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Stromal sarcoma

MedGen UID:
235091
•Concept ID:
C1370723
•
Neoplastic Process
Synonyms: Malignant stromal tumor; Stromal Sarcoma; stromal sarcoma; stromal sarcoma, malignant; stromal tumor, malignant
SNOMED CT: Stromal sarcoma (128753005); Malignant stromal tumor (253048008)
 
Monarch Initiative: MONDO:0044337

Definition

A malignant neoplasm characterized by the presence of atypical mesenchymal-stromal cells. Representative examples include endometrial stromal sarcoma and prostate stromal sarcoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVStromal sarcoma

Professional guidelines

PubMed

Current Treatment Options: Uterine Sarcoma.
Lewis D, Liang A, Mason T, Ferriss JS
Curr Treat Options Oncol 2024 Jul;25(7):829-853. Epub 2024 May 31 doi: 10.1007/s11864-024-01214-3. PMID: 38819624
Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Advances in the diagnosis and treatment of uterine sarcomas.
Dizon DS, Birrer MJ
Discov Med 2014 Jun;17(96):339-45. PMID: 24979254

Recent clinical studies

Etiology

Current Concepts in the Imaging of Uterine Sarcomas.
Petrocelli R, Hindman N, Reinhold C
Radiol Clin North Am 2023 Jul;61(4):627-638. Epub 2023 Apr 3 doi: 10.1016/j.rcl.2023.02.008. PMID: 37169428
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Molecular pathogenesis and prognostication of "low-grade'' and "high-grade" endometrial stromal sarcoma.
Micci F, Heim S, Panagopoulos I
Genes Chromosomes Cancer 2021 Mar;60(3):160-167. Epub 2020 Nov 10 doi: 10.1002/gcc.22907. PMID: 33099834Free PMC Article
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439

Diagnosis

Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
Update on Uterine Mesenchymal Neoplasms.
Kertowidjojo EC, Bennett JA
Surg Pathol Clin 2022 Jun;15(2):315-340. Epub 2022 May 20 doi: 10.1016/j.path.2022.02.008. PMID: 35715164
Molecular pathogenesis and prognostication of "low-grade'' and "high-grade" endometrial stromal sarcoma.
Micci F, Heim S, Panagopoulos I
Genes Chromosomes Cancer 2021 Mar;60(3):160-167. Epub 2020 Nov 10 doi: 10.1002/gcc.22907. PMID: 33099834Free PMC Article
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article

Therapy

Prognostic significance of lymphadenectomy in uterine leiomyosarcomas and endometrial stromal sarcomas: Systematic review and meta-analysis.
Li Y, Gong Q, Peng J, Liu Y, Jiang Y, Zhang S
Eur J Obstet Gynecol Reprod Biol 2022 Dec;279:94-101. Epub 2022 Oct 21 doi: 10.1016/j.ejogrb.2022.10.013. PMID: 36308940
Current Status of Magnetic Resonance Imaging in Patients with Malignant Uterine Neoplasms: A Review.
Huang YT, Huang YL, Ng KK, Lin G
Korean J Radiol 2019 Jan;20(1):18-33. Epub 2018 Dec 27 doi: 10.3348/kjr.2018.0090. PMID: 30627019Free PMC Article
Current management of uterine sarcomas.
García-Martínez E, Egea Prefasi L, García-Donas J, Escolar-Pérez PP, Pastor F, González-Martín A
Clin Transl Oncol 2011 May;13(5):307-14. doi: 10.1007/s12094-011-0659-0. PMID: 21596658
Aromatase inhibitors in gynecologic cancers.
Krasner C
J Steroid Biochem Mol Biol 2007 Aug-Sep;106(1-5):76-80. Epub 2007 May 24 doi: 10.1016/j.jsbmb.2007.05.026. PMID: 17826626
Uterine sarcomas.
Moinfar F, Azodi M, Tavassoli FA
Pathology 2007 Feb;39(1):55-71. doi: 10.1080/00313020601136146. PMID: 17365823

