U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Prostate neuroendocrine neoplasm

MedGen UID:
277537
•Concept ID:
C1335515
•
Neoplastic Process
Synonyms: Neuroendocrine Neoplasm of Prostate; neuroendocrine neoplasm of prostate; neuroendocrine neoplasm of prostate gland; Neuroendocrine Neoplasm of the Prostate; neuroendocrine neoplasm of the prostate; neuroendocrine tumor of the prostate; neuroendocrine tumour of the prostate; prostate gland NET; prostate gland neuroendocrine neoplasm; prostate gland neuroendocrine tumor; prostate gland neuroendocrine tumor, well differentiated, low or intermediate grade; prostate gland neuroendocrine tumour; prostate neuroendocrine carcinoma; Prostate Neuroendocrine Neoplasm; prostate neuroendocrine neoplasm
 
Monarch Initiative: MONDO:0002477

Definition

A neoplasm with neuroendocrine differentiation that arises from the prostate gland. [from NCI]

Professional guidelines

PubMed

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Molecular profiling stratifies diverse phenotypes of treatment-refractory metastatic castration-resistant prostate cancer.
Labrecque MP, Coleman IM, Brown LG, True LD, Kollath L, Lakely B, Nguyen HM, Yang YC, da Costa RMG, Kaipainen A, Coleman R, Higano CS, Yu EY, Cheng HH, Mostaghel EA, Montgomery B, Schweizer MT, Hsieh AC, Lin DW, Corey E, Nelson PS, Morrissey C
J Clin Invest 2019 Jul 30;129(10):4492-4505. doi: 10.1172/JCI128212. PMID: 31361600Free PMC Article
Cancer treatment and survivorship statistics, 2016.
Miller KD, Siegel RL, Lin CC, Mariotto AB, Kramer JL, Rowland JH, Stein KD, Alteri R, Jemal A
CA Cancer J Clin 2016 Jul;66(4):271-89. Epub 2016 Jun 2 doi: 10.3322/caac.21349. PMID: 27253694

Recent clinical studies

Etiology

Epidemiology of Cancer.
Schwartz SM
Clin Chem 2024 Jan 4;70(1):140-149. doi: 10.1093/clinchem/hvad202. PMID: 38175589
Cancer statistics, 2023.
Siegel RL, Miller KD, Wagle NS, Jemal A
CA Cancer J Clin 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763. PMID: 36633525
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Microbiome analyses of blood and tissues suggest cancer diagnostic approach.
Poore GD, Kopylova E, Zhu Q, Carpenter C, Fraraccio S, Wandro S, Kosciolek T, Janssen S, Metcalf J, Song SJ, Kanbar J, Miller-Montgomery S, Heaton R, Mckay R, Patel SP, Swafford AD, Knight R
Nature 2020 Mar;579(7800):567-574. Epub 2020 Mar 11 doi: 10.1038/s41586-020-2095-1. PMID: 32214244Free PMC Article
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.
Beltran H, Prandi D, Mosquera JM, Benelli M, Puca L, Cyrta J, Marotz C, Giannopoulou E, Chakravarthi BV, Varambally S, Tomlins SA, Nanus DM, Tagawa ST, Van Allen EM, Elemento O, Sboner A, Garraway LA, Rubin MA, Demichelis F
Nat Med 2016 Mar;22(3):298-305. Epub 2016 Feb 8 doi: 10.1038/nm.4045. PMID: 26855148Free PMC Article

Diagnosis

Diagnosis and management of neuroendocrine prostate cancer.
de Kouchkovsky I, Chan E, Schloss C, Poehlein C, Aggarwal R
Prostate 2024 Apr;84(5):426-440. Epub 2024 Jan 3 doi: 10.1002/pros.24664. PMID: 38173302
Prostate Pathology: What is New in the 2022 WHO Classification of Urinary and Male Genital Tumors?
Surintrspanont J, Zhou M
Pathologica 2022 Feb;115(1):41-56. Epub 2023 Jan 16 doi: 10.32074/1591-951X-822. PMID: 36645399Free PMC Article
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Clinical and Biological Features of Neuroendocrine Prostate Cancer.
Yamada Y, Beltran H
Curr Oncol Rep 2021 Jan 12;23(2):15. doi: 10.1007/s11912-020-01003-9. PMID: 33433737Free PMC Article
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article

