U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Crystal arthropathy

MedGen UID:
508879
•Concept ID:
C0152087
•
Disease or Syndrome
Synonyms: Arthritides, Crystal; Arthritides, Crystalline; Arthritis, Crystal; Arthritis, Crystalline; Arthropathies, Crystal; Arthropathies, Crystalline; Arthropathy, Crystal; Arthropathy, Crystalline; Crystal Arthritides; Crystal Arthritis; Crystal Arthropathies; Crystal Arthropathy; Crystalline Arthritides; Crystalline Arthritis; Crystalline Arthropathies; Crystalline Arthropathy
SNOMED CT: Crystal-related arthropathy and periarthropathy (18834007); Crystal arthropathy (18834007); Crystal-induced arthritis AND/OR synovitis (18834007); Crystalline arthritis (18834007)
 
Monarch Initiative: MONDO:0022208

Definition

Joint disorders that are characterized by accumulation of microcrystals in and around the joint including in the SYNOVIAL FLUID. They are classified according to the chemical nature of the crystals such as CALCIUM PYROPHOSPHATE; basic CALCIUM PHOSPHATES; and monosodium urate (see URIC ACID). [from MeSH]

Professional guidelines

PubMed

The Effect of Crystal Arthropathy on the Diagnostic Criteria of Native Septic Arthritis.
Pesante BD, Salimi M, Miller WL, Young HL, Jenkins TC, Parry JA
J Am Acad Orthop Surg 2024 Jun 15;32(12):570-575. Epub 2024 Apr 17 doi: 10.5435/JAAOS-D-23-00857. PMID: 38652879
Subgroups of patients with osteoarthritis and medial meniscus tear or crystal arthropathy benefit from arthroscopic treatment.
Karpinski K, Müller-Rath R, Niemeyer P, Angele P, Petersen W
Knee Surg Sports Traumatol Arthrosc 2019 Mar;27(3):782-796. Epub 2018 Aug 20 doi: 10.1007/s00167-018-5086-0. PMID: 30128683
Treatment of crystal arthropathy--history and advances.
Nuki G
Rheum Dis Clin North Am 2006 May;32(2):333-57, vi. doi: 10.1016/j.rdc.2006.03.003. PMID: 16716883

Recent clinical studies

Etiology

Gout and incidence of 12 cardiovascular diseases: a case-control study including 152 663 individuals with gout and 709 981 matched controls.
Ferguson LD, Molenberghs G, Verbeke G, Rahimi K, Rao S, McInnes IB, McMurray JJV, Sattar N, Conrad N
Lancet Rheumatol 2024 Mar;6(3):e156-e167. doi: 10.1016/S2665-9913(23)00338-7. PMID: 38383089
Imaging of Crystal Disorders:: Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Calcium Hydroxyapatite Crystal Deposition Disease and Gout Pathophysiology, Imaging, and Diagnosis.
Reijnierse M, Schwabl C, Klauser A
Radiol Clin North Am 2022 Jul;60(4):641-656. doi: 10.1016/j.rcl.2022.03.007. PMID: 35672096
Can drugs trigger CPPD acute attacks?
Huang YJ, Kuo CF
Joint Bone Spine 2019 Mar;86(2):131-134. Epub 2018 Jun 6 doi: 10.1016/j.jbspin.2018.05.010. PMID: 29885550
Epidemiology of calcium pyrophosphate crystal arthritis and basic calcium phosphate crystal arthropathy.
Abhishek A, Doherty M
Rheum Dis Clin North Am 2014 May;40(2):177-91. Epub 2014 Feb 20 doi: 10.1016/j.rdc.2014.01.002. PMID: 24703342
Approach to septic arthritis.
Horowitz DL, Katzap E, Horowitz S, Barilla-LaBarca ML
Am Fam Physician 2011 Sep 15;84(6):653-60. PMID: 21916390