Prognosis

Endometrial stromal tumors of the uterus: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, De Vitis LA, Cosio S, Carinelli S, Aletti GD
Gynecol Oncol 2023 Apr;171:95-105. Epub 2023 Feb 24 doi: 10.1016/j.ygyno.2023.02.009. PMID: 36842409
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Beyond Smooth Muscle-Other Mesenchymal Neoplasms of the Uterus.
Dickson BC
Surg Pathol Clin 2019 Mar;12(1):107-137. Epub 2018 Dec 24 doi: 10.1016/j.path.2018.10.005. PMID: 30709439
Uterine sarcomas.
Mbatani N, Olawaiye AB, Prat J
Int J Gynaecol Obstet 2018 Oct;143 Suppl 2:51-58. doi: 10.1002/ijgo.12613. PMID: 30306577
Atypical prostatic stromal lesions.
Cohen MB
Adv Anat Pathol 1998 Nov;5(6):359-66. doi: 10.1097/00125480-199811000-00002. PMID: 10095877

Clinical prediction guides

Uterine sarcomas and rare uterine mesenchymal tumors with malignant potential. Diagnostic guidelines of the French Sarcoma Group and the Rare Gynecological Tumors Group.
Croce S, Devouassoux-Shisheboran M, Pautier P, Ray-Coquard I, Treilleux I, Neuville A, Arnould L, Just PA, Belda MALF, Averous G, Leroux A, Mery E, Loussouarn D, Weinbreck N, Le Guellec S, Mishellany F, Morice P, Guyon F, Genestie C
Gynecol Oncol 2022 Nov;167(2):373-389. Epub 2022 Sep 14 doi: 10.1016/j.ygyno.2022.07.031. PMID: 36114030
A nomogram for predicting overall survival in patients with low-grade endometrial stromal sarcoma: A population-based analysis.
Wu J, Zhang H, Li L, Hu M, Chen L, Xu B, Song Q
Cancer Commun (Lond) 2020 Jul;40(7):301-312. Epub 2020 Jun 18 doi: 10.1002/cac2.12067. PMID: 32558385Free PMC Article
Aromatase inhibitor therapy for endometrial stromal sarcoma - two-centre experience.
Serkies K, Abacjew-Chmyłko A, Wieczorek-Rutkowska M, Pęksa R
Ginekol Pol 2018;89(11):607-610. doi: 10.5603/GP.a2018.0104. PMID: 30508212
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974
Malignant Transformation of Vaginal Endometriosis - A Review of Literature.
Cozzolino M, Nasioudis D, Sisti G, Coccia ME
Gynecol Obstet Invest 2017;82(2):105-112. Epub 2016 Sep 13 doi: 10.1159/000449198. PMID: 27618565

Recent systematic reviews

Prognostic significance of lymphadenectomy in uterine leiomyosarcomas and endometrial stromal sarcomas: Systematic review and meta-analysis.
Li Y, Gong Q, Peng J, Liu Y, Jiang Y, Zhang S
Eur J Obstet Gynecol Reprod Biol 2022 Dec;279:94-101. Epub 2022 Oct 21 doi: 10.1016/j.ejogrb.2022.10.013. PMID: 36308940
Extrauterine endometrial stromal sarcoma: A systematic review and outcome analysis.
Deb PQ, Heller DS
Ann Diagn Pathol 2022 Aug;59:151966. Epub 2022 May 10 doi: 10.1016/j.anndiagpath.2022.151966. PMID: 35569210
Ovarian preservation for low-grade endometrial stromal sarcoma: a systematic review of the literature and meta-analysis.
Nasioudis D, Ko EM, Kolovos G, Vagios S, Kalliouris D, Giuntoli RL
Int J Gynecol Cancer 2019 Jan;29(1):126-132. doi: 10.1136/ijgc-2018-000063. PMID: 30640694
Uterine sarcoma Part II-Uterine endometrial stromal sarcoma: The TAG systematic review.
Horng HC, Wen KC, Wang PH, Chen YJ, Yen MS, Ng HT; Taiwan Association of Gynecology Systematic Review Group
Taiwan J Obstet Gynecol 2016 Aug;55(4):472-9. doi: 10.1016/j.tjog.2016.04.034. PMID: 27590366
Endometrial stromal sarcoma: a systematic review.
Rauh-Hain JA, del Carmen MG
Obstet Gynecol 2013 Sep;122(3):676-83. doi: 10.1097/AOG.0b013e3182a189ac. PMID: 23921879

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