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Calcium channel antibody positivity

MedGen UID:
868185
•Concept ID:
C4022577
•
Finding
Synonyms: Ca channel antibody positivity; Ca2+ channel antibody positivity
 
HPO: HP:0030209

Definition

The presence of autoantibodies (immunoglobulins) in the serum that react against voltage-gated calcium channels. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVCalcium channel antibody positivity

Professional guidelines

PubMed

DOG1 as a novel antibody-drug conjugate target for the treatment of multiple gastrointestinal tumors and liver metastasis.
Wu Y, Li W, Chen X, Wang H, Su S, Xu Y, Deng X, Yang T, Wei M, Li L, Liu Y, Yang J, Li W
Front Immunol 2023;14:1051506. Epub 2023 Jan 26 doi: 10.3389/fimmu.2023.1051506. PMID: 36776873Free PMC Article
Single nucleotide polymorphisms and genotypes of transient receptor potential ion channel and acetylcholine receptor genes from isolated B lymphocytes in myalgic encephalomyelitis/chronic fatigue syndrome patients.
Marshall-Gradisnik S, Johnston S, Chacko A, Nguyen T, Smith P, Staines D
J Int Med Res 2016 Dec;44(6):1381-1394. Epub 2016 Nov 11 doi: 10.1177/0300060516671622. PMID: 27834303Free PMC Article
Responses to and Outcomes of Treatment of Autoimmune Cerebellar Ataxia in Adults.
Jones AL, Flanagan EP, Pittock SJ, Mandrekar JN, Eggers SD, Ahlskog JE, McKeon A
JAMA Neurol 2015 Nov;72(11):1304-12. doi: 10.1001/jamaneurol.2015.2378. PMID: 26414229

Recent clinical studies

Etiology

Neurological autoimmunity in patients with non-pulmonary neuroendocrine neoplasms: clinical manifestations and neural autoantibody profiles.
Mangioris G, Halfdanarson TR, Lennon VA, Chang BK, Dubey D, Dyck PJB, Flanagan EP, McKeon A, Mills JR, Pittock SJ, Zekeridou A
Eur J Neurol 2024 Jun;31(6):e16273. Epub 2024 Mar 11 doi: 10.1111/ene.16273. PMID: 38466015Free PMC Article
Myasthenia gravis.
Gilhus NE, Tzartos S, Evoli A, Palace J, Burns TM, Verschuuren JJGM
Nat Rev Dis Primers 2019 May 2;5(1):30. doi: 10.1038/s41572-019-0079-y. PMID: 31048702
Utility of Paraneoplastic Antibody Testing in the Diagnosis of Motor Neuron Disease.
Al-Bustani N, Simonson W, Marshall DA, Vetrovs J, Wener MH, Weiss MD, Wang LH
J Clin Neuromuscul Dis 2015 Dec;17(2):63-8. doi: 10.1097/CND.0000000000000080. PMID: 26583492
Drug-induced lupus erythematosus.
Vedove CD, Del Giglio M, Schena D, Girolomoni G
Arch Dermatol Res 2009 Jan;301(1):99-105. Epub 2008 Sep 17 doi: 10.1007/s00403-008-0895-5. PMID: 18797892
Neonatal lupus.
Brucato A, Cimaz R, Stramba-Badiale M
Clin Rev Allergy Immunol 2002 Dec;23(3):279-99. doi: 10.1385/CRIAI:23:3:279. PMID: 12402413

Diagnosis

An Elderly Man with Dementia.
Brier MR, Bucelli RC, Day GS
Clin Chem 2020 Mar 1;66(3):415-420. doi: 10.1093/clinchem/hvz002. PMID: 32109302
Myasthenia gravis.
Gilhus NE, Tzartos S, Evoli A, Palace J, Burns TM, Verschuuren JJGM
Nat Rev Dis Primers 2019 May 2;5(1):30. doi: 10.1038/s41572-019-0079-y. PMID: 31048702
Drug-induced lupus erythematosus.
Vedove CD, Del Giglio M, Schena D, Girolomoni G
Arch Dermatol Res 2009 Jan;301(1):99-105. Epub 2008 Sep 17 doi: 10.1007/s00403-008-0895-5. PMID: 18797892
Ca(2+) signaling in antigen receptor-activated B lymphocytes.
Engelke M, Engels N, Dittmann K, Stork B, Wienands J
Immunol Rev 2007 Aug;218:235-46. doi: 10.1111/j.1600-065X.2007.00539.x. PMID: 17624956
Neonatal lupus.
Brucato A, Cimaz R, Stramba-Badiale M
Clin Rev Allergy Immunol 2002 Dec;23(3):279-99. doi: 10.1385/CRIAI:23:3:279. PMID: 12402413

