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Abnormality of the umbilical cord

MedGen UID:
488829
Concept ID:
C0266785
Anatomical Abnormality
Synonyms: Abnormal umbilical cord; Umbilical cord issue
SNOMED CT: Abnormal umbilical cord (90009001)
 
HPO: HP:0010881

Definition

An abnormality of the umbilical cord, which is the cord connecting the developing embryo or fetus to the placenta. [from HPO]

Professional guidelines

PubMed

Ross N, Roman AS
Clin Obstet Gynecol 2025 Mar 1;68(1):93-97. Epub 2024 Dec 23 doi: 10.1097/GRF.0000000000000913. PMID: 39846882

Recent clinical studies

Etiology

Katheria AC, Clark E, Yoder B, Schmölzer GM, Yan Law BH, El-Naggar W, Rittenberg D, Sheth S, Mohamed MA, Martin C, Vora F, Lakshminrusimha S, Underwood M, Mazela J, Kaempf J, Tomlinson M, Gollin Y, Fulford K, Goff Y, Wozniak P, Baker K, Rich W, Morales A, Varner M, Poeltler D, Vaucher Y, Mercer J, Finer N, El Ghormli L, Rice MM; of the Milking In Nonvigorous Infants group
Am J Obstet Gynecol 2023 Feb;228(2):217.e1-217.e14. Epub 2022 Aug 13 doi: 10.1016/j.ajog.2022.08.015. PMID: 35970202Free PMC Article
Hammad IA, Blue NR, Allshouse AA, Silver RM, Gibbins KJ, Page JM, Goldenberg RL, Reddy UM, Saade GR, Dudley DJ, Thorsten VR, Conway DL, Pinar H, Pysher TJ; NICHD Stillbirth Collaborative Research Network Group
Obstet Gynecol 2020 Mar;135(3):644-652. doi: 10.1097/AOG.0000000000003676. PMID: 32028503Free PMC Article
Sánchez-Códez MI, Lubián-Gutiérrez M, Méndez-Abad P
Fetal Pediatr Pathol 2019 Aug;38(4):359-360. Epub 2019 Apr 5 doi: 10.1080/15513815.2019.1584656. PMID: 30947594
Heider A
Arch Pathol Lab Med 2017 Nov;141(11):1484-1489. doi: 10.5858/arpa.2017-0212-RA. PMID: 29072954
MCKAY RJ Jr
N Engl J Med 1964 Jun 11;270:1292-9 CONCL. doi: 10.1056/NEJM196406112702406. PMID: 14133668

Diagnosis

Fite EL, Rivera BK, McNabb R, Smith CV, Hill KD, Katheria A, Maitre N, Backes CH
Semin Perinatol 2023 Jun;47(4):151747. Epub 2023 Mar 18 doi: 10.1016/j.semperi.2023.151747. PMID: 37002126
Ranzini AC, Oyelese Y
Ultrasound Obstet Gynecol 2021 May;57(5):720-725. doi: 10.1002/uog.23520. PMID: 33085148
Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y
Drug Des Devel Ther 2019;13:4331-4340. Epub 2019 Dec 19 doi: 10.2147/DDDT.S225613. PMID: 31908418Free PMC Article
Sánchez-Códez MI, Lubián-Gutiérrez M, Méndez-Abad P
Fetal Pediatr Pathol 2019 Aug;38(4):359-360. Epub 2019 Apr 5 doi: 10.1080/15513815.2019.1584656. PMID: 30947594
MCKAY RJ Jr
N Engl J Med 1964 Jun 11;270:1292-9 CONCL. doi: 10.1056/NEJM196406112702406. PMID: 14133668

Therapy

Katheria AC, Clark E, Yoder B, Schmölzer GM, Yan Law BH, El-Naggar W, Rittenberg D, Sheth S, Mohamed MA, Martin C, Vora F, Lakshminrusimha S, Underwood M, Mazela J, Kaempf J, Tomlinson M, Gollin Y, Fulford K, Goff Y, Wozniak P, Baker K, Rich W, Morales A, Varner M, Poeltler D, Vaucher Y, Mercer J, Finer N, El Ghormli L, Rice MM; of the Milking In Nonvigorous Infants group
Am J Obstet Gynecol 2023 Feb;228(2):217.e1-217.e14. Epub 2022 Aug 13 doi: 10.1016/j.ajog.2022.08.015. PMID: 35970202Free PMC Article
Lees CC, Romero R, Stampalija T, Dall'Asta A, DeVore GA, Prefumo F, Frusca T, Visser GHA, Hobbins JC, Baschat AA, Bilardo CM, Galan HL, Campbell S, Maulik D, Figueras F, Lee W, Unterscheider J, Valensise H, Da Silva Costa F, Salomon LJ, Poon LC, Ferrazzi E, Mari G, Rizzo G, Kingdom JC, Kiserud T, Hecher K
Am J Obstet Gynecol 2022 Mar;226(3):366-378. Epub 2022 Jan 10 doi: 10.1016/j.ajog.2021.11.1357. PMID: 35026129Free PMC Article
Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y
Drug Des Devel Ther 2019;13:4331-4340. Epub 2019 Dec 19 doi: 10.2147/DDDT.S225613. PMID: 31908418Free PMC Article
Wraith JE, Jones S
Pediatr Endocrinol Rev 2014 Sep;12 Suppl 1:102-6. PMID: 25345091
Block SL
Pediatr Ann 2012 Oct;41(10):400-3. doi: 10.3928/00904481-20120924-05. PMID: 23052142

