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Central Nervous System Paraganglioma

MedGen UID:
232042
•Concept ID:
C1332890
•
Neoplastic Process
Synonyms: CNS Paraganglioma; Paraganglioma of Central Nervous System; Paraganglioma of CNS; Paraganglioma of the Central Nervous System; Paraganglioma of the CNS

Definition

An extra-adrenal paraganglioma arising from the central nervous system. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCentral Nervous System Paraganglioma

Professional guidelines

PubMed

Management recommendations for pancreatic manifestations of von Hippel-Lindau disease.
Laks S, van Leeuwaarde R, Patel D, Keutgen XM, Hammel P, Nilubol N, Links TP, Halfdanarson TR, Daniels AB, Tirosh A; Pancreatic Manifestations Recommendations Development Subcommittee of the VHL Alliance
Cancer 2022 Feb 1;128(3):435-446. Epub 2021 Nov 4 doi: 10.1002/cncr.33978. PMID: 34735022
Imaging Evaluation and Treatment of Vascular Lesions at the Skull Base.
Jindal G, Miller T, Raghavan P, Gandhi D
Radiol Clin North Am 2017 Jan;55(1):151-166. Epub 2016 Oct 25 doi: 10.1016/j.rcl.2016.08.003. PMID: 27890183
TUMORS OF THE LATERAL VENTRICLES OF THE BRAIN. REPORT OF EIGHT CASES, WITH SUGGESTIONS FOR CLINICAL MANAGEMENT.
DELATORRE E, ALEXANDER E Jr, DAVIS CH Jr, CRANDELL DL
J Neurosurg 1963 Jun;20:461-70. doi: 10.3171/jns.1963.20.6.0461. PMID: 14192110

Recent clinical studies

Etiology

ETV as a last resort.
Mandiwanza T, Zakaria Z, Khalil A, Crimmins D, Caird J
Childs Nerv Syst 2014 May;30(5):859-66. Epub 2013 Nov 30 doi: 10.1007/s00381-013-2330-2. PMID: 24292271
VHL disease.
Barontini M, Dahia PL
Best Pract Res Clin Endocrinol Metab 2010 Jun;24(3):401-13. doi: 10.1016/j.beem.2010.01.002. PMID: 20833332
Temporal paragangliomas.
Suárez C, Sevilla MA, Llorente JL
Eur Arch Otorhinolaryngol 2007 Jul;264(7):719-31. Epub 2007 Mar 2 doi: 10.1007/s00405-007-0267-3. PMID: 17333230
Glomus jugulare tumors with intracranial extension.
Jackson CG, Kaylie DM, Coppit G, Gardner EK
Neurosurg Focus 2004 Aug 15;17(2):E7. doi: 10.3171/foc.2004.17.2.7. PMID: 15329022
Central nervous system gangliogliomas. Part 1: Pathology.
Miller DC, Lang FF, Epstein FJ
J Neurosurg 1993 Dec;79(6):859-66. doi: 10.3171/jns.1993.79.6.0859. PMID: 8246054

Diagnosis

Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia.
Toledo RA, Jimenez C, Armaiz-Pena G, Arenillas C, Capdevila J, Dahia PLM
Endocr Rev 2023 Mar 4;44(2):312-322. doi: 10.1210/endrev/bnac025. PMID: 36301191Free PMC Article
Imaging diagnosis and the role of endovascular embolization treatment for vascular intraspinal tumors.
dos Santos MP, Zhang J, Ghinda D, Glikstein R, Agid R, Rodesch G, Tampieri D, terBrugge KG
Neurosurg Focus 2015 Aug;39(2):E16. doi: 10.3171/2015.5.FOCUS1514. PMID: 26235014
Temporal paragangliomas.
Suárez C, Sevilla MA, Llorente JL
Eur Arch Otorhinolaryngol 2007 Jul;264(7):719-31. Epub 2007 Mar 2 doi: 10.1007/s00405-007-0267-3. PMID: 17333230
Intracerebral paraganglioma.
Reithmeier T, Gumprecht H, Stölzle A, Lumenta CB
Acta Neurochir (Wien) 2000;142(9):1063-6. doi: 10.1007/s007010070064. PMID: 11086818
Catecholamines--a symposium.
Calif Med 1972 Sep;117(3):32-62. PMID: 4341831Free PMC Article

Therapy

Belzutifan: First Approval.
Deeks ED
Drugs 2021 Nov;81(16):1921-1927. doi: 10.1007/s40265-021-01606-x. PMID: 34613603
¹⁸F-DOPA PET/computed tomography imaging.
Chondrogiannis S, Marzola MC, Rubello D
PET Clin 2014 Jul;9(3):307-21. Epub 2014 Apr 29 doi: 10.1016/j.cpet.2014.03.007. PMID: 25030394
Propranolol safety profile in children.
El-Shabrawi M, Hassanin F
Curr Drug Saf 2011 Sep 1;6(4):259-66. doi: 10.2174/157488611798280889. PMID: 22129321
Glomus jugulare tumors with intracranial extension.
Jackson CG, Kaylie DM, Coppit G, Gardner EK
Neurosurg Focus 2004 Aug 15;17(2):E7. doi: 10.3171/foc.2004.17.2.7. PMID: 15329022
Perioperative evaluation and management of the patient with endocrine dysfunction.
Schiff RL, Welsh GA
Med Clin North Am 2003 Jan;87(1):175-92. doi: 10.1016/s0025-7125(02)00150-5. PMID: 12575889

