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High urinary gonadotropin level

MedGen UID:
871135
•Concept ID:
C4025606
•
Finding
HPO: HP:0003492

Definition

An elevated concentration of a gonadotropin hormone (stimulating hormone or luteinizing hormone) in the urine, consistent with the diagnosis of primary hypogonadism. [from HPO]

Term Hierarchy

CClinical test,  RResearch test,  OOMIM,  GGeneReviews,  VClinVar  
  • CROGVHigh urinary gonadotropin level

Professional guidelines

PubMed

Acute Abdominal Pain in Children: Evaluation and Management.
Buel KL, Wilcox J, Mingo PT
Am Fam Physician 2024 Dec;110(6):621-631. PMID: 39700366
Premature ovarian failure: diagnosis and treatment.
Slopień R, Warenik-Szymankiewicz A
Clin Exp Obstet Gynecol 2014;41(6):659-61. PMID: 25551958
Urinary gonadotropin fragment (UGF) measurements in the diagnosis and management of ovarian cancer.
Cole LA, Nam JH
Yale J Biol Med 1989 Jul-Aug;62(4):367-78. PMID: 2596125Free PMC Article

Recent clinical studies

Etiology

Changes in bone and mineral homeostasis after short-term androgen deprivation therapy with or without androgen receptor signalling inhibitor - substudy of a single-centre, double blind, randomised, placebo-controlled phase 2 trial.
David K, Devos G, Narinx N, Antonio L, Devlies W, Deboel L, Schollaert D, Eisenhauer A, Cavalier E, Vanderschueren D, Claessens F, Joniau S, Decallonne B
EBioMedicine 2023 Nov;97:104817. Epub 2023 Oct 5 doi: 10.1016/j.ebiom.2023.104817. PMID: 37804569Free PMC Article
Impaired Cardiometabolic Effects of Bromocriptine in Men With Early-Onset Androgenic Alopecia.
Krysiak R, Basiak M, Szkróbka W, Okopień B
J Clin Pharmacol 2023 Mar;63(3):345-351. Epub 2022 Nov 2 doi: 10.1002/jcph.2163. PMID: 36222207
Persistently elevated β-human chorionic gonadotropin level after vacuum-assisted uterine aspiration: a case report.
Sinha A, Patterson B
J Med Case Rep 2022 Jul 17;16(1):279. doi: 10.1186/s13256-022-03511-7. PMID: 35842706Free PMC Article
Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age.
Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, Baird DD
JAMA 2017 Oct 10;318(14):1367-1376. doi: 10.1001/jama.2017.14588. PMID: 29049585Free PMC Article
Biomarker development, from bench to bedside.
Stenman UH
Crit Rev Clin Lab Sci 2016;53(2):69-86. Epub 2015 Aug 18 doi: 10.3109/10408363.2015.1075468. PMID: 26287282

Diagnosis

Impaired Cardiometabolic Effects of Bromocriptine in Men With Early-Onset Androgenic Alopecia.
Krysiak R, Basiak M, Szkróbka W, Okopień B
J Clin Pharmacol 2023 Mar;63(3):345-351. Epub 2022 Nov 2 doi: 10.1002/jcph.2163. PMID: 36222207
Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age.
Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, Baird DD
JAMA 2017 Oct 10;318(14):1367-1376. doi: 10.1001/jama.2017.14588. PMID: 29049585Free PMC Article
Biomarker development, from bench to bedside.
Stenman UH
Crit Rev Clin Lab Sci 2016;53(2):69-86. Epub 2015 Aug 18 doi: 10.3109/10408363.2015.1075468. PMID: 26287282
Premature ovarian failure: diagnosis and treatment.
Slopień R, Warenik-Szymankiewicz A
Clin Exp Obstet Gynecol 2014;41(6):659-61. PMID: 25551958
High levels of hCG in choriocarcinoma can result in renal failure and a false-negative pregnancy test in men.
Meyer T, Cole LA, Richman PI, Mitchell HD, Myers J, Rustin GJ
Clin Oncol (R Coll Radiol) 2001;13(4):301-3. doi: 10.1053/clon.2001.9274. PMID: 11554631

Therapy

Changes in bone and mineral homeostasis after short-term androgen deprivation therapy with or without androgen receptor signalling inhibitor - substudy of a single-centre, double blind, randomised, placebo-controlled phase 2 trial.
David K, Devos G, Narinx N, Antonio L, Devlies W, Deboel L, Schollaert D, Eisenhauer A, Cavalier E, Vanderschueren D, Claessens F, Joniau S, Decallonne B
EBioMedicine 2023 Nov;97:104817. Epub 2023 Oct 5 doi: 10.1016/j.ebiom.2023.104817. PMID: 37804569Free PMC Article
Impaired Cardiometabolic Effects of Bromocriptine in Men With Early-Onset Androgenic Alopecia.
Krysiak R, Basiak M, Szkróbka W, Okopień B
J Clin Pharmacol 2023 Mar;63(3):345-351. Epub 2022 Nov 2 doi: 10.1002/jcph.2163. PMID: 36222207
Parabens and Menopause-Related Health Outcomes in Midlife Women: A Pilot Study.
Pacyga DC, Chiang C, Li Z, Strakovsky RS, Ziv-Gal A
J Womens Health (Larchmt) 2022 Nov;31(11):1645-1654. Epub 2022 Jul 5 doi: 10.1089/jwh.2022.0004. PMID: 35787012Free PMC Article
Endocrine effects of high-dose ketoconazole therapy in advanced prostatic cancer.
Heyns W, Drochmans A, van der Schueren E, Verhoeven G
Acta Endocrinol (Copenh) 1985 Oct;110(2):276-83. doi: 10.1530/acta.0.1100276. PMID: 3933237
The use of gonadotropins for induction of ovulation.
Schwartz M, Jewelewicz R
Fertil Steril 1981 Jan;35(1):3-12. doi: 10.1016/s0015-0282(16)45249-0. PMID: 6780378

