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Refractory Hodgkin Lymphoma

MedGen UID:
208949
Concept ID:
C0855082
Neoplastic Process
Synonyms: Refractory Hodgkin lymphoma; Refractory Hodgkin's disease; Refractory Hodgkin's Lymphoma; Refractory Hodgkin's lymphoma
SNOMED CT: Refractory Hodgkin's disease (461311000124107); Refractory Hodgkin's lymphoma (461311000124107); Refractory Hodgkin lymphoma (461311000124107)

Definition

Hodgkin lymphoma resistant to treatment [from NCI]

Professional guidelines

PubMed

Aoki T, Jiang A, Xu A, Yin Y, Gamboa A, Milne K, Takata K, Miyata-Takata T, Chung S, Rai S, Wu S, Warren M, Strong C, Goodyear T, Morris K, Chong LC, Hav M, Colombo AR, Telenius A, Boyle M, Ben-Neriah S, Power M, Gerrie AS, Weng AP, Karsan A, Roth A, Farinha P, Scott DW, Savage KJ, Nelson BH, Merchant A, Steidl C
J Clin Oncol 2024 Mar 20;42(9):1077-1087. Epub 2023 Dec 19 doi: 10.1200/JCO.23.01115. PMID: 38113419Free PMC Article
Rutherford SC, Leonard JP
JAMA Oncol 2018 Aug 1;4(8):1120-1121. doi: 10.1001/jamaoncol.2018.1767. PMID: 30003234
Constine LS, Yahalom J, Ng AK, Hodgson DC, Wirth A, Milgrom SA, Mikhaeel NG, Eich HT, Illidge T, Ricardi U, Dieckmann K, Moskowitz CH, Advani R, Mauch PM, Specht L, Hoppe RT
Int J Radiat Oncol Biol Phys 2018 Apr 1;100(5):1100-1118. Epub 2018 Jan 9 doi: 10.1016/j.ijrobp.2018.01.011. PMID: 29722655

Recent clinical studies

Etiology

Aoki T, Jiang A, Xu A, Yin Y, Gamboa A, Milne K, Takata K, Miyata-Takata T, Chung S, Rai S, Wu S, Warren M, Strong C, Goodyear T, Morris K, Chong LC, Hav M, Colombo AR, Telenius A, Boyle M, Ben-Neriah S, Power M, Gerrie AS, Weng AP, Karsan A, Roth A, Farinha P, Scott DW, Savage KJ, Nelson BH, Merchant A, Steidl C
J Clin Oncol 2024 Mar 20;42(9):1077-1087. Epub 2023 Dec 19 doi: 10.1200/JCO.23.01115. PMID: 38113419Free PMC Article
Advani RH, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Christian BA, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF
Blood 2021 Aug 12;138(6):427-438. doi: 10.1182/blood.2020009178. PMID: 33827139
Chen R, Zinzani PL, Lee HJ, Armand P, Johnson NA, Brice P, Radford J, Ribrag V, Molin D, Vassilakopoulos TP, Tomita A, von Tresckow B, Shipp MA, Lin J, Kim E, Nahar A, Balakumaran A, Moskowitz CH
Blood 2019 Oct 3;134(14):1144-1153. Epub 2019 Aug 13 doi: 10.1182/blood.2019000324. PMID: 31409671Free PMC Article
Constine LS, Yahalom J, Ng AK, Hodgson DC, Wirth A, Milgrom SA, Mikhaeel NG, Eich HT, Illidge T, Ricardi U, Dieckmann K, Moskowitz CH, Advani R, Mauch PM, Specht L, Hoppe RT
Int J Radiat Oncol Biol Phys 2018 Apr 1;100(5):1100-1118. Epub 2018 Jan 9 doi: 10.1016/j.ijrobp.2018.01.011. PMID: 29722655
Hertzberg M
Hematol Oncol Clin North Am 2014 Feb;28(1):123-47. doi: 10.1016/j.hoc.2013.09.001. PMID: 24287072

