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Benign neoplasm of corpus uteri

MedGen UID:
57808
•Concept ID:
C0153998
•
Neoplastic Process
Synonyms: Benign Corpus Uteri Neoplasm; benign corpus uteri neoplasm; Benign Corpus Uteri Tumor; benign corpus uteri tumor; benign corpus uteri tumour; Benign neoplasm of body of uterus; Benign Neoplasm of Body of Uterus; benign neoplasm of body of uterus; Benign Neoplasm of Corpus Uteri; benign neoplasm of corpus uteri; Benign Neoplasm of the Body of Uterus; benign neoplasm of the body of uterus; Benign Neoplasm of the Corpus Uteri; benign neoplasm of the corpus uteri; Benign Neoplasm of the Uterine Body; benign neoplasm of the uterine body; Benign Neoplasm of the Uterine Corpus; benign neoplasm of the uterine corpus; Benign Neoplasm of Uterine Body; benign neoplasm of uterine body; Benign Neoplasm of Uterine Corpus; benign neoplasm of uterine corpus; Benign Tumor of Body of Uterus; benign tumor of body of uterus; Benign Tumor of Corpus Uteri; benign tumor of corpus uteri; Benign Tumor of the Body of Uterus; benign tumor of the body of uterus; Benign Tumor of the Corpus Uteri; benign tumor of the corpus uteri; Benign Tumor of the Uterine Body; benign tumor of the uterine body; Benign Tumor of the Uterine Corpus; benign tumor of the uterine corpus; Benign Tumor of Uterine Body; benign tumor of uterine body; Benign Tumor of Uterine Corpus; benign tumor of uterine corpus; benign tumour of body of uterus; benign tumour of corpus uteri; benign tumour of the body of uterus; benign tumour of the corpus uteri; benign tumour of the uterine body; benign tumour of the uterine corpus; benign tumour of uterine body; benign tumour of uterine corpus; Benign Uterine Body Neoplasm; benign uterine body neoplasm; Benign Uterine Body Tumor; benign uterine body tumor; benign uterine body tumour; Benign Uterine Corpus Neoplasm; benign uterine corpus neoplasm; Benign Uterine Corpus Tumor; benign uterine corpus tumor; benign uterine corpus tumour; body of uterus benign neoplasm
SNOMED CT: Benign neoplasm of body of uterus (92021007); Benign neoplasm of corpus uteri (92021007)
 
Monarch Initiative: MONDO:0021525

Definition

A neoplasm that arises from the uterine corpus and is characterized by the absence of atypical or malignant cytological and architectural features, and absence of invasive features or metastatic potential. Representative examples include leiomyoma, adenomyoma, endometrial stromal nodule, and endometrial polyp. [from NCI]

Professional guidelines

PubMed

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
FIGO staging for carcinoma of the vulva, cervix, and corpus uteri.
FIGO Committee on Gynecologic Oncology
Int J Gynaecol Obstet 2014 May;125(2):97-8. Epub 2014 Feb 22 doi: 10.1016/j.ijgo.2014.02.003. PMID: 24630859
Selection of treatment for corpus cancer.
GUSBERG SB, JONES HC Jr, TOVELL HM
Am J Obstet Gynecol 1960 Aug;80:374-80. doi: 10.1016/0002-9378(60)90141-1. PMID: 13709911

Recent clinical studies

Etiology

Role of radiotherapy in the management of rare gynaecological cancers.
Morcet-Delattre R, Espenel S, Tas P, Chargari C, Escande A
Cancer Radiother 2023 Dec;27(8):778-788. Epub 2023 Nov 2 doi: 10.1016/j.canrad.2023.08.006. PMID: 37925347
Cancer of the corpus uteri: 2021 update.
Koskas M, Amant F, Mirza MR, Creutzberg CL
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):45-60. doi: 10.1002/ijgo.13866. PMID: 34669196Free PMC Article
Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article

