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Clear cell adenocarcinoma

MedGen UID:
64629
•Concept ID:
C0206681
•
Neoplastic Process
Synonyms: Adenocarcinoma, Clear Cell; Adenocarcinomas, Clear Cell; Clear Cell Adenocarcinoma; Clear Cell Adenocarcinomas
SNOMED CT: Mesonephroid clear cell adenocarcinoma (30546008); Clear cell adenocarcinoma (30546008); Clear cell carcinoma (30546008)
 
Monarch Initiative: MONDO:0005004

Definition

A malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid. [from NCI]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVClear cell adenocarcinoma

Professional guidelines

PubMed

Management and clinical outcomes of patients with recurrent/progressive ovarian clear cell carcinoma.
Huang HJ, Yang LY, Tung HJ, Ku FC, Wu RC, Tang YH, Chang WY, Jung SM, Wang CC, Lin CT, Liu FY, Lin G, Chen MY, Chou HH, Chang TC, Chao A, Lai CH
J Formos Med Assoc 2020 Apr;119(4):793-804. Epub 2019 Dec 6 doi: 10.1016/j.jfma.2019.11.018. PMID: 31818713
Management of adenosis and clear-cell adenocarcinoma of vagina and cervix.
Morrow CP, Townsend DE
J Reprod Med 1975 Jul;15(1):25-8. PMID: 1151940
Vaginal adenosis, dysplasia, and clear cell adenocarcinoma after diethylstilbestrol treatment in pregnancy.
Barber HR, Sommers SC
Obstet Gynecol 1974 May;43(5):645-52. PMID: 4822648

Recent clinical studies

Etiology

Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Endometriosis-associated Ovarian Cancers.
Anglesio MS, Yong PJ
Clin Obstet Gynecol 2017 Dec;60(4):711-727. doi: 10.1097/GRF.0000000000000320. PMID: 28990985
Hyalinizing clear cell carcinoma of the head and neck: Case series and update.
Albergotti WG, Bilodeau EA, Byrd JK, Mims MM, Lee S, Kim S
Head Neck 2016 Mar;38(3):426-33. Epub 2015 Jun 18 doi: 10.1002/hed.23902. PMID: 25352039
Endometrial carcinoma tumorigenesis and pharmacotherapy research.
Shu J, Fang S, Teichman PG, Xing L, Huang H
Minerva Endocrinol 2012 Jun;37(2):117-32. PMID: 22691886
Clinical implications of DES.
Kruse K, Lauver D, Hanson K
Nurse Pract 2003 Jul;28(7 Pt 1):26-32,35, table of contents; quiz 35-7. doi: 10.1097/00006205-200307000-00005. PMID: 12861092

Diagnosis

Prognostic and Theranostic Biomarkers in Ovarian Clear Cell Carcinoma.
Wiedemeyer K, Wang L, Kang EY, Liu S, Ou Y, Kelemen LE, Feil L, Anglesio MS, Glaze S, Ghatage P, Nelson GS, Köbel M
Int J Gynecol Pathol 2022 Mar 1;41(2):168-179. doi: 10.1097/PGP.0000000000000780. PMID: 33770057
Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Gastrointestinal malignancy in cystic fibrosis.
Hough NE, Chapman SJ, Flight WG
Paediatr Respir Rev 2020 Sep;35:90-92. Epub 2020 Apr 9 doi: 10.1016/j.prrv.2020.03.002. PMID: 32505496
Translational genomics of ovarian clear cell carcinoma.
Khalique S, Lord CJ, Banerjee S, Natrajan R
Semin Cancer Biol 2020 Apr;61:121-131. Epub 2019 Nov 4 doi: 10.1016/j.semcancer.2019.10.025. PMID: 31698086
Clinical implications of DES.
Kruse K, Lauver D, Hanson K
Nurse Pract 2003 Jul;28(7 Pt 1):26-32,35, table of contents; quiz 35-7. doi: 10.1097/00006205-200307000-00005. PMID: 12861092

Therapy

New therapies for clear cell ovarian carcinoma.
Stewart J, Cunningham N, Banerjee S
Int J Gynecol Cancer 2023 Mar 6;33(3):385-393. doi: 10.1136/ijgc-2022-003704. PMID: 36878571
Clear cell carcinoma of the ovary: Epidemiology, pathological and biological features, treatment options and clinical outcomes.
Gadducci A, Multinu F, Cosio S, Carinelli S, Ghioni M, Aletti GD
Gynecol Oncol 2021 Sep;162(3):741-750. Epub 2021 Jul 8 doi: 10.1016/j.ygyno.2021.06.033. PMID: 34247767
Gastrointestinal malignancy in cystic fibrosis.
Hough NE, Chapman SJ, Flight WG
Paediatr Respir Rev 2020 Sep;35:90-92. Epub 2020 Apr 9 doi: 10.1016/j.prrv.2020.03.002. PMID: 32505496
Clear Cell Conundrum.
Schroeder SR, Albuquerque K
Int J Radiat Oncol Biol Phys 2019 Nov 15;105(4):690-691. doi: 10.1016/j.ijrobp.2018.02.167. PMID: 31655652
Clinical implications of DES.
Kruse K, Lauver D, Hanson K
Nurse Pract 2003 Jul;28(7 Pt 1):26-32,35, table of contents; quiz 35-7. doi: 10.1097/00006205-200307000-00005. PMID: 12861092

