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Testicular embryonal carcinoma

MedGen UID:
66771
Concept ID:
C0238448
Neoplastic Process
Synonyms: Embryonal Carcinoma of Testis; embryonal carcinoma of testis; Embryonal Carcinoma of the Testis; embryonal carcinoma of the testis; embryonal testis carcinoma; Testicular Embryonal Carcinoma; testicular embryonal carcinoma; testis embryonal carcinoma
 
Monarch Initiative: MONDO:0006446

Definition

A malignant germ cell neoplasm arising from the testis. It is composed of primitive epithelial cells arranged in solid, papillary, and glandular configurations. Most patients present with a testicular mass, which may be associated with pain. More than half of the patients have metastatic disease at diagnosis. The form of treatment following radical orchiectomy is stage dependent. [from NCI]

Professional guidelines

PubMed

Gupta M, Cheaib JG, Patel HD, Sharma R, Zhang A, Bass EB, Pierorazio PM
J Urol 2020 Jul;204(1):33-41. Epub 2020 Jan 22 doi: 10.1097/JU.0000000000000758. PMID: 31967523
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Giwercman A, Skakkebaek NE
Eur Urol 1993;23 Suppl 2:19-21. doi: 10.1159/000474694. PMID: 8390358

Recent clinical studies

Etiology

Anami T, Ibe Y, Li L, Komohara Y, Hirao H, Harada M, Yano H, Fujiwara Y, Motoshima T, Yatsuda J, Hibi T, Kamba T
Med Mol Morphol 2024 Mar;57(1):68-75. Epub 2023 Nov 22 doi: 10.1007/s00795-023-00374-9. PMID: 37991604
Muramoto A, Inamura S, Hoshino H, Terada N, Kobayashi M
J Histochem Cytochem 2023 Oct;71(10):555-563. Epub 2023 Sep 7 doi: 10.1369/00221554231199134. PMID: 37675782Free PMC Article
Cheung HH, Yang Y, Lee TL, Rennert O, Chan WY
Br J Cancer 2016 Jan 19;114(2):230-6. Epub 2015 Dec 1 doi: 10.1038/bjc.2015.408. PMID: 26625006Free PMC Article
Patai K, Sobel G, Csömör S, Paulin F
Int Urogynecol J Pelvic Floor Dysfunct 2005 Jul-Aug;16(4):313-4. Epub 2004 Nov 10 doi: 10.1007/s00192-004-1251-8. PMID: 16211371
Willis GW, Hajdu SI
Am J Clin Pathol 1973 Mar;59(3):338-43. doi: 10.1093/ajcp/59.3.338. PMID: 4687350

Diagnosis

Chandra S, McKean H
S D Med 2023 Aug;76(8):342-344. PMID: 37734076
Muramoto A, Inamura S, Hoshino H, Terada N, Kobayashi M
J Histochem Cytochem 2023 Oct;71(10):555-563. Epub 2023 Sep 7 doi: 10.1369/00221554231199134. PMID: 37675782Free PMC Article
Liu L, Lian J, Zhang H, Tian H, Liang M, Yin M, Sun F
J Cell Physiol 2013 Dec;228(12):2294-304. doi: 10.1002/jcp.24394. PMID: 23625774
Waseda Y, Tanaka H, Nakagomi K, Goto S, Ido A
Jpn J Clin Oncol 2012 Aug;42(8):767-9. Epub 2012 Jun 11 doi: 10.1093/jjco/hys089. PMID: 22689918
Manenti A, Botticelli A, De Pasquale A
Eur Urol 1981;7(3):187-8. doi: 10.1159/000473214. PMID: 6162645

Therapy

Senniappan S, Wood D, Hakeem V, Stoneham S, Freeman A, Dattani M
Horm Res Paediatr 2014;82(4):272-7. Epub 2014 Jul 5 doi: 10.1159/000362187. PMID: 25012595
Abada PB, Howell SB
PLoS One 2014;9(1):e87444. Epub 2014 Jan 27 doi: 10.1371/journal.pone.0087444. PMID: 24475288Free PMC Article
Grande L, Bretones G, Rosa-Garrido M, Garrido-Martin EM, Hernandez T, Fraile S, Botella L, de Alava E, Vidal A, Garcia del Muro X, Villanueva A, Delgado MD, Fernandez-Luna JL
J Biol Chem 2012 Aug 3;287(32):26495-505. Epub 2012 Jun 20 doi: 10.1074/jbc.M112.376319. PMID: 22718761Free PMC Article
Yao PL, Lin YC, Richburg JH
Biol Reprod 2012 May;86(5):160, 1-10. Epub 2012 May 31 doi: 10.1095/biolreprod.111.097295. PMID: 22321834Free PMC Article
Patai K, Sobel G, Csömör S, Paulin F
Int Urogynecol J Pelvic Floor Dysfunct 2005 Jul-Aug;16(4):313-4. Epub 2004 Nov 10 doi: 10.1007/s00192-004-1251-8. PMID: 16211371

Prognosis

Allende-Vega N, Sparks A, Lane DP, Saville MK
Oncogene 2010 Jan 21;29(3):432-41. Epub 2009 Oct 19 doi: 10.1038/onc.2009.330. PMID: 19838211
Patai K, Sobel G, Csömör S, Paulin F
Int Urogynecol J Pelvic Floor Dysfunct 2005 Jul-Aug;16(4):313-4. Epub 2004 Nov 10 doi: 10.1007/s00192-004-1251-8. PMID: 16211371
Poulopoulos AK, Antoniades K, Kiziridou A, Antoniades V
Oral Oncol 2001 Jun;37(4):397-9. doi: 10.1016/s1368-8375(00)00104-4. PMID: 11337274
Kontozoglou TE, Banerjee D, Cherian MG
Virchows Arch A Pathol Anat Histopathol 1989;415(6):545-9. doi: 10.1007/BF00718648. PMID: 2508311
Willis GW, Hajdu SI
Am J Clin Pathol 1973 Mar;59(3):338-43. doi: 10.1093/ajcp/59.3.338. PMID: 4687350

Clinical prediction guides

Yao PL, Chen LP, Dobrzański TP, Phillips DA, Zhu B, Kang BH, Gonzalez FJ, Peters JM
Oncotarget 2015 Nov 3;6(34):36319-37. doi: 10.18632/oncotarget.5415. PMID: 26431381Free PMC Article
Liu L, Lian J, Zhang H, Tian H, Liang M, Yin M, Sun F
J Cell Physiol 2013 Dec;228(12):2294-304. doi: 10.1002/jcp.24394. PMID: 23625774
Kato M, Ikeda Y, Namiki S, Saito S, Ito A, Arai Y
Int J Urol 2008 Mar;15(3):265-6. doi: 10.1111/j.1442-2042.2007.01969.x. PMID: 18304227
Kontozoglou TE, Banerjee D, Cherian MG
Virchows Arch A Pathol Anat Histopathol 1989;415(6):545-9. doi: 10.1007/BF00718648. PMID: 2508311
Yamamoto T, Komatsubara S, Suzuki T, Oboshi S
Gan 1979 Oct;70(5):677-80. PMID: 520758

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