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Melanotic neuroectodermal tumor

MedGen UID:
60073
•Concept ID:
C0206094
•
Neoplastic Process
Synonyms: Anlage Tumor, Retinal; Anlage Tumors, Retinal; Melanoameloblastoma; Melanoameloblastomas; Melanotic Neuroectodermal Tumor; Melanotic Neuroectodermal Tumors; Melanotic Progonoma; Melanotic Progonomas; Neuroectodermal Tumor, Melanotic; Neuroectodermal Tumors, Melanotic; Progonoma, Melanotic; Progonomas, Melanotic; Retinal Anlage Tumor; Retinal Anlage Tumors; Tumor, Melanotic Neuroectodermal; Tumor, Retinal Anlage; Tumors, Melanotic Neuroectodermal; Tumors, Retinal Anlage
SNOMED CT: Pigmented neuroectodermal tumor of infancy (404042005); Retinal anlage tumor (404042005); Melanotic progonoma (404042005); Melanotic neuroectodermal tumor (1513001); Retinal anlage tumor (1513001); Melanoameloblastoma (1513001); Melanotic progonoma (1513001); Melanotic neuroectodermal tumor of infancy (767047005); MNTI - melanotic neuroectodermal tumor of infancy (767047005)
 
Monarch Initiative: MONDO:0002072

Definition

A rare neoplasm usually occurring in infants. It is characterized by the presence of a mixture of melanin-containing epithelial cells and smaller neuroblast-like cells. It may involve the skull and facial bones, or the epididymis. It usually has a benign clinical course. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVMelanotic neuroectodermal tumor

Professional guidelines

PubMed

Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment.
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2019 Jan;48(1):1-8. Epub 2018 Aug 28 doi: 10.1016/j.ijom.2018.08.006. PMID: 30170777

Recent clinical studies

Etiology

Pineal anlage tumor: A case report and clinico-pathological review.
Uppal DK, Madan R, Chatterjee D, Mohindra S, Bhatia V, Goyal S
Clin Neurol Neurosurg 2021 Jul;206:106629. Epub 2021 May 5 doi: 10.1016/j.clineuro.2021.106629. PMID: 34030077
Obturator Prostheses for Melanotic Neuroectodermal Tumor of Infancy in the Maxilla.
Brandão TB, Vechiato-Filho AJ, Silva AR
J Craniofac Surg 2016 Jan;27(1):e64-5. doi: 10.1097/SCS.0000000000002228. PMID: 26703043
Melanotic neuroectodermal tumor of infancy of the maxilla: a case report with review of literature.
Rustagi A, Roychoudhury A, Karak AK
J Oral Maxillofac Surg 2011 Apr;69(4):1120-4. doi: 10.1016/j.joms.2010.01.017. PMID: 20619949
Melanotic neuroectodermal tumor of infancy: review of literature and case report.
Selim H, Shaheen S, Barakat K, Selim AA
J Pediatr Surg 2008 Jun;43(6):E25-9. doi: 10.1016/j.jpedsurg.2008.02.068. PMID: 18558161
Melanotic neuroectodermal tumor of the skull and meninges in infancy.
Pierre-Kahn A, Cinalli G, Lellouch-Tubiana A, Villarejo FJ, Sainte-Rose C, Pfister A, Couly G
Pediatr Neurosurg 1992;18(1):6-15. doi: 10.1159/000120636. PMID: 1329922

Diagnosis

Odontogenic and Developmental Oral Lesions in Pediatric Patients.
Bilodeau EA, Hunter KD
Head Neck Pathol 2021 Mar;15(1):71-84. Epub 2021 Mar 15 doi: 10.1007/s12105-020-01284-3. PMID: 33723756Free PMC Article
Pigmented Lesions.
Ko E, Panchal N
Dermatol Clin 2020 Oct;38(4):485-494. doi: 10.1016/j.det.2020.05.009. PMID: 32892857
Melanotic Neuroectodermal Tumor of Infancy.
Soles BS, Wilson A, Lucas DR, Heider A
Arch Pathol Lab Med 2018 Nov;142(11):1358-1363. doi: 10.5858/arpa.2018-0241-RA. PMID: 30407852
GI tract tumors with melanocytic differentiation.
Karamchandani DM, Patil DT, Goldblum JR
Adv Anat Pathol 2013 Nov;20(6):398-406. doi: 10.1097/PAP.0b013e3182a92e42. PMID: 24113310
Melanotic neuroectodermal tumor of infancy of the maxilla: a case report with review of literature.
Rustagi A, Roychoudhury A, Karak AK
J Oral Maxillofac Surg 2011 Apr;69(4):1120-4. doi: 10.1016/j.joms.2010.01.017. PMID: 20619949

Therapy

Pigmented Lesions.
Ko E, Panchal N
Dermatol Clin 2020 Oct;38(4):485-494. doi: 10.1016/j.det.2020.05.009. PMID: 32892857
Spontaneous Regression of Diffuse Periosteal Melanotic Neuroectodermal Tumor of Infancy in the Tibia, With 13-Year Follow-up.
Lei L, Ellsworth BD, Young LW, Kheradpour A, Zuppan CW
J Pediatr Hematol Oncol 2019 Mar;41(2):148-151. doi: 10.1097/MPH.0000000000001130. PMID: 29621061
Melanotic neuroectodermal tumour of infancy: surgical and chemotherapeutic management.
Murphy C, Pears J, Kearns GJ
Ir J Med Sci 2016 Aug;185(3):753-756. Epub 2015 Jun 28 doi: 10.1007/s11845-015-1323-4. PMID: 26123944
Melanotic neuroectodermal tumor of infancy disseminated by a ventriculoperitoneal shunt and diagnosed from the inguinal sac.
Yoo IH, Yum SK, Oh SJ, Kim KM, Jeong DC
J Pediatr Hematol Oncol 2014 Jan;36(1):e61-4. doi: 10.1097/MPH.0b013e31829dd114. PMID: 23823108
Central nervous system melanotic neuroectodermal tumor of infancy: value of chemotherapy in management.
Cohen BH, Handler MS, De Vivo DC, Garvin JH Jr, Hays AP, Carmel P
Neurology 1988 Jan;38(1):163-4. doi: 10.1212/wnl.38.1.163-a. PMID: 2827053