Therapy

Myasthenia gravis.
Gilhus NE, Tzartos S, Evoli A, Palace J, Burns TM, Verschuuren JJGM
Nat Rev Dis Primers 2019 May 2;5(1):30. doi: 10.1038/s41572-019-0079-y. PMID: 31048702
A cell-based assay for the detection of pathogenic anti-voltage-gated calcium channel autoantibodies in immunoglobulin G from patients with type 1 diabetes.
Alshehri AM, Mendis T, Jackson MW
J Immunol Methods 2018 Sep;460:79-86. Epub 2018 Jun 22 doi: 10.1016/j.jim.2018.06.012. PMID: 29940155
Favorable response to rituximab in a patient with anti-VGCC-positive Lambert-Eaton myasthenic syndrome and cerebellar dysfunction.
Pellkofer HL, Voltz R, Kuempfel T
Muscle Nerve 2009 Aug;40(2):305-8. doi: 10.1002/mus.21315. PMID: 19609921
Drug-induced lupus erythematosus.
Vedove CD, Del Giglio M, Schena D, Girolomoni G
Arch Dermatol Res 2009 Jan;301(1):99-105. Epub 2008 Sep 17 doi: 10.1007/s00403-008-0895-5. PMID: 18797892
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134

Prognosis

Anti-Ro/SSA Antibodies Blocking Calcium Channels as a Potentially Reversible Cause of Atrioventricular Block in Adults.
Lazzerini PE, Murthy Ginjupalli VK, Srivastava U, Bertolozzi I, Bacarelli MR, Verrengia D, Salvini V, Accioli R, Carbone SF, Santoro A, Cartocci A, Cevenini G, Cantara S, Cantore A, Bisogno S, Brucato A, Laghi-Pasini F, Acampa M, Capecchi PL, Boutjdir M
JACC Clin Electrophysiol 2023 Aug;9(8 Pt 3):1631-1648. Epub 2023 May 24 doi: 10.1016/j.jacep.2023.03.007. PMID: 37227349
An Elderly Man with Dementia.
Brier MR, Bucelli RC, Day GS
Clin Chem 2020 Mar 1;66(3):415-420. doi: 10.1093/clinchem/hvz002. PMID: 32109302
Utility of Paraneoplastic Antibody Testing in the Diagnosis of Motor Neuron Disease.
Al-Bustani N, Simonson W, Marshall DA, Vetrovs J, Wener MH, Weiss MD, Wang LH
J Clin Neuromuscul Dis 2015 Dec;17(2):63-8. doi: 10.1097/CND.0000000000000080. PMID: 26583492
Renal complications and scleroderma renal crisis.
Denton CP, Lapadula G, Mouthon L, Müller-Ladner U
Rheumatology (Oxford) 2009 Jun;48 Suppl 3:iii32-5. doi: 10.1093/rheumatology/ken483. PMID: 19487221
Localized and systemic scleroderma.
Hawk A, English JC 3rd
Semin Cutan Med Surg 2001 Mar;20(1):27-37. doi: 10.1053/sder.2001.23093. PMID: 11308134

Clinical prediction guides

An Elderly Man with Dementia.
Brier MR, Bucelli RC, Day GS
Clin Chem 2020 Mar 1;66(3):415-420. doi: 10.1093/clinchem/hvz002. PMID: 32109302
Enhanced differentiation potential of human amniotic mesenchymal stromal cells by using three-dimensional culturing.
Lin X, Li HY, Chen LF, Liu BJ, Yao Y, Zhu WL
Cell Tissue Res 2013 Jun;352(3):523-35. Epub 2013 Mar 21 doi: 10.1007/s00441-013-1576-z. PMID: 23515591
Anti-ryanodine receptor antibodies and FK506 in myasthenia gravis.
Takamori M, Motomura M, Kawaguchi N, Nemoto Y, Hattori T, Yoshikawa H, Otsuka K
Neurology 2004 May 25;62(10):1894-6. doi: 10.1212/01.wnl.0000125254.99397.68. PMID: 15159506
Decreased potassium channel IK1 and its regulator neurotrophin-3 (NT-3) in inflamed human bowel.
Arnold SJ, Facer P, Yiangou Y, Chen MX, Plumpton C, Tate SN, Bountra C, Chan CL, Williams NS, Anand P
Neuroreport 2003 Feb 10;14(2):191-5. doi: 10.1097/00001756-200302100-00006. PMID: 12598727
Neonatal lupus.
Brucato A, Cimaz R, Stramba-Badiale M
Clin Rev Allergy Immunol 2002 Dec;23(3):279-99. doi: 10.1385/CRIAI:23:3:279. PMID: 12402413

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