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Osteoradionecrosis of the mandible

MedGen UID:
713081
Concept ID:
C1290728
Disease or Syndrome
Synonyms: Aseptic necrosis of mandible caused by ionizing radiation; Avascular necrosis of mandible caused by ionizing radiation; Osteoradionecrosis of mandible; osteoradionecrosis of the mandible
SNOMED CT: Aseptic necrosis of mandible caused by ionizing radiation (109716001); Avascular necrosis of mandible caused by ionizing radiation (109716001); Osteoradionecrosis of mandible (109716001)
 
Monarch Initiative: MONDO:0033839
Orphanet: ORPHA521127

Definition

A rare radiation-induced disorder characterized by exposed irradiated bone that fails to heal over a period of three months without evidence of persisting or recurrent tumor. Patients present with pain, dysesthesia, dysgeusia, fetor oris, trismus, ulceration or necrosis of the mucosa with exposure of necrotic bone, and local suppuration. Complications include pathological fractures, formation of intra- or extra-oral fistulae, and infection. MRI shows cortical destruction, abnormal bone marrow signal, and irregular contrast enhancement. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVOsteoradionecrosis of the mandible

Professional guidelines

PubMed

Akashi M
Oral Oncol 2024 Feb;149:106662. Epub 2023 Dec 19 doi: 10.1016/j.oraloncology.2023.106662. PMID: 38118250
Robard L, Louis MY, Blanchard D, Babin E, Delanian S
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):333-338. Epub 2014 Jun 30 doi: 10.1016/j.anorl.2013.11.006. PMID: 24993781
Carlson ER
Recent Results Cancer Res 1994;134:191-9. doi: 10.1007/978-3-642-84971-8_21. PMID: 8153436

Recent clinical studies

Etiology

Gaio-Lima C, Castedo J, Cruz M, Candeias M, Camacho Ó
Clin Transl Oncol 2022 Dec;24(12):2466-2474. Epub 2022 Aug 17 doi: 10.1007/s12094-022-02892-x. PMID: 35976581
Robard L, Louis MY, Blanchard D, Babin E, Delanian S
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):333-338. Epub 2014 Jun 30 doi: 10.1016/j.anorl.2013.11.006. PMID: 24993781
Teng MS, Futran ND
Curr Opin Otolaryngol Head Neck Surg 2005 Aug;13(4):217-21. doi: 10.1097/01.moo.0000170527.59017.ff. PMID: 16012245
Marciani RD, Ownby HE
J Oral Maxillofac Surg 1986 Mar;44(3):218-23. doi: 10.1016/0278-2391(86)90111-4. PMID: 3456444
Cheng VS, Wang CC
Radiology 1974 Sep;112(3):685-9. doi: 10.1148/112.3.685. PMID: 4210523

Diagnosis

Boromand G, Haugen-Cange H, Asparusova M, Ekestubbe A, Kjeller G
Acta Odontol Scand 2024 Jan;82(1):48-54. Epub 2023 Dec 28 doi: 10.1080/00016357.2023.2257316. PMID: 37772879
He Y, Ma C, Hou J, Li X, Peng X, Wang H, Wang S, Liu L, Liu B, Tian L, Liu Z, Liu X, Xu X, Zhang D, Jiang C, Wang J, Yao Y, Zhu G, Bai Y, Wang S, Sun C, Li J, He S, Wang C, Zhang Z, Qiu W
Int J Oral Maxillofac Surg 2020 Mar;49(3):411-419. Epub 2019 Jul 26 doi: 10.1016/j.ijom.2019.06.015. PMID: 31353174
Deshpande SS, Thakur MH, Dholam K, Mahajan A, Arya S, Juvekar S
Clin Radiol 2015 Feb;70(2):197-205. Epub 2014 Oct 18 doi: 10.1016/j.crad.2014.09.012. PMID: 25446325
Maurer P, Meyer L
J Oral Maxillofac Surg 2006 Mar;64(3):560-2. doi: 10.1016/j.joms.2005.10.030. PMID: 16487824
Harris LF
South Med J 1986 Jun;79(6):696-7. doi: 10.1097/00007611-198606000-00012. PMID: 3715533

