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Early Hepatocellular Carcinoma

MedGen UID:
474652
•Concept ID:
C3273019
•
Neoplastic Process

Definition

A low grade, well differentiated small hepatocellular carcinoma. It lacks obvious stromal invasion and significant atypia. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVEarly Hepatocellular Carcinoma

Professional guidelines

PubMed

Liquid biopsy in the clinical management of hepatocellular carcinoma.
von Felden J, Garcia-Lezana T, Schulze K, Losic B, Villanueva A
Gut 2020 Nov;69(11):2025-2034. Epub 2020 Sep 3 doi: 10.1136/gutjnl-2019-320282. PMID: 32883873
Non-alcoholic fatty liver disease: a review of epidemiology, risk factors, diagnosis and management.
Huang TD, Behary J, Zekry A
Intern Med J 2020 Sep;50(9):1038-1047. doi: 10.1111/imj.14709. PMID: 31760676
Liver Ablation: Best Practice.
Wells SA, Hinshaw JL, Lubner MG, Ziemlewicz TJ, Brace CL, Lee FT Jr
Radiol Clin North Am 2015 Sep;53(5):933-71. doi: 10.1016/j.rcl.2015.05.012. PMID: 26321447Free PMC Article

Recent clinical studies

Etiology

Hepatic Precancerous Lesions and Early Hepatocellular Carcinoma.
Wen KW, Kakar S
Gastroenterol Clin North Am 2024 Mar;53(1):109-132. Epub 2023 Dec 16 doi: 10.1016/j.gtc.2023.11.005. PMID: 38280744
AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation.
Norman JS, Li PJ, Kotwani P, Shui AM, Yao F, Mehta N
J Hepatol 2023 Dec;79(6):1469-1477. Epub 2023 Sep 7 doi: 10.1016/j.jhep.2023.08.020. PMID: 37683735Free PMC Article
No-Touch Radiofrequency Ablation for Early Hepatocellular Carcinoma: 2023 Korean Society of Image-Guided Tumor Ablation Guidelines.
Han S, Lee MW, Lee YJ, Hong HP, Lee DH, Lee JM
Korean J Radiol 2023 Aug;24(8):719-728. doi: 10.3348/kjr.2023.0423. PMID: 37500573Free PMC Article
Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma.
Ren Z, Li A, Jiang J, Zhou L, Yu Z, Lu H, Xie H, Chen X, Shao L, Zhang R, Xu S, Zhang H, Cui G, Chen X, Sun R, Wen H, Lerut JP, Kan Q, Li L, Zheng S
Gut 2019 Jun;68(6):1014-1023. Epub 2018 Jul 25 doi: 10.1136/gutjnl-2017-315084. PMID: 30045880Free PMC Article
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Diagnosis

Hepatic Precancerous Lesions and Early Hepatocellular Carcinoma.
Wen KW, Kakar S
Gastroenterol Clin North Am 2024 Mar;53(1):109-132. Epub 2023 Dec 16 doi: 10.1016/j.gtc.2023.11.005. PMID: 38280744
AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation.
Norman JS, Li PJ, Kotwani P, Shui AM, Yao F, Mehta N
J Hepatol 2023 Dec;79(6):1469-1477. Epub 2023 Sep 7 doi: 10.1016/j.jhep.2023.08.020. PMID: 37683735Free PMC Article
Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma.
Ren Z, Li A, Jiang J, Zhou L, Yu Z, Lu H, Xie H, Chen X, Shao L, Zhang R, Xu S, Zhang H, Cui G, Chen X, Sun R, Wen H, Lerut JP, Kan Q, Li L, Zheng S
Gut 2019 Jun;68(6):1014-1023. Epub 2018 Jul 25 doi: 10.1136/gutjnl-2017-315084. PMID: 30045880Free PMC Article
Pathologic diagnosis of early hepatocellular carcinoma: a report of the international consensus group for hepatocellular neoplasia.
International Consensus Group for Hepatocellular NeoplasiaThe International Consensus Group for Hepatocellular Neoplasia
Hepatology 2009 Feb;49(2):658-64. doi: 10.1002/hep.22709. PMID: 19177576
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039

Therapy

Gut microbiome analysis as a tool towards targeted non-invasive biomarkers for early hepatocellular carcinoma.
Ren Z, Li A, Jiang J, Zhou L, Yu Z, Lu H, Xie H, Chen X, Shao L, Zhang R, Xu S, Zhang H, Cui G, Chen X, Sun R, Wen H, Lerut JP, Kan Q, Li L, Zheng S
Gut 2019 Jun;68(6):1014-1023. Epub 2018 Jul 25 doi: 10.1136/gutjnl-2017-315084. PMID: 30045880Free PMC Article
Exploring the role of oncolytic viruses in hepatobiliary cancers.
Tenneti P, Borad MJ, Babiker HM
Immunotherapy 2018 Aug;10(11):971-986. Epub 2018 Jun 14 doi: 10.2217/imt-2018-0048. PMID: 29900755
Combination of Transarterial Chemoembolization (TACE) and Radiofrequency Ablation (RFA) vs. Surgical Resection (SR) on Survival Outcome of Early Hepatocellular Carcinoma: A Meta-Analysis.
Guo W, He X, Li Z, Li Y
Hepatogastroenterology 2015 May;62(139):710-4. PMID: 26897959
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039
Image guided tumour ablation.
Gillams AR
Cancer Imaging 2005 Sep 21;5(1):103-9. doi: 10.1102/1470-7330.2005.0015. PMID: 16305946Free PMC Article

