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Cerebral abscess

MedGen UID:
307135
•Concept ID:
C1510428
•
Disease or Syndrome
Synonyms: Abscess, Cerebral; Abscesses, Cerebral; Cerebral Abscess; Cerebral Abscesses
SNOMED CT: Cerebral abscess (60404007); Parenchymal intracranial abscess (60404007)

Definition

A bacterial, fungal, or parasitic abscess that develops in the cerebral hemispheres. Causes include skull trauma, middle ear infection, congenital heart disease, and frontal and ethmoid sinus infection. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCerebral abscess

Professional guidelines

PubMed

Primary central nervous system lymphoma: Imaging features and differential diagnosis.
Ribas GA, de Mori LH, Freddi TAL, Oliveira LDS, de Souza SR, Corrêa DG
Neuroradiol J 2024 Dec;37(6):705-722. Epub 2024 May 4 doi: 10.1177/19714009241252625. PMID: 38703015Free PMC Article
"European Society of Clinical Microbiology and infectious Diseases Guidelines on diagnosis and treatment of brain abscess in children and adults" Author's reply.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):149-150. Epub 2023 Oct 19 doi: 10.1016/j.cmi.2023.10.012. PMID: 37865338
European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062

Recent clinical studies

Etiology

European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Brain abscess in pediatric age: a review.
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Central nervous system melioidosis in the pediatric age group: review.
Prasad GL, Kini P, Divya S
Childs Nerv Syst 2017 Jun;33(6):1-6. Epub 2017 Apr 27 doi: 10.1007/s00381-017-3422-1. PMID: 28451778
Pulmonary arteriovenous malformations.
Cartin-Ceba R, Swanson KL, Krowka MJ
Chest 2013 Sep;144(3):1033-1044. doi: 10.1378/chest.12-0924. PMID: 24008954
Diagnosis and treatment of pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: An overview.
Lacombe P, Lacout A, Marcy PY, Binsse S, Sellier J, Bensalah M, Chinet T, Bourgault-Villada I, Blivet S, Roume J, Lesur G, Blondel JH, Fagnou C, Ozanne A, Chagnon S, El Hajjam M
Diagn Interv Imaging 2013 Sep;94(9):835-48. Epub 2013 Jun 12 doi: 10.1016/j.diii.2013.03.014. PMID: 23763987

Diagnosis

European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Brain abscess in pediatric age: a review.
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Maxillofacial cellulitis.
de-Vicente-Rodríguez JC
Med Oral Patol Oral Cir Bucal 2004;9 Suppl:133-8; 126-33. PMID: 15580131
Esophageal-atrial fistula.
Lambert DR, Llaneza PP, Gaglani RD, Lach RD, Beaver WL
J Clin Gastroenterol 1987 Jun;9(3):345-9. doi: 10.1097/00004836-198706000-00021. PMID: 3611691
Cerebral cladosporiosis.
Sandhyamani S, Bhatia R, Mohapatra LN, Roy S
Surg Neurol 1981 Jun;15(6):431-4. doi: 10.1016/s0090-3019(81)80030-4. PMID: 7280955

Therapy

European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Brain abscess in pediatric age: a review.
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Maxillofacial cellulitis.
de-Vicente-Rodríguez JC
Med Oral Patol Oral Cir Bucal 2004;9 Suppl:133-8; 126-33. PMID: 15580131
Non-otogenic cerebral abscess.
Martin G
J Neurol Neurosurg Psychiatry 1973 Aug;36(4):607-10. doi: 10.1136/jnnp.36.4.607. PMID: 4147239Free PMC Article
Cerebral abscess in children.
DeVivo DC
Dev Med Child Neurol 1971 Dec;13(6):800-4. PMID: 4944988

