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Disseminated peritoneal leiomyomatosis

MedGen UID:
78634
•Concept ID:
C0267785
•
Neoplastic Process
Synonyms: Diffuse Peritoneal Leiomyomatosis; Diffuse peritoneal leiomyomatosis; diffuse peritoneal leiomyomatosis; Disseminated Peritoneal Leiomyomatosis; disseminated peritoneal leiomyomatosis; DPL; DPL - disseminated peritoneal leiomyomatosis; Leiomyomatosis Peritonealis Disseminata; Leiomyomatosis peritonealis disseminata; leiomyomatosis peritonealis disseminata; Leiomyomatosis peritonealis disseminate; leiomyomatosis peritonealis disseminate; Leiomyomatosis, peritonealis disseminata; LPD; LPD - leiomyomatosis peritonealis disseminata; LPD - leiomyomatosis peritonealis disseminate
SNOMED CT: Leiomyomatosis peritonealis disseminata (62557001); Leiomyomatosis, peritonealis disseminata (703634007); Disseminated peritoneal leiomyomatosis (62557001); DPL - disseminated peritoneal leiomyomatosis (62557001); LPD - leiomyomatosis peritonealis disseminate (62557001); LPD - leiomyomatosis peritonealis disseminata (62557001)
Modes of inheritance:
Unknown inheritance
MedGen UID:
989040
•Concept ID:
CN307042
•
Finding
Source: Orphanet
Hereditary clinical entity whose mode of inheritance is unknown.
See: This record
Unknown inheritance (Orphanet)
 
Monarch Initiative: MONDO:0006183
Orphanet: ORPHA71274

Definition

Disseminated peritoneal leiomyomatosis (DPL) is characterized by the proliferation of multiple benign smooth muscle cell-containing nodules in the peritoneal cavity. [from ORDO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVDisseminated peritoneal leiomyomatosis

Recent clinical studies

Etiology

Disseminated peritoneal leiomyomatosis and malignant transformation: A case series in a single referral center.
Rosati A, Vargiu V, Angelico G, Zannoni GF, Ciccarone F, Scambia G, Fanfani F
Eur J Obstet Gynecol Reprod Biol 2021 Jul;262:21-27. Epub 2021 May 5 doi: 10.1016/j.ejogrb.2021.05.006. PMID: 33989940
Long-term sequelae of unconfined morcellation during laparoscopic gynecological surgery.
Cohen A, Tulandi T
Maturitas 2017 Mar;97:1-5. Epub 2016 Nov 18 doi: 10.1016/j.maturitas.2016.11.007. PMID: 28159054
Disseminated peritoneal leiomyomatosis postmorcellated resection of uterine leiomyomatous tissue.
Sekulic M, Moench L, Movahedi-Lankarani S
APMIS 2016 Dec;124(12):1063-1071. Epub 2016 Sep 20 doi: 10.1111/apm.12601. PMID: 27649643
Nonmalignant Sequelae of Unconfined Morcellation at Laparoscopic Hysterectomy or Myomectomy.
Tulandi T, Leung A, Jan N
J Minim Invasive Gynecol 2016 Mar-Apr;23(3):331-7. Epub 2016 Jan 21 doi: 10.1016/j.jmig.2016.01.017. PMID: 26802909
A case of disseminated peritoneal leiomyomatosis developing after laparoscope-assisted myomectomy.
Miyake T, Enomoto T, Ueda Y, Ikuma K, Morii E, Matsuzaki S, Murata Y
Gynecol Obstet Invest 2009;67(2):96-102. Epub 2008 Oct 23 doi: 10.1159/000164949. PMID: 18946223

Diagnosis

Disseminated Peritoneal Leiomyomatosis Presenting as Liver Mass.
Nduwimana MJ, Olson JC, Venkatesh SK
Clin Gastroenterol Hepatol 2024 Jun;22(6):A13-A14. Epub 2024 Jan 4 doi: 10.1016/j.cgh.2023.12.024. PMID: 38184098
Laparoscopic Management of Disseminated Peritoneal Leiomyomatosis.
Kriplani I, Kriplani A, Sharma S, Sodhi M, Jain N
J Minim Invasive Gynecol 2023 Jun;30(6):443-444. Epub 2023 Mar 17 doi: 10.1016/j.jmig.2023.03.006. PMID: 36934877
Iatrogenic parasitic myoma: a case report and review of the literature.
Huang PS, Chang WC, Huang SC
Taiwan J Obstet Gynecol 2014 Sep;53(3):392-6. doi: 10.1016/j.tjog.2013.11.007. PMID: 25286798
Disseminated peritoneal leiomyomatosis clinically and radiologically mimicking malignancy.
Anila KR, Rema P, Jayasree K
Int J Surg Pathol 2014 Apr;22(2):158-9. Epub 2013 Nov 6 doi: 10.1177/1066896913507600. PMID: 24196195
Disseminated peritoneal leiomyomatosis with endometriosis.
Mueller F, Kuehn K, Neudeck H, Siedentopf N, Ulrich U
J Minim Invasive Gynecol 2012 May-Jun;19(3):380-2. doi: 10.1016/j.jmig.2011.12.016. PMID: 22546423