Prognosis

Pineal anlage tumor: A case report and clinico-pathological review.
Uppal DK, Madan R, Chatterjee D, Mohindra S, Bhatia V, Goyal S
Clin Neurol Neurosurg 2021 Jul;206:106629. Epub 2021 May 5 doi: 10.1016/j.clineuro.2021.106629. PMID: 34030077
Odontogenic and Developmental Oral Lesions in Pediatric Patients.
Bilodeau EA, Hunter KD
Head Neck Pathol 2021 Mar;15(1):71-84. Epub 2021 Mar 15 doi: 10.1007/s12105-020-01284-3. PMID: 33723756Free PMC Article
Pitfalls and uncertain prognosis in pathological diagnosis of psammomatous melanotic schwannoma.
Ng J, Munoz DG
J Clin Neurosci 2016 Nov;33:236-239. Epub 2016 Jul 25 doi: 10.1016/j.jocn.2016.05.020. PMID: 27460453
GI tract tumors with melanocytic differentiation.
Karamchandani DM, Patil DT, Goldblum JR
Adv Anat Pathol 2013 Nov;20(6):398-406. doi: 10.1097/PAP.0b013e3182a92e42. PMID: 24113310
Melanotic neuroectodermal tumor of infancy of the maxilla: a case report with review of literature.
Rustagi A, Roychoudhury A, Karak AK
J Oral Maxillofac Surg 2011 Apr;69(4):1120-4. doi: 10.1016/j.joms.2010.01.017. PMID: 20619949

Clinical prediction guides

Melanotic Neuroectodermal Tumor of Infancy at Skull: Rare and Rapid-Growing Tumor but Histologically Benign.
Yindeedej V, Kittisangvara L
Pediatr Neurosurg 2021;56(3):306-311. Epub 2021 Apr 16 doi: 10.1159/000515686. PMID: 33866319
Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment.
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2019 Jan;48(1):1-8. Epub 2018 Aug 28 doi: 10.1016/j.ijom.2018.08.006. PMID: 30170777
Melanotic neuroectodermal tumor of infancy: clinical, radiological, and pathological features.
Fowler DJ, Chisholm J, Roebuck D, Newman L, Malone M, Sebire NJ
Fetal Pediatr Pathol 2006 Mar-Apr;25(2):59-72. doi: 10.1080/15513810600788715. PMID: 16908456
A clinicopathologic and immunohistochemical analysis of melanotic neuroectodermal tumor of infancy.
Barrett AW, Morgan M, Ramsay AD, Farthing PM, Newman L, Speight PM
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2002 Jun;93(6):688-98. doi: 10.1067/moe.2002.124000. PMID: 12142876
Malignant melanotic neuroectodermal tumor of infancy: a clinical, pathologic, ultrastructural and tissue culture study.
Dehner LP, Sibley RK, Sauk JJ Jr, Vickers RA, Nesbit ME, Leonard AS, Waite DE, Neeley JE, Ophoven J
Cancer 1979 Apr;43(4):1389-410. doi: 10.1002/1097-0142(197904)43:4<1389::aid-cncr2820430429>3.0.co;2-v. PMID: 221089

Recent systematic reviews

Computed tomographic imaging features of maxillary and mandibular melanotic neuroectodermal tumor of infancy: Report of 2 cases and systematic review.
Vasilyeva D, Philipone E, Perschbacher SE, Chan KC
Oral Surg Oral Med Oral Pathol Oral Radiol 2022 Oct;134(4):470-483. Epub 2022 May 13 doi: 10.1016/j.oooo.2022.04.053. PMID: 35970752
Melanotic Neuroectodermal Tumor of Infancy Arising in the Skull and Brain: A Systematic Review.
Ren Q, Chen H, Wang Y, Xu J
World Neurosurg 2019 Oct;130:170-178. Epub 2019 Jul 8 doi: 10.1016/j.wneu.2019.07.017. PMID: 31295620
Melanotic neuroectodermal tumour of infancy of the jaws: an analysis of diagnostic features and treatment.
Chrcanovic BR, Gomez RS
Int J Oral Maxillofac Surg 2019 Jan;48(1):1-8. Epub 2018 Aug 28 doi: 10.1016/j.ijom.2018.08.006. PMID: 30170777
Melanotic Neuroectodermal Tumor of Infancy: A Systematic Review.
Rachidi S, Sood AJ, Patel KG, Nguyen SA, Hamilton H, Neville BW, Day TA
J Oral Maxillofac Surg 2015 Oct;73(10):1946-56. Epub 2015 Apr 7 doi: 10.1016/j.joms.2015.03.061. PMID: 25936939
Melanotic neuroectodermal tumor of infancy: systematic review of the literature and presentation of a case.
Kruse-Lösler B, Gaertner C, Bürger H, Seper L, Joos U, Kleinheinz J
Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2006 Aug;102(2):204-16. Epub 2006 Jun 8 doi: 10.1016/j.tripleo.2005.08.010. PMID: 16876064

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