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Non-Functioning Pancreatic Neuroendocrine Tumor G2

MedGen UID:
313502
•Concept ID:
C1709241
•
Neoplastic Process
Synonyms: Non-Functional Pancreatic Neuroendocrine Tumor G2; Non-Functioning Well Differentiated Pancreatic Endocrine Carcinoma; Nonfunctional Pancreatic Neuroendocrine Tumor G2; Nonfunctioning Pancreatic Neuroendocrine Tumor G2

Definition

An intermediate grade well differentiated neoplasm with neuroendocrine differentiation that arises from the pancreas. It is characterized by the absence of a hormone-related clinical syndrome. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVNon-Functioning Pancreatic Neuroendocrine Tumor G2

Professional guidelines

PubMed

Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Prognostic Assessment of Non-functioning Neuroendocrine Pancreatic Neoplasms as a Basis for Risk-Adapted Resection Strategies.
Watzka FM, Meyer F, Staubitz JI, Fottner C, Schad A, Lang H, Musholt TJ
World J Surg 2020 Feb;44(2):594-603. doi: 10.1007/s00268-019-05220-7. PMID: 31605171
Management of small asymptomatic nonfunctioning pancreatic neuroendocrine tumors: Limitations to apply guidelines into real life.
Partelli S, Mazza M, Andreasi V, Muffatti F, Crippa S, Tamburrino D, Falconi M
Surgery 2019 Aug;166(2):157-163. Epub 2019 May 17 doi: 10.1016/j.surg.2019.04.003. PMID: 31109657

Recent clinical studies

Etiology

Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Patients with non-functional metastatic G2 pancreatic neuroendocrine tumor benefit from palliative surgery: A 20-year single-center retrospective analysis.
You T, Tang H, Xu X, Ying H, Sun Z, Cheng Y, Bai C
J Neuroendocrinol 2022 Dec;34(12):e13211. Epub 2022 Nov 13 doi: 10.1111/jne.13211. PMID: 36373196
Management and outcomes of patients for non-functioning pancreatic neuroendocrine tumours: a multi-institutional analysis.
Du B, Wang X, Zhang W, Tan Q, Wei Y, Shao Z
ANZ J Surg 2022 Apr;92(4):787-793. Epub 2021 Nov 1 doi: 10.1111/ans.17326. PMID: 34723424
Prediction of non-functioning pancreatic neuroendocrine tumor grades with fractal analysis of preoperative contrast-enhanced computed tomography images.
Nakano A, Hayano K, Tochigi T, Mashiko T, Masuoka Y, Yamamoto S, Ozawa S, Nakagohri T
Eur J Radiol 2021 Aug;141:109803. Epub 2021 May 29 doi: 10.1016/j.ejrad.2021.109803. PMID: 34090111
Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis.
Ricci C, Partelli S, Landoni L, Rinzivillo M, Ingaldi C, Andreasi V, Nessi C, Muffatti F, Fontana M, Tamburrino D, Deiro G, Alberici L, Campana D, Panzuto F, Bassi C, Falconi M, Casadei R
Br J Surg 2021 Jul 23;108(7):811-816. doi: 10.1093/bjs/znaa141. PMID: 33724300

Diagnosis

Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Patients with non-functional metastatic G2 pancreatic neuroendocrine tumor benefit from palliative surgery: A 20-year single-center retrospective analysis.
You T, Tang H, Xu X, Ying H, Sun Z, Cheng Y, Bai C
J Neuroendocrinol 2022 Dec;34(12):e13211. Epub 2022 Nov 13 doi: 10.1111/jne.13211. PMID: 36373196
Prediction of non-functioning pancreatic neuroendocrine tumor grades with fractal analysis of preoperative contrast-enhanced computed tomography images.
Nakano A, Hayano K, Tochigi T, Mashiko T, Masuoka Y, Yamamoto S, Ozawa S, Nakagohri T
Eur J Radiol 2021 Aug;141:109803. Epub 2021 May 29 doi: 10.1016/j.ejrad.2021.109803. PMID: 34090111
Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis.
Ricci C, Partelli S, Landoni L, Rinzivillo M, Ingaldi C, Andreasi V, Nessi C, Muffatti F, Fontana M, Tamburrino D, Deiro G, Alberici L, Campana D, Panzuto F, Bassi C, Falconi M, Casadei R
Br J Surg 2021 Jul 23;108(7):811-816. doi: 10.1093/bjs/znaa141. PMID: 33724300

Therapy

Accurate non-invasive grading of nonfunctional pancreatic neuroendocrine tumors with a CT derived radiomics signature.
Javed AA, Zhu Z, Kinny-Köster B, Habib JR, Kawamoto S, Hruban RH, Fishman EK, Wolfgang CL, He J, Chu LC
Diagn Interv Imaging 2024 Jan;105(1):33-39. Epub 2023 Aug 17 doi: 10.1016/j.diii.2023.08.002. PMID: 37598013Free PMC Article
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Somatostatin analogs in patients with Zollinger Ellison syndrome (ZES): an observational study.
Massironi S, Cavalcoli F, Elvevi A, Quatrini M, Invernizzi P
Endocrine 2022 Mar;75(3):942-948. Epub 2021 Oct 29 doi: 10.1007/s12020-021-02915-7. PMID: 34716542
Solid non-functioning endocrine tumors of the pancreas: correlating computed tomography and pathology.
Zamboni GA, Ambrosetti MC, Zivelonghi C, Lombardo F, Butturini G, Cingarlini S, Capelli P, Pozzi Mucelli R
HPB (Oxford) 2017 Nov;19(11):986-991. Epub 2017 Aug 4 doi: 10.1016/j.hpb.2017.06.013. PMID: 28784262
Medical treatment of gastrinomas.
Auernhammer CJ, Göke B
Wien Klin Wochenschr 2007;119(19-20):609-15. doi: 10.1007/s00508-007-0877-1. PMID: 17985097

