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Non-gestational ovarian choriocarcinoma

MedGen UID:
274798
•Concept ID:
C1518355
•
Neoplastic Process
Synonyms: Non-Gestational Ovarian Choriocarcinoma; non-gestational ovarian choriocarcinoma
 
Monarch Initiative: MONDO:0004322

Definition

A malignant germ cell tumor that arises from the ovary and is composed of cytotrophoblasts, syncytiotrophoblasts, and extravillous trophoblasts. The prognosis is less favorable than gestational choriocarcinoma. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-gestational ovarian choriocarcinoma

Recent clinical studies

Etiology

Imaging in gynecological disease (22): clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors.
Moro F, Castellano LM, Franchi D, Epstein E, Fischerova D, Froyman W, Timmerman D, Zannoni GF, Scambia G, Valentin L, Testa AC, Mascilini F
Ultrasound Obstet Gynecol 2021 Jun;57(6):987-994. doi: 10.1002/uog.23529. PMID: 33142349
Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma.
Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P
Arch Gynecol Obstet 2020 Apr;301(4):901-912. Epub 2020 Mar 17 doi: 10.1007/s00404-020-05502-9. PMID: 32185550

Diagnosis

Imaging in gynecological disease (22): clinical and ultrasound characteristics of ovarian embryonal carcinomas, non-gestational choriocarcinomas and malignant mixed germ cell tumors.
Moro F, Castellano LM, Franchi D, Epstein E, Fischerova D, Froyman W, Timmerman D, Zannoni GF, Scambia G, Valentin L, Testa AC, Mascilini F
Ultrasound Obstet Gynecol 2021 Jun;57(6):987-994. doi: 10.1002/uog.23529. PMID: 33142349
Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma.
Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P
Arch Gynecol Obstet 2020 Apr;301(4):901-912. Epub 2020 Mar 17 doi: 10.1007/s00404-020-05502-9. PMID: 32185550
A positive urine pregnancy test (UPT) with adnexal mass; ectopic pregnancy is not the ultimate diagnosis.
Ahmad MF, Abu MA, Chew KT, Sheng KL, Zakaria MA
Horm Mol Biol Clin Investig 2018 Mar 20;34(2) doi: 10.1515/hmbci-2018-0004. PMID: 29558344
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite.
Hu T, Yang M, Zhu H, Shi G, Wang H
J Obstet Gynaecol Res 2011 Dec;37(12):1900-5. Epub 2011 Nov 9 doi: 10.1111/j.1447-0756.2011.01693.x. PMID: 22070612

Prognosis

Clinicopathological factors and prognosis analysis of 39 cases of non-gestational ovarian choriocarcinoma.
Liu X, Zhang X, Pang Y, Ma Y, Zhang X, Liu P
Arch Gynecol Obstet 2020 Apr;301(4):901-912. Epub 2020 Mar 17 doi: 10.1007/s00404-020-05502-9. PMID: 32185550
A positive urine pregnancy test (UPT) with adnexal mass; ectopic pregnancy is not the ultimate diagnosis.
Ahmad MF, Abu MA, Chew KT, Sheng KL, Zakaria MA
Horm Mol Biol Clin Investig 2018 Mar 20;34(2) doi: 10.1515/hmbci-2018-0004. PMID: 29558344
Pure non-gestational ovarian choriocarcinoma in a 45,XO/46,XX SRY-negative true hermaphrodite.
Hu T, Yang M, Zhu H, Shi G, Wang H
J Obstet Gynaecol Res 2011 Dec;37(12):1900-5. Epub 2011 Nov 9 doi: 10.1111/j.1447-0756.2011.01693.x. PMID: 22070612
Choriocarcinoma of the ovary in a post-menopausal woman.
Babu MK, Kini U
Indian J Cancer 1996 Jun;33(2):111-5. PMID: 8979475

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