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Childhood Benign Germ Cell Tumor

MedGen UID:
272354
Concept ID:
C1332485
Neoplastic Process
Synonyms: Benign Childhood Germ Cell Neoplasm; Benign Childhood Germ Cell Tumor; Benign Pediatric Germ Cell Neoplasm; Benign Pediatric Germ Cell Tumor

Definition

A germ cell tumor that occurs during childhood and is characterized by the absence of atypia and metastatic potential. [from NCI]

Professional guidelines

PubMed

Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Han LM, Weiel JJ, Longacre TA, Folkins AK
Adv Anat Pathol 2022 Sep 1;29(5):297-308. Epub 2022 Jul 1 doi: 10.1097/PAP.0000000000000351. PMID: 35778792
MacCollin M, Mautner VF
Semin Pediatr Neurol 1998 Dec;5(4):243-52. doi: 10.1016/s1071-9091(98)80003-x. PMID: 9874852

Recent clinical studies

Etiology

Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Ardern-Holmes S, Fisher G, North K
J Child Neurol 2017 Jan;32(1):9-22. Epub 2016 Sep 29 doi: 10.1177/0883073816666736. PMID: 27655473
Rivers JK
Lancet 2004 Feb 28;363(9410):728-30. doi: 10.1016/S0140-6736(04)15649-3. PMID: 15005091
Char DH
Mayo Clin Proc 1993 Nov;68(11):1081-96. doi: 10.1016/s0025-6196(12)60902-1. PMID: 8231272

Diagnosis

Gan HW, Morillon P, Albanese A, Aquilina K, Chandler C, Chang YC, Drimtzias E, Farndon S, Jacques TS, Korbonits M, Kuczynski A, Limond J, Robinson L, Simmons I, Thomas N, Thomas S, Thorp N, Vargha-Khadem F, Warren D, Zebian B, Mallucci C, Spoudeas HA
Lancet Diabetes Endocrinol 2023 Sep;11(9):694-706. Epub 2023 Aug 4 doi: 10.1016/S2213-8587(23)00162-6. PMID: 37549682
Bansal R, Honavar SG, Talloju SS, Mulay K
Indian J Ophthalmol 2022 Feb;70(2):709. doi: 10.4103/ijo.IJO_145_22. PMID: 35086291Free PMC Article
McCrea HJ, George E, Settler A, Schwartz TH, Greenfield JP
J Child Neurol 2016 Oct;31(12):1367-76. Epub 2015 Dec 15 doi: 10.1177/0883073815620671. PMID: 26676303
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
MacCollin M, Mautner VF
Semin Pediatr Neurol 1998 Dec;5(4):243-52. doi: 10.1016/s1071-9091(98)80003-x. PMID: 9874852

Therapy

Nguyen Quoc A, Beccaria K, González Briceño L, Pinto G, Samara-Boustani D, Stoupa A, Beltrand J, Besançon A, Thalassinos C, Puget S, Blauwblomme T, Alapetite C, Bolle S, Doz F, Grill J, Dufour C, Bourdeaut F, Abbou S, Guerrini-Rousseau L, Leruste A, Brabant S, Cavadias I, Viaud M, Boddaert N, Polak M, Kariyawasam D
J Clin Endocrinol Metab 2023 Jul 14;108(8):1929-1936. doi: 10.1210/clinem/dgad079. PMID: 36794424
Massimi L, Tufo T, Di Rocco C
Expert Rev Anticancer Ther 2007 Nov;7(11):1591-610. doi: 10.1586/14737140.7.11.1591. PMID: 18020927
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
Rivers JK
Lancet 2004 Feb 28;363(9410):728-30. doi: 10.1016/S0140-6736(04)15649-3. PMID: 15005091

Prognosis

Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
Jamshidi AM, Soldozy S, Elarjani T, Burks JD, Luther E, Starke RM
World Neurosurg 2022 Jun;162:77-84. Epub 2021 Sep 20 doi: 10.1016/j.wneu.2021.09.058. PMID: 34555575
Massimi L, Tufo T, Di Rocco C
Expert Rev Anticancer Ther 2007 Nov;7(11):1591-610. doi: 10.1586/14737140.7.11.1591. PMID: 18020927
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
Perry A, Dehner LP
Brain Pathol 2003 Jul;13(3):386-408. doi: 10.1111/j.1750-3639.2003.tb00038.x. PMID: 12946028Free PMC Article

Clinical prediction guides

Kresbach C, Neyazi S, Schüller U
Brain Pathol 2022 Jul;32(4):e13068. Epub 2022 Mar 21 doi: 10.1111/bpa.13068. PMID: 35307892Free PMC Article
May JA, Krieger MD, Bowen I, Geffner ME
Adv Pediatr 2006;53:183-209. doi: 10.1016/j.yapd.2006.04.013. PMID: 17089867
Karavitaki N, Cudlip S, Adams CB, Wass JA
Endocr Rev 2006 Jun;27(4):371-97. Epub 2006 Mar 16 doi: 10.1210/er.2006-0002. PMID: 16543382
Rivers JK
Lancet 2004 Feb 28;363(9410):728-30. doi: 10.1016/S0140-6736(04)15649-3. PMID: 15005091
Schwartz AM, Ghatak NR
Cancer 1990 Jan 15;65(2):333-6. doi: 10.1002/1097-0142(19900115)65:2<333::aid-cncr2820650225>3.0.co;2-3. PMID: 2403835

Recent systematic reviews

Jamshidi AM, Soldozy S, Elarjani T, Burks JD, Luther E, Starke RM
World Neurosurg 2022 Jun;162:77-84. Epub 2021 Sep 20 doi: 10.1016/j.wneu.2021.09.058. PMID: 34555575
Zhang S, Fang Y, Cai BW, Xu JG, You C
Cochrane Database Syst Rev 2016 Jul 14;7(7):CD008890. doi: 10.1002/14651858.CD008890.pub4. PMID: 27416004Free PMC Article
Zheng J, Fang Y, Cai BW, Zhang H, Liu W, Wu B, Xu JG, You C
Cochrane Database Syst Rev 2014 Sep 19;(9):CD008890. doi: 10.1002/14651858.CD008890.pub3. PMID: 25233847
Fang Y, Cai BW, Zhang H, Liu W, Wu B, Xu JG, You C
Cochrane Database Syst Rev 2012 Apr 18;(4):CD008890. doi: 10.1002/14651858.CD008890.pub2. PMID: 22513968
Grill J, Pascal C, Chantal K
Paediatr Drugs 2003;5(8):533-43. doi: 10.2165/00148581-200305080-00004. PMID: 12895136

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