Prognosis

Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Patients with non-functional metastatic G2 pancreatic neuroendocrine tumor benefit from palliative surgery: A 20-year single-center retrospective analysis.
You T, Tang H, Xu X, Ying H, Sun Z, Cheng Y, Bai C
J Neuroendocrinol 2022 Dec;34(12):e13211. Epub 2022 Nov 13 doi: 10.1111/jne.13211. PMID: 36373196
Management and outcomes of patients for non-functioning pancreatic neuroendocrine tumours: a multi-institutional analysis.
Du B, Wang X, Zhang W, Tan Q, Wei Y, Shao Z
ANZ J Surg 2022 Apr;92(4):787-793. Epub 2021 Nov 1 doi: 10.1111/ans.17326. PMID: 34723424
Chemotherapy in NEN: still has a role?
Espinosa-Olarte P, La Salvia A, Riesco-Martinez MC, Anton-Pascual B, Garcia-Carbonero R
Rev Endocr Metab Disord 2021 Sep;22(3):595-614. Epub 2021 Apr 11 doi: 10.1007/s11154-021-09638-0. PMID: 33843007Free PMC Article
Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis.
Ricci C, Partelli S, Landoni L, Rinzivillo M, Ingaldi C, Andreasi V, Nessi C, Muffatti F, Fontana M, Tamburrino D, Deiro G, Alberici L, Campana D, Panzuto F, Bassi C, Falconi M, Casadei R
Br J Surg 2021 Jul 23;108(7):811-816. doi: 10.1093/bjs/znaa141. PMID: 33724300

Clinical prediction guides

Factors Affecting Nonfunctioning Small Pancreatic Neuroendocrine Neoplasms and Proposed New Treatment Strategies.
Hijioka S, Yamashige D, Esaki M, Honda G, Higuchi R, Masui T, Shimizu Y, Ohtsuka M, Kumamoto Y, Katanuma A, Gotohda N, Akita H, Unno M, Endo I, Yokoyama Y, Yamada S, Matsumoto I, Ohtsuka T, Hirano S, Yasuda H, Kawai M, Aoki T, Nakamura M, Hashimoto D, Rikiyama T, Horiguchi A, Fujii T, Mizuno S, Hanada K, Tani M, Hatori T, Ito T, Okuno M, Kagawa S, Tajima H, Ishii T, Sugimoto M, Onoe S, Takami H, Takada R, Miura T, Kurita Y, Kamei K, Mataki Y, Okazaki K, Takeyama Y, Yamaue H, Satoi S; Japan Pancreas Society Clinical Research Promotion Committee Group (Corporate Authorship)
Clin Gastroenterol Hepatol 2024 Jul;22(7):1416-1426.e5. Epub 2024 Apr 13 doi: 10.1016/j.cgh.2024.03.029. PMID: 38615727
Machine learning-based model for prediction and feature analysis of recurrence in pancreatic neuroendocrine tumors G1/G2.
Murakami M, Fujimori N, Nakata K, Nakamura M, Hashimoto S, Kurahara H, Nishihara K, Abe T, Hashigo S, Kugiyama N, Ozawa E, Okamoto K, Ishida Y, Okano K, Takaki R, Shimamatsu Y, Ito T, Miki M, Oza N, Yamaguchi D, Yamamoto H, Takedomi H, Kawabe K, Akashi T, Miyahara K, Ohuchida J, Ogura Y, Nakashima Y, Ueki T, Ishigami K, Umakoshi H, Ueda K, Oono T, Ogawa Y
J Gastroenterol 2023 Jun;58(6):586-597. Epub 2023 Apr 26 doi: 10.1007/s00535-023-01987-8. PMID: 37099152
Management and outcomes of patients for non-functioning pancreatic neuroendocrine tumours: a multi-institutional analysis.
Du B, Wang X, Zhang W, Tan Q, Wei Y, Shao Z
ANZ J Surg 2022 Apr;92(4):787-793. Epub 2021 Nov 1 doi: 10.1111/ans.17326. PMID: 34723424
Prediction of non-functioning pancreatic neuroendocrine tumor grades with fractal analysis of preoperative contrast-enhanced computed tomography images.
Nakano A, Hayano K, Tochigi T, Mashiko T, Masuoka Y, Yamamoto S, Ozawa S, Nakagohri T
Eur J Radiol 2021 Aug;141:109803. Epub 2021 May 29 doi: 10.1016/j.ejrad.2021.109803. PMID: 34090111
Sporadic non-functioning pancreatic neuroendocrine tumours: multicentre analysis.
Ricci C, Partelli S, Landoni L, Rinzivillo M, Ingaldi C, Andreasi V, Nessi C, Muffatti F, Fontana M, Tamburrino D, Deiro G, Alberici L, Campana D, Panzuto F, Bassi C, Falconi M, Casadei R
Br J Surg 2021 Jul 23;108(7):811-816. doi: 10.1093/bjs/znaa141. PMID: 33724300

Recent systematic reviews

Predictors of disease recurrence after curative surgery for nonfunctioning pancreatic neuroendocrine neoplasms (NF-PanNENs): a systematic review and meta-analysis.
Andreasi V, Ricci C, Partelli S, Guarneri G, Ingaldi C, Muffatti F, Crippa S, Casadei R, Falconi M
J Endocrinol Invest 2022 Apr;45(4):705-718. Epub 2021 Nov 13 doi: 10.1007/s40618-021-01705-2. PMID: 34773595

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