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Urothelial neoplasm

MedGen UID:
275551
•Concept ID:
C1519840
•
Neoplastic Process
Synonyms: neoplasm of urothelium; Transitional Cell Neoplasm of the Urinary Tract; transitional cell neoplasm of the urinary tract; tumor of urothelium; tumour of urothelium; Urothelial Neoplasm; urothelial neoplasm; urothelium neoplasm; urothelium neoplasm (disease); urothelium tumor; urothelium tumour
 
Monarch Initiative: MONDO:0024337

Definition

A benign or malignant neoplasm that arises from the urothelial lining of the urinary tract (bladder, renal pelvis, ureter, or urethra). [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVUrothelial neoplasm

Professional guidelines

PubMed

Risk of malignancy assessment for the Paris System for reporting urinary cytology.
Moulavasilis N, Lazaris A, Katafigiotis I, Stravodimos K, Constantinides C, Mikou P
Diagn Cytopathol 2020 Dec;48(12):1194-1198. Epub 2020 Aug 6 doi: 10.1002/dc.24575. PMID: 32762032
Evaluation of MUC1 and P53 expressions in noninvasive papillary urothelial neoplasms of bladder, their relationship with tumor grade and role in the differential diagnosis.
Kaymaz E, Ozer E, Unverdi H, Hucumenoglu S
Indian J Pathol Microbiol 2017 Oct-Dec;60(4):510-514. doi: 10.4103/IJPM.IJPM_204_16. PMID: 29323063
Immunohistochemistry and Fluorescence In Situ Hybridization Can Inform the Differential Diagnosis of Low-Grade Noninvasive Urothelial Carcinoma with an Inverted Growth Pattern and Inverted Urothelial Papilloma.
Sun JJ, Wu Y, Lu YM, Zhang HZ, Wang T, Yang XQ, Sun MH, Wang CF
PLoS One 2015;10(7):e0133530. Epub 2015 Jul 24 doi: 10.1371/journal.pone.0133530. PMID: 26208279Free PMC Article

Curated

NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

Recent clinical studies

Etiology

Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Relapsed papillary urothelial neoplasm of low malignant potential (PUNLMP) of the young age: a case report and a review of the literature.
Maurizi P, Capozza MA, Triarico S, Perrotta ML, Briganti V, Ruggiero A
BMC Urol 2019 May 9;19(1):36. doi: 10.1186/s12894-019-0469-1. PMID: 31072376Free PMC Article
Efficacy and Tolerability of Bacillus Calmette-Guérin Therapy as the First-Line Therapy for Upper Urinary Tract Carcinoma In Situ.
Tomisaki I, Kubo T, Minato A, Fujimoto N
Cancer Invest 2018 Feb 7;36(2):152-157. Epub 2018 Feb 2 doi: 10.1080/07357907.2018.1430815. PMID: 29393701
Urothelial Carcinoma Concomitant With Malakoplakia In Non-Functioning Nephrolithic Kidneys.
Kocarslan S, Dokumaci DS, Karakas EY, Boyaci FN, Ulas T
Folia Med (Plovdiv) 2015 Jan-Mar;57(1):78-9. doi: 10.1515/folmed-2015-0024. PMID: 26431100
The 2004 WHO classification of bladder tumors: a summary and commentary.
Montironi R, Lopez-Beltran A
Int J Surg Pathol 2005 Apr;13(2):143-53. doi: 10.1177/106689690501300203. PMID: 15864376

Diagnosis

Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Reappraisal of the papillary urothelial neoplasm of low malignant potential (PUNLMP).
Jones TD, Cheng L
Histopathology 2020 Oct;77(4):525-535. Epub 2020 Sep 13 doi: 10.1111/his.14192. PMID: 32562556
Relapsed papillary urothelial neoplasm of low malignant potential (PUNLMP) of the young age: a case report and a review of the literature.
Maurizi P, Capozza MA, Triarico S, Perrotta ML, Briganti V, Ruggiero A
BMC Urol 2019 May 9;19(1):36. doi: 10.1186/s12894-019-0469-1. PMID: 31072376Free PMC Article
Transitional Cell Carcinoma in the Pediatric Patient: A Review of the Literature.
Chu S, Singer J
Urology 2016 May;91:175-9. Epub 2016 Jan 21 doi: 10.1016/j.urology.2015.12.032. PMID: 26802795
Urothelial Carcinoma With Villoglandular Differentiation: A Rare Entity.
Mitra S, Sundaram AK, Gupta K, Devana SK
Int J Surg Pathol 2016 Jun;24(4):356-9. Epub 2015 Dec 31 doi: 10.1177/1066896915621387. PMID: 26721305

