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Metastatic Ewing Sarcoma

MedGen UID:
75839
Concept ID:
C0278586
Neoplastic Process
Synonyms: Ewing's Sarcoma, Metastatic; Metastatic Ewing sarcoma; Metastatic Ewing's Sarcoma; Metastatic Ewing's sarcoma
SNOMED CT: Metastatic Ewing's sarcoma (50601000146101); Metastatic Ewing sarcoma (50601000146101)

Definition

Ewing sarcoma that has spread from its original site of growth to another anatomic site. [from NCI]

Professional guidelines

PubMed

Ramamurthy A, Connolly EA, Mar J, Lewin J, Bhadri VA, Phillips MB, Winstanley M, Orme LM, Grimison P, Connor J, Lazarakis S, Hong AM, Omer N, Cayrol J
Cancer Treat Rev 2024 Mar;124:102694. Epub 2024 Feb 2 doi: 10.1016/j.ctrv.2024.102694. PMID: 38325070
Zhang WT, Zhang WW, He ZY, Sun JY, Zhang L, Xia Q, Wu SG
Expert Rev Anticancer Ther 2018 May;18(5):501-506. Epub 2018 Mar 21 doi: 10.1080/14737140.2018.1453360. PMID: 29537323
Cote GM, Choy E
Hematol Oncol Clin North Am 2013 Oct;27(5):1007-19. Epub 2013 Aug 3 doi: 10.1016/j.hoc.2013.07.001. PMID: 24093173

Recent clinical studies

Etiology

Reiter AJ, Huang L, Craig BT, Davidoff AM, Talbot LJ, Coggins J, Smith J, Aldrink JH, Bergus KC, MacArthur TA, Polites SF, Boehmer C, Brungardt J, Malek MM, Rinehardt HN, Kastenberg ZJ, Arkin CM, Gourmel A, Piche N, Wallace M, Liang J, Lovvorn HN 3rd, Petroze RT, Gillies G, Marquart JP, Becktell K, Le HD, Favela J, Rich BS, Glick RD, Seemann NM, Davidson J, Wilson CA, Roach J, Brown EG, Doyle KE, Coakley BA, Emengo P, Merola P, Grant CN, Tirumani A, Tracy ET, Moya-Mendez ME, Dasgupta R, Lautz TB; Pediatric Surgical Oncology Research Collaborative
Pediatr Blood Cancer 2024 Jul;71(7):e31026. Epub 2024 Apr 28 doi: 10.1002/pbc.31026. PMID: 38679864Free PMC Article
Wiemels JL, Wang R, Feng Q, Yee AC, Morimoto LM, Metayer C, Ma X
Cancer Causes Control 2023 Oct;34(10):837-843. Epub 2023 Jun 19 doi: 10.1007/s10552-023-01737-4. PMID: 37335392Free PMC Article
DuBois SG, Krailo MD, Glade-Bender J, Buxton A, Laack N, Randall RL, Chen HX, Seibel NL, Boron M, Terezakis S, Hill-Kayser C, Hayes A, Reid JM, Teot L, Rakheja D, Womer R, Arndt C, Lessnick SL, Crompton BD, Kolb EA, Daldrup-Link H, Eutsler E, Reed DR, Janeway KA, Gorlick RG
J Clin Oncol 2023 Apr 10;41(11):2098-2107. Epub 2023 Jan 20 doi: 10.1200/JCO.22.01815. PMID: 36669140Free PMC Article
Koch R, Gelderblom H, Haveman L, Brichard B, Jürgens H, Cyprova S, van den Berg H, Hassenpflug W, Raciborska A, Ek T, Baumhoer D, Egerer G, Eich HT, Renard M, Hauser P, Burdach S, Bovee J, Bonar F, Reichardt P, Kruseova J, Hardes J, Kühne T, Kessler T, Collaud S, Bernkopf M, Butterfaß-Bahloul T, Dhooge C, Bauer S, Kiss J, Paulussen M, Hong A, Ranft A, Timmermann B, Rascon J, Vieth V, Kanerva J, Faldum A, Metzler M, Hartmann W, Hjorth L, Bhadri V, Dirksen U
J Clin Oncol 2022 Jul 20;40(21):2307-2320. Epub 2022 Apr 15 doi: 10.1200/JCO.21.01942. PMID: 35427190
Breda JR, Aljure O, Sfakianaki AK, Loebe M
J Card Surg 2021 Dec;36(12):4756-4758. Epub 2021 Sep 15 doi: 10.1111/jocs.15984. PMID: 34523160

