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Candidiasis, invasive

MedGen UID:
296300
•Concept ID:
C1609535
•
Disease or Syndrome
Synonyms: Candidiases, Invasive; Candidiasis, Invasive; Invasive Candidiases; Invasive Candidiasis
 
Monarch Initiative: MONDO:0044067

Definition

A fungal infection by any of the Candida species in a sterile body compartment. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCandidiasis, invasive

Professional guidelines

PubMed

ESICM/ESCMID task force on practical management of invasive candidiasis in critically ill patients.
Martin-Loeches I, Antonelli M, Cuenca-Estrella M, Dimopoulos G, Einav S, De Waele JJ, Garnacho-Montero J, Kanj SS, Machado FR, Montravers P, Sakr Y, Sanguinetti M, Timsit JF, Bassetti M
Intensive Care Med 2019 Jun;45(6):789-805. Epub 2019 Mar 25 doi: 10.1007/s00134-019-05599-w. PMID: 30911804
Executive Summary: Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.
Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD
Clin Infect Dis 2016 Feb 15;62(4):409-17. doi: 10.1093/cid/civ1194. PMID: 26810419
Clinical Practice Guideline for the Management of Candidiasis: 2016 Update by the Infectious Diseases Society of America.
Pappas PG, Kauffman CA, Andes DR, Clancy CJ, Marr KA, Ostrosky-Zeichner L, Reboli AC, Schuster MG, Vazquez JA, Walsh TJ, Zaoutis TE, Sobel JD
Clin Infect Dis 2016 Feb 15;62(4):e1-50. Epub 2015 Dec 16 doi: 10.1093/cid/civ933. PMID: 26679628Free PMC Article

Recent clinical studies

Etiology

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Candidemia and Invasive Candidiasis.
McCarty TP, White CM, Pappas PG
Infect Dis Clin North Am 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007. PMID: 34016283
EORTC/MSGERC Definitions of Invasive Fungal Diseases: Summary of Activities of the Intensive Care Unit Working Group.
Bassetti M, Azoulay E, Kullberg BJ, Ruhnke M, Shoham S, Vazquez J, Giacobbe DR, Calandra T
Clin Infect Dis 2021 Mar 12;72(Suppl 2):S121-S127. doi: 10.1093/cid/ciaa1751. PMID: 33709127
Invasive candidiasis.
Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ
Nat Rev Dis Primers 2018 May 11;4:18026. doi: 10.1038/nrdp.2018.26. PMID: 29749387
Invasive Candidiasis.
McCarty TP, Pappas PG
Infect Dis Clin North Am 2016 Mar;30(1):103-24. Epub 2015 Dec 29 doi: 10.1016/j.idc.2015.10.013. PMID: 26739610

Diagnosis

Candidemia and Invasive Candidiasis.
McCarty TP, White CM, Pappas PG
Infect Dis Clin North Am 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007. PMID: 34016283
EORTC/MSGERC Definitions of Invasive Fungal Diseases: Summary of Activities of the Intensive Care Unit Working Group.
Bassetti M, Azoulay E, Kullberg BJ, Ruhnke M, Shoham S, Vazquez J, Giacobbe DR, Calandra T
Clin Infect Dis 2021 Mar 12;72(Suppl 2):S121-S127. doi: 10.1093/cid/ciaa1751. PMID: 33709127
Invasive candidiasis.
Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ
Nat Rev Dis Primers 2018 May 11;4:18026. doi: 10.1038/nrdp.2018.26. PMID: 29749387
Invasive candidiasis.
Nat Rev Dis Primers 2018 May 11;4:18027. doi: 10.1038/nrdp.2018.27. PMID: 29749385
Invasive Candidiasis.
McCarty TP, Pappas PG
Infect Dis Clin North Am 2016 Mar;30(1):103-24. Epub 2015 Dec 29 doi: 10.1016/j.idc.2015.10.013. PMID: 26739610

Therapy

Invasive candidiasis.
Lass-Flörl C, Kanj SS, Govender NP, Thompson GR 3rd, Ostrosky-Zeichner L, Govrins MA
Nat Rev Dis Primers 2024 Mar 21;10(1):20. doi: 10.1038/s41572-024-00503-3. PMID: 38514673
Candidemia and Invasive Candidiasis.
McCarty TP, White CM, Pappas PG
Infect Dis Clin North Am 2021 Jun;35(2):389-413. doi: 10.1016/j.idc.2021.03.007. PMID: 34016283
Invasive Candidiasis.
Gonzalez-Lara MF, Ostrosky-Zeichner L
Semin Respir Crit Care Med 2020 Feb;41(1):3-12. Epub 2020 Jan 30 doi: 10.1055/s-0040-1701215. PMID: 32000280
Invasive candidiasis.
Pappas PG, Lionakis MS, Arendrup MC, Ostrosky-Zeichner L, Kullberg BJ
Nat Rev Dis Primers 2018 May 11;4:18026. doi: 10.1038/nrdp.2018.26. PMID: 29749387
Invasive Candidiasis.
Kullberg BJ, Arendrup MC
N Engl J Med 2015 Oct 8;373(15):1445-56. doi: 10.1056/NEJMra1315399. PMID: 26444731