Therapy

Next generation radiotheranostics promoting precision medicine.
Pomykala KL, Hadaschik BA, Sartor O, Gillessen S, Sweeney CJ, Maughan T, Hofman MS, Herrmann K
Ann Oncol 2023 Jun;34(6):507-519. Epub 2023 Mar 15 doi: 10.1016/j.annonc.2023.03.001. PMID: 36924989
FOXA2 drives lineage plasticity and KIT pathway activation in neuroendocrine prostate cancer.
Han M, Li F, Zhang Y, Dai P, He J, Li Y, Zhu Y, Zheng J, Huang H, Bai F, Gao D
Cancer Cell 2022 Nov 14;40(11):1306-1323.e8. Epub 2022 Nov 3 doi: 10.1016/j.ccell.2022.10.011. PMID: 36332622
Molecular events in neuroendocrine prostate cancer development.
Wang Y, Wang Y, Ci X, Choi SYC, Crea F, Lin D, Wang Y
Nat Rev Urol 2021 Oct;18(10):581-596. Epub 2021 Jul 21 doi: 10.1038/s41585-021-00490-0. PMID: 34290447Free PMC Article
Somatostatin Analogs in Clinical Practice: a Review.
Gomes-Porras M, Cárdenas-Salas J, Álvarez-Escolá C
Int J Mol Sci 2020 Feb 29;21(5) doi: 10.3390/ijms21051682. PMID: 32121432Free PMC Article
Androgen Receptor Pathway-Independent Prostate Cancer Is Sustained through FGF Signaling.
Bluemn EG, Coleman IM, Lucas JM, Coleman RT, Hernandez-Lopez S, Tharakan R, Bianchi-Frias D, Dumpit RF, Kaipainen A, Corella AN, Yang YC, Nyquist MD, Mostaghel E, Hsieh AC, Zhang X, Corey E, Brown LG, Nguyen HM, Pienta K, Ittmann M, Schweizer M, True LD, Wise D, Rennie PS, Vessella RL, Morrissey C, Nelson PS
Cancer Cell 2017 Oct 9;32(4):474-489.e6. doi: 10.1016/j.ccell.2017.09.003. PMID: 29017058Free PMC Article

Prognosis

Cancer statistics, 2024.
Siegel RL, Giaquinto AN, Jemal A
CA Cancer J Clin 2024 Jan-Feb;74(1):12-49. Epub 2024 Jan 17 doi: 10.3322/caac.21820. PMID: 38230766
Cancer statistics, 2023.
Siegel RL, Miller KD, Wagle NS, Jemal A
CA Cancer J Clin 2023 Jan;73(1):17-48. doi: 10.3322/caac.21763. PMID: 36633525
Prostate Pathology: What is New in the 2022 WHO Classification of Urinary and Male Genital Tumors?
Surintrspanont J, Zhou M
Pathologica 2022 Feb;115(1):41-56. Epub 2023 Jan 16 doi: 10.32074/1591-951X-822. PMID: 36645399Free PMC Article
Neuroendocrine neoplasms of the appendix, colon and rectum.
Volante M, Grillo F, Massa F, Maletta F, Mastracci L, Campora M, Ferro J, Vanoli A, Papotti M
Pathologica 2021 Feb;113(1):19-27. doi: 10.32074/1591-951X-230. PMID: 33686307Free PMC Article
Clinical and Biological Features of Neuroendocrine Prostate Cancer.
Yamada Y, Beltran H
Curr Oncol Rep 2021 Jan 12;23(2):15. doi: 10.1007/s11912-020-01003-9. PMID: 33433737Free PMC Article