Prognosis

Changes in bone and mineral homeostasis after short-term androgen deprivation therapy with or without androgen receptor signalling inhibitor - substudy of a single-centre, double blind, randomised, placebo-controlled phase 2 trial.
David K, Devos G, Narinx N, Antonio L, Devlies W, Deboel L, Schollaert D, Eisenhauer A, Cavalier E, Vanderschueren D, Claessens F, Joniau S, Decallonne B
EBioMedicine 2023 Nov;97:104817. Epub 2023 Oct 5 doi: 10.1016/j.ebiom.2023.104817. PMID: 37804569Free PMC Article
Reproducibility and Refinement of Urinary LH in the Screening of Progressive Puberty in Girls.
Zung A, Nachmany A, Burundukov E, Glaser T, Straussman S
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1673-e1678. doi: 10.1210/clinem/dgab806. PMID: 34758085
Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age.
Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, Baird DD
JAMA 2017 Oct 10;318(14):1367-1376. doi: 10.1001/jama.2017.14588. PMID: 29049585Free PMC Article
Biomarker development, from bench to bedside.
Stenman UH
Crit Rev Clin Lab Sci 2016;53(2):69-86. Epub 2015 Aug 18 doi: 10.3109/10408363.2015.1075468. PMID: 26287282
Evolution of a primary intrasellar germinomatous teratoma into a choriocarcinoma. Case report.
Giuffrè R, Di Lorenzo N
J Neurosurg 1975 May;42(5):602-4. doi: 10.3171/jns.1975.42.5.0602. PMID: 1171163

Clinical prediction guides

Changes in bone and mineral homeostasis after short-term androgen deprivation therapy with or without androgen receptor signalling inhibitor - substudy of a single-centre, double blind, randomised, placebo-controlled phase 2 trial.
David K, Devos G, Narinx N, Antonio L, Devlies W, Deboel L, Schollaert D, Eisenhauer A, Cavalier E, Vanderschueren D, Claessens F, Joniau S, Decallonne B
EBioMedicine 2023 Nov;97:104817. Epub 2023 Oct 5 doi: 10.1016/j.ebiom.2023.104817. PMID: 37804569Free PMC Article
Reproducibility and Refinement of Urinary LH in the Screening of Progressive Puberty in Girls.
Zung A, Nachmany A, Burundukov E, Glaser T, Straussman S
J Clin Endocrinol Metab 2022 Mar 24;107(4):e1673-e1678. doi: 10.1210/clinem/dgab806. PMID: 34758085
Association Between Biomarkers of Ovarian Reserve and Infertility Among Older Women of Reproductive Age.
Steiner AZ, Pritchard D, Stanczyk FZ, Kesner JS, Meadows JW, Herring AH, Baird DD
JAMA 2017 Oct 10;318(14):1367-1376. doi: 10.1001/jama.2017.14588. PMID: 29049585Free PMC Article
Endocrine effects of high-dose ketoconazole therapy in advanced prostatic cancer.
Heyns W, Drochmans A, van der Schueren E, Verhoeven G
Acta Endocrinol (Copenh) 1985 Oct;110(2):276-83. doi: 10.1530/acta.0.1100276. PMID: 3933237
Diet and reproductive hormones: a study of vegetarian and nonvegetarian postmenopausal women.
Armstrong BK, Brown JB, Clarke HT, Crooke DK, Hähnel R, Masarei JR, Ratajczak T
J Natl Cancer Inst 1981 Oct;67(4):761-7. PMID: 6944545

Recent systematic reviews

WITHDRAWN: Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction cycles.
Daya S, Gunby J
Cochrane Database Syst Rev 2007 Jul 18;2006(3):CD002810. doi: 10.1002/14651858.CD002810.pub2. PMID: 17636708Free PMC Article
Recombinant versus urinary follicle stimulating hormone for ovarian stimulation in assisted reproduction cycles.
Daya S, Gunby J
Cochrane Database Syst Rev 2000;(4):CD002810. doi: 10.1002/14651858.CD002810. PMID: 11034767
Ovulation induction with urinary follicle stimulating hormone versus human menopausal gonadotropin for clomiphene-resistant polycystic ovary syndrome.
Hughes E, Collins J, Vandekerckhove P
Cochrane Database Syst Rev 2000;1996(2):CD000087. doi: 10.1002/14651858.CD000087. PMID: 10796690Free PMC Article
WITHDRAWN: Ovulation induction with urinary follicle stimulating hormone versus human menopausal gonadotropin for clomiphene-resistant polycystic ovary syndrome.
Hughes E, Collins J, Vandekerckhove P
Cochrane Database Syst Rev 1996 Apr 22;(1):CD000087. doi: 10.1002/14651858.CD000087. PMID: 17636586

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