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Refractory Chronic Myeloid Leukemia, BCR-ABL1 Positive

MedGen UID:
234587
Concept ID:
C1370868
Neoplastic Process
Synonyms: Refractory CGL; Refractory Chronic Granulocytic Leukemia; Refractory Chronic Myelocytic Leukemia; Refractory Chronic Myelogenous Leukemia; Refractory Chronic Myelogenous Leukemia, BCR-ABL1 Positive; Refractory Chronic Myelogenous Leukemia, BCR::ABL1 Positive; Refractory Chronic Myeloid Leukemia; Refractory Chronic Myeloid Leukemia, BCR::ABL1 Positive

Definition

Chronic myeloid leukemia, BCR-ABL1 positive that is resistant to treatment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVRefractory Chronic Myeloid Leukemia, BCR-ABL1 Positive

Professional guidelines

PubMed

García Molina A
Farm Hosp 2024 Sep-Oct;48(5):T222-T229. Epub 2024 Jul 15 doi: 10.1016/j.farma.2024.06.004. PMID: 39013681
Garcia Molina A
Farm Hosp 2024 Sep-Oct;48(5):222-229. Epub 2024 Apr 27 doi: 10.1016/j.farma.2024.03.008. PMID: 38679535
Li X, Zhang J, Liu F, Liu T, Zhang R, Chen Y, Guo Y, Fang Y, Xu X, Pui CH, Zhu X
Clin Lymphoma Myeloma Leuk 2023 Sep;23(9):660-666. Epub 2023 May 11 doi: 10.1016/j.clml.2023.04.012. PMID: 37301632

Recent clinical studies

Etiology

Mughal TI, Mascarenhas J, Rampal RK, Bose P, Lion T, Ajufo H, Yacoub A, Meshinchi S, Masarova L, Mesa R, Jamieson C, Barbui T, Saglio G, Van Etten RA
Hematol Oncol 2025 Jan;43(1):e70013. doi: 10.1002/hon.70013. PMID: 39825826
Short NJ, Nguyen D, Jabbour E, Senapati J, Zeng Z, Issa GC, Abbas H, Nasnas C, Qiao W, Huang X, Borthakur G, Chien K, Haddad FG, Pemmaraju N, Karrar OS, Nguyen D, Konopleva M, Kantarjian H, Ravandi F
Lancet Haematol 2024 Nov;11(11):e839-e849. Epub 2024 Sep 17 doi: 10.1016/S2352-3026(24)00250-3. PMID: 39303729Free PMC Article
Zou JY, Huang SM, Zhoub HX, Xu MZ, Sun AN, Wu DP, Xue SL, Zhang TT
Hematology 2023 Dec;28(1):2237790. doi: 10.1080/16078454.2023.2237790. PMID: 37477259
Wästerlid T, Cavelier L, Haferlach C, Konopleva M, Fröhling S, Östling P, Bullinger L, Fioretos T, Smedby KE
J Intern Med 2022 Aug;292(2):243-261. Epub 2022 Jun 4 doi: 10.1111/joim.13508. PMID: 35599019Free PMC Article
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article

Diagnosis

Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
Rosshandler Y, Shen AQ, Cortes J, Khoury HJ
Expert Rev Hematol 2016 May;9(5):419-24. Epub 2016 Apr 21 doi: 10.1586/17474086.2016.1151351. PMID: 26853281
Ernst T, Hochhaus A
Semin Oncol 2012 Feb;39(1):58-66. doi: 10.1053/j.seminoncol.2011.11.002. PMID: 22289492
Cazzola M, Malcovati L, Invernizzi R
Hematology Am Soc Hematol Educ Program 2011;2011:264-72. doi: 10.1182/asheducation-2011.1.264. PMID: 22160044