Clinical prediction guides

Targeted Alpha-Particle Therapy: A Review of Current Trials.
Jang A, Kendi AT, Johnson GB, Halfdanarson TR, Sartor O
Int J Mol Sci 2023 Jul 19;24(14) doi: 10.3390/ijms241411626. PMID: 37511386Free PMC Article
Microbiome analyses of blood and tissues suggest cancer diagnostic approach.
Poore GD, Kopylova E, Zhu Q, Carpenter C, Fraraccio S, Wandro S, Kosciolek T, Janssen S, Metcalf J, Song SJ, Kanbar J, Miller-Montgomery S, Heaton R, Mckay R, Patel SP, Swafford AD, Knight R
Nature 2020 Mar;579(7800):567-574. Epub 2020 Mar 11 doi: 10.1038/s41586-020-2095-1. PMID: 32214244Free PMC Article
The emerging role of copper-64 radiopharmaceuticals as cancer theranostics.
Boschi A, Martini P, Janevik-Ivanovska E, Duatti A
Drug Discov Today 2018 Aug;23(8):1489-1501. Epub 2018 Apr 7 doi: 10.1016/j.drudis.2018.04.002. PMID: 29635027
Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway.
Viswanathan VS, Ryan MJ, Dhruv HD, Gill S, Eichhoff OM, Seashore-Ludlow B, Kaffenberger SD, Eaton JK, Shimada K, Aguirre AJ, Viswanathan SR, Chattopadhyay S, Tamayo P, Yang WS, Rees MG, Chen S, Boskovic ZV, Javaid S, Huang C, Wu X, Tseng YY, Roider EM, Gao D, Cleary JM, Wolpin BM, Mesirov JP, Haber DA, Engelman JA, Boehm JS, Kotz JD, Hon CS, Chen Y, Hahn WC, Levesque MP, Doench JG, Berens ME, Shamji AF, Clemons PA, Stockwell BR, Schreiber SL
Nature 2017 Jul 27;547(7664):453-457. Epub 2017 Jul 5 doi: 10.1038/nature23007. PMID: 28678785Free PMC Article
Divergent clonal evolution of castration-resistant neuroendocrine prostate cancer.
Beltran H, Prandi D, Mosquera JM, Benelli M, Puca L, Cyrta J, Marotz C, Giannopoulou E, Chakravarthi BV, Varambally S, Tomlins SA, Nanus DM, Tagawa ST, Van Allen EM, Elemento O, Sboner A, Garraway LA, Rubin MA, Demichelis F
Nat Med 2016 Mar;22(3):298-305. Epub 2016 Feb 8 doi: 10.1038/nm.4045. PMID: 26855148Free PMC Article

Recent systematic reviews

Endocrine and paracrine characteristics of neuroendocrine prostate cancer.
Arman T, Nelson PS
Front Endocrinol (Lausanne) 2022;13:1012005. Epub 2022 Nov 11 doi: 10.3389/fendo.2022.1012005. PMID: 36440195Free PMC Article
Metastasis to the rectum: A systematic review of the literature.
Janjic O, Labgaa I, Hübner M, Demartines N, Joliat GR
Eur J Surg Oncol 2022 Apr;48(4):822-833. Epub 2021 Oct 10 doi: 10.1016/j.ejso.2021.10.004. PMID: 34656391
Prostate cancer risk in patients with melanoma: A systematic review and meta-analysis.
Acharya P, Mathur M
Cancer Med 2020 May;9(10):3604-3612. Epub 2020 Mar 16 doi: 10.1002/cam4.2995. PMID: 32175697Free PMC Article
Cardiotoxicity with immune system targeting drugs: a meta-analysis of anti-PD/PD-L1 immunotherapy randomized clinical trials.
Rahouma M, Karim NA, Baudo M, Yahia M, Kamel M, Eldessouki I, Abouarab A, Saad I, Elmously A, Gray KD, Ghaly G, Gaber O, Kamal M, A Hassan A, Rahouma M, D'Ascenzo F, Morris J, Mohamed A, Girardi L, Gaudino M
Immunotherapy 2019 Jun;11(8):725-735. doi: 10.2217/imt-2018-0118. PMID: 31088241
The role of serum neuron-specific enolase in patients with prostate cancer: a systematic review of the recent literature.
Muoio B, Pascale M, Roggero E
Int J Biol Markers 2018 Jan;33(1):10-21. doi: 10.5301/ijbm.5000286. PMID: 28885659

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Consumer resources

    Reviews

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...