Therapy

Disseminated peritoneal leiomyomatosis (DPL): a case report.
Gehring A, Gerber B, Tolla-Jensen C, Wiessner R
J Obstet Gynaecol 2018 Nov;38(8):1179-1180. Epub 2018 Apr 5 doi: 10.1080/01443615.2018.1431614. PMID: 29620425
Long-term sequelae of unconfined morcellation during laparoscopic gynecological surgery.
Cohen A, Tulandi T
Maturitas 2017 Mar;97:1-5. Epub 2016 Nov 18 doi: 10.1016/j.maturitas.2016.11.007. PMID: 28159054
A Case of Simultaneous Benign Metastasizing Leiomyomas and Disseminated Peritoneal Leiomyomatosis Following Endoscopic Power Morcellation for Uterine Disease.
Park BY, Leslie KO, Chen L, Vaszar LT, Cornella JL
Female Pelvic Med Reconstr Surg 2017 Jan/Feb;23(1):e1-e3. doi: 10.1097/SPV.0000000000000342. PMID: 27748666
Disseminated peritoneal leiomyomatosis postmorcellated resection of uterine leiomyomatous tissue.
Sekulic M, Moench L, Movahedi-Lankarani S
APMIS 2016 Dec;124(12):1063-1071. Epub 2016 Sep 20 doi: 10.1111/apm.12601. PMID: 27649643
A case of disseminated peritoneal leiomyomatosis developing after laparoscope-assisted myomectomy.
Miyake T, Enomoto T, Ueda Y, Ikuma K, Morii E, Matsuzaki S, Murata Y
Gynecol Obstet Invest 2009;67(2):96-102. Epub 2008 Oct 23 doi: 10.1159/000164949. PMID: 18946223

Prognosis

A RARE UTERINE TUMOR: DISSEMINATED PERITONEAL LEIOMYOMATOSIS. CLINICAL OBSERVATIONS.
Svintsitskyi V, Krotevych M, Iegorov M, Trokhymych S, Sendetskyi S
Exp Oncol 2023 Dec 28;45(3):370-378. doi: 10.15407/exp-oncology.2023.03.370. PMID: 38186018
Disseminated peritoneal leiomyomatosis: a case report and review of the literature.
Liu X, Hu Y, Chen L, Zhou Q
J Int Med Res 2021 Aug;49(8):3000605211033194. doi: 10.1177/03000605211033194. PMID: 34369191Free PMC Article
Ulipristal Acetate for Disseminated Peritoneal Leiomyomatosis.
Benlolo S, Papillon-Smith J, Murji A
Obstet Gynecol 2019 Mar;133(3):434-436. doi: 10.1097/AOG.0000000000003112. PMID: 30741799
Disseminated peritoneal leiomyomatosis with endometriosis.
Mueller F, Kuehn K, Neudeck H, Siedentopf N, Ulrich U
J Minim Invasive Gynecol 2012 May-Jun;19(3):380-2. doi: 10.1016/j.jmig.2011.12.016. PMID: 22546423
A case of disseminated peritoneal leiomyomatosis developing after laparoscope-assisted myomectomy.
Miyake T, Enomoto T, Ueda Y, Ikuma K, Morii E, Matsuzaki S, Murata Y
Gynecol Obstet Invest 2009;67(2):96-102. Epub 2008 Oct 23 doi: 10.1159/000164949. PMID: 18946223

Clinical prediction guides

A RARE UTERINE TUMOR: DISSEMINATED PERITONEAL LEIOMYOMATOSIS. CLINICAL OBSERVATIONS.
Svintsitskyi V, Krotevych M, Iegorov M, Trokhymych S, Sendetskyi S
Exp Oncol 2023 Dec 28;45(3):370-378. doi: 10.15407/exp-oncology.2023.03.370. PMID: 38186018
Disseminated peritoneal leiomyomatosis: a case report and review of the literature.
Liu X, Hu Y, Chen L, Zhou Q
J Int Med Res 2021 Aug;49(8):3000605211033194. doi: 10.1177/03000605211033194. PMID: 34369191Free PMC Article
A clinicopathological and molecular analysis in uterine leiomyomas and concurrent/metachronous peritoneal nodules: New insights into disseminated peritoneal leiomyomatosis.
Ma Y, Wang S, Liu Q, Lu B
Pathol Res Pract 2020 May;216(5):152938. Epub 2020 Mar 24 doi: 10.1016/j.prp.2020.152938. PMID: 32234244
Disseminated peritoneal leiomyomatosis with malignant change, in a male.
Lausen I, Jensen OJ, Andersen E, Lindahl F
Virchows Arch A Pathol Anat Histopathol 1990;417(2):173-5. doi: 10.1007/BF02190536. PMID: 2114697
Immunohistologic detection of estrogen and progesterone receptors in disseminated peritoneal leiomyomatosis.
Düe W, Pickartz H
Int J Gynecol Pathol 1989;8(1):46-53. doi: 10.1097/00004347-198903000-00006. PMID: 2707953

Recent systematic reviews

The Uterine Plexiform Lesions Revisited.
Karpathiou G, Papoudou-Bai A, Clemenson A, Chauleur C, Peoc'h M
Am J Clin Pathol 2020 Jul 7;154(2):178-189. doi: 10.1093/ajcp/aqaa054. PMID: 32459343
Parasitic leiomyomas: a systematic review.
Lete I, González J, Ugarte L, Barbadillo N, Lapuente O, Álvarez-Sala J
Eur J Obstet Gynecol Reprod Biol 2016 Aug;203:250-9. Epub 2016 Jun 10 doi: 10.1016/j.ejogrb.2016.05.025. PMID: 27359081
Nonmalignant Sequelae of Unconfined Morcellation at Laparoscopic Hysterectomy or Myomectomy.
Tulandi T, Leung A, Jan N
J Minim Invasive Gynecol 2016 Mar-Apr;23(3):331-7. Epub 2016 Jan 21 doi: 10.1016/j.jmig.2016.01.017. PMID: 26802909

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