Therapy

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Active surveillance for non-muscle invasive bladder cancer: A systematic review and pooled-analysis.
Petrelli F, Giannatempo P, Maccagnano C, Contieri R, Hurle R
Cancer Treat Res Commun 2021;27:100369. Epub 2021 Apr 3 doi: 10.1016/j.ctarc.2021.100369. PMID: 33838570
Update on early instillation of chemotherapy after transurethral resection of non-muscle-invasive bladder cancer.
Oosterlinck W, Decaestecker K
Expert Rev Anticancer Ther 2018 May;18(5):437-443. Epub 2018 Mar 15 doi: 10.1080/14737140.2018.1451748. PMID: 29528758
Efficacy and Tolerability of Bacillus Calmette-Guérin Therapy as the First-Line Therapy for Upper Urinary Tract Carcinoma In Situ.
Tomisaki I, Kubo T, Minato A, Fujimoto N
Cancer Invest 2018 Feb 7;36(2):152-157. Epub 2018 Feb 2 doi: 10.1080/07357907.2018.1430815. PMID: 29393701
Variant hairy cell leukemia following papillary urothelial neoplasm of bladder.
Beyan C, Kaptan K
J Coll Physicians Surg Pak 2014 Mar;24 Suppl 1:S27-8. PMID: 24717996

Prognosis

Pediatric urothelial bladder neoplasm.
Galiya R, Stanislav K, Jawdat J, Benjamin H, Boris C
J Pediatr Urol 2022 Dec;18(6):833.e1-833.e4. Epub 2022 Jun 30 doi: 10.1016/j.jpurol.2022.06.026. PMID: 35871900
Efficacy and Tolerability of Bacillus Calmette-Guérin Therapy as the First-Line Therapy for Upper Urinary Tract Carcinoma In Situ.
Tomisaki I, Kubo T, Minato A, Fujimoto N
Cancer Invest 2018 Feb 7;36(2):152-157. Epub 2018 Feb 2 doi: 10.1080/07357907.2018.1430815. PMID: 29393701
Pearls and Pitfalls in Diagnosing Pediatric Urinary Bladder Masses.
Shelmerdine SC, Lorenzo AJ, Gupta AA, Chavhan GB
Radiographics 2017 Oct;37(6):1872-1891. doi: 10.1148/rg.2017170031. PMID: 29019749
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article
Urothelial Carcinoma With Villoglandular Differentiation: A Rare Entity.
Mitra S, Sundaram AK, Gupta K, Devana SK
Int J Surg Pathol 2016 Jun;24(4):356-9. Epub 2015 Dec 31 doi: 10.1177/1066896915621387. PMID: 26721305

Clinical prediction guides

Clinicopathologic Features of Noninvasive Inverted Urothelial Papillary Tumor.
Liu Z, Wei S, Tang J
Am J Clin Oncol 2023 Sep 1;46(9):409-413. Epub 2023 Jun 28 doi: 10.1097/COC.0000000000001027. PMID: 37370208
Diagnostic difficulties in cases of papillary urothelial neoplasm of low malignant potential, urothelial proliferation of uncertain malignant potential, urothelial dysplasia and urothelial papilloma: A review of current literature.
Jaworski D, Szylberg Ł, Gzil A, Stawinski P, Kasperska A, Marszałek A
Ann Diagn Pathol 2019 Jun;40:182-188. Epub 2017 Dec 17 doi: 10.1016/j.anndiagpath.2017.12.007. PMID: 29395466
Efficacy and Tolerability of Bacillus Calmette-Guérin Therapy as the First-Line Therapy for Upper Urinary Tract Carcinoma In Situ.
Tomisaki I, Kubo T, Minato A, Fujimoto N
Cancer Invest 2018 Feb 7;36(2):152-157. Epub 2018 Feb 2 doi: 10.1080/07357907.2018.1430815. PMID: 29393701
Urothelial neoplasm of the bladder in childhood and adolescence: a rare disease.
Polat H, Utangac MM, Gulpinar MT, Cift A, Erdogdu IH, Turkcu G
Int Braz J Urol 2016 Mar-Apr;42(2):242-6. doi: 10.1590/S1677-5538.IBJU.2015.0200. PMID: 27256177Free PMC Article
Concomitant carcinoid tumor and papillary urothelial neoplasm of low malignant potential in a patient with Crohn's disease: a case report.
Owczarek D, Cibor D, Szczepański W, Kosowski B, Mach T
Eur J Gastroenterol Hepatol 2008 Dec;20(12):1231-4. doi: 10.1097/MEG.0b013e328302f484. PMID: 18936711

Recent systematic reviews

Impact of implementing the first edition of the Paris system for reporting: A systematic review and meta-analysis.
Farahani SJ, Li J, Minder B, Vielh P, Glisic M, Muka T
Cytopathology 2024 Sep;35(5):616-633. Epub 2024 Jun 27 doi: 10.1111/cyt.13407. PMID: 38934101
Active surveillance for non-muscle invasive bladder cancer: A systematic review and pooled-analysis.
Petrelli F, Giannatempo P, Maccagnano C, Contieri R, Hurle R
Cancer Treat Res Commun 2021;27:100369. Epub 2021 Apr 3 doi: 10.1016/j.ctarc.2021.100369. PMID: 33838570

Supplemental Content

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    Clinical resources

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    Curated

    • NCCN, 2024
      NCCN Clinical Practice Guidelines in Oncology (NCCN Guidelines®) Bladder Cancer, 2024

    Consumer resources

    Reviews

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    • PMC Articles
      Related information in PubMed Central Links
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