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Abnormal circulating gonadotropin concentration

MedGen UID:
892748
•Concept ID:
C4072886
•
Finding
Synonym: Abnormal circulating gonadotropin level
 
HPO: HP:0030338

Definition

An anomaly of the circulating level of a gonadotropin, that is, of a protein hormone secreted by gonadotrope cells of the anterior pituitary of vertebrates. The primary gonadotropins are luteinizing hormone (LH) and follicle-stimulating hormone (FSH). [from HPO]

Professional guidelines

PubMed

Circulating gonadotropin pattern in anorchia syndrome. Response to treatment.
Mendoza-Morfin F, Rodríguez-López M, Oliveros-Rodríguez A, Altamirano-Bustamante P, Navarrete-López R, Gutiérrez-Pérez H, Oseguera-Valladares R
Arch Invest Med (Mex) 1980;11(2):239-47. PMID: 6775612

Recent clinical studies

Etiology

Impaired forearm blood flow and vasodilator reserve in healthy postmenopausal women.
Mercuro G, Longu G, Zoncu S, Cherchi A
Am Heart J 1999 Apr;137(4 Pt 1):692-7. doi: 10.1016/s0002-8703(99)70225-5. PMID: 10097232
Circulating maternal corticotropin-releasing hormone and gonadotropin-releasing hormone in normal and abnormal pregnancies.
Sorem KA, Smikle CB, Spencer DK, Yoder BA, Graveson MA, Siler-Khodr TM
Am J Obstet Gynecol 1996 Oct;175(4 Pt 1):912-6. doi: 10.1016/s0002-9378(96)80024-x. PMID: 8885747
Aetiological factors involved in the low response to gonadotrophins in infertile women with normal basal serum follicle stimulating hormone levels.
Pellicer A, Ballester MJ, Serrano MD, Mir A, Serra-Serra V, Remohi J, Bonilla-Musoles FM
Hum Reprod 1994 May;9(5):806-11. doi: 10.1093/oxfordjournals.humrep.a138600. PMID: 7929726
Comparison of human chorionic gonadotrophin concentrations in the sera of patients with normal and abnormal pregnancy measured by radio-immunoassay and immunoradiometric assay.
Norman RJ, Buck RH, Joubert SM
S Afr Med J 1989 Apr 1;75(7):318-9. PMID: 2538933
Endocrine and immunogenetic evaluation of an XX male infant with perineoscrotal hypospadias.
Kofman-Alfaro S, Valdés E, Terán J, Wachtel SS, Chávez B, Bassol S, Medina M, Pérez-Palacios G
Acta Endocrinol (Copenh) 1985 Mar;108(3):421-7. doi: 10.1530/acta.0.1080421. PMID: 3920857

Diagnosis

Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism.
Aksglaede L, Christiansen P, Sørensen K, Boas M, Linneberg A, Main KM, Andersson AM, Skakkebaek NE, Juul A
Acta Paediatr 2011 Jun;100(6):839-45. Epub 2011 Feb 25 doi: 10.1111/j.1651-2227.2011.02148.x. PMID: 21251056
Prenatal sonographic features of fetuses in trisomy 13 pregnancies. IV.
Chen CP
Taiwan J Obstet Gynecol 2010 Mar;49(1):3-12. doi: 10.1016/S1028-4559(10)60002-2. PMID: 20466286
The growth without growth hormone syndrome.
Geffner ME
Endocrinol Metab Clin North Am 1996 Sep;25(3):649-63. doi: 10.1016/s0889-8529(05)70345-5. PMID: 8879991
Serum relaxin concentrations in patients with out-of-phase endometrial biopsies.
Stewart DR, Cragun JR, Boyers SP, Oi R, Overstreet JW, Lasley BL
Fertil Steril 1992 Feb;57(2):453-5. PMID: 1735502
Endocrine and immunogenetic evaluation of an XX male infant with perineoscrotal hypospadias.
Kofman-Alfaro S, Valdés E, Terán J, Wachtel SS, Chávez B, Bassol S, Medina M, Pérez-Palacios G
Acta Endocrinol (Copenh) 1985 Mar;108(3):421-7. doi: 10.1530/acta.0.1080421. PMID: 3920857

