Full Report

Format

Full Report
Summary (Text)
Summary (XML)

Send to:

Choose Destination

File
Clipboard
Collections

Abnormalities, Severe Teratoid

MedGen UID:: 438147
•Concept ID:: C2713367
•: Congenital Abnormality

Synonyms:

Abnormality, Severe Teratoid; Severe Teratoid Abnormalities; Severe Teratoid Abnormality; Teratoid Abnormalities, Severe; Teratoid Abnormality, Severe

Definition

Marked developmental anomalies of a fetus or infant. [from MeSH]

Term Hierarchy

GTR
MeSH

CClinical test, RResearch test, OOMIM, GGeneReviews, VClinVar

CROGVAbnormalities, Severe Teratoid

Phenotypic abnormality
- Abnormality of prenatal development or birth
  - Fetal anomaly
    - Abnormalities, Severe Teratoid
      - Anencephaly
        Hydranencephaly
      - Conjoined twins

Professional guidelines

PubMed

Prenatal diagnosis of holoprosencephaly.

Kousa YA, du Plessis AJ, Vezina G
Am J Med Genet C Semin Med Genet 2018 Jun;178(2):206-213. Epub 2018 May 17 doi: 10.1002/ajmg.c.31618. PMID: 29770996

History of treatment of conjoined twins.

Kobylarz K
Anaesthesiol Intensive Ther 2014 Apr-Jun;46(2):116-23. doi: 10.5603/AIT.2014.0022. PMID: 24858972

Current concepts in genetics. Prenatal diagnosis of genetic disorders.

Milunsky A
N Engl J Med 1976 Aug 12;295(7):377-80. doi: 10.1056/NEJM197608122950708. PMID: 59313

See all (106)

Recent clinical studies

Etiology

Holoacardius: radiologic investigation.

Dicker D, Peleg D, Samuel N, Feldberg D, Goldman JA
Early Hum Dev 1983 Dec;9(1):59-65. doi: 10.1016/0378-3782(83)90102-0. PMID: 6667651

Chromosomal abnormalities associated with cyclopia and synophthalmia.

Howard RO
Trans Am Ophthalmol Soc 1977;75:505-38. PMID: 418547 Free PMC Article

Homo monstrosus.

Malefijt AD
Sci Am 1968 Oct;219(4):113-8. PMID: 4878740

ANENCEPHALY IN ONE OF MONOZYGOUS TWINS.

DESA DJ, STRONG SJ, CORNEY G
Biol Neonat 1964;7:328-34. doi: 10.1159/000239937. PMID: 14319195

ANENCEPHALY IN LIVERPOOL.

SMITHELLS RW, CHINN ER, FRANKLIN D
Dev Med Child Neurol 1964 Jun;6:231-40. doi: 10.1111/j.1469-8749.1964.tb10782.x. PMID: 14155181

See all (20)

Diagnosis

Conjoined twins-early prenatal diagnosis.

Gica N, Gana N, Mat C, Panaitescu AM, Peltecu G, Vayna AM
J Obstet Gynaecol 2020 Jul;40(5):723-724. Epub 2019 Oct 12 doi: 10.1080/01443615.2019.1650012. PMID: 31607199

Heteropagus (parasitic) twins: a review.

Sharma G, Mobin SS, Lypka M, Urata M
J Pediatr Surg 2010 Dec;45(12):2454-63. doi: 10.1016/j.jpedsurg.2010.07.002. PMID: 21129567

Thoracopagus conjoined twins.

Collins RT 2nd, Bhatti TR, Huff DS, Weinberg PM
Circulation 2008 Sep 30;118(14):1496. doi: 10.1161/CIRCULATIONAHA.108.789941. PMID: 18824656

Fetus-in-fetu.

Nocera RM, Davis M, Hayden CK Jr, Schwartz M, Swischuk LE
AJR Am J Roentgenol 1982 Apr;138(4):762-4. doi: 10.2214/ajr.138.4.762. PMID: 6978047

Cebo-anancephaly.