Diagnosis

Axial crystal arthropathy mimicking facet joint septic arthritis with epidural abscess.
Poole H, Crowe A, Daffy J
Med J Aust 2023 Apr 17;218(7):301-303. Epub 2023 Mar 17 doi: 10.5694/mja2.51891. PMID: 36929477
Imaging of Crystal Disorders:: Calcium Pyrophosphate Dihydrate Crystal Deposition Disease, Calcium Hydroxyapatite Crystal Deposition Disease and Gout Pathophysiology, Imaging, and Diagnosis.
Reijnierse M, Schwabl C, Klauser A
Radiol Clin North Am 2022 Jul;60(4):641-656. doi: 10.1016/j.rcl.2022.03.007. PMID: 35672096
Imaging of gout: findings and pitfalls. A pictorial review.
Sudoł-Szopińska I, Afonso PD, Jacobson JA, Teh J
Acta Reumatol Port 2020 Jan-Mar;45(1):20-25. PMID: 32572014
Computed Tomography and MR Imaging in Crystalline-Induced Arthropathies.
Buckens CF, Terra MP, Maas M
Radiol Clin North Am 2017 Sep;55(5):1023-1034. Epub 2017 Jun 12 doi: 10.1016/j.rcl.2017.04.008. PMID: 28774446
Approach to septic arthritis.
Horowitz DL, Katzap E, Horowitz S, Barilla-LaBarca ML
Am Fam Physician 2011 Sep 15;84(6):653-60. PMID: 21916390

Therapy

Gout and incidence of 12 cardiovascular diseases: a case-control study including 152 663 individuals with gout and 709 981 matched controls.
Ferguson LD, Molenberghs G, Verbeke G, Rahimi K, Rao S, McInnes IB, McMurray JJV, Sattar N, Conrad N
Lancet Rheumatol 2024 Mar;6(3):e156-e167. doi: 10.1016/S2665-9913(23)00338-7. PMID: 38383089
Can drugs trigger CPPD acute attacks?
Huang YJ, Kuo CF
Joint Bone Spine 2019 Mar;86(2):131-134. Epub 2018 Jun 6 doi: 10.1016/j.jbspin.2018.05.010. PMID: 29885550
Digit-Threatening Severe Tophaceous Gout.
Kuiper B, Aronowitz P
J Gen Intern Med 2016 Jun;31(6):699. doi: 10.1007/s11606-015-3548-3. PMID: 26608304Free PMC Article
Approach to septic arthritis.
Horowitz DL, Katzap E, Horowitz S, Barilla-LaBarca ML
Am Fam Physician 2011 Sep 15;84(6):653-60. PMID: 21916390
Clinical trials in crystal arthropathy.
Joseph-Ridge N, Cazzetta S, MacDonald P
Rheum Dis Clin North Am 2006 May;32(2):359-82, vii. doi: 10.1016/j.rdc.2006.02.002. PMID: 16716884

Prognosis

Gout and incidence of 12 cardiovascular diseases: a case-control study including 152 663 individuals with gout and 709 981 matched controls.
Ferguson LD, Molenberghs G, Verbeke G, Rahimi K, Rao S, McInnes IB, McMurray JJV, Sattar N, Conrad N
Lancet Rheumatol 2024 Mar;6(3):e156-e167. doi: 10.1016/S2665-9913(23)00338-7. PMID: 38383089
Extra-pulmonary applications of procalcitonin: an updated literature review.
Atallah CJ, Panossian VS, Atallah NJ, Roberts MB, Mansour MK
Expert Rev Mol Diagn 2022 May;22(5):537-544. Epub 2022 Jul 13 doi: 10.1080/14737159.2022.2094705. PMID: 35757858
Prevalence and incidence of non-gout crystal arthropathy in southern Sweden.
Hameed M, Turkiewicz A, Englund M, Jacobsson L, Kapetanovic MC
Arthritis Res Ther 2019 Dec 17;21(1):291. doi: 10.1186/s13075-019-2077-6. PMID: 31847885Free PMC Article
Inflammatory arthritis and crystal arthropathy: Current concepts of skin and systemic manifestations.
Fazel M, Merola JF, Kurtzman DJB
Clin Dermatol 2018 Jul-Aug;36(4):533-550. Epub 2018 Apr 10 doi: 10.1016/j.clindermatol.2018.04.010. PMID: 30047436
Tophaceous gouty arthropathy of the lumbar spine.
Saripalli K, Baskar S
Clin Med (Lond) 2014 Dec;14(6):683-4. doi: 10.7861/clinmedicine.14-6-683. PMID: 25468860Free PMC Article