Diagnosis

Aoki T, Jiang A, Xu A, Yin Y, Gamboa A, Milne K, Takata K, Miyata-Takata T, Chung S, Rai S, Wu S, Warren M, Strong C, Goodyear T, Morris K, Chong LC, Hav M, Colombo AR, Telenius A, Boyle M, Ben-Neriah S, Power M, Gerrie AS, Weng AP, Karsan A, Roth A, Farinha P, Scott DW, Savage KJ, Nelson BH, Merchant A, Steidl C
J Clin Oncol 2024 Mar 20;42(9):1077-1087. Epub 2023 Dec 19 doi: 10.1200/JCO.23.01115. PMID: 38113419Free PMC Article
Gordon LI
J Natl Compr Canc Netw 2017 May;15(5S):716-718. doi: 10.6004/jnccn.2017.0082. PMID: 28515253
Hertzberg M
Hematol Oncol Clin North Am 2014 Feb;28(1):123-47. doi: 10.1016/j.hoc.2013.09.001. PMID: 24287072
von Tresckow B, Engert A
Curr Opin Oncol 2013 Sep;25(5):463-9. doi: 10.1097/01.cco.0000432524.62475.60. PMID: 23942291
van de Donk NW, Dhimolea E
MAbs 2012 Jul-Aug;4(4):458-65. Epub 2012 Jul 1 doi: 10.4161/mabs.20230. PMID: 22684302Free PMC Article

Therapy

Advani RH, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Christian BA, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF
Blood 2021 Aug 12;138(6):427-438. doi: 10.1182/blood.2020009178. PMID: 33827139
Ramos CA, Grover NS, Beaven AW, Lulla PD, Wu MF, Ivanova A, Wang T, Shea TC, Rooney CM, Dittus C, Park SI, Gee AP, Eldridge PW, McKay KL, Mehta B, Cheng CJ, Buchanan FB, Grilley BJ, Morrison K, Brenner MK, Serody JS, Dotti G, Heslop HE, Savoldo B
J Clin Oncol 2020 Nov 10;38(32):3794-3804. Epub 2020 Jul 23 doi: 10.1200/JCO.20.01342. PMID: 32701411Free PMC Article
Chen R, Zinzani PL, Lee HJ, Armand P, Johnson NA, Brice P, Radford J, Ribrag V, Molin D, Vassilakopoulos TP, Tomita A, von Tresckow B, Shipp MA, Lin J, Kim E, Nahar A, Balakumaran A, Moskowitz CH
Blood 2019 Oct 3;134(14):1144-1153. Epub 2019 Aug 13 doi: 10.1182/blood.2019000324. PMID: 31409671Free PMC Article
Constine LS, Yahalom J, Ng AK, Hodgson DC, Wirth A, Milgrom SA, Mikhaeel NG, Eich HT, Illidge T, Ricardi U, Dieckmann K, Moskowitz CH, Advani R, Mauch PM, Specht L, Hoppe RT
Int J Radiat Oncol Biol Phys 2018 Apr 1;100(5):1100-1118. Epub 2018 Jan 9 doi: 10.1016/j.ijrobp.2018.01.011. PMID: 29722655
van de Donk NW, Dhimolea E
MAbs 2012 Jul-Aug;4(4):458-65. Epub 2012 Jul 1 doi: 10.4161/mabs.20230. PMID: 22684302Free PMC Article

Prognosis

Aoki T, Jiang A, Xu A, Yin Y, Gamboa A, Milne K, Takata K, Miyata-Takata T, Chung S, Rai S, Wu S, Warren M, Strong C, Goodyear T, Morris K, Chong LC, Hav M, Colombo AR, Telenius A, Boyle M, Ben-Neriah S, Power M, Gerrie AS, Weng AP, Karsan A, Roth A, Farinha P, Scott DW, Savage KJ, Nelson BH, Merchant A, Steidl C
J Clin Oncol 2024 Mar 20;42(9):1077-1087. Epub 2023 Dec 19 doi: 10.1200/JCO.23.01115. PMID: 38113419Free PMC Article
Advani RH, Moskowitz AJ, Bartlett NL, Vose JM, Ramchandren R, Feldman TA, LaCasce AS, Christian BA, Ansell SM, Moskowitz CH, Brown L, Zhang C, Taft D, Ansari S, Sacchi M, Ho L, Herrera AF
Blood 2021 Aug 12;138(6):427-438. doi: 10.1182/blood.2020009178. PMID: 33827139
Chen R, Zinzani PL, Lee HJ, Armand P, Johnson NA, Brice P, Radford J, Ribrag V, Molin D, Vassilakopoulos TP, Tomita A, von Tresckow B, Shipp MA, Lin J, Kim E, Nahar A, Balakumaran A, Moskowitz CH
Blood 2019 Oct 3;134(14):1144-1153. Epub 2019 Aug 13 doi: 10.1182/blood.2019000324. PMID: 31409671Free PMC Article
Rutherford SC, Leonard JP
JAMA Oncol 2018 Aug 1;4(8):1120-1121. doi: 10.1001/jamaoncol.2018.1767. PMID: 30003234
Hertzberg M
Hematol Oncol Clin North Am 2014 Feb;28(1):123-47. doi: 10.1016/j.hoc.2013.09.001. PMID: 24287072