Diagnosis

Fleury AS, Zhuang H
Clin Nucl Med 2024 Jun 1;49(6):589-591. Epub 2024 Mar 25 doi: 10.1097/RLU.0000000000005202. PMID: 38537215
Wiemels JL, Wang R, Feng Q, Yee AC, Morimoto LM, Metayer C, Ma X
Cancer Causes Control 2023 Oct;34(10):837-843. Epub 2023 Jun 19 doi: 10.1007/s10552-023-01737-4. PMID: 37335392Free PMC Article
DuBois SG, Krailo MD, Glade-Bender J, Buxton A, Laack N, Randall RL, Chen HX, Seibel NL, Boron M, Terezakis S, Hill-Kayser C, Hayes A, Reid JM, Teot L, Rakheja D, Womer R, Arndt C, Lessnick SL, Crompton BD, Kolb EA, Daldrup-Link H, Eutsler E, Reed DR, Janeway KA, Gorlick RG
J Clin Oncol 2023 Apr 10;41(11):2098-2107. Epub 2023 Jan 20 doi: 10.1200/JCO.22.01815. PMID: 36669140Free PMC Article
Civan C, Apaydin Arikan E, Has Simsek D, Sanli O, Kuyumcu S
Clin Nucl Med 2022 Mar 1;47(3):e296-e297. doi: 10.1097/RLU.0000000000004043. PMID: 35025778
Stieglitz E, Hsiang MS, Simko JP, Hirose S, Goldsby RE
J Pediatr Hematol Oncol 2014 Jan;36(1):e57-60. doi: 10.1097/MPH.0b013e318286d4fd. PMID: 23588326

Therapy

Reiter AJ, Huang L, Craig BT, Davidoff AM, Talbot LJ, Coggins J, Smith J, Aldrink JH, Bergus KC, MacArthur TA, Polites SF, Boehmer C, Brungardt J, Malek MM, Rinehardt HN, Kastenberg ZJ, Arkin CM, Gourmel A, Piche N, Wallace M, Liang J, Lovvorn HN 3rd, Petroze RT, Gillies G, Marquart JP, Becktell K, Le HD, Favela J, Rich BS, Glick RD, Seemann NM, Davidson J, Wilson CA, Roach J, Brown EG, Doyle KE, Coakley BA, Emengo P, Merola P, Grant CN, Tirumani A, Tracy ET, Moya-Mendez ME, Dasgupta R, Lautz TB; Pediatric Surgical Oncology Research Collaborative
Pediatr Blood Cancer 2024 Jul;71(7):e31026. Epub 2024 Apr 28 doi: 10.1002/pbc.31026. PMID: 38679864Free PMC Article
DuBois SG, Krailo MD, Glade-Bender J, Buxton A, Laack N, Randall RL, Chen HX, Seibel NL, Boron M, Terezakis S, Hill-Kayser C, Hayes A, Reid JM, Teot L, Rakheja D, Womer R, Arndt C, Lessnick SL, Crompton BD, Kolb EA, Daldrup-Link H, Eutsler E, Reed DR, Janeway KA, Gorlick RG
J Clin Oncol 2023 Apr 10;41(11):2098-2107. Epub 2023 Jan 20 doi: 10.1200/JCO.22.01815. PMID: 36669140Free PMC Article
Zandaki D, Ismael T, Halalsheh H, Ibrahimi AKH, Sarhan N, Ghandour K, Shehadeh A, Sultan I
J Pediatr Hematol Oncol 2023 Apr 1;45(3):111-115. Epub 2022 May 9 doi: 10.1097/MPH.0000000000002478. PMID: 35537074
Koch R, Gelderblom H, Haveman L, Brichard B, Jürgens H, Cyprova S, van den Berg H, Hassenpflug W, Raciborska A, Ek T, Baumhoer D, Egerer G, Eich HT, Renard M, Hauser P, Burdach S, Bovee J, Bonar F, Reichardt P, Kruseova J, Hardes J, Kühne T, Kessler T, Collaud S, Bernkopf M, Butterfaß-Bahloul T, Dhooge C, Bauer S, Kiss J, Paulussen M, Hong A, Ranft A, Timmermann B, Rascon J, Vieth V, Kanerva J, Faldum A, Metzler M, Hartmann W, Hjorth L, Bhadri V, Dirksen U
J Clin Oncol 2022 Jul 20;40(21):2307-2320. Epub 2022 Apr 15 doi: 10.1200/JCO.21.01942. PMID: 35427190
Lim D, Aussedat M, Maillet-Lebel N, Marcoux D
Pediatr Dermatol 2017 Sep;34(5):e257-e259. Epub 2017 Aug 14 doi: 10.1111/pde.13234. PMID: 28804924