Chaurasia BD, Dharker SR
Anat Anz 1976;140(5):514-9. PMID: 828460

See all (88)

Therapy

An assessment of the general public's knowledge of fatal fetal anomalies.

Power S, Meaney S, O'Donoghue K
Prenat Diagn 2018 Oct;38(11):883-890. Epub 2018 Aug 31 doi: 10.1002/pd.5348. PMID: 30144106

"Monstre". Etienne Geoffroy Saint-Hilaire and the science of monstrosity.

Mazzocut-Mis M
Med Secoli 2014;26(1):145-65. PMID: 25702384

Sympodia.

Ho NK, Loo DS
Am J Dis Child 1974 Sep;128(3):391-3. doi: 10.1001/archpedi.1974.02110280121019. PMID: 4472335

Cyclopia.

Khudr G, Olding L
Am J Dis Child 1973 Jan;125(1):120-2. doi: 10.1001/archpedi.1973.04160010082020. PMID: 4630624

A case of cyclopia.

Batts JA Jr, Punnett HH, Valdes-Dapena M, Coles JW, Green WR
Am J Obstet Gynecol 1972 Mar;112(5):657-61. doi: 10.1016/0002-9378(72)90791-0. PMID: 5059596

See all (17)

Prognosis

A case of craniopagus parasiticus: an antenatal diagnosis by ultrasound screening at 16 weeks of gestation and a literature review of recently reported cases.

Al-Yaqoubi HN, Fatema N, Al-Fahdi BS
Turk J Pediatr 2019;61(6):941-945. doi: 10.24953/turkjped.2019.06.017. PMID: 32134590

Treatment of acardiac twinning.

Arias F, Sunderji S, Gimpelson R, Colton E
Obstet Gynecol 1998 May;91(5 Pt 2):818-21. doi: 10.1016/s0029-7844(97)00708-4. PMID: 9572174

Multiple pregnancy. 1.

Benirschke K, Kim CK
N Engl J Med 1973 Jun 14;288(24):1276-84. doi: 10.1056/NEJM197306142882406. PMID: 4574107

PREGNANCY WITH ANENCEPHALY.

COMERFORD JB
Lancet 1965 Mar 27;1(7387):679-80. doi: 10.1016/s0140-6736(65)91832-5. PMID: 14258549

Anencephalus, spina bifida, and hydrocephalus incidence related to sex, race, and season of birth, and incidence in siblings.

MACMAHON B, PUGH TF, INGALLS TH
Br J Prev Soc Med 1953 Oct;7(4):211-9. doi: 10.1136/jech.7.4.211. PMID: 13106264 Free PMC Article

See all (23)

Clinical prediction guides

Heteropagus (parasitic) twins: a review.

Sharma G, Mobin SS, Lypka M, Urata M
J Pediatr Surg 2010 Dec;45(12):2454-63. doi: 10.1016/j.jpedsurg.2010.07.002. PMID: 21129567

Severe brain and limb defects with possible autosomal recessive inheritance: a series of six cases and review of the literature.

Labrune P, Trioche P, Fallet-Bianco C, Roume J, Narcy F, Le Merrer M
Am J Med Genet 1997 Dec 12;73(2):144-9. PMID: 9409864

Anencephalus, Spina Bifida, twins, and teratoma.

Rogers SC
Br J Prev Soc Med 1976 Mar;30(1):26-8. doi: 10.1136/jech.30.1.26. PMID: 779911 Free PMC Article

A ten-year study of anencephaly.

SMILKSTEIN G
Calif Med 1962 May;96(5):350-3. PMID: 13914041 Free PMC Article

Human parabiotic pygopagus twins with hypertension; report of a case with clinical, psychologic and endocrinologic observations.

JONES SH, YOUNGHUSBAND OZ, EVANS JA
J Am Med Assoc 1948 Oct 30;138(9):642-5. doi: 10.1001/jama.1948.02900090016004. PMID: 18888595

See all (15)

MedGen

National Center for Biotechnology Information