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Abnormal astrocyte morphology

MedGen UID:
867605
•Concept ID:
C4021991
•
Finding
Synonym: Abnormality of the astrocytes
 
HPO: HP:0100707

Definition

An abnormality of astrocytes. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVAbnormal astrocyte morphology

Professional guidelines

PubMed

APOE genotype dependent molecular abnormalities in the cerebrovasculature of Alzheimer's disease and age-matched non-demented brains.
Ojo JO, Reed JM, Crynen G, Vallabhaneni P, Evans J, Shackleton B, Eisenbaum M, Ringland C, Edsell A, Mullan M, Crawford F, Bachmeier C
Mol Brain 2021 Jul 8;14(1):110. doi: 10.1186/s13041-021-00803-9. PMID: 34238312Free PMC Article
Mesencephalic astrocyte-derived neurotrophic factor: A treatment option for parkinson's disease.
Yang C, Gao Y
Front Biosci (Landmark Ed) 2020 Jun 1;25(9):1718-1731. doi: 10.2741/4874. PMID: 32472754
The first NINDS/NIBIB consensus meeting to define neuropathological criteria for the diagnosis of chronic traumatic encephalopathy.
McKee AC, Cairns NJ, Dickson DW, Folkerth RD, Keene CD, Litvan I, Perl DP, Stein TD, Vonsattel JP, Stewart W, Tripodis Y, Crary JF, Bieniek KF, Dams-O'Connor K, Alvarez VE, Gordon WA; TBI/CTE group
Acta Neuropathol 2016 Jan;131(1):75-86. Epub 2015 Dec 14 doi: 10.1007/s00401-015-1515-z. PMID: 26667418Free PMC Article

Recent clinical studies

Etiology

Glial cells in schizophrenia: a unified hypothesis.
Dietz AG, Goldman SA, Nedergaard M
Lancet Psychiatry 2020 Mar;7(3):272-281. Epub 2019 Nov 6 doi: 10.1016/S2215-0366(19)30302-5. PMID: 31704113Free PMC Article
Evidence for brain glucose dysregulation in Alzheimer's disease.
An Y, Varma VR, Varma S, Casanova R, Dammer E, Pletnikova O, Chia CW, Egan JM, Ferrucci L, Troncoso J, Levey AI, Lah J, Seyfried NT, Legido-Quigley C, O'Brien R, Thambisetty M
Alzheimers Dement 2018 Mar;14(3):318-329. Epub 2017 Oct 19 doi: 10.1016/j.jalz.2017.09.011. PMID: 29055815Free PMC Article
The neuropathology of chronic traumatic encephalopathy.
McKee AC, Stein TD, Kiernan PT, Alvarez VE
Brain Pathol 2015 May;25(3):350-64. doi: 10.1111/bpa.12248. PMID: 25904048Free PMC Article
Diffusion Tensor Imaging findings and their implications in schizophrenia.
Kubicki M, Shenton ME
Curr Opin Psychiatry 2014 May;27(3):179-84. doi: 10.1097/YCO.0000000000000053. PMID: 24613986
Gene therapy for leukodystrophies.
Biffi A, Aubourg P, Cartier N
Hum Mol Genet 2011 Apr 15;20(R1):R42-53. Epub 2011 Mar 31 doi: 10.1093/hmg/ddr142. PMID: 21459776

Diagnosis

Congenital Opticmeningoceles.
Cruz AAV, Akaishi PMS, Bernardini F, Chahud F
Ophthalmic Plast Reconstr Surg 2021 May-Jun 01;37(3):e109-e111. doi: 10.1097/IOP.0000000000001864. PMID: 33229952
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
The neuropathology of chronic traumatic encephalopathy.
Mckee AC, Abdolmohammadi B, Stein TD
Handb Clin Neurol 2018;158:297-307. doi: 10.1016/B978-0-444-63954-7.00028-8. PMID: 30482357
The neuropathology of chronic traumatic encephalopathy.
McKee AC, Stein TD, Kiernan PT, Alvarez VE
Brain Pathol 2015 May;25(3):350-64. doi: 10.1111/bpa.12248. PMID: 25904048Free PMC Article
Gliomas.
Collins VP
Cancer Surv 1998;32:37-51. PMID: 10489622

Therapy

Microglia in depression: current perspectives.
Jia X, Gao Z, Hu H
Sci China Life Sci 2021 Jun;64(6):911-925. Epub 2020 Oct 14 doi: 10.1007/s11427-020-1815-6. PMID: 33068286
Astrocyte´s RAGE: More Than Just a Question of Mood.
Gonzalez-Reyes RE, Rubiano MG
Cent Nerv Syst Agents Med Chem 2018 Jan 26;18(1):39-48. doi: 10.2174/1871524916999160505105121. PMID: 27149992
Brain metabolism and Alzheimer's disease: the prospect of a metabolite-based therapy.
Thomas SC, Alhasawi A, Appanna VP, Auger C, Appanna VD
J Nutr Health Aging 2015 Jan;19(1):58-63. doi: 10.1007/s12603-014-0511-7. PMID: 25560817
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ
Nat Med 2014 Aug;20(8):886-96. Epub 2014 Jun 29 doi: 10.1038/nm.3639. PMID: 24973918Free PMC Article
Molecular dissection of reactive astrogliosis and glial scar formation.
Sofroniew MV
Trends Neurosci 2009 Dec;32(12):638-47. Epub 2009 Sep 24 doi: 10.1016/j.tins.2009.08.002. PMID: 19782411Free PMC Article

