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Breast Carcinoma Metastatic in the Brain

MedGen UID:
234049
•Concept ID:
C1332624
•
Neoplastic Process
Synonym: Breast Carcinoma Metastatic to the Brain

Definition

A carcinoma that has spread to the brain from its original site in the breast, through the hematogenous route. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVBreast Carcinoma Metastatic in the Brain

Professional guidelines

PubMed

Oncogene-addicted metastatic non-small-cell lung cancer: ESMO Clinical Practice Guideline for diagnosis, treatment and follow-up.
Hendriks LE, Kerr KM, Menis J, Mok TS, Nestle U, Passaro A, Peters S, Planchard D, Smit EF, Solomon BJ, Veronesi G, Reck M; ESMO Guidelines Committee. Electronic address: clinicalguidelines@esmo.org
Ann Oncol 2023 Apr;34(4):339-357. Epub 2023 Jan 23 doi: 10.1016/j.annonc.2022.12.009. PMID: 36872130
Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors.
Lange M, Joly F, Vardy J, Ahles T, Dubois M, Tron L, Winocur G, De Ruiter MB, Castel H
Ann Oncol 2019 Dec 1;30(12):1925-1940. doi: 10.1093/annonc/mdz410. PMID: 31617564Free PMC Article

Recent clinical studies

Etiology

Metastatic HER2-Positive Breast Cancer: Is There an Optimal Sequence of Therapy?
Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).
Biganzoli L, Battisti NML, Wildiers H, McCartney A, Colloca G, Kunkler IH, Cardoso MJ, Cheung KL, de Glas NA, Trimboli RM, Korc-Grodzicki B, Soto-Perez-de-Celis E, Ponti A, Tsang J, Marotti L, Benn K, Aapro MS, Brain EGC
Lancet Oncol 2021 Jul;22(7):e327-e340. Epub 2021 May 14 doi: 10.1016/S1470-2045(20)30741-5. PMID: 34000244
Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in HER2-Positive Metastatic Breast Cancer Previously Treated With ≥ 2 HER2-Directed Regimens: Phase III NALA Trial.
Saura C, Oliveira M, Feng YH, Dai MS, Chen SW, Hurvitz SA, Kim SB, Moy B, Delaloge S, Gradishar W, Masuda N, Palacova M, Trudeau ME, Mattson J, Yap YS, Hou MF, De Laurentiis M, Yeh YM, Chang HT, Yau T, Wildiers H, Haley B, Fagnani D, Lu YS, Crown J, Lin J, Takahashi M, Takano T, Yamaguchi M, Fujii T, Yao B, Bebchuk J, Keyvanjah K, Bryce R, Brufsky A; NALA Investigators
J Clin Oncol 2020 Sep 20;38(27):3138-3149. Epub 2020 Jul 17 doi: 10.1200/JCO.20.00147. PMID: 32678716Free PMC Article
Molecular and cellular mechanisms underlying brain metastasis of breast cancer.
Hosonaga M, Saya H, Arima Y
Cancer Metastasis Rev 2020 Sep;39(3):711-720. doi: 10.1007/s10555-020-09881-y. PMID: 32399646Free PMC Article
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Diagnosis

Breast Cancer Brain Metastasis: A Comprehensive Review.
Raghavendra AS, Ibrahim NK
JCO Oncol Pract 2024 Oct;20(10):1348-1359. Epub 2024 May 15 doi: 10.1200/OP.23.00794. PMID: 38748968Free PMC Article
Organ-Specificity of Breast Cancer Metastasis.
Ibragimova MK, Tsyganov MM, Kravtsova EA, Tsydenova IA, Litviakov NV
Int J Mol Sci 2023 Oct 26;24(21) doi: 10.3390/ijms242115625. PMID: 37958607Free PMC Article
Metastatic HER2-Positive Breast Cancer: Is There an Optimal Sequence of Therapy?
Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Epidemiology of brain metastases.
Nayak L, Lee EQ, Wen PY
Curr Oncol Rep 2012 Feb;14(1):48-54. doi: 10.1007/s11912-011-0203-y. PMID: 22012633
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Therapy

