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Acral lentiginous melanoma

MedGen UID:
87530
Concept ID:
C0346037
Neoplastic Process
Synonyms: Acral lentiginous melanoma (disease); Palmar/plantar melanoma; Subungual melanoma
SNOMED CT: Acral lentiginous melanoma, malignant (16974005); Acral lentiginous malignant melanoma of skin (254732008); Acral lentiginous melanoma of skin (254732008); ALM - Acral lentiginous melanoma of skin (254732008); ALMM - Acral lentiginous malignant melanoma of skin (254732008)
 
HPO: HP:0012060
Monarch Initiative: MONDO:0003865

Definition

A type of cutaneous melanoma localized to the palm, sole, or beneath the nail (subungual melanoma). Acral lentiginous melanoma starts as a slowly-enlarging flat patch of discolored skin and usually displays a size above 6 mm and often several centimeters or more in diameter upon diagnosis and variable pigmentation with a mixutre of colors including brown, and blue-grey, black and red. The surface of the lesion is initially smooth but later in the course may become thicker and irregular, and may ulcerate or bleed. [from HPO]

Professional guidelines

PubMed

Alhaskawi A, Ezzi SHA, Dong Y, Zhou H, Wang Z, Lai J, Yao C, Kota VG, Abdulla MHAH, Lu H
J Zhejiang Univ Sci B 2024 Feb 15;25(2):106-122. doi: 10.1631/jzus.B2300221. PMID: 38303495Free PMC Article
Ingrassia JP, Stein JA, Levine A, Liebman TN
Dermatol Surg 2023 Oct 1;49(10):926-931. Epub 2023 Aug 8 doi: 10.1097/DSS.0000000000003891. PMID: 37556446
Nakamura Y, Fujisawa Y
Curr Treat Options Oncol 2018 Jun 27;19(8):42. doi: 10.1007/s11864-018-0560-y. PMID: 29951919

Recent clinical studies

Etiology

Roster K, Rajeh A, Wu F, Wan G, Thang C, Rashdan H, Nguyen N, Semenov YR
J Am Acad Dermatol 2023 Dec;89(6):1276-1279. Epub 2023 Aug 13 doi: 10.1016/j.jaad.2023.06.064. PMID: 37582472
Luu YT, Goldstein AM, Sargen MR
J Am Acad Dermatol 2023 Feb;88(2):433-434. Epub 2022 May 16 doi: 10.1016/j.jaad.2022.05.022. PMID: 35588927Free PMC Article
Brunsgaard EK, Wu YP, Grossman D
J Am Acad Dermatol 2023 Sep;89(3):445-456. Epub 2022 May 6 doi: 10.1016/j.jaad.2022.04.056. PMID: 35533771
Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705
Revuz J, Clerici T
J Am Acad Dermatol 1989 Apr;20(4):567-70. doi: 10.1016/s0190-9622(89)70064-5. PMID: 2715403

Diagnosis

Brunsgaard EK, Wu YP, Grossman D
J Am Acad Dermatol 2023 Sep;89(3):445-456. Epub 2022 May 6 doi: 10.1016/j.jaad.2022.04.056. PMID: 35533771
Usatine RP, Heath CR
J Fam Pract 2022 May;71(4):178-179. doi: 10.12788/jfp.0410. PMID: 35730705
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Liu XK, Li J
Lancet 2018 Jun 9;391(10137):e21. doi: 10.1016/S0140-6736(18)31071-7. PMID: 29900875
Revuz J, Clerici T
J Am Acad Dermatol 1989 Apr;20(4):567-70. doi: 10.1016/s0190-9622(89)70064-5. PMID: 2715403

