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Abnormality of somatosensory evoked potentials

MedGen UID:
867219
Concept ID:
C4021577
Anatomical Abnormality
Synonym: Abnormality of SSEPs
 
HPO: HP:0007377

Definition

An abnormality of somatosensory evoked potentials (SSEP), i.e., of the electrical signals of sensation going from the body to the brain in response to a defined stimulus. Recording electrodes are placed over the scalp, spine, and peripheral nerves proximal to the stimulation site. Clinical studies generally use electrical stimulation of peripheral nerves to elicit potentials. SSEP testing determines whether peripheral sensory nerves are able to transmit sensory information like pain, temperature, and touch to the brain. Abnormal SSEPs can result from dysfunction at the level of the peripheral nerve, plexus, spinal root, spinal cord, brain stem, thalamocortical projections, or primary somatosensory cortex. [from HPO]

Conditions with this feature

Hereditary spastic paraplegia 7
MedGen UID:
339552
Concept ID:
C1846564
Disease or Syndrome
Spastic paraplegia 7 (SPG7) is characterized by insidiously progressive bilateral leg weakness and spasticity. Most affected individuals have decreased vibration sense and cerebellar signs. Onset is mostly in adulthood, although symptoms may start as early as age 11 years and as late as age 72 years. Additional features including ataxia (gait and limbs), spastic dysarthria, dysphagia, pale optic disks, ataxia, nystagmus, strabismus, ptosis, hearing loss, motor and sensory neuropathy, amyotrophy, scoliosis, pes cavus, and urinary sphincter disturbances may be observed.

Professional guidelines

PubMed

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Clin Neurosurg 1993;40:139-73. PMID: 8111980

Recent clinical studies

Etiology

Zhang Z, Wang Y, Luo T, Qi H, Cai L, Yuan Y, Li J
BMC Neurol 2022 Feb 15;22(1):58. doi: 10.1186/s12883-022-02579-4. PMID: 35168549Free PMC Article
Eftimov F, Lucke IM, Querol LA, Rajabally YA, Verhamme C
Brain 2020 Dec 5;143(11):3214-3224. doi: 10.1093/brain/awaa265. PMID: 33155018Free PMC Article
Zhu B, Coppola G, Shoaran M
Cephalalgia 2019 Aug;39(9):1143-1155. Epub 2019 Mar 26 doi: 10.1177/0333102419839975. PMID: 30913908
Kuwabara S, Sekiguchi Y, Misawa S
Clin Neurophysiol 2017 Jan;128(1):215-219. Epub 2016 Nov 20 doi: 10.1016/j.clinph.2016.11.009. PMID: 27923188
Whyte HE
Clin Perinatol 1993 Jun;20(2):451-61. PMID: 8358960

Diagnosis

Eftimov F, Lucke IM, Querol LA, Rajabally YA, Verhamme C
Brain 2020 Dec 5;143(11):3214-3224. doi: 10.1093/brain/awaa265. PMID: 33155018Free PMC Article
Kuwabara S, Sekiguchi Y, Misawa S
Clin Neurophysiol 2017 Jan;128(1):215-219. Epub 2016 Nov 20 doi: 10.1016/j.clinph.2016.11.009. PMID: 27923188
Tsao B
Neurol Clin 2007 May;25(2):473-94. doi: 10.1016/j.ncl.2007.02.001. PMID: 17445739
Eisen A
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Jones SJ
Ann N Y Acad Sci 1982;388:369-87. doi: 10.1111/j.1749-6632.1982.tb50803.x. PMID: 6953877

Therapy

Lee S, Lee H, Choi BS, Jin SC
Br J Neurosurg 2020 Jun;34(3):342-345. Epub 2020 Mar 2 doi: 10.1080/02688697.2020.1719036. PMID: 32116042
Zhu B, Coppola G, Shoaran M
Cephalalgia 2019 Aug;39(9):1143-1155. Epub 2019 Mar 26 doi: 10.1177/0333102419839975. PMID: 30913908
Sène D
Joint Bone Spine 2018 Oct;85(5):553-559. Epub 2017 Nov 16 doi: 10.1016/j.jbspin.2017.11.002. PMID: 29154979
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Prognosis

Lori S, Bertini G, Bastianelli ME, Gabbanini S, Cossu C, Mortilla M, Dani C
Dev Med Child Neurol 2022 Sep;64(9):1123-1130. Epub 2022 Feb 28 doi: 10.1111/dmcn.15190. PMID: 35225350
Horn J, Tjepkema-Cloostermans MC
Semin Neurol 2017 Feb;37(1):60-65. Epub 2017 Feb 1 doi: 10.1055/s-0036-1594252. PMID: 28147419
Kuwabara S, Sekiguchi Y, Misawa S
Clin Neurophysiol 2017 Jan;128(1):215-219. Epub 2016 Nov 20 doi: 10.1016/j.clinph.2016.11.009. PMID: 27923188
Whyte HE
Clin Perinatol 1993 Jun;20(2):451-61. PMID: 8358960
Bhatia K, Thompson PD, Marsden CD
J Neurol Neurosurg Psychiatry 1992 Nov;55(11):1089-91. doi: 10.1136/jnnp.55.11.1089. PMID: 1469409Free PMC Article

Clinical prediction guides

Latorre A, Belvisi D, Rothwell JC, Bhatia KP, Rocchi L
Clin Neurophysiol 2023 Dec;156:125-139. Epub 2023 Oct 31 doi: 10.1016/j.clinph.2023.10.007. PMID: 37948946
Macerollo A, Brown MJN, Kilner JM, Chen R
Trends Neurosci 2018 May;41(5):294-310. Epub 2018 Mar 14 doi: 10.1016/j.tins.2018.02.007. PMID: 29549962
Horn J, Tjepkema-Cloostermans MC
Semin Neurol 2017 Feb;37(1):60-65. Epub 2017 Feb 1 doi: 10.1055/s-0036-1594252. PMID: 28147419
Mastaglia FL
Nat Clin Pract Neurol 2006 Jun;2(6):304-5. doi: 10.1038/ncpneuro0201. PMID: 16932572
Whyte HE
Clin Perinatol 1993 Jun;20(2):451-61. PMID: 8358960

Recent systematic reviews

Paramento M, Passarotto E, Maccarone MC, Agostini M, Contessa P, Rubega M, Formaggio E, Masiero S
PLoS One 2024;19(5):e0303086. Epub 2024 May 22 doi: 10.1371/journal.pone.0303086. PMID: 38776317Free PMC Article
Sysoeva OV, Smirnov K, Stroganova TA
Clin Neurophysiol 2020 Jan;131(1):213-224. Epub 2019 Nov 21 doi: 10.1016/j.clinph.2019.11.003. PMID: 31812082
Tedesco Triccas L, Meyer S, Mantini D, Camilleri K, Falzon O, Camilleri T, Verheyden G
J Neurosci Methods 2019 Jan 1;311:318-330. Epub 2018 Aug 14 doi: 10.1016/j.jneumeth.2018.08.009. PMID: 30118725
Alcantara J, Alcantara JD, Alcantara J
Explore (NY) 2011 Nov-Dec;7(6):384-90. doi: 10.1016/j.explore.2011.08.001. PMID: 22051563
Robinson LR, Micklesen PJ, Tirschwell DL, Lew HL
Crit Care Med 2003 Mar;31(3):960-7. doi: 10.1097/01.CCM.0000053643.21751.3B. PMID: 12627012

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