Therapy

Serum concentrations of Anti-Müllerian Hormone (AMH) in 95 patients with Klinefelter syndrome with or without cryptorchidism.
Aksglaede L, Christiansen P, Sørensen K, Boas M, Linneberg A, Main KM, Andersson AM, Skakkebaek NE, Juul A
Acta Paediatr 2011 Jun;100(6):839-45. Epub 2011 Feb 25 doi: 10.1111/j.1651-2227.2011.02148.x. PMID: 21251056
Indirect evidence of hormone abuse. Proof of doping?
Minuto F, Barreca A, Melioli G
J Endocrinol Invest 2003 Sep;26(9):919-23. doi: 10.1007/BF03345244. PMID: 14964446
Aetiological factors involved in the low response to gonadotrophins in infertile women with normal basal serum follicle stimulating hormone levels.
Pellicer A, Ballester MJ, Serrano MD, Mir A, Serra-Serra V, Remohi J, Bonilla-Musoles FM
Hum Reprod 1994 May;9(5):806-11. doi: 10.1093/oxfordjournals.humrep.a138600. PMID: 7929726
Absorption of 17 beta-estradiol in a neovagina constructed from the peritoneum.
Willemsen WN, Mastboom JL, Thomas CM, Rolland R
Eur J Obstet Gynecol Reprod Biol 1985 Apr;19(4):247-53. doi: 10.1016/0028-2243(85)90036-x. PMID: 3924675
Prolactin secretion in Parkinson disease.
Eisler T, Thorner MO, MacLeod RM, Kaiser DL, Calne DB
Neurology 1981 Oct;31(10):1356-9. doi: 10.1212/wnl.31.10.1356. PMID: 6810204

Prognosis

The utility of circulating LHCGR as a predictor of Down's syndrome in early pregnancy.
Chambers AE, Mills WE, Mercadé I, Crovetto F, Crispi F, Bodi LR, Pugia M, Mira A, Lasalvia L, Banerjee S, Casals E, Gratacos E
BMC Pregnancy Childbirth 2014 Jun 6;14:197. doi: 10.1186/1471-2393-14-197. PMID: 24906955Free PMC Article
Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve.
Merhi Z, Irani M, Doswell AD, Ambroggio J
J Clin Endocrinol Metab 2014 Feb;99(2):E226-33. Epub 2013 Nov 25 doi: 10.1210/jc.2013-3839. PMID: 24276462
Evidence for abnormal granulosa cell responsiveness to follicle-stimulating hormone in women with polycystic ovary syndrome.
Coffler MS, Patel K, Dahan MH, Malcom PJ, Kawashima T, Deutsch R, Chang RJ
J Clin Endocrinol Metab 2003 Apr;88(4):1742-7. doi: 10.1210/jc.2002-021280. PMID: 12679467
Diurnal variation of sex hormone binding globulin and insulin-like growth factor binding protein-1 in women with polycystic ovary syndrome.
Hamilton-Fairley D, White D, Griffiths M, Anyaoku V, Koistinen R, Seppälä M, Franks S
Clin Endocrinol (Oxf) 1995 Aug;43(2):159-65. doi: 10.1111/j.1365-2265.1995.tb01910.x. PMID: 7554310
Improvement of pituitary function after surgical decompression for pituitary tumor apoplexy.
Arafah BM, Harrington JF, Madhoun ZT, Selman WR
J Clin Endocrinol Metab 1990 Aug;71(2):323-8. doi: 10.1210/jcem-71-2-323. PMID: 2166068

Clinical prediction guides

MKRN3 circulating levels in Prader-Willi syndrome: a pilot study.
Mariani M, Fintini D, Cirillo G, Palumbo S, Del Giudice EM, Bocchini S, Manco M, Cappa M, Grandone A
J Endocrinol Invest 2022 Nov;45(11):2165-2170. Epub 2022 Jul 19 doi: 10.1007/s40618-022-01860-0. PMID: 35854182
Indirect evidence of hormone abuse. Proof of doping?
Minuto F, Barreca A, Melioli G
J Endocrinol Invest 2003 Sep;26(9):919-23. doi: 10.1007/BF03345244. PMID: 14964446
Impaired forearm blood flow and vasodilator reserve in healthy postmenopausal women.
Mercuro G, Longu G, Zoncu S, Cherchi A
Am Heart J 1999 Apr;137(4 Pt 1):692-7. doi: 10.1016/s0002-8703(99)70225-5. PMID: 10097232
Aetiological factors involved in the low response to gonadotrophins in infertile women with normal basal serum follicle stimulating hormone levels.
Pellicer A, Ballester MJ, Serrano MD, Mir A, Serra-Serra V, Remohi J, Bonilla-Musoles FM
Hum Reprod 1994 May;9(5):806-11. doi: 10.1093/oxfordjournals.humrep.a138600. PMID: 7929726
Endocrine and immunogenetic evaluation of an XX male infant with perineoscrotal hypospadias.
Kofman-Alfaro S, Valdés E, Terán J, Wachtel SS, Chávez B, Bassol S, Medina M, Pérez-Palacios G
Acta Endocrinol (Copenh) 1985 Mar;108(3):421-7. doi: 10.1530/acta.0.1080421. PMID: 3920857

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