Diagnosis

Corded and Hyalinized Endometrioid Adenocarcinoma (CHEC) of the Uterine Corpus are Characterized by CTNNB1 Mutations and Can Show Adverse Clinical Outcomes.
Ladwig NR, Umetsu SE, Zaloudek C, Rabban J, Garg K
Int J Gynecol Pathol 2021 Mar 1;40(2):103-115. doi: 10.1097/PGP.0000000000000671. PMID: 32909971
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article
Cancer of the corpus uteri.
Amant F, Mirza MR, Koskas M, Creutzberg CL
Int J Gynaecol Obstet 2015 Oct;131 Suppl 2:S96-104. doi: 10.1016/j.ijgo.2015.06.005. PMID: 26433681
Cancer of the corpus uteri.
Amant F, Mirza MR, Creutzberg CL
Int J Gynaecol Obstet 2012 Oct;119 Suppl 2:S110-7. doi: 10.1016/S0020-7292(12)60024-1. PMID: 22999502
Pathology of the uterine corpus.
Clement PB
Hum Pathol 1991 Aug;22(8):776-91. doi: 10.1016/0046-8177(91)90207-6. PMID: 1651282

Therapy

Mitochondrial DNA copy number and cancer risks: A comprehensive Mendelian randomization analysis.
Cai X, Liang C, Zhang M, Dong Z, Weng Y, Yu W
Int J Cancer 2024 Apr 15;154(8):1504-1513. Epub 2023 Dec 27 doi: 10.1002/ijc.34833. PMID: 38151753
Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
CT and MRI of early intrauterine pregnancy.
Shin DS, Poder L, Courtier J, Naeger DM, Westphalen AC, Coakley FV
AJR Am J Roentgenol 2011 Feb;196(2):325-30. doi: 10.2214/AJR.09.3723. PMID: 21257883
Carcinoma of the corpus uteri.
Creasman WT, Odicino F, Maisonneuve P, Beller U, Benedet JL, Heintz AP, Ngan HY, Sideri M, Pecorelli S
J Epidemiol Biostat 2001;6(1):47-86. PMID: 11385776
Luteal phase insufficiency.
Jones GS
Clin Obstet Gynecol 1973 Sep;16(3):255-73. doi: 10.1097/00003081-197309000-00016. PMID: 4590322

Prognosis

Cancer of the corpus uteri: 2021 update.
Koskas M, Amant F, Mirza MR, Creutzberg CL
Int J Gynaecol Obstet 2021 Oct;155 Suppl 1(Suppl 1):45-60. doi: 10.1002/ijgo.13866. PMID: 34669196Free PMC Article
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article
Cancer of the corpus uteri.
Amant F, Mirza MR, Creutzberg CL
Int J Gynaecol Obstet 2012 Oct;119 Suppl 2:S110-7. doi: 10.1016/S0020-7292(12)60024-1. PMID: 22999502
Carcinoma of the corpus uteri.
Creasman WT, Odicino F, Maisonneuve P, Beller U, Benedet JL, Heintz AP, Ngan HY, Pecorelli S
Int J Gynaecol Obstet 2003 Oct;83 Suppl 1:79-118. doi: 10.1016/s0020-7292(03)90116-0. PMID: 14763170