Prognosis

The Role of Liver Transplantation in Hepatocellular Carcinoma.
Jakhete N, Majeed NA, Maluf D, Shetty K
Clin Liver Dis 2025 Feb;29(1):73-85. Epub 2024 Oct 28 doi: 10.1016/j.cld.2024.08.009. PMID: 39608959
AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation.
Norman JS, Li PJ, Kotwani P, Shui AM, Yao F, Mehta N
J Hepatol 2023 Dec;79(6):1469-1477. Epub 2023 Sep 7 doi: 10.1016/j.jhep.2023.08.020. PMID: 37683735Free PMC Article
Is anatomical resection necessary for early hepatocellular carcinoma? A single institution retrospective experience.
Shi F, Zhou Z, Huang X, Liu Q, Lin A
Future Oncol 2019 Jun;15(17):2041-2051. Epub 2019 Apr 10 doi: 10.2217/fon-2019-0117. PMID: 30968698
Hepatocellular carcinoma.
Marrero JA
Curr Opin Gastroenterol 2006 May;22(3):248-53. doi: 10.1097/01.mog.0000218961.86182.8c. PMID: 16550039
Pathological evolution of early hepatocellular carcinoma.
Kojiro M
Oncology 2002;62 Suppl 1:43-7. doi: 10.1159/000048275. PMID: 11868784

Clinical prediction guides

The Role of Liver Transplantation in Hepatocellular Carcinoma.
Jakhete N, Majeed NA, Maluf D, Shetty K
Clin Liver Dis 2025 Feb;29(1):73-85. Epub 2024 Oct 28 doi: 10.1016/j.cld.2024.08.009. PMID: 39608959
Clinical guidelines for early hepatocellular carcinoma treatment options: a systematic review and bibliometric analysis.
Wu CY, Lin LY, Lee TY, Hsu YC, Yeh CC, Chen C, Kang YN, Huang TW
Int J Surg 2024 Nov 1;110(11):7234-7244. doi: 10.1097/JS9.0000000000001950. PMID: 39041955Free PMC Article
Cell-free DNA testing for early hepatocellular carcinoma surveillance.
Chen L, Wu T, Fan R, Qian YS, Liu JF, Bai J, Zheng B, Liu XL, Zheng D, Du LT, Jiang GQ, Wang YC, Fan XT, Deng GH, Wang CY, Shen F, Hu HP, Zhang QZ, Ye YN, Zhang J, Gao YH, Xia J, Yan HD, Liang MF, Yu YL, Sun FM, Gao YJ, Sun J, Zhong CX, Wang Y, Wang H, Kong F, Chen JM, Wen H, Wu BM, Wang CX, Wu L, Hou JL, Wang HY
EBioMedicine 2024 Feb;100:104962. Epub 2024 Jan 6 doi: 10.1016/j.ebiom.2023.104962. PMID: 38184937Free PMC Article
AFP-L3 and DCP strongly predict early hepatocellular carcinoma recurrence after liver transplantation.
Norman JS, Li PJ, Kotwani P, Shui AM, Yao F, Mehta N
J Hepatol 2023 Dec;79(6):1469-1477. Epub 2023 Sep 7 doi: 10.1016/j.jhep.2023.08.020. PMID: 37683735Free PMC Article
Extracellular vesicles as biomarkers in liver diseases: A clinician's point of view.
Thietart S, Rautou PE
J Hepatol 2020 Dec;73(6):1507-1525. Epub 2020 Jul 15 doi: 10.1016/j.jhep.2020.07.014. PMID: 32682050

Recent systematic reviews

Clinical guidelines for early hepatocellular carcinoma treatment options: a systematic review and bibliometric analysis.
Wu CY, Lin LY, Lee TY, Hsu YC, Yeh CC, Chen C, Kang YN, Huang TW
Int J Surg 2024 Nov 1;110(11):7234-7244. doi: 10.1097/JS9.0000000000001950. PMID: 39041955Free PMC Article
Ablative and non-surgical therapies for early and very early hepatocellular carcinoma: a systematic review and network meta-analysis.
Wade R, South E, Anwer S, Sharif-Hurst S, Harden M, Fulbright H, Hodgson R, Dias S, Simmonds M, Rowe I, Thornton P, Eastwood A
Health Technol Assess 2023 Dec;27(29):1-172. doi: 10.3310/GK5221. PMID: 38149643Free PMC Article
Systematic Review: Clinical Metabolomics to Forecast Outcomes in Liver Transplantation Surgery.
Attard JA, Dunn WB, Mergental H, Mirza DF, Afford SC, Perera MTPR
OMICS 2019 Oct;23(10):463-476. Epub 2019 Sep 12 doi: 10.1089/omi.2019.0086. PMID: 31513460
Exploring the role of oncolytic viruses in hepatobiliary cancers.
Tenneti P, Borad MJ, Babiker HM
Immunotherapy 2018 Aug;10(11):971-986. Epub 2018 Jun 14 doi: 10.2217/imt-2018-0048. PMID: 29900755
Management of people with early- or very early-stage hepatocellular carcinoma: an attempted network meta-analysis.
Majumdar A, Roccarina D, Thorburn D, Davidson BR, Tsochatzis E, Gurusamy KS
Cochrane Database Syst Rev 2017 Mar 28;3(3):CD011650. doi: 10.1002/14651858.CD011650.pub2. PMID: 28351116Free PMC Article

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