Prognosis

Neuroimaging for Radiation Therapy of Brain Tumors.
Popp I, Weber WA, Combs SE, Yuh WTC, Grosu AL
Top Magn Reson Imaging 2019 Apr;28(2):63-71. doi: 10.1097/RMR.0000000000000198. PMID: 31022049
Surgical technique and results of cable graft interpositioning of the facial nerve in lateral skull base surgeries: experience with 213 consecutive cases.
Prasad SC, Balasubramanian K, Piccirillo E, Taibah A, Russo A, He J, Sanna M
J Neurosurg 2018 Feb;128(2):631-638. Epub 2017 Apr 7 doi: 10.3171/2016.9.JNS16997. PMID: 28387625
Long-term follow-up of an infratentorial primary paraganglioma: a case report.
Xhumari A, Couvelard A, Redondo A, Kalamarides M
Br J Neurosurg 2007 Oct;21(5):531-5. doi: 10.1080/02688690701432448. PMID: 17852107
Temporal paragangliomas.
Suárez C, Sevilla MA, Llorente JL
Eur Arch Otorhinolaryngol 2007 Jul;264(7):719-31. Epub 2007 Mar 2 doi: 10.1007/s00405-007-0267-3. PMID: 17333230
The microsurgical anatomy of the glossopharyngeal nerve with respect to the jugular foramen lesions.
Ozveren MF, Türe U
Neurosurg Focus 2004 Aug 15;17(2):E3. doi: 10.3171/foc.2004.17.2.3. PMID: 15329018

Clinical prediction guides

Hemangioblastomas and Other Vascular Origating Tumors of Brain or Spinal Cord.
Vetrano IG, Gioppo A, Faragò G, Pinzi V, Pollo B, Broggi M, Schiariti M, Ferroli P, Acerbi F
Adv Exp Med Biol 2023;1405:377-403. doi: 10.1007/978-3-031-23705-8_14. PMID: 37452946
Hypoxia-Inducible Factor 2 Alpha (HIF2α) Inhibitors: Targeting Genetically Driven Tumor Hypoxia.
Toledo RA, Jimenez C, Armaiz-Pena G, Arenillas C, Capdevila J, Dahia PLM
Endocr Rev 2023 Mar 4;44(2):312-322. doi: 10.1210/endrev/bnac025. PMID: 36301191Free PMC Article
Paraganglioma in the spinal cord histologically mimicking ependymoma - a case report.
Stefanova N, Enchev Y, Dzhenkov D, Hachmeryan A
Folia Med (Plovdiv) 2022 Dec 31;64(6):1007-1011. doi: 10.3897/folmed.64.e71407. PMID: 36876561
Von Hippel-Lindau disease: clinical and pathological manifestations in nine families with 50 affected members.
Horton WA, Wong V, Eldridge R
Arch Intern Med 1976 Jul;136(7):769-77. doi: 10.1001/archinte.136.7.769. PMID: 945722
The role of noradrenaline and other transmitter hormones in the pathogenesis of hypertension.
Louis WJ, Jarrott B, Doyle AE
Clin Sci Mol Med Suppl 1976 Dec;3:427s-430s. doi: 10.1042/cs051427s. PMID: 799556

Recent systematic reviews

Primary and metastatic paraganglioma of the cranial vault.
Kakodkar P, Houlihan LM, Preul M, Bermingham N, Lim C
Br J Neurosurg 2023 Oct;37(5):967-975. Epub 2021 Mar 19 doi: 10.1080/02688697.2021.1902477. PMID: 33739182
The scalp hair collar and tuft signs: A retrospective multicenter study of 78 patients with a systematic review of the literature.
Bessis D, Bigorre M, Malissen N, Captier G, Chiaverini C, Abasq C, Barbarot S, Boccara O, Bourrat E, El Fertit H, Eschard C, Hubiche T, Lacour JP, Leboucq N, Mahé E, Mallet S, Marque M, Martin L, Mazereeuw-Hautier J, Milla N, Phan A, Plantin P, Picot MC, Puzenat E, Rigau V, Vabres P, Fraitag S, Boralevi F; Groupe de Recherche Clinique en Dermatologie Pédiatrique
J Am Acad Dermatol 2017 Mar;76(3):478-487. Epub 2016 Oct 11 doi: 10.1016/j.jaad.2016.08.046. PMID: 27742172
Regression and local control rates after radiotherapy for jugulotympanic paragangliomas: systematic review and meta-analysis.
van Hulsteijn LT, Corssmit EP, Coremans IE, Smit JW, Jansen JC, Dekkers OM
Radiother Oncol 2013 Feb;106(2):161-8. Epub 2013 Jan 16 doi: 10.1016/j.radonc.2012.11.002. PMID: 23332889

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