Prognosis

Reiter AJ, Huang L, Craig BT, Davidoff AM, Talbot LJ, Coggins J, Smith J, Aldrink JH, Bergus KC, MacArthur TA, Polites SF, Boehmer C, Brungardt J, Malek MM, Rinehardt HN, Kastenberg ZJ, Arkin CM, Gourmel A, Piche N, Wallace M, Liang J, Lovvorn HN 3rd, Petroze RT, Gillies G, Marquart JP, Becktell K, Le HD, Favela J, Rich BS, Glick RD, Seemann NM, Davidson J, Wilson CA, Roach J, Brown EG, Doyle KE, Coakley BA, Emengo P, Merola P, Grant CN, Tirumani A, Tracy ET, Moya-Mendez ME, Dasgupta R, Lautz TB; Pediatric Surgical Oncology Research Collaborative
Pediatr Blood Cancer 2024 Jul;71(7):e31026. Epub 2024 Apr 28 doi: 10.1002/pbc.31026. PMID: 38679864Free PMC Article
Ramamurthy A, Connolly EA, Mar J, Lewin J, Bhadri VA, Phillips MB, Winstanley M, Orme LM, Grimison P, Connor J, Lazarakis S, Hong AM, Omer N, Cayrol J
Cancer Treat Rev 2024 Mar;124:102694. Epub 2024 Feb 2 doi: 10.1016/j.ctrv.2024.102694. PMID: 38325070
Lin TY, Park JA, Long A, Guo HF, Cheung NV
J Immunother Cancer 2021 Sep;9(9) doi: 10.1136/jitc-2021-003114. PMID: 34497115Free PMC Article
Haveman LM, van Ewijk R, van Dalen EC, Breunis WB, Kremer LC, van den Berg H, Dirksen U, Merks JH
Cochrane Database Syst Rev 2021 Sep 2;9(9):CD011405. doi: 10.1002/14651858.CD011405.pub2. PMID: 34472082Free PMC Article
Jiang Y, Ludwig J, Janku F
Cancer Treat Rev 2015 May;41(5):391-400. Epub 2015 Mar 27 doi: 10.1016/j.ctrv.2015.03.008. PMID: 25869102Free PMC Article

Clinical prediction guides

Koch R, Gelderblom H, Haveman L, Brichard B, Jürgens H, Cyprova S, van den Berg H, Hassenpflug W, Raciborska A, Ek T, Baumhoer D, Egerer G, Eich HT, Renard M, Hauser P, Burdach S, Bovee J, Bonar F, Reichardt P, Kruseova J, Hardes J, Kühne T, Kessler T, Collaud S, Bernkopf M, Butterfaß-Bahloul T, Dhooge C, Bauer S, Kiss J, Paulussen M, Hong A, Ranft A, Timmermann B, Rascon J, Vieth V, Kanerva J, Faldum A, Metzler M, Hartmann W, Hjorth L, Bhadri V, Dirksen U
J Clin Oncol 2022 Jul 20;40(21):2307-2320. Epub 2022 Apr 15 doi: 10.1200/JCO.21.01942. PMID: 35427190
Umeda K, Miyamura T, Yamada K, Sano H, Hosono A, Sumi M, Okita H, Kamio T, Maeda N, Fujisaki H, Jyoko R, Watanabe A, Hosoya Y, Hasegawa D, Takenaka S, Nakagawa S, Chin M, Ozaki T; Japan Ewing Sarcoma Study Group
Pediatr Blood Cancer 2021 Mar;68(3):e28844. Epub 2020 Dec 19 doi: 10.1002/pbc.28844. PMID: 33340261
Halalsheh H, Kaste SC, Krasin MJ, Sykes A, Sahr N, Spunt SL, Federico SM, Bishop MW
Pediatr Blood Cancer 2020 Apr;67(4):e28150. Epub 2020 Jan 15 doi: 10.1002/pbc.28150. PMID: 31944574
Jiang Y, Ludwig J, Janku F
Cancer Treat Rev 2015 May;41(5):391-400. Epub 2015 Mar 27 doi: 10.1016/j.ctrv.2015.03.008. PMID: 25869102Free PMC Article
Paioli A, Luksch R, Fagioli F, Tamburini A, Cesari M, Palmerini E, Abate ME, Marchesi E, Balladelli A, Pratelli L, Ferrari S
J Chemother 2014 Feb;26(1):49-56. Epub 2013 Dec 6 doi: 10.1179/1973947813Y.0000000103. PMID: 24091100

Recent systematic reviews

Ramamurthy A, Connolly EA, Mar J, Lewin J, Bhadri VA, Phillips MB, Winstanley M, Orme LM, Grimison P, Connor J, Lazarakis S, Hong AM, Omer N, Cayrol J
Cancer Treat Rev 2024 Mar;124:102694. Epub 2024 Feb 2 doi: 10.1016/j.ctrv.2024.102694. PMID: 38325070
Haveman LM, van Ewijk R, van Dalen EC, Breunis WB, Kremer LC, van den Berg H, Dirksen U, Merks JH
Cochrane Database Syst Rev 2021 Sep 2;9(9):CD011405. doi: 10.1002/14651858.CD011405.pub2. PMID: 34472082Free PMC Article
Parcesepe P, Giordano G, Zanella C, Giuliani J, Greco F, Bonetti A, Pancione M, Manfrin E, Molinari E, Latiano TP, D'Andrea MR, Fassan M, Olivieri N, Remo A
Pathol Res Pract 2019 Feb;215(2):387-391. Epub 2018 Nov 29 doi: 10.1016/j.prp.2018.11.021. PMID: 30553605

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