Prognosis

New Perspectives on Antimicrobial Agents: Isavuconazole.
Lewis JS 2nd, Wiederhold NP, Hakki M, Thompson GR 3rd
Antimicrob Agents Chemother 2022 Sep 20;66(9):e0017722. Epub 2022 Aug 15 doi: 10.1128/aac.00177-22. PMID: 35969068Free PMC Article
Inborn Errors of Immunity in the Premature Infant: Challenges in Recognition and Diagnosis.
Gordon SM, O'Connell AE
Front Immunol 2021;12:758373. Epub 2021 Dec 24 doi: 10.3389/fimmu.2021.758373. PMID: 35003071Free PMC Article
Mind the gaps: challenges in the clinical management of invasive candidiasis in critically ill patients.
Peçanha-Pietrobom PM, Colombo AL
Curr Opin Infect Dis 2020 Dec;33(6):441-448. doi: 10.1097/QCO.0000000000000684. PMID: 33044240
Invasive candidiasis in critical care: challenges and future directions.
Logan C, Martin-Loeches I, Bicanic T
Intensive Care Med 2020 Nov;46(11):2001-2014. Epub 2020 Sep 29 doi: 10.1007/s00134-020-06240-x. PMID: 32990778
Breakthrough candidemia in children: clinical and microbiological characteristics, therapeutic strategies and impact on outcomes.
Lai MY, Hsu JF, Chu SM, Wu IH, Huang HR, Lin CC, Lee IT, Chiang MC, Fu RH, Tsai MH
Future Microbiol 2017 Jun;12:695-705. Epub 2017 Mar 13 doi: 10.2217/fmb-2016-0223. PMID: 28326813

Clinical prediction guides

The Role of Novel Antifungals in the Management of Candidiasis: A Clinical Perspective.
Ordaya EE, Clement J, Vergidis P
Mycopathologia 2023 Dec;188(6):937-948. Epub 2023 Jul 20 doi: 10.1007/s11046-023-00759-5. PMID: 37470902Free PMC Article
Invasive candidiasis: current clinical challenges and unmet needs in adult populations.
Soriano A, Honore PM, Puerta-Alcalde P, Garcia-Vidal C, Pagotto A, Gonçalves-Bradley DC, Verweij PE
J Antimicrob Chemother 2023 Jul 5;78(7):1569-1585. doi: 10.1093/jac/dkad139. PMID: 37220664Free PMC Article
New Perspectives on Antimicrobial Agents: Isavuconazole.
Lewis JS 2nd, Wiederhold NP, Hakki M, Thompson GR 3rd
Antimicrob Agents Chemother 2022 Sep 20;66(9):e0017722. Epub 2022 Aug 15 doi: 10.1128/aac.00177-22. PMID: 35969068Free PMC Article
Rezafungin Versus Caspofungin in a Phase 2, Randomized, Double-blind Study for the Treatment of Candidemia and Invasive Candidiasis: The STRIVE Trial.
Thompson GR, Soriano A, Skoutelis A, Vazquez JA, Honore PM, Horcajada JP, Spapen H, Bassetti M, Ostrosky-Zeichner L, Das AF, Viani RM, Sandison T, Pappas PG
Clin Infect Dis 2021 Dec 6;73(11):e3647-e3655. doi: 10.1093/cid/ciaa1380. PMID: 32955088Free PMC Article
Invasive candidiasis in critical care: challenges and future directions.
Logan C, Martin-Loeches I, Bicanic T
Intensive Care Med 2020 Nov;46(11):2001-2014. Epub 2020 Sep 29 doi: 10.1007/s00134-020-06240-x. PMID: 32990778

Recent systematic reviews

Comparative efficacy and safety of systemic antifungal agents for candidemia: a systematic review with network meta-analysis and multicriteria acceptability analyses.
Domingos EL, Vilhena RO, Santos JMMF, Fachi MM, Böger B, Adam LM, Tonin FS, Pontarolo R
Int J Antimicrob Agents 2022 Aug;60(2):106614. Epub 2022 Jun 9 doi: 10.1016/j.ijantimicag.2022.106614. PMID: 35691603
Risk Factors for Invasive Candida Infection in Critically Ill Patients: A Systematic Review and Meta-analysis.
Thomas-Rüddel DO, Schlattmann P, Pletz M, Kurzai O, Bloos F
Chest 2022 Feb;161(2):345-355. Epub 2021 Oct 18 doi: 10.1016/j.chest.2021.08.081. PMID: 34673022Free PMC Article
Comparison of Antifungal Prophylaxis Drugs in Patients With Hematological Disease or Undergoing Hematopoietic Stem Cell Transplantation: A Systematic Review and Network Meta-analysis.
Wang J, Zhou M, Xu JY, Zhou RF, Chen B, Wan Y
JAMA Netw Open 2020 Oct 1;3(10):e2017652. doi: 10.1001/jamanetworkopen.2020.17652. PMID: 33030550Free PMC Article
The Economic Burden of Candidemia and Invasive Candidiasis: A Systematic Review.
Wan Ismail WNA, Jasmi N, Khan TM, Hong YH, Neoh CF
Value Health Reg Issues 2020 May;21:53-58. Epub 2019 Oct 22 doi: 10.1016/j.vhri.2019.07.002. PMID: 31648147
Current status of the etiology of candidiasis in Mexico.
Reyes-Montes MDR, Duarte-Escalante E, Martínez-Herrera E, Acosta-Altamirano G, Frías-De León MG
Rev Iberoam Micol 2017 Oct-Dec;34(4):203-210. Epub 2017 Oct 10 doi: 10.1016/j.riam.2017.05.001. PMID: 29032925

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