Clinical prediction guides

Driessen J, de Wit F, Herrera AF, Zinzani PL, LaCasce AS, Cole PD, Moskowitz CH, García-Sanz R, Fuchs M, Müller H, Borchmann P, Santoro A, Schöder H, Zijlstra JM, Hutten BA, Moskowitz AJ, Kersten MJ
Blood Adv 2024 Jun 11;8(11):2740-2752. doi: 10.1182/bloodadvances.2023012145. PMID: 38502227Free PMC Article
Aoki T, Jiang A, Xu A, Yin Y, Gamboa A, Milne K, Takata K, Miyata-Takata T, Chung S, Rai S, Wu S, Warren M, Strong C, Goodyear T, Morris K, Chong LC, Hav M, Colombo AR, Telenius A, Boyle M, Ben-Neriah S, Power M, Gerrie AS, Weng AP, Karsan A, Roth A, Farinha P, Scott DW, Savage KJ, Nelson BH, Merchant A, Steidl C
J Clin Oncol 2024 Mar 20;42(9):1077-1087. Epub 2023 Dec 19 doi: 10.1200/JCO.23.01115. PMID: 38113419Free PMC Article
Marouf A, Molinari N, Sibon D, Cottereau AS, Kanoun S, Antoine C, Debureaux PE, Cavalieri D, Fornecker LM, Casasnovas RO, Herbaux C, Amorim S, Rossi C, Bouscary D, Brice P, Ghesquieres H, Tamburini J, Deau B
Br J Haematol 2023 Jul;202(2):379-383. Epub 2023 May 16 doi: 10.1111/bjh.18859. PMID: 37192755
Ramos CA, Grover NS, Beaven AW, Lulla PD, Wu MF, Ivanova A, Wang T, Shea TC, Rooney CM, Dittus C, Park SI, Gee AP, Eldridge PW, McKay KL, Mehta B, Cheng CJ, Buchanan FB, Grilley BJ, Morrison K, Brenner MK, Serody JS, Dotti G, Heslop HE, Savoldo B
J Clin Oncol 2020 Nov 10;38(32):3794-3804. Epub 2020 Jul 23 doi: 10.1200/JCO.20.01342. PMID: 32701411Free PMC Article
LaCasce AS, Bociek RG, Sawas A, Caimi P, Agura E, Matous J, Ansell SM, Crosswell HE, Islas-Ohlmayer M, Behler C, Cheung E, Forero-Torres A, Vose J, O'Connor OA, Josephson N, Wang Y, Advani R
Blood 2018 Jul 5;132(1):40-48. Epub 2018 Apr 27 doi: 10.1182/blood-2017-11-815183. PMID: 29703778Free PMC Article

Recent systematic reviews

Plattel WJ, Bergamasco A, Trinchese F, Gavini F, Bent-Ennakhil N, Zomas A, Castillon G, Arredondo-Bisono T, Cristarella T, Moride Y, von Tresckow B
Leuk Lymphoma 2021 Dec;62(14):3320-3332. Epub 2021 Jul 29 doi: 10.1080/10428194.2021.1957865. PMID: 34323643
Zinzani PL, Sasse S, Radford J, Gautam A, Bonthapally V
Crit Rev Oncol Hematol 2016 Aug;104:65-70. Epub 2016 May 21 doi: 10.1016/j.critrevonc.2016.04.019. PMID: 27279289
Dada R, Zekri J, Al Saadi R
Expert Opin Biol Ther 2016 Jun;16(6):739-45. Epub 2016 May 3 doi: 10.1080/14712598.2016.1180362. PMID: 27096887
Martino M, Festuccia M, Fedele R, Console G, Cimminiello M, Gavarotti P, Bruno B
Expert Opin Biol Ther 2016;16(3):347-64. Epub 2016 Feb 6 doi: 10.1517/14712598.2015.1130821. PMID: 26652934
Bonthapally V, Wu E, Macalalad A, Yang H, Shonukan O, Liu Y, Chi A, Huebner D
Curr Med Res Opin 2015 May;31(5):993-1001. Epub 2015 Apr 9 doi: 10.1185/03007995.2015.1030378. PMID: 25772232

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