Clinical prediction guides

Mitochondrial DNA copy number and cancer risks: A comprehensive Mendelian randomization analysis.
Cai X, Liang C, Zhang M, Dong Z, Weng Y, Yu W
Int J Cancer 2024 Apr 15;154(8):1504-1513. Epub 2023 Dec 27 doi: 10.1002/ijc.34833. PMID: 38151753
Risk Factors for Local Failure Following Chemoradiation and Magnetic Resonance Image-Guided Brachytherapy in Locally Advanced Cervical Cancer: Results From the EMBRACE-I Study.
Schmid MP, Lindegaard JC, Mahantshetty U, Tanderup K, Jürgenliemk-Schulz I, Haie-Meder C, Fokdal LU, Sturdza A, Hoskin P, Segedin B, Bruheim K, Huang F, Rai B, Cooper R, van der Steen-Banasik E, Van Limbergen E, Pieters BR, Petric P, Ramazanova D, Ristl R, Kannan S, Hawaldar R, Ecker S, Kirchheiner K, Tan LT, Nout R, Nesvacil N, de Leeuw A, Pötter R, Kirisits C; EMBRACE Collaborative Group
J Clin Oncol 2023 Apr 1;41(10):1933-1942. Epub 2023 Jan 4 doi: 10.1200/JCO.22.01096. PMID: 36599120
Dedifferentiated Mesonephric-like Adenocarcinoma of the Uterine Corpus.
Choi S, Na K, Kim SW, Kim HS
Anticancer Res 2021 May;41(5):2719-2726. doi: 10.21873/anticanres.15053. PMID: 33952503
Uterine PEComas: A Morphologic, Immunohistochemical, and Molecular Analysis of 32 Tumors.
Bennett JA, Braga AC, Pinto A, Van de Vijver K, Cornejo K, Pesci A, Zhang L, Morales-Oyarvide V, Kiyokawa T, Zannoni GF, Carlson J, Slavik T, Tornos C, Antonescu CR, Oliva E
Am J Surg Pathol 2018 Oct;42(10):1370-1383. doi: 10.1097/PAS.0000000000001119. PMID: 30001237Free PMC Article
Familial Risk and Heritability of Cancer Among Twins in Nordic Countries.
Mucci LA, Hjelmborg JB, Harris JR, Czene K, Havelick DJ, Scheike T, Graff RE, Holst K, Möller S, Unger RH, McIntosh C, Nuttall E, Brandt I, Penney KL, Hartman M, Kraft P, Parmigiani G, Christensen K, Koskenvuo M, Holm NV, Heikkilä K, Pukkala E, Skytthe A, Adami HO, Kaprio J; Nordic Twin Study of Cancer (NorTwinCan) Collaboration
JAMA 2016 Jan 5;315(1):68-76. doi: 10.1001/jama.2015.17703. PMID: 26746459Free PMC Article

Recent systematic reviews

Risks of second non-breast primaries following breast cancer in women: a systematic review and meta-analysis.
Allen I, Hassan H, Sofianopoulou E, Eccles D, Turnbull C, Tischkowitz M, Pharoah P, Antoniou AC
Breast Cancer Res 2023 Feb 10;25(1):18. doi: 10.1186/s13058-023-01610-x. PMID: 36765408Free PMC Article
Impact of maternal reproductive factors on cancer risks of offspring: A systematic review and meta-analysis of cohort studies.
Han MA, Storman D, Al-Rammahy H, Tang S, Hao Q, Leung G, Kandi M, Moradi R, Bartoszko JJ, Arnold C, Rehman N, Guyatt G
PLoS One 2020;15(3):e0230721. Epub 2020 Mar 30 doi: 10.1371/journal.pone.0230721. PMID: 32226046Free PMC Article
Mistletoe in oncological treatment: a systematic review : Part 1: survival and safety.
Freuding M, Keinki C, Micke O, Buentzel J, Huebner J
J Cancer Res Clin Oncol 2019 Mar;145(3):695-707. Epub 2019 Jan 23 doi: 10.1007/s00432-018-02837-4. PMID: 30673873
Mistletoe in oncological treatment: a systematic review : Part 2: quality of life and toxicity of cancer treatment.
Freuding M, Keinki C, Kutschan S, Micke O, Buentzel J, Huebner J
J Cancer Res Clin Oncol 2019 Apr;145(4):927-939. Epub 2019 Jan 23 doi: 10.1007/s00432-018-02838-3. PMID: 30673872
Is periodontitis a risk indicator for cancer? A meta-analysis.
Corbella S, Veronesi P, Galimberti V, Weinstein R, Del Fabbro M, Francetti L
PLoS One 2018;13(4):e0195683. Epub 2018 Apr 17 doi: 10.1371/journal.pone.0195683. PMID: 29664916Free PMC Article

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