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Renal hypomagnesemia 6(HOMG6)

MedGen UID:
462645
•Concept ID:
C3151295
•
Disease or Syndrome
Synonyms: HOMG6; HYPOMAGNESEMIA 6, RENAL
 
Gene (location): CNNM2 (10q24.32)
 
Monarch Initiative: MONDO:0013480
OMIM®: 613882

Clinical features

From HPO
Impaired renal tubular reabsorption of magnesium
MedGen UID:
1778245
•Concept ID:
C5539797
•
Finding
Decreased renal tubular reabsorption of magnesium.
See: Feature record | Search on this feature
Vertigo
MedGen UID:
53006
•Concept ID:
C0042571
•
Sign or Symptom
An abnormal sensation of spinning while the body is actually stationary.
See: Feature record | Search on this feature
Headache
MedGen UID:
9149
•Concept ID:
C0018681
•
Sign or Symptom
Cephalgia, or pain sensed in various parts of the head, not confined to the area of distribution of any nerve.
See: Feature record | Search on this feature
Muscle weakness
MedGen UID:
57735
•Concept ID:
C0151786
•
Finding
Reduced strength of muscles.
See: Feature record | Search on this feature
Hypomagnesemia
MedGen UID:
57481
•Concept ID:
C0151723
•
Disease or Syndrome
An abnormally decreased magnesium concentration in the blood.
See: Feature record | Search on this feature
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Professional guidelines

PubMed

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Neurologic conditions and disorders of uremic syndrome of chronic kidney disease: presentations, causes, and treatment strategies.
Hamed SA
Expert Rev Clin Pharmacol 2019 Jan;12(1):61-90. Epub 2019 Jan 11 doi: 10.1080/17512433.2019.1555468. PMID: 30501441
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article

Recent clinical studies

Etiology

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Obesity and hypomagnesemia.
Guerrero-Romero F, Flores-García A, Saldaña-Guerrero S, Simental-Mendía LE, Rodríguez-Morán M
Eur J Intern Med 2016 Oct;34:29-33. Epub 2016 Jun 25 doi: 10.1016/j.ejim.2016.06.015. PMID: 27353277
Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article

Diagnosis

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Pathophysiologic approach in genetic hypokalemia: An update.
Blanchard A
Ann Endocrinol (Paris) 2023 Apr;84(2):298-307. Epub 2023 Jan 10 doi: 10.1016/j.ando.2022.11.005. PMID: 36639120
Rather Unusual Cause of Seizures.
Singh P, Miao J, Schwartz GL
Am J Med 2021 Jun;134(6):e380-e381. Epub 2021 Jan 14 doi: 10.1016/j.amjmed.2020.11.015. PMID: 33359777
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
How should hypomagnesaemia be investigated and treated?
Ayuk J, Gittoes NJ
Clin Endocrinol (Oxf) 2011 Dec;75(6):743-6. doi: 10.1111/j.1365-2265.2011.04092.x. PMID: 21569071

Therapy

AGA Clinical Practice Update on Diagnosis and Management of Acute Hepatic Porphyrias: Expert Review.
Wang B, Bonkovsky HL, Lim JK, Balwani M
Gastroenterology 2023 Mar;164(3):484-491. Epub 2023 Jan 13 doi: 10.1053/j.gastro.2022.11.034. PMID: 36642627Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article
How should hypomagnesaemia be investigated and treated?
Ayuk J, Gittoes NJ
Clin Endocrinol (Oxf) 2011 Dec;75(6):743-6. doi: 10.1111/j.1365-2265.2011.04092.x. PMID: 21569071