Therapy

Nazir ZH, Haliasos HC, Busam KJ, Marchetti MA, Linos K, Marghoob AA
JAMA Dermatol 2023 Oct 1;159(10):1147-1149. doi: 10.1001/jamadermatol.2023.2669. PMID: 37672258
Straker RJ 3rd, Thaler AS, Shannon AB, Miura JT, Chu EY, Karakousis GC, Ming ME
J Am Acad Dermatol 2022 Jul;87(1):169-172. Epub 2021 Jul 10 doi: 10.1016/j.jaad.2021.06.887. PMID: 34252466
Wada M, Ito T, Tsuji G, Nakahara T, Hagihara A, Furue M, Uchi H
J Dermatol 2017 Aug;44(8):932-938. Epub 2017 Mar 24 doi: 10.1111/1346-8138.13834. PMID: 28342269
Stubblefield J, Kelly B
Surg Clin North Am 2014 Oct;94(5):1115-26, ix. Epub 2014 Aug 19 doi: 10.1016/j.suc.2014.07.008. PMID: 25245971
Robertson SJ, Leonard J, Chamberlain AJ
Australas J Dermatol 2010 Aug;51(3):220-2. doi: 10.1111/j.1440-0960.2010.00652.x. PMID: 20695869

Prognosis

Choi ME, Won CH, Chang SE, Lee MW, Lee WJ
J Am Acad Dermatol 2023 Feb;88(2):476-479. Epub 2022 Jun 17 doi: 10.1016/j.jaad.2022.06.026. PMID: 35724894
Darmawan CC, Jo G, Montenegro SE, Kwak Y, Cheol L, Cho KH, Mun JH
J Am Acad Dermatol 2019 Sep;81(3):805-812. Epub 2019 Feb 5 doi: 10.1016/j.jaad.2019.01.081. PMID: 30731177
Gong HZ, Zheng HY, Li J
Melanoma Res 2019 Jun;29(3):221-230. doi: 10.1097/CMR.0000000000000571. PMID: 30672881
Goydos JS, Shoen SL
Cancer Treat Res 2016;167:321-9. doi: 10.1007/978-3-319-22539-5_14. PMID: 26601870
Revuz J, Clerici T
J Am Acad Dermatol 1989 Apr;20(4):567-70. doi: 10.1016/s0190-9622(89)70064-5. PMID: 2715403

Clinical prediction guides

Mitre M, Hosein S, Mitri A, Kurtansky NR, Mancebo SE, Fonseca M, Jacobs AK, Rotemberg V, Marchetti MA
J Am Acad Dermatol 2024 Jul;91(1):146-148. Epub 2024 Mar 19 doi: 10.1016/j.jaad.2024.02.058. PMID: 38513834Free PMC Article
Lee TL, Lin MH, Liao YH, Liau JY, Sheen YS
J Formos Med Assoc 2022 Nov;121(11):2338-2344. Epub 2021 Dec 25 doi: 10.1016/j.jfma.2021.12.001. PMID: 34961669
Bernardes SS, Ferreira I, Elder DE, Nobre AB, Martínez-Said H, Adams DJ, Robles-Espinoza CD, Possik PA
J Pathol Clin Res 2021 Nov;7(6):531-541. Epub 2021 Jul 2 doi: 10.1002/cjp2.233. PMID: 34213090Free PMC Article
Robertson SJ, Leonard J, Chamberlain AJ
Australas J Dermatol 2010 Aug;51(3):220-2. doi: 10.1111/j.1440-0960.2010.00652.x. PMID: 20695869
Revuz J, Clerici T
J Am Acad Dermatol 1989 Apr;20(4):567-70. doi: 10.1016/s0190-9622(89)70064-5. PMID: 2715403

Recent systematic reviews

Tsai SY, Hamilton CE, Mologousis MA, Hawryluk EB
Pediatr Dermatol 2024 Jul-Aug;41(4):613-620. Epub 2024 Mar 18 doi: 10.1111/pde.15597. PMID: 38500311
Steeb T, Wessely A, Petzold A, Kohl C, Erdmann M, Berking C, Heppt MV
Eur J Cancer 2021 Nov;157:348-357. Epub 2021 Sep 22 doi: 10.1016/j.ejca.2021.08.015. PMID: 34562816
Häfliger EM, Ramelyte E, Mangana J, Kunz M, Kazakov DV, Dummer R, Cheng PF
Melanoma Res 2018 Oct;28(5):442-450. doi: 10.1097/CMR.0000000000000465. PMID: 29847461
Durbec F, Martin L, Derancourt C, Grange F
Br J Dermatol 2012 Apr;166(4):727-39. doi: 10.1111/j.1365-2133.2011.10772.x. PMID: 22175696

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