Therapy

Robard L, Louis MY, Blanchard D, Babin E, Delanian S
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):333-338. Epub 2014 Jun 30 doi: 10.1016/j.anorl.2013.11.006. PMID: 24993781
Graupera BB
Radiol Technol 1977 Sep-Oct;49(2):139-42. PMID: 905558
Marciani RD, Plezia RA
J Oral Surg 1974 Jun;32(6):435-40. PMID: 4598137
Cheng VS, Wang CC
Radiology 1974 Sep;112(3):685-9. doi: 10.1148/112.3.685. PMID: 4210523
Rankow RM, Weissman B
Ann Otol Rhinol Laryngol 1971 Aug;80(4):603-11. doi: 10.1177/000348947108000426. PMID: 5154528

Prognosis

Boromand G, Haugen-Cange H, Asparusova M, Ekestubbe A, Kjeller G
Acta Odontol Scand 2024 Jan;82(1):48-54. Epub 2023 Dec 28 doi: 10.1080/00016357.2023.2257316. PMID: 37772879
Gaio-Lima C, Castedo J, Cruz M, Candeias M, Camacho Ó
Clin Transl Oncol 2022 Dec;24(12):2466-2474. Epub 2022 Aug 17 doi: 10.1007/s12094-022-02892-x. PMID: 35976581
Studer G, Bredell M, Studer S, Huber G, Glanzmann C
Strahlenther Onkol 2016 Jan;192(1):32-9. Epub 2015 Aug 12 doi: 10.1007/s00066-015-0875-6. PMID: 26265308Free PMC Article
Teng MS, Futran ND
Curr Opin Otolaryngol Head Neck Surg 2005 Aug;13(4):217-21. doi: 10.1097/01.moo.0000170527.59017.ff. PMID: 16012245
Cheng VS, Wang CC
Radiology 1974 Sep;112(3):685-9. doi: 10.1148/112.3.685. PMID: 4210523

Clinical prediction guides

Boromand G, Haugen-Cange H, Asparusova M, Ekestubbe A, Kjeller G
Acta Odontol Scand 2024 Jan;82(1):48-54. Epub 2023 Dec 28 doi: 10.1080/00016357.2023.2257316. PMID: 37772879
Lee M, Chin RY, Eslick GD, Sritharan N, Paramaesvaran S
J Craniomaxillofac Surg 2015 Dec;43(10):2026-33. Epub 2015 Mar 20 doi: 10.1016/j.jcms.2015.03.006. PMID: 26427619
Chronopoulos A, Zarra T, Tröltzsch M, Mahaini S, Ehrenfeld M, Otto S
J Craniomaxillofac Surg 2015 Jul;43(6):837-46. Epub 2015 Apr 1 doi: 10.1016/j.jcms.2015.03.024. PMID: 25939311
Robard L, Louis MY, Blanchard D, Babin E, Delanian S
Eur Ann Otorhinolaryngol Head Neck Dis 2014 Dec;131(6):333-338. Epub 2014 Jun 30 doi: 10.1016/j.anorl.2013.11.006. PMID: 24993781
Hahn LJ
Taiwan Yi Xue Hui Za Zhi 1983 Mar;82(3):451-60. PMID: 6577139

Recent systematic reviews

Jagtiani K, Gurav S, Singh G, Dholam K
J Prosthet Dent 2024 Jul;132(1):270-277. Epub 2022 Jul 11 doi: 10.1016/j.prosdent.2022.06.001. PMID: 35835619
Gundestrup AK, Lynggaard CD, Forner L, Heino TJ, Jakobsen KK, Fischer-Nielsen A, Grønhøj C, von Buchwald C
Stem Cell Rev Rep 2020 Dec;16(6):1208-1221. doi: 10.1007/s12015-020-10034-5. PMID: 32869179
Lee M, Chin RY, Eslick GD, Sritharan N, Paramaesvaran S
J Craniomaxillofac Surg 2015 Dec;43(10):2026-33. Epub 2015 Mar 20 doi: 10.1016/j.jcms.2015.03.006. PMID: 26427619

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