Therapy

Liu W, Wang C, Ouyang W, Hao J, Ren J, Peng L, Tang S, Liu Y, Zhu Y, Weng X, Jing D, Chen S, Wang J, Mi JQ
Br J Haematol 2024 Dec;205(6):2228-2233. Epub 2024 Oct 3 doi: 10.1111/bjh.19804. PMID: 39363594
Li X, Zhang J, Liu F, Liu T, Zhang R, Chen Y, Guo Y, Fang Y, Xu X, Pui CH, Zhu X
Clin Lymphoma Myeloma Leuk 2023 Sep;23(9):660-666. Epub 2023 May 11 doi: 10.1016/j.clml.2023.04.012. PMID: 37301632
Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
Rosshandler Y, Shen AQ, Cortes J, Khoury HJ
Expert Rev Hematol 2016 May;9(5):419-24. Epub 2016 Apr 21 doi: 10.1586/17474086.2016.1151351. PMID: 26853281
Al Ustwani O, Griffiths EA, Wang ES, Wetzler M
Expert Opin Pharmacother 2014 Nov;15(16):2397-405. doi: 10.1517/14656566.2014.964642. PMID: 25301179

Prognosis

Mughal TI, Mascarenhas J, Rampal RK, Bose P, Lion T, Ajufo H, Yacoub A, Meshinchi S, Masarova L, Mesa R, Jamieson C, Barbui T, Saglio G, Van Etten RA
Hematol Oncol 2025 Jan;43(1):e70013. doi: 10.1002/hon.70013. PMID: 39825826
Wästerlid T, Cavelier L, Haferlach C, Konopleva M, Fröhling S, Östling P, Bullinger L, Fioretos T, Smedby KE
J Intern Med 2022 Aug;292(2):243-261. Epub 2022 Jun 4 doi: 10.1111/joim.13508. PMID: 35599019Free PMC Article
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Marsola APZC, Simões BP, Palma LC, Berzoti-Coelho MG, Burin SM, de Castro FA
Med Oncol 2018 Jan 31;35(3):26. doi: 10.1007/s12032-018-1079-6. PMID: 29387948
Cazzola M, Malcovati L, Invernizzi R
Hematology Am Soc Hematol Educ Program 2011;2011:264-72. doi: 10.1182/asheducation-2011.1.264. PMID: 22160044

Clinical prediction guides

Jabbour E, Short NJ, Jain N, Huang X, Montalban-Bravo G, Banerjee P, Rezvani K, Jiang X, Kim KH, Kanagal-Shamanna R, Khoury JD, Patel K, Kadia TM, Daver N, Chien K, Alvarado Y, Garcia-Manero G, Issa GC, Haddad FG, Kwari M, Thankachan J, Delumpa R, Macaron W, Garris R, Konopleva M, Ravandi F, Kantarjian H
Lancet Haematol 2023 Jan;10(1):e24-e34. Epub 2022 Nov 16 doi: 10.1016/S2352-3026(22)00319-2. PMID: 36402146
Vetrie D, Helgason GV, Copland M
Nat Rev Cancer 2020 Mar;20(3):158-173. Epub 2020 Jan 6 doi: 10.1038/s41568-019-0230-9. PMID: 31907378
Piedimonte M, Ottone T, Alfonso V, Ferrari A, Conte E, Divona M, Bianchi MP, Ricciardi MR, Mirabilii S, Licchetta R, Campagna A, Cicconi L, Galassi G, Pelliccia S, Leporace A, Lo Coco F, Tafuri A
BMC Cancer 2019 Jan 10;19(1):50. doi: 10.1186/s12885-019-5265-5. PMID: 30630459Free PMC Article
Marsola APZC, Simões BP, Palma LC, Berzoti-Coelho MG, Burin SM, de Castro FA
Med Oncol 2018 Jan 31;35(3):26. doi: 10.1007/s12032-018-1079-6. PMID: 29387948
Parker WT, Yeung DT, Yeoman AL, Altamura HK, Jamison BA, Field CR, Hodgson JG, Lustgarten S, Rivera VM, Hughes TP, Branford S
Blood 2016 Apr 14;127(15):1870-80. Epub 2016 Jan 14 doi: 10.1182/blood-2015-09-666214. PMID: 26773037Free PMC Article

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