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Detrusor sphincter dyssynergia

MedGen UID:
574618
•Concept ID:
C0341747
•
Disease or Syndrome
Synonyms: Detrusor and sphincter dyssynergia; detrusor sphincter dyssynergia; detrusor sphincter dyssynergia (disease); DSD - Detrusor and sphincter dyssynergia
SNOMED CT: Detrusor and sphincter dyssynergia (236655005); DSD - Detrusor and sphincter dyssynergia (236655005)
 
HPO: HP:0025488
Monarch Initiative: MONDO:0001447

Definition

A urodynamic anomaly characterized by bladder outlet obstruction from detrusor muscle contraction with concomitant involuntary urethral sphincter activation. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDetrusor sphincter dyssynergia

Professional guidelines

PubMed

The management of paediatric neurogenic bladder: an approach in a resource-poor setting.
Maison POM, Lazarus J
Paediatr Int Child Health 2017 Nov;37(4):280-285. Epub 2017 Jul 17 doi: 10.1080/20469047.2017.1351745. PMID: 28714784
Prevalence and treatment of LUTS in patients with Parkinson disease or multiple system atrophy.
Ogawa T, Sakakibara R, Kuno S, Ishizuka O, Kitta T, Yoshimura N
Nat Rev Urol 2017 Feb;14(2):79-89. Epub 2016 Dec 13 doi: 10.1038/nrurol.2016.254. PMID: 27958390
Evidence-based review and assessment of botulinum neurotoxin for the treatment of urologic conditions.
Chancellor MB, Elovic E, Esquenazi A, Naumann M, Segal KR, Schiavo G, Smith CP, Ward AB
Toxicon 2013 Jun 1;67:129-40. Epub 2013 Feb 13 doi: 10.1016/j.toxicon.2013.01.020. PMID: 23415704

Recent clinical studies

Etiology

Functional MRI in patients with detrusor sphincter dyssynergia: Is the neural circuit affected?
Seseke S, Leitsmann C, Hijazi S, Trojan L, Dechent P
Neurourol Urodyn 2019 Nov;38(8):2104-2111. Epub 2019 Aug 8 doi: 10.1002/nau.24112. PMID: 31396992
Epidemiology and pathophysiology of neurogenic bladder after spinal cord injury.
Hamid R, Averbeck MA, Chiang H, Garcia A, Al Mousa RT, Oh SJ, Patel A, Plata M, Del Popolo G
World J Urol 2018 Oct;36(10):1517-1527. Epub 2018 May 11 doi: 10.1007/s00345-018-2301-z. PMID: 29752515
Diagnosis and clinical evaluation of neurogenic bladder.
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
Voiding Dysfunction: What Can Radiologists Tell Patients and Pediatric Urologists?
Zderic SA, Weiss DA
AJR Am J Roentgenol 2015 Nov;205(5):W532-41. doi: 10.2214/AJR.14.14019. PMID: 26496575
Role of permanent stents.
Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859

Diagnosis

Diagnosis and clinical evaluation of neurogenic bladder.
Amarenco G, Sheikh Ismaël S, Chesnel C, Charlanes A, LE Breton F
Eur J Phys Rehabil Med 2017 Dec;53(6):975-980. Epub 2017 Oct 25 doi: 10.23736/S1973-9087.17.04992-9. PMID: 29072046
Voiding Dysfunction: What Can Radiologists Tell Patients and Pediatric Urologists?
Zderic SA, Weiss DA
AJR Am J Roentgenol 2015 Nov;205(5):W532-41. doi: 10.2214/AJR.14.14019. PMID: 26496575
Urodynamics: with a focus on appropriate indications.
Lenherr SM, Clemens JQ
Urol Clin North Am 2013 Nov;40(4):545-57. Epub 2013 Aug 8 doi: 10.1016/j.ucl.2013.07.001. PMID: 24182974
Diagnosing detrusor sphincter dyssynergia in the neurological patient.
Bacsu CD, Chan L, Tse V
BJU Int 2012 Apr;109 Suppl 3:31-4. doi: 10.1111/j.1464-410X.2012.11042.x. PMID: 22458490
Detrusor-sphincter dyssynergia.
Castro-Diaz D, Taracena Lafuente JM
Int J Clin Pract Suppl 2006 Dec;(151):17-21. doi: 10.1111/j.1742-1241.2006.01183.x. PMID: 17169006

Therapy

A Review of Botulinum Toxin A for the Treatment of Neurogenic Bladder.
Cooley LF, Kielb S
PM R 2019 Feb;11(2):192-200. Epub 2019 Feb 13 doi: 10.1016/j.pmrj.2018.07.016. PMID: 30138720
Urethral stents for detrusor sphincter dyssynergia.
Nambirajan T, Woolsey S, Mahendra V, Stone AR, Walsh IK
BJU Int 2005 Feb;95(3):350-3. doi: 10.1111/j.1464-410X.2005.05298.x. PMID: 15679792
Interventional neurophysiology of the sacral nervous system.
Vodusek DB
Neurophysiol Clin 2001 Aug;31(4):239-46. doi: 10.1016/s0987-7053(01)00264-7. PMID: 11596531
Role of permanent stents.
Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859
Detrusor-sphincter dyssynergia.
McGuire EJ, Brady S
J Urol 1979 Jun;121(6):774-7. doi: 10.1016/s0022-5347(17)56987-6. PMID: 458950