Prognosis

Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Glioblastoma: pathology, molecular mechanisms and markers.
Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A
Acta Neuropathol 2015 Jun;129(6):829-48. Epub 2015 May 6 doi: 10.1007/s00401-015-1432-1. PMID: 25943888
Neurofibromin in the brain.
Gutmann DH
J Child Neurol 2002 Aug;17(8):592-601; discussion 602-4, 646-51. doi: 10.1177/088307380201700809. PMID: 12403558
Roles of the functional loss of p53 and other genes in astrocytoma tumorigenesis and progression.
Nozaki M, Tada M, Kobayashi H, Zhang CL, Sawamura Y, Abe H, Ishii N, Van Meir EG
Neuro Oncol 1999 Apr;1(2):124-37. doi: 10.1093/neuonc/1.2.124. PMID: 11550308Free PMC Article
Cytogenetics of astrocytomas.
Limon J
Folia Neuropathol 1994;32(4):205-7. PMID: 7889331

Clinical prediction guides

The genomic landscape across 474 surgically accessible epileptogenic human brain lesions.
López-Rivera JA, Leu C, Macnee M, Khoury J, Hoffmann L, Coras R, Kobow K, Bhattarai N, Pérez-Palma E, Hamer H, Brandner S, Rössler K, Bien CG, Kalbhenn T, Pieper T, Hartlieb T, Butler E, Genovese G, Becker K, Altmüller J, Niestroj LM, Ferguson L, Busch RM, Nürnberg P, Najm I, Blümcke I, Lal D
Brain 2023 Apr 19;146(4):1342-1356. doi: 10.1093/brain/awac376. PMID: 36226386Free PMC Article
Motor neuron pathology in CANVAS due to RFC1 expansions.
Huin V, Coarelli G, Guemy C, Boluda S, Debs R, Mochel F, Stojkovic T, Grabli D, Maisonobe T, Gaymard B, Lenglet T, Tard C, Davion JB, Sablonnière B, Monin ML, Ewenczyk C, Viala K, Charles P, Le Ber I, Reilly MM, Houlden H, Cortese A, Seilhean D, Brice A, Durr A
Brain 2022 Jun 30;145(6):2121-2132. doi: 10.1093/brain/awab449. PMID: 34927205
Autoimmune Glial Fibrillary Acidic Protein Astrocytopathy: A Review of the Literature.
Shan F, Long Y, Qiu W
Front Immunol 2018;9:2802. Epub 2018 Dec 5 doi: 10.3389/fimmu.2018.02802. PMID: 30568655Free PMC Article
Glioblastoma: pathology, molecular mechanisms and markers.
Aldape K, Zadeh G, Mansouri S, Reifenberger G, von Deimling A
Acta Neuropathol 2015 Jun;129(6):829-48. Epub 2015 May 6 doi: 10.1007/s00401-015-1432-1. PMID: 25943888
GABA from reactive astrocytes impairs memory in mouse models of Alzheimer's disease.
Jo S, Yarishkin O, Hwang YJ, Chun YE, Park M, Woo DH, Bae JY, Kim T, Lee J, Chun H, Park HJ, Lee DY, Hong J, Kim HY, Oh SJ, Park SJ, Lee H, Yoon BE, Kim Y, Jeong Y, Shim I, Bae YC, Cho J, Kowall NW, Ryu H, Hwang E, Kim D, Lee CJ
Nat Med 2014 Aug;20(8):886-96. Epub 2014 Jun 29 doi: 10.1038/nm.3639. PMID: 24973918Free PMC Article

Recent systematic reviews

Glial Markers of Suicidal Behavior in the Human Brain-A Systematic Review of Postmortem Studies.
Yamamoto M, Sakai M, Yu Z, Nakanishi M, Yoshii H
Int J Mol Sci 2024 May 25;25(11) doi: 10.3390/ijms25115750. PMID: 38891940Free PMC Article
Clinical and neuroimaging phenotypes of autoimmune glial fibrillary acidic protein astrocytopathy: A systematic review and meta-analysis.
Hagbohm C, Ouellette R, Flanagan EP, Jonsson DI, Piehl F, Banwell B, Wickström R, Iacobaeus E, Granberg T, Ineichen BV
Eur J Neurol 2024 Jul;31(7):e16284. Epub 2024 Mar 20 doi: 10.1111/ene.16284. PMID: 38506182Free PMC Article
The role of radiotherapy in the management of patients with diffuse low grade glioma: A systematic review and evidence-based clinical practice guideline.
Ryken TC, Parney I, Buatti J, Kalkanis SN, Olson JJ
J Neurooncol 2015 Dec;125(3):551-83. Epub 2015 Nov 3 doi: 10.1007/s11060-015-1948-1. PMID: 26530266
Heterogeneity of small vessel disease: a systematic review of MRI and histopathology correlations.
Gouw AA, Seewann A, van der Flier WM, Barkhof F, Rozemuller AM, Scheltens P, Geurts JJ
J Neurol Neurosurg Psychiatry 2011 Feb;82(2):126-35. Epub 2010 Oct 9 doi: 10.1136/jnnp.2009.204685. PMID: 20935330
High incidence of progressive postnatal cerebellar enlargement in Costello syndrome: brain overgrowth associated with HRAS mutations as the likely cause of structural brain and spinal cord abnormalities.
Gripp KW, Hopkins E, Doyle D, Dobyns WB
Am J Med Genet A 2010 May;152A(5):1161-8. doi: 10.1002/ajmg.a.33391. PMID: 20425820Free PMC Article

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