Prognosis

Gastrointestinal malignancy in cystic fibrosis.
Hough NE, Chapman SJ, Flight WG
Paediatr Respir Rev 2020 Sep;35:90-92. Epub 2020 Apr 9 doi: 10.1016/j.prrv.2020.03.002. PMID: 32505496
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Invasive Epithelial Ovarian Cancer Survival by Histotype and Disease Stage.
Peres LC, Cushing-Haugen KL, Köbel M, Harris HR, Berchuck A, Rossing MA, Schildkraut JM, Doherty JA
J Natl Cancer Inst 2019 Jan 1;111(1):60-68. doi: 10.1093/jnci/djy071. PMID: 29718305Free PMC Article
Safety and Antitumor Activity of Anti-PD-1 Antibody, Nivolumab, in Patients With Platinum-Resistant Ovarian Cancer.
Hamanishi J, Mandai M, Ikeda T, Minami M, Kawaguchi A, Murayama T, Kanai M, Mori Y, Matsumoto S, Chikuma S, Matsumura N, Abiko K, Baba T, Yamaguchi K, Ueda A, Hosoe Y, Morita S, Yokode M, Shimizu A, Honjo T, Konishi I
J Clin Oncol 2015 Dec 1;33(34):4015-22. Epub 2015 Sep 8 doi: 10.1200/JCO.2015.62.3397. PMID: 26351349
Photo capsules.
Dlova NC
Skinmed 2006 May-Jun;5(3):147. doi: 10.1111/j.1540-9740.2006.05428.x. PMID: 16687986

Clinical prediction guides

New therapies for clear cell ovarian carcinoma.
Stewart J, Cunningham N, Banerjee S
Int J Gynecol Cancer 2023 Mar 6;33(3):385-393. doi: 10.1136/ijgc-2022-003704. PMID: 36878571
Prognostic and Theranostic Biomarkers in Ovarian Clear Cell Carcinoma.
Wiedemeyer K, Wang L, Kang EY, Liu S, Ou Y, Kelemen LE, Feil L, Anglesio MS, Glaze S, Ghatage P, Nelson GS, Köbel M
Int J Gynecol Pathol 2022 Mar 1;41(2):168-179. doi: 10.1097/PGP.0000000000000780. PMID: 33770057
TIP-B1 promotes kidney clear cell carcinoma growth and metastasis via EGFR/AKT signaling.
Yin L, Gao S, Shi H, Wang K, Yang H, Peng B
Aging (Albany NY) 2019 Sep 27;11(18):7914-7937. doi: 10.18632/aging.102298. PMID: 31562290Free PMC Article
Antitumor activity and safety of pembrolizumab in patients with advanced recurrent ovarian cancer: results from the phase II KEYNOTE-100 study.
Matulonis UA, Shapira-Frommer R, Santin AD, Lisyanskaya AS, Pignata S, Vergote I, Raspagliesi F, Sonke GS, Birrer M, Provencher DM, Sehouli J, Colombo N, González-Martín A, Oaknin A, Ottevanger PB, Rudaitis V, Katchar K, Wu H, Keefe S, Ruman J, Ledermann JA
Ann Oncol 2019 Jul 1;30(7):1080-1087. doi: 10.1093/annonc/mdz135. PMID: 31046082
Endometriosis-associated ovarian neoplasia.
Matias-Guiu X, Stewart CJR
Pathology 2018 Feb;50(2):190-204. Epub 2017 Dec 11 doi: 10.1016/j.pathol.2017.10.006. PMID: 29241974

Recent systematic reviews

Clear cell carcinoma of the ovary and venous thromboembolism: a systematic review and meta-analysis.
Didar H, Farzaneh F, Najafiarab H, Namakin K, Gohari K, Sheidaei A, Ramezani S
Curr Med Res Opin 2023 Jun;39(6):901-910. Epub 2023 May 7 doi: 10.1080/03007995.2023.2208488. PMID: 37104696
Uterine carcinosarcoma vs endometrial serous and clear cell carcinoma: A systematic review and meta-analysis of survival.
Raffone A, Travaglino A, Raimondo D, Maletta M, De Vivo V, Visiello U, Casadio P, Seracchioli R, Zullo F, Insabato L, Mollo A
Int J Gynaecol Obstet 2022 Sep;158(3):520-527. Epub 2021 Dec 11 doi: 10.1002/ijgo.14033. PMID: 34797919Free PMC Article
Clear cell endometrial carcinomas with mismatch repair deficiency have a favorable prognosis: A systematic review and meta-analysis.
Travaglino A, Raffone A, Santoro A, Raimondo D, Angelico G, Valente M, Arciuolo D, Scaglione G, D'alessandris N, Casadio P, Inzani F, Mollo A, Seracchioli R, Zannoni GF
Gynecol Oncol 2021 Sep;162(3):804-808. Epub 2021 Jul 12 doi: 10.1016/j.ygyno.2021.07.007. PMID: 34266691
Clear cell carcinoma of the urinary bladder: a systematic review.
Chan EO, Chan VW, Poon JY, Chan BH, Yu CP, Chiu PK, Ng CF, Teoh JY
Int Urol Nephrol 2021 May;53(5):815-824. Epub 2021 Jan 18 doi: 10.1007/s11255-020-02725-2. PMID: 33462714
Systemic therapy for non-clear cell renal cell carcinomas: a systematic review and meta-analysis.
Vera-Badillo FE, Templeton AJ, Duran I, Ocana A, de Gouveia P, Aneja P, Knox JJ, Tannock IF, Escudier B, Amir E
Eur Urol 2015 Apr;67(4):740-9. Epub 2014 Jun 2 doi: 10.1016/j.eururo.2014.05.010. PMID: 24882670

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