Prognosis

The management of paediatric neurogenic bladder: an approach in a resource-poor setting.
Maison POM, Lazarus J
Paediatr Int Child Health 2017 Nov;37(4):280-285. Epub 2017 Jul 17 doi: 10.1080/20469047.2017.1351745. PMID: 28714784
Lower urinary tract dysfunction in patients with multiple sclerosis.
Panicker JN, Fowler CJ
Handb Clin Neurol 2015;130:371-81. doi: 10.1016/B978-0-444-63247-0.00021-3. PMID: 26003255
Bladder-sphincter dysfunction in myelomeningocele.
van Gool JD, Dik P, de Jong TP
Eur J Pediatr 2001 Jul;160(7):414-20. doi: 10.1007/s004310100741. PMID: 11475578
Role of permanent stents.
Badlani GH
J Endourol 1997 Dec;11(6):473-5. doi: 10.1089/end.1997.11.473. PMID: 9440859
Transurethral sphincterotomy in quadriplegic patients: long-term-follow-up.
Noll F, Sauerwein D, Stöhrer M
Neurourol Urodyn 1995;14(4):351-8. doi: 10.1002/nau.1930140409. PMID: 7581471

Clinical prediction guides

Determination of tibial somatosensory evoked potentials predicts detrusor sphincter dyssynergia in children with neurogenic bladder dysfunction.
Erdogan ET, Ozel K, Matur Z, Alizada O, Canaz H, Alatas I
Neurourol Urodyn 2023 Jun;42(5):1132-1139. Epub 2023 Apr 26 doi: 10.1002/nau.25185. PMID: 37185999
The Relationship Between Urinary Symptom Severity And Functional Status İn Patients With Stroke.
Özcan F, Özişler Z
Scott Med J 2022 May;67(2):64-70. Epub 2022 Jan 5 doi: 10.1177/00369330211072247. PMID: 34985348
Sacral Anterior Root Stimulation and Visceral Function Outcomes in Spinal Cord Injury-A Systematic Review of the Literature Over Four Decades.
Guiho T, Azevedo-Coste C, Bauchet L, Delleci C, Vignes JR, Guiraud D, Fattal C
World Neurosurg 2022 Jan;157:218-232.e14. Epub 2021 Sep 20 doi: 10.1016/j.wneu.2021.09.041. PMID: 34547528
Detrusor sphincter dyssynergia: can a more specific definition distinguish between patients with and without an underlying neurological disorder?
Gross O, Leitner L, Rasenack M, Schubert M, Kessler TM
Spinal Cord 2021 Sep;59(9):1026-1033. Epub 2021 May 7 doi: 10.1038/s41393-021-00635-3. PMID: 33963273Free PMC Article
Evaluation of the urinary tract in children with myelomeningocele.
Petersen T, Jensen PB
Acta Neurol Scand 1987 Jan;75(1):46-51. doi: 10.1111/j.1600-0404.1987.tb07887.x. PMID: 3577667

Recent systematic reviews

Sacral Anterior Root Stimulation and Visceral Function Outcomes in Spinal Cord Injury-A Systematic Review of the Literature Over Four Decades.
Guiho T, Azevedo-Coste C, Bauchet L, Delleci C, Vignes JR, Guiraud D, Fattal C
World Neurosurg 2022 Jan;157:218-232.e14. Epub 2021 Sep 20 doi: 10.1016/j.wneu.2021.09.041. PMID: 34547528
Iatrogenic urological triggers of autonomic dysreflexia: a systematic review.
Liu N, Zhou M, Biering-Sørensen F, Krassioukov AV
Spinal Cord 2015 Jul;53(7):500-9. Epub 2015 Mar 24 doi: 10.1038/sc.2015.39. PMID: 25800696
An updated systematic review and statistical comparison of standardised mean outcomes for the use of botulinum toxin in the management of lower urinary tract disorders.
Mangera A, Apostolidis A, Andersson KE, Dasgupta P, Giannantoni A, Roehrborn C, Novara G, Chapple C
Eur Urol 2014 May;65(5):981-90. Epub 2013 Nov 1 doi: 10.1016/j.eururo.2013.10.033. PMID: 24239446
Contemporary management of lower urinary tract disease with botulinum toxin A: a systematic review of botox (onabotulinumtoxinA) and dysport (abobotulinumtoxinA).
Mangera A, Andersson KE, Apostolidis A, Chapple C, Dasgupta P, Giannantoni A, Gravas S, Madersbacher S
Eur Urol 2011 Oct;60(4):784-95. Epub 2011 Jul 13 doi: 10.1016/j.eururo.2011.07.001. PMID: 21782318
A review of non-invasive electro neuromodulation as an intervention for non-neurogenic bladder dysfunction in children.
Bower WF, Yeung CK
Neurourol Urodyn 2004;23(1):63-7. doi: 10.1002/nau.10171. PMID: 14694460

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