Prognosis

Electrolyte Imbalance in Anti-LGI1 Encephalitis: It Is Not All in Your Head.
Gadoth A, Nisnboym M, Alcalay Y, Zubkov A, Schwartz I, Schwartz D, Abboud M, Rubinek T, Yossepowitch O, Weinstein T
Neurol Neuroimmunol Neuroinflamm 2023 Nov;10(6) Epub 2023 Aug 17 doi: 10.1212/NXI.0000000000200155. PMID: 37591767Free PMC Article
Hypocalcaemia of malignancy.
Schattner A, Dubin I, Huber R, Gelber M
Neth J Med 2016 Jul;74(6):231-9. PMID: 27571720
Cabozantinib versus everolimus in advanced renal cell carcinoma (METEOR): final results from a randomised, open-label, phase 3 trial.
Choueiri TK, Escudier B, Powles T, Tannir NM, Mainwaring PN, Rini BI, Hammers HJ, Donskov F, Roth BJ, Peltola K, Lee JL, Heng DYC, Schmidinger M, Agarwal N, Sternberg CN, McDermott DF, Aftab DT, Hessel C, Scheffold C, Schwab G, Hutson TE, Pal S, Motzer RJ; METEOR investigators
Lancet Oncol 2016 Jul;17(7):917-927. Epub 2016 Jun 5 doi: 10.1016/S1470-2045(16)30107-3. PMID: 27279544
Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis.
Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A
QJM 2016 Jul;109(7):453-459. Epub 2016 Mar 24 doi: 10.1093/qjmed/hcw048. PMID: 27016536
New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia.
Lainez S, Schlingmann KP, van der Wijst J, Dworniczak B, van Zeeland F, Konrad M, Bindels RJ, Hoenderop JG
Eur J Hum Genet 2014 Apr;22(4):497-504. Epub 2013 Aug 14 doi: 10.1038/ejhg.2013.178. PMID: 23942199Free PMC Article

Clinical prediction guides

Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis.
Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A
QJM 2016 Jul;109(7):453-459. Epub 2016 Mar 24 doi: 10.1093/qjmed/hcw048. PMID: 27016536
Protocol for the detection and nutritional management of high-output stomas.
Arenas Villafranca JJ, López-Rodríguez C, Abilés J, Rivera R, Gándara Adán N, Utrilla Navarro P
Nutr J 2015 May 9;14:45. doi: 10.1186/s12937-015-0034-z. PMID: 25956387Free PMC Article
New TRPM6 missense mutations linked to hypomagnesemia with secondary hypocalcemia.
Lainez S, Schlingmann KP, van der Wijst J, Dworniczak B, van Zeeland F, Konrad M, Bindels RJ, Hoenderop JG
Eur J Hum Genet 2014 Apr;22(4):497-504. Epub 2013 Aug 14 doi: 10.1038/ejhg.2013.178. PMID: 23942199Free PMC Article
Linkage of Gitelman syndrome to the thiazide-sensitive sodium-chloride cotransporter gene with identification of mutations in Dutch families.
Lemmink HH, van den Heuvel LP, van Dijk HA, Merkx GF, Smilde TJ, Taschner PE, Monnens LA, Hebert SC, Knoers NV
Pediatr Nephrol 1996 Aug;10(4):403-7. doi: 10.1007/s004670050129. PMID: 8865231

Recent systematic reviews

Hypomagnesaemia, an independent risk factor for the development of post-transplant diabetes mellitus in liver and renal transplant recipients? A systematic review.
Chen S, Bowen DG, Liu K, Vidot H
J Hum Nutr Diet 2024 Dec;37(6):1407-1419. Epub 2024 Jul 29 doi: 10.1111/jhn.13354. PMID: 39073157
Magnesium Metabolism in Chronic Alcohol-Use Disorder: Meta-Analysis and Systematic Review.
Vanoni FO, Milani GP, Agostoni C, Treglia G, Faré PB, Camozzi P, Lava SAG, Bianchetti MG, Janett S
Nutrients 2021 Jun 7;13(6) doi: 10.3390/nu13061959. PMID: 34200366Free PMC Article
Serum Magnesium after Kidney Transplantation: A Systematic Review.
Garnier AS, Duveau A, Planchais M, Subra JF, Sayegh J, Augusto JF
Nutrients 2018 Jun 6;10(6) doi: 10.3390/nu10060729. PMID: 29882768Free PMC Article
Risk factors for QTc-prolongation: systematic review of the evidence.
Vandael E, Vandenberk B, Vandenberghe J, Willems R, Foulon V
Int J Clin Pharm 2017 Feb;39(1):16-25. Epub 2016 Dec 23 doi: 10.1007/s11096-016-0414-2. PMID: 28012118
Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis.
Upala S, Jaruvongvanich V, Wijarnpreecha K, Sanguankeo A
QJM 2016 Jul;109(7):453-459. Epub 2016 Mar 24 doi: 10.1093/qjmed/hcw048. PMID: 27016536

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