Clinical prediction guides

Gout and incidence of 12 cardiovascular diseases: a case-control study including 152 663 individuals with gout and 709 981 matched controls.
Ferguson LD, Molenberghs G, Verbeke G, Rahimi K, Rao S, McInnes IB, McMurray JJV, Sattar N, Conrad N
Lancet Rheumatol 2024 Mar;6(3):e156-e167. doi: 10.1016/S2665-9913(23)00338-7. PMID: 38383089
Acute Calcium Pyrophosphate Crystal Arthritis Flare Rate and Risk Factors for Recurrence.
Yates KA, Yoshida K, Xu C, Lyu H, Norvang V, Solomon DH, Tedeschi SK
J Rheumatol 2020 Aug 1;47(8):1261-1266. Epub 2019 Nov 1 doi: 10.3899/jrheum.190778. PMID: 31676701Free PMC Article
Subgroups of patients with osteoarthritis and medial meniscus tear or crystal arthropathy benefit from arthroscopic treatment.
Karpinski K, Müller-Rath R, Niemeyer P, Angele P, Petersen W
Knee Surg Sports Traumatol Arthrosc 2019 Mar;27(3):782-796. Epub 2018 Aug 20 doi: 10.1007/s00167-018-5086-0. PMID: 30128683
M1/M2 Macrophages in Diabetic Nephropathy: Nrf2/HO-1 as Therapeutic Targets.
Landis RC, Quimby KR, Greenidge AR
Curr Pharm Des 2018;24(20):2241-2249. doi: 10.2174/1381612824666180716163845. PMID: 30014796
Clinical trials in crystal arthropathy.
Joseph-Ridge N, Cazzetta S, MacDonald P
Rheum Dis Clin North Am 2006 May;32(2):359-82, vii. doi: 10.1016/j.rdc.2006.02.002. PMID: 16716884

Recent systematic reviews

The diagnostic value of conventional radiography and musculoskeletal ultrasonography in calcium pyrophosphate deposition disease: a systematic literature review and meta-analysis.
Cipolletta E, Filippou G, Scirè CA, Di Matteo A, Di Battista J, Salaffi F, Grassi W, Filippucci E
Osteoarthritis Cartilage 2021 May;29(5):619-632. Epub 2021 Feb 10 doi: 10.1016/j.joca.2021.01.007. PMID: 33577959
Subgroups of patients with osteoarthritis and medial meniscus tear or crystal arthropathy benefit from arthroscopic treatment.
Karpinski K, Müller-Rath R, Niemeyer P, Angele P, Petersen W
Knee Surg Sports Traumatol Arthrosc 2019 Mar;27(3):782-796. Epub 2018 Aug 20 doi: 10.1007/s00167-018-5086-0. PMID: 30128683

Supplemental Content

Table of contents

    Clinical resources

    Practice guidelines

    • PubMed
      See practice and clinical guidelines in PubMed. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.
    • Bookshelf
      See practice and clinical guidelines in NCBI Bookshelf. The search results may include broader topics and may not capture all published guidelines. See the FAQ for details.

    Reviews

    Related information

    • PMC Articles
      Related information in PubMed Central Links
    • PubMed
      Related literature resources in PubMed

    Recent activity

    Clear Turn Off Turn On

    Your browsing activity is empty.

    Activity recording is turned off.

    Turn recording back on

    See more...