Prognosis

Pediatric brain abscess with fatal outcome caused by hypervirulent Klebsiella pneumoniae, serotype K2-ST65.
En ETS, Ismail N, Nasir NSM, Ismadi YKM, Zuraina NMNN, Hassan SA
J Infect Public Health 2023 Jul;16(7):1089-1092. Epub 2023 May 13 doi: 10.1016/j.jiph.2023.05.015. PMID: 37224619
Pulmonary arteriovenous malformations.
Cartin-Ceba R, Swanson KL, Krowka MJ
Chest 2013 Sep;144(3):1033-1044. doi: 10.1378/chest.12-0924. PMID: 24008954
Diagnosis and treatment of pulmonary arteriovenous malformations in hereditary hemorrhagic telangiectasia: An overview.
Lacombe P, Lacout A, Marcy PY, Binsse S, Sellier J, Bensalah M, Chinet T, Bourgault-Villada I, Blivet S, Roume J, Lesur G, Blondel JH, Fagnou C, Ozanne A, Chagnon S, El Hajjam M
Diagn Interv Imaging 2013 Sep;94(9):835-48. Epub 2013 Jun 12 doi: 10.1016/j.diii.2013.03.014. PMID: 23763987
Cerebral Dermabacter hominis abscess.
Bavbek M, Caner H, Arslan H, Demirhan B, Tunçbilek S, Altinörs N
Infection 1998 May-Jun;26(3):181-3. doi: 10.1007/BF02771848. PMID: 9646113
Cerebral abscess.
Nielsen H
Dan Med Bull 1985 Jun;32(3):170-8. PMID: 3893916

Clinical prediction guides

European society of Clinical Microbiology and Infectious Diseases guidelines on diagnosis and treatment of brain abscess in children and adults.
Bodilsen J, D'Alessandris QG, Humphreys H, Iro MA, Klein M, Last K, Montesinos IL, Pagliano P, Sipahi OR, San-Juan R, Tattevin P, Thurnher M, de J Treviño-Rangel R, Brouwer MC; ESCMID Study Group for Infections of the Brain (ESGIB)
Clin Microbiol Infect 2024 Jan;30(1):66-89. Epub 2023 Aug 29 doi: 10.1016/j.cmi.2023.08.016. PMID: 37648062
Brain abscess in pediatric age: a review.
Mameli C, Genoni T, Madia C, Doneda C, Penagini F, Zuccotti G
Childs Nerv Syst 2019 Jul;35(7):1117-1128. Epub 2019 May 6 doi: 10.1007/s00381-019-04182-4. PMID: 31062139
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2018 Jan 4;1(1):CD008017. doi: 10.1002/14651858.CD008017.pub5. PMID: 29298459Free PMC Article
Intracranial complications of Serratia marcescens infection in neonates.
Madide A, Smith J
S Afr Med J 2016 Mar 15;106(4):36-8. doi: 10.7196/SAMJ.2016.v106i4.10206. PMID: 27032843
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Thompson SA, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2015 Jan 29;1:CD008017. doi: 10.1002/14651858.CD008017.pub4. PMID: 25634560

Recent systematic reviews

The connection between brain abscess and odontogenic infections: A systematic review.
Lisboa ECC, Silva WO, Rodrigues RCV, Brum SC, Alves FRF
Arch Oral Biol 2022 Mar;135:105360. Epub 2022 Jan 31 doi: 10.1016/j.archoralbio.2022.105360. PMID: 35121265
Nocardia farcinica cerebral abscess: A systematic review of treatment strategies.
Beucler N, Farah K, Choucha A, Meyer M, Fuentes S, Seng P, Dufour H
Neurochirurgie 2022 Jan;68(1):94-101. Epub 2021 May 11 doi: 10.1016/j.neuchi.2021.04.022. PMID: 33989644
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2018 Jan 4;1(1):CD008017. doi: 10.1002/14651858.CD008017.pub5. PMID: 29298459Free PMC Article
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Thompson SA, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2015 Jan 29;1:CD008017. doi: 10.1002/14651858.CD008017.pub4. PMID: 25634560
Embolisation for pulmonary arteriovenous malformation.
Hsu CC, Kwan GN, Thompson SA, Evans-Barns H, van Driel ML
Cochrane Database Syst Rev 2012 Aug 15;(8):CD008017. doi: 10.1002/14651858.CD008017.pub3. PMID: 22895972

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