Metastatic HER2-Positive Breast Cancer: Is There an Optimal Sequence of Therapy?
Dempsey N, Sandoval A, Mahtani R
Curr Treat Options Oncol 2023 Sep;24(9):1120-1137. Epub 2023 Jul 10 doi: 10.1007/s11864-023-01108-w. PMID: 37428332
Neratinib Plus Capecitabine Versus Lapatinib Plus Capecitabine in HER2-Positive Metastatic Breast Cancer Previously Treated With ≥ 2 HER2-Directed Regimens: Phase III NALA Trial.
Saura C, Oliveira M, Feng YH, Dai MS, Chen SW, Hurvitz SA, Kim SB, Moy B, Delaloge S, Gradishar W, Masuda N, Palacova M, Trudeau ME, Mattson J, Yap YS, Hou MF, De Laurentiis M, Yeh YM, Chang HT, Yau T, Wildiers H, Haley B, Fagnani D, Lu YS, Crown J, Lin J, Takahashi M, Takano T, Yamaguchi M, Fujii T, Yao B, Bebchuk J, Keyvanjah K, Bryce R, Brufsky A; NALA Investigators
J Clin Oncol 2020 Sep 20;38(27):3138-3149. Epub 2020 Jul 17 doi: 10.1200/JCO.20.00147. PMID: 32678716Free PMC Article
The Effect of Exercise on Cancer-Related Cognitive Impairment and Applications for Physical Therapy: Systematic Review of Randomized Controlled Trials.
Campbell KL, Zadravec K, Bland KA, Chesley E, Wolf F, Janelsins MC
Phys Ther 2020 Mar 10;100(3):523-542. doi: 10.1093/ptj/pzz090. PMID: 32065236Free PMC Article
Neratinib and capecitabine for breast cancer brain metastases.
Stirrups R
Lancet Oncol 2019 Apr;20(4):e197. Epub 2019 Mar 22 doi: 10.1016/S1470-2045(19)30184-6. PMID: 30910514
Investigational chemotherapy and novel pharmacokinetic mechanisms for the treatment of breast cancer brain metastases.
Shah N, Mohammad AS, Saralkar P, Sprowls SA, Vickers SD, John D, Tallman RM, Lucke-Wold BP, Jarrell KE, Pinti M, Nolan RL, Lockman PR
Pharmacol Res 2018 Jun;132:47-68. Epub 2018 Mar 28 doi: 10.1016/j.phrs.2018.03.021. PMID: 29604436Free PMC Article

Prognosis

Targeting brain metastases in breast cancer.
Corti C, Antonarelli G, Criscitiello C, Lin NU, Carey LA, Cortés J, Poortmans P, Curigliano G
Cancer Treat Rev 2022 Feb;103:102324. Epub 2021 Dec 16 doi: 10.1016/j.ctrv.2021.102324. PMID: 34953200
Breast cancer brain metastasis: insight into molecular mechanisms and therapeutic strategies.
Wang Y, Ye F, Liang Y, Yang Q
Br J Cancer 2021 Oct;125(8):1056-1067. Epub 2021 Jul 5 doi: 10.1038/s41416-021-01424-8. PMID: 34226684Free PMC Article
The incidence of brain metastases among patients with metastatic breast cancer: a systematic review and meta-analysis.
Kuksis M, Gao Y, Tran W, Hoey C, Kiss A, Komorowski AS, Dhaliwal AJ, Sahgal A, Das S, Chan KK, Jerzak KJ
Neuro Oncol 2021 Jun 1;23(6):894-904. doi: 10.1093/neuonc/noaa285. PMID: 33367836Free PMC Article
Metastatic heterogeneity of breast cancer: Molecular mechanism and potential therapeutic targets.
Liang Y, Zhang H, Song X, Yang Q
Semin Cancer Biol 2020 Feb;60:14-27. Epub 2019 Aug 14 doi: 10.1016/j.semcancer.2019.08.012. PMID: 31421262
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Clinical prediction guides

