatoblastoma treated successfully with chemotherapy and liver-kidney transplant.
Ortiz D, Harden A, Corrales-Medina FF, Saigal G, Tekin A, Garcia J
Pediatr Transplant 2018 Mar;22(2) Epub 2018 Jan 22 doi: 10.1111/petr.13123. PMID: 29356335
Living-related liver transplantation with removal of inferior vena cava for unresectable hepatoblastoma.
Hasegawa T, Kimura T, Ihara Y, Tazuke Y, Yoneda A, Kusafuka T, Fukuzawa M, Okuyama H, Inoue M
Pediatr Transplant 2006 Jun;10(4):521-4. doi: 10.1111/j.1399-3046.2006.00516.x. PMID: 16712615
Living-donor liver transplantation for hepatoblastoma.
Kasahara M, Ueda M, Haga H, Hiramatsu H, Kobayashi M, Adachi S, Sakamoto S, Oike F, Egawa H, Takada Y, Tanaka K
Am J Transplant 2005 Sep;5(9):2229-35. doi: 10.1111/j.1600-6143.2005.01003.x. PMID: 16095502
Complete disappearance of unresectable hepatoblastoma by continuous infusion therapy through hepatic artery.
Yokomori K, Hori T, Asoh S, Tuji A, Takemura T
J Pediatr Surg 1991 Jul;26(7):844-6. doi: 10.1016/0022-3468(91)90152-j. PMID: 1654408
Preoperative irradiation and chemotherapy for initially unresectable hepatoblastoma.
Shafer AD, Selinkoff PM
J Pediatr Surg 1977 Dec;12(6):1001-7. doi: 10.1016/0022-3468(77)90612-1. PMID: 201740

Prognosis

Prognostic Factors for Liver Transplantation in Unresectable Hepatoblastoma.
Triana Junco P, Cano EM, Dore M, Jimenez Gomez J, Sánchez Galán A, Vilanova-Sánchez A, Andres A, Encinas JL, Martinez L, Hernandez F, Lopez Santamaria M
Eur J Pediatr Surg 2019 Feb;29(1):28-32. Epub 2018 Aug 7 doi: 10.1055/s-0038-1668148. PMID: 30086577
Loss of EGFR-ASAP1 signaling in metastatic and unresectable hepatoblastoma.
Ranganathan S, Ningappa M, Ashokkumar C, Higgs BW, Min J, Sun Q, Schmitt L, Subramaniam S, Hakonarson H, Sindhi R
Sci Rep 2016 Dec 2;6:38347. doi: 10.1038/srep38347. PMID: 27910913Free PMC Article
Living-related liver transplantation with removal of inferior vena cava for unresectable hepatoblastoma.
Hasegawa T, Kimura T, Ihara Y, Tazuke Y, Yoneda A, Kusafuka T, Fukuzawa M, Okuyama H, Inoue M
Pediatr Transplant 2006 Jun;10(4):521-4. doi: 10.1111/j.1399-3046.2006.00516.x. PMID: 16712615
Living-donor liver transplantation for hepatoblastoma.
Kasahara M, Ueda M, Haga H, Hiramatsu H, Kobayashi M, Adachi S, Sakamoto S, Oike F, Egawa H, Takada Y, Tanaka K
Am J Transplant 2005 Sep;5(9):2229-35. doi: 10.1111/j.1600-6143.2005.01003.x. PMID: 16095502
Conversion of unresectable to resectable hepatoblastoma and long-term follow-up study.
Reynolds M
World J Surg 1995 Nov-Dec;19(6):814-6. doi: 10.1007/BF00299776. PMID: 8553671

Clinical prediction guides

Glomerular filtration rate in liver transplant for unresectable hepatoblastoma.
Peña Zavala R, Marzouki M, Beaunoyer M, Alvarez F
Pediatr Transplant 2020 Sep;24(6):e13746. Epub 2020 May 27 doi: 10.1111/petr.13746. PMID: 32459045
Microwave ablation combined with transcatheter arterial chemoembolization is effective for treating unresectable hepatoblastoma in infants and children.
Jiang Y, Zhou S, Shen G, Jiang H, Zhang J
Medicine (Baltimore) 2018 Oct;97(42):e12607. doi: 10.1097/MD.0000000000012607. PMID: 30334945Free PMC Article
Loss of EGFR-ASAP1 signaling in metastatic and unresectable hepatoblastoma.
Ranganathan S, Ningappa M, Ashokkumar C, Higgs BW, Min J, Sun Q, Schmitt L, Subramaniam S, Hakonarson H, Sindhi R
Sci Rep 2016 Dec 2;6:38347. doi: 10.1038/srep38347. PMID: 27910913Free PMC Article
Liver transplantation in the management of unresectable hepatoblastoma in children.
Meyers RL, Tiao GM, Dunn SP, Langham MR Jr
Front Biosci (Elite Ed) 2012 Jan 1;4(4):1293-302. doi: 10.2741/e460. PMID: 22201955
Preoperative transcatheter selective arterial chemoembolization in treatment of unresectable hepatoblastoma in infants and children.
Li JP, Chu JP, Yang JY, Chen W, Wang Y, Huang YH
Cardiovasc Intervent Radiol 2008 Nov-Dec;31(6):1117-23. Epub 2008 Jun 17 doi: 10.1007/s00270-008-9373-x. PMID: 18560935

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