Prognosis

Pagan M, Eads L, Sward L, Manning N, Hunzicker A, Magann EF
Obstet Gynecol Surv 2020 Aug;75(8):510-518. doi: 10.1097/OGX.0000000000000818. PMID: 32856717
Muniraman H, Sardesai T, Sardesai S
Pediatr Rev 2018 Jul;39(7):332-341. doi: 10.1542/pir.2017-0202. PMID: 29967078
Fukada Y, Yasumizu T, Hoshi K
Int J Gynaecol Obstet 1998 Apr;61(1):67-8. doi: 10.1016/s0020-7292(98)00020-4. PMID: 9622177
Brenner WE, Bruce RD, Hendricks CH
Am J Obstet Gynecol 1974 Mar 1;118(5):700-12. doi: 10.1016/s0002-9378(16)33744-9. PMID: 4813810
Brant HA, Lewis BV
Lancet 1966 Dec 31;2(7479):1443-5. doi: 10.1016/s0140-6736(66)90599-x. PMID: 4163444

Clinical prediction guides

Tang Y, Zou X, Liu P, Dai Y, Wang S, Su X, Yu Y, Tang W, Zhou J, Li C, Mei H, Xiao N, Ou Y, Wang J, Lu G, Lin G, Cheng L
J Med Virol 2024 Jun;96(6):e29757. doi: 10.1002/jmv.29757. PMID: 38899432
Olofsson P
Am J Obstet Gynecol 2023 May;228(5S):S1222-S1240. Epub 2023 Mar 19 doi: 10.1016/j.ajog.2022.07.001. PMID: 37164495
Katheria AC, Clark E, Yoder B, Schmölzer GM, Yan Law BH, El-Naggar W, Rittenberg D, Sheth S, Mohamed MA, Martin C, Vora F, Lakshminrusimha S, Underwood M, Mazela J, Kaempf J, Tomlinson M, Gollin Y, Fulford K, Goff Y, Wozniak P, Baker K, Rich W, Morales A, Varner M, Poeltler D, Vaucher Y, Mercer J, Finer N, El Ghormli L, Rice MM; of the Milking In Nonvigorous Infants group
Am J Obstet Gynecol 2023 Feb;228(2):217.e1-217.e14. Epub 2022 Aug 13 doi: 10.1016/j.ajog.2022.08.015. PMID: 35970202Free PMC Article
Wang L, Huang S, Li S, Li M, Shi J, Bai W, Wang Q, Zheng L, Liu Y
Drug Des Devel Ther 2019;13:4331-4340. Epub 2019 Dec 19 doi: 10.2147/DDDT.S225613. PMID: 31908418Free PMC Article
Kalafat E, Khalil A
Curr Opin Obstet Gynecol 2018 Dec;30(6):344-354. doi: 10.1097/GCO.0000000000000490. PMID: 30299319

Recent systematic reviews

Dolanc Merc M, Peterlin B, Lovrecic L
Prenat Diagn 2023 Aug;43(9):1220-1228. Epub 2023 May 11 doi: 10.1002/pd.6354. PMID: 37072878
Mirbeyk M, Saghazadeh A, Rezaei N
Arch Gynecol Obstet 2021 Jul;304(1):5-38. Epub 2021 Apr 2 doi: 10.1007/s00404-021-06049-z. PMID: 33797605Free PMC Article
Shan D, Liu X, Cai Y, Qiao X, Xu L, Zou L
Eur J Obstet Gynecol Reprod Biol 2020 Nov;254:25-32. Epub 2020 Sep 2 doi: 10.1016/j.ejogrb.2020.08.045. PMID: 32942074
Boie S, Glavind J, Velu AV, Mol BWJ, Uldbjerg N, de Graaf I, Thornton JG, Bor P, Bakker JJ
Cochrane Database Syst Rev 2018 Aug 20;8(8):CD012274. doi: 10.1002/14651858.CD012274.pub2. PMID: 30125998Free PMC Article
Jessop FA, Lees CC, Pathak S, Hook CE, Sebire NJ
Virchows Arch 2014 Jan;464(1):105-12. Epub 2013 Nov 21 doi: 10.1007/s00428-013-1513-2. PMID: 24259031

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