Density of tertiary lymphoid structures predicts clinical outcome in breast cancer brain metastasis.
Zhao YY, Fan Z, Tao BR, Du ZG, Shi ZF
J Immunother Cancer 2024 Jul 27;12(7) doi: 10.1136/jitc-2024-009232. PMID: 39067874Free PMC Article
Updated recommendations regarding the management of older patients with breast cancer: a joint paper from the European Society of Breast Cancer Specialists (EUSOMA) and the International Society of Geriatric Oncology (SIOG).
Biganzoli L, Battisti NML, Wildiers H, McCartney A, Colloca G, Kunkler IH, Cardoso MJ, Cheung KL, de Glas NA, Trimboli RM, Korc-Grodzicki B, Soto-Perez-de-Celis E, Ponti A, Tsang J, Marotti L, Benn K, Aapro MS, Brain EGC
Lancet Oncol 2021 Jul;22(7):e327-e340. Epub 2021 May 14 doi: 10.1016/S1470-2045(20)30741-5. PMID: 34000244
Molecular Mechanisms of Breast Cancer Metastasis to the Lung: Clinical and Experimental Perspectives.
Medeiros B, Allan AL
Int J Mol Sci 2019 May 8;20(9) doi: 10.3390/ijms20092272. PMID: 31071959Free PMC Article
Complement Component 3 Adapts the Cerebrospinal Fluid for Leptomeningeal Metastasis.
Boire A, Zou Y, Shieh J, Macalinao DG, Pentsova E, Massagué J
Cell 2017 Mar 9;168(6):1101-1113.e13. doi: 10.1016/j.cell.2017.02.025. PMID: 28283064Free PMC Article
Metastatic behavior of breast cancer subtypes.
Kennecke H, Yerushalmi R, Woods R, Cheang MC, Voduc D, Speers CH, Nielsen TO, Gelmon K
J Clin Oncol 2010 Jul 10;28(20):3271-7. Epub 2010 May 24 doi: 10.1200/JCO.2009.25.9820. PMID: 20498394

Recent systematic reviews

Treatment for Brain Metastases: ASCO-SNO-ASTRO Guideline.
Vogelbaum MA, Brown PD, Messersmith H, Brastianos PK, Burri S, Cahill D, Dunn IF, Gaspar LE, Gatson NTN, Gondi V, Jordan JT, Lassman AB, Maues J, Mohile N, Redjal N, Stevens G, Sulman E, van den Bent M, Wallace HJ, Weinberg JS, Zadeh G, Schiff D
J Clin Oncol 2022 Feb 10;40(5):492-516. Epub 2021 Dec 21 doi: 10.1200/JCO.21.02314. PMID: 34932393
The genomic landscape of breast cancer brain metastases: a systematic review.
Morgan AJ, Giannoudis A, Palmieri C
Lancet Oncol 2021 Jan;22(1):e7-e17. doi: 10.1016/S1470-2045(20)30556-8. PMID: 33387511
The incidence of brain metastases among patients with metastatic breast cancer: a systematic review and meta-analysis.
Kuksis M, Gao Y, Tran W, Hoey C, Kiss A, Komorowski AS, Dhaliwal AJ, Sahgal A, Das S, Chan KK, Jerzak KJ
Neuro Oncol 2021 Jun 1;23(6):894-904. doi: 10.1093/neuonc/noaa285. PMID: 33367836Free PMC Article
The Effect of Exercise on Cancer-Related Cognitive Impairment and Applications for Physical Therapy: Systematic Review of Randomized Controlled Trials.
Campbell KL, Zadravec K, Bland KA, Chesley E, Wolf F, Janelsins MC
Phys Ther 2020 Mar 10;100(3):523-542. doi: 10.1093/ptj/pzz090. PMID: 32065236Free PMC Article
Recommendations on Disease Management for Patients With Advanced Human Epidermal Growth Factor Receptor 2-Positive Breast Cancer and Brain Metastases: ASCO Clinical Practice Guideline Update Summary.
Ramakrishna N, Temin S, Lin NU
J Oncol Pract 2018 Aug;14(8):505-507. Epub 2018 Jul 10 doi: 10.1200